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1. 发明授权

US07041634B2 Method of inhibiting immune system destruction of transplanted viable cells 失效
标题翻译：抑制移植活细胞免疫系统破坏的方法
公开(公告)号：US07041634B2
公开(公告)日：2006-05-09
申请号：US09049865
申请日：1998-03-27
申请人： Collin J. Weber , Mary K. Hagler , Peter S. Linsley , Judith A. Kapp , Susan A. Safley
发明人： Collin J. Weber , Mary K. Hagler , Peter S. Linsley , Judith A. Kapp , Susan A. Safley
IPC分类号： A61K38/00
CPC分类号： A61K9/5073 , A61K35/39 , A61K38/00 , A61K48/00 , C07K14/70521 , C07K2319/30 , C12N5/0676 , C12N5/0677 , Y10S424/812 , A61K2300/00
摘要： This invention provides a method of inhibiting viable cells transplanted into a subject from being destroyed by the subject's immune system which comprises: a) containing the viable cells, or tissue comprising the viable cells, prior to transplantation within a device comprising a semipermeable membrane; and b) treating the subject with a substance which inhibits an immune-system costimulation event in an amount effective to inhibit the subject's immune system from responding to said contained cells or tissue. In one embodiment, the substance which inhibits an immune-system costimulation event is CTLA4. Also provided by this invention is a method of treating diabetes in a subject which comprises: a) containing viable insulin-producing cells, or tissue comprising such cells, within a device comprising a semipermeable membrane; b) transplanting an effective amount of such contained viable insulin-producing cells into the subject; and c) treating the subject with an effective amount of a substance which inhibits an immune-system costimulation event.
摘要翻译：本发明提供一种抑制移植到受试者中的活细胞被受试者的免疫系统破坏的方法，该方法包括：a）在包含半透膜的装置内移植前含有活细胞或包含活细胞的组织; 和b）用抑制免疫系统共刺激事件的物质以有效抑制受试者的免疫系统对所述包含的细胞或组织的反应的物质治疗受试者。在一个实施方案中，抑制免疫系统共刺激事件的物质是CTLA4。本发明还提供了一种治疗受试者的糖尿病的方法，其包括：a）在包含半透膜的装置内含有存活的产生胰岛素的细胞或包含此类细胞的组织; b）将有效量的这种含有活体胰岛素的细胞移植到受试者中; 和c）用有效量的抑制免疫系统共刺激事件的物质治疗受试者。

2. 发明申请

US20140105974A1 COMPOSITIONS FOR ENCAPSULATING BIOMATERIALS AND USES RELATED THERETO 有权
标题翻译：用于包埋生物材料的组合物及其相关用途
公开(公告)号：US20140105974A1
公开(公告)日：2014-04-17
申请号：US14000471
申请日：2012-03-14
申请人： Collin J. Weber , Susan A. Safley , Kereen S. Gordon , Nicholas E. Simpson
发明人： Collin J. Weber , Susan A. Safley , Kereen S. Gordon , Nicholas E. Simpson
IPC分类号： A61K9/48 , A61K35/39
CPC分类号： A61K9/4891 , A61K35/39 , A61K47/6925
摘要： This disclosure relates to compositions and methods for encapsulating biomaterials such as cells to prevent immune responses. In certain embodiments the disclosure relates to capsules comprising a cell or cells gelled in alginate coated with a layer that prevents migration of immune molecules to the cell surface and an outer capsule layer comprising non-immunogenic material optionally containing immunosuppressive agents. In certain embodiments, the cells are capable of generating insulin that emanates from the capsule.
摘要翻译：本公开涉及包封生物材料例如细胞以防止免疫应答的组合物和方法。在某些实施方案中，本公开涉及包含细胞或细胞的胶囊，该细胞或细胞涂覆有防止免疫分子向细胞表面迁移的层的藻酸盐，以及包含任选含有免疫抑制剂的非免疫原性材料的外胶囊层。在某些实施方案中，细胞能够产生从胶囊发出的胰岛素。

3. 发明授权

US09901548B2 Compositions for encapsulating biomaterials and uses related thereto 有权
公开(公告)号：US09901548B2
公开(公告)日：2018-02-27
申请号：US14000471
申请日：2012-03-14
申请人： Collin J. Weber , Susan A. Safley , Kereen S. Gordon , Nicholas E. Simpson
发明人： Collin J. Weber , Susan A. Safley , Kereen S. Gordon , Nicholas E. Simpson
IPC分类号： A61K9/48 , A61K35/39 , A61K47/69
CPC分类号： A61K9/4891 , A61K35/39 , A61K47/6925
摘要： This disclosure relates to compositions and methods for encapsulating biomaterials such as cells to prevent immune responses. In certain embodiments, the disclosure relates to capsules comprising a cell or cells gelled in alginate coated with a layer that prevents migration of immune molecules to the cell surface and an outer capsule layer comprising non-immunogenic material optionally containing immunosuppressive agents. In certain embodiments, the cells are capable of generating insulin that emanates from the capsule.

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