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1. 发明授权

US08657775B2 Method of treating a subject suffering from end stage renal disease against cardiovascular disease 有权
标题翻译：治疗终末期肾病患者抗心血管疾病的方法
公开(公告)号：US08657775B2
公开(公告)日：2014-02-25
申请号：US12585054
申请日：2009-09-01
申请人： Colin Hutchison , Paul Cockwell , Hermann Göhl , Bernd Krause , Markus Storr
发明人： Colin Hutchison , Paul Cockwell , Hermann Göhl , Bernd Krause , Markus Storr
IPC分类号： A61M1/14 , A61M1/18 , A61M1/34 , B01D61/24 , B01D61/28 , B01D69/08 , B01D63/02
CPC分类号： B01D61/243 , A61M1/16 , B01D67/0013 , B01D69/08 , B01D69/12 , B01D2325/022 , B01D2325/20
摘要： The present invention relates to high cut-off hemodialysis membranes for the treatment of chronic hemodialysis (CHD) patients, with the potential to improve long-term survival of these patients by reducing the risk of cardiovascular disease, through down-regulation of monocyte activation in the blood. Monocytes are the major circulating blood cells involved in the progression of cardiovascular disease. High cut-off hemodialysis in chronic dialysis patients results in a sustained decrease in expression of monocyte cell-surface proteins that direct the movement of these cells from the blood to the walls of blood vessels, where they promote the progression of arterial disease (atherosclerosis) that leads to cardiovascular disease (CVD); heart disease, strokes and peripheral vascular disease.
摘要翻译：本发明涉及用于治疗慢性血液透析（CHD）患者的高截止血液透析膜，可通过降低心血管疾病的风险来改善这些患者的长期存活，通过下调单核细胞活化血液。单核细胞是涉及心血管疾病进展的主要循环血细胞。慢性透析患者的高截止血液透析导致单核细胞表面蛋白质的表达持续下降，从而将这些细胞从血液移动到血管壁，在那里它们促进动脉疾病（动脉粥样硬化）的进展，导致心血管疾病（CVD）; 心脏病，中风和外周血管疾病。

2. 发明申请

US20100084339A1 High cut-off hemodialysis membranes for the treatment of chronic hemodialysis patients 有权
标题翻译：高截止血液透析膜用于治疗慢性血液透析患者
公开(公告)号：US20100084339A1
公开(公告)日：2010-04-08
申请号：US12585054
申请日：2009-09-01
申请人： Colin Hutchison , Paul Cockwell , Hermann Göhl , Bernd Krause , Markus Storr
发明人： Colin Hutchison , Paul Cockwell , Hermann Göhl , Bernd Krause , Markus Storr
IPC分类号： B01D61/32
CPC分类号： B01D61/243 , A61M1/16 , B01D67/0013 , B01D69/08 , B01D69/12 , B01D2325/022 , B01D2325/20
摘要： The present invention relates to high cut-off hemodialysis membranes for the treatment of chronic hemodialysis (CHD) patients, with the potential to improve long-term survival of these patients by reducing the risk of cardiovascular disease, through down-regulation of monocyte activation in the blood. Monocytes are the major circulating blood cells involved in the progression of cardiovascular disease. High cut-off hemodialysis in chronic dialysis patients results in a sustained decrease in expression of monocyte cell-surface proteins that direct the movement of these cells from the blood to the walls of blood vessels, where they promote the progression of arterial disease (atherosclerosis) that leads to cardiovascular disease (CVD); heart disease, strokes and peripheral vascular disease.
摘要翻译：本发明涉及用于治疗慢性血液透析（CHD）患者的高截止血液透析膜，可通过降低心血管疾病的风险来改善这些患者的长期存活，通过下调单核细胞活化血液。单核细胞是涉及心血管疾病进展的主要循环血细胞。慢性透析患者的高截止血液透析导致单核细胞表面蛋白质的表达持续下降，从而将这些细胞从血液移动到血管壁，在那里它们促进动脉疾病（动脉粥样硬化）的进展，导致心血管疾病（CVD）; 心脏病，中风和外周血管疾病。

3. 发明授权

US07968153B2 Continuous method for production of a regioselective porous hollow fibre membrane 有权
标题翻译：连续法生产区域选择性多孔中空纤维膜
公开(公告)号：US07968153B2
公开(公告)日：2011-06-28
申请号：US11631786
申请日：2005-07-04
申请人： Bernd Krause , Hermann Göhl , Christoph Beck , Jürgen Dannenmaier , Michael Müller , Edmund Kurz , Heinrich Malthaner , Christian Oehr , Markus Storr
发明人： Bernd Krause , Hermann Göhl , Christoph Beck , Jürgen Dannenmaier , Michael Müller , Edmund Kurz , Heinrich Malthaner , Christian Oehr , Markus Storr
IPC分类号： B01D39/00 , B01D67/00 , H05H1/00
CPC分类号： B01D61/00 , B01D67/0093 , B01D69/02 , B01D69/08 , B01D71/68 , B01D2323/38 , B01J20/261 , B01J20/262 , B01J20/265 , B01J20/28004 , B01J20/28021 , B01J20/28023 , B01J20/28033 , B01J20/28069 , B01J20/28085 , B01J20/3085 , B01J20/321 , B01J20/3212 , B01J20/3217 , B01J20/3219 , B01J20/3248 , B01J20/3253 , B01J20/3274 , B01J2220/445
摘要： A continuous method for production of a porous hollow fibre membrane having regioselective affinity for compounds in blood or other biologically active fluids to be removed during purification of blood or said fluids is disclosed, as well as a porous hollow fibre membrane produced by said method, an adsorption device containing such a porous hollow fibre membrane, and use of such a porous hollow fibre membrane.
摘要翻译：公开了一种用于生产在血液或所述流体净化期间除去的血液或其它生物活性流体中的化合物的区域选择性亲和性的多孔中空纤维膜的连续方法，以及通过所述方法制备的多孔中空纤维膜，含有这种多孔中空纤维膜的吸附装置，以及这种多孔中空纤维膜的使用。

4. 发明授权

US07644825B2 Membrane and use thereof 失效
标题翻译：膜及其用途
公开(公告)号：US07644825B2
公开(公告)日：2010-01-12
申请号：US10532131
申请日：2003-10-17
申请人： Bernd Krause , Matthias Wessling , Hermann Göhl , Markus Storr
发明人： Bernd Krause , Matthias Wessling , Hermann Göhl , Markus Storr
IPC分类号： B01D71/06 , B01D71/68 , B01D71/28 , B01D71/00
CPC分类号： B01D67/002 , B01D67/0083 , B01D69/02 , B01D71/68 , B01D71/80 , B01D2325/36 , B29C44/3403
摘要： The membrane producible by shaping a polymer blend or a block copolymer comprising blocks of monomer units, loading the polymer blend or block copolymer with a blowing gas concentration within the polymer blend or block polymer above a critical concentration at a temperature below a critical temperature, but above the glass transition temperature of the polymer blend/gas or block copolymer/gas mixture and finally stabilizing the foam structure is characterized in that as polymer blend a homogeneous polymer blend comprising at least one hydrophilic and at least one hydrophobic polymer and/or a block copolymer of alternating blocks of hydrophilic and hydrophobic monomer units is used, both the polymer blend and the block copolymer having a solubility relating to the used foaming gas above the critical concentration. The said membrane is used for medical purposes, especially for the haemodialysis, haemofiltration, haemodiafiltration, plasmapherese, immunotherapy, micro- or ultrafiltration or gas separation.
摘要翻译：该膜可以通过将包含单体单元的嵌段的聚合物共混物或嵌段共聚物成型，将聚合物共混物或嵌段共聚物以高于临界温度的临界浓度的聚合物共混物或嵌段聚合物内的吹入气体浓度加载，高于聚合物共混物/气体或嵌段共聚物/气体混合物的玻璃化转变温度，并且最终稳定泡沫结构的特征在于，作为聚合物共混物，包含至少一种亲水和至少一种疏水性聚合物和/或嵌段的均匀聚合物共混物使用亲水和疏水单体单元的交替嵌段的共聚物，聚合物共混物和嵌段共聚物具有高于临界浓度的所用发泡气体的溶解度。所述膜用于医疗目的，特别用于血液透析，血液透析，血液透析，血浆置换，免疫治疗，微量或超滤或气体分离。

5. 发明申请

US20120208256A1 ENZYME-FUNCTIONALIZED SUPPORTS 审中-公开
标题翻译：酶功能化支持
公开(公告)号：US20120208256A1
公开(公告)日：2012-08-16
申请号：US13503204
申请日：2010-10-20
申请人： Ralf Flieg , Manuela Klotz , Markus Storr , Martin Rempfer , Wolfgang Freudemann , Cornelia Winz , Bernd Krause , Markus Hornung
发明人： Ralf Flieg , Manuela Klotz , Markus Storr , Martin Rempfer , Wolfgang Freudemann , Cornelia Winz , Bernd Krause , Markus Hornung
IPC分类号： C12N11/06 , C12N11/02
CPC分类号： C12N9/18 , C09D133/14 , C12N9/80 , C12N11/06 , C12N11/08
摘要： An immobilized enzyme comprises a solid support, an enzyme linked to the solid support and a spacer for coupling the enzyme to the solid support. A method for the production of immobilized enzymes comprises: providing a solid support having amino-functional groups coupled to the support surface; covalently coupling the amino-functional groups with a thermally labile radical initiator; and, contacting the support surface with a solution of polymerizable monomers. The polymerizable monomers comprise functional groups which do not take part in radical polymerization, under conditions where thermally initiated graft copolymerization of the monomers takes place, to form polymer chains on the surface of the support. If the polymer chains do not already comprise primary amino-functional groups, the method further comprises transforming the functional groups in the polymer chains into groups comprising primary amino-functional groups. The method further comprises coupling the enzyme to amino-functional groups of the polymer chains.
摘要翻译：固定化酶包括固体支持物，与固体支持物连接的酶和用于将酶偶联到固体支持物的间隔物。制备固定化酶的方法包括：提供具有与支持表面偶联的氨基官能团的固体支持物; 将氨基官能团与热不稳定的自由基引发剂共价偶联; 并且使支撑体表面与可聚合单体的溶液接触。可聚合单体包括在发生单体的热引发接枝共聚的条件下不参与自由基聚合的官能团，以在载体的表面上形成聚合物链。如果聚合物链不包括伯氨基官能团，则该方法还包括将聚合物链中的官能团转化为包含伯氨基官能团的基团。该方法还包括将酶偶联到聚合物链的氨基官能团。

6. 发明申请

US20130137784A1 GRAFT COPOLYMERS 有权
标题翻译： GRAFT共聚物
公开(公告)号：US20130137784A1
公开(公告)日：2013-05-30
申请号：US13583827
申请日：2011-03-09
申请人： Bernd Krause , Hermann Goehl , Markus Storr , Ralf Menda , Hans-Georg Herz , Joerg Williardt
发明人： Bernd Krause , Hermann Goehl , Markus Storr , Ralf Menda , Hans-Georg Herz , Joerg Williardt
IPC分类号： C08F271/02
CPC分类号： C08F271/02 , B01D67/0011 , B01D67/0016 , B01D71/44 , B01D71/68 , B01D71/78 , B01D2323/08 , B01D2323/38 , C08G81/024 , C08L39/06 , C08L81/06 , C08L2666/04
摘要： Graft copolymers of hydrophobic polymers and hydrophilic polymers, a method for their preparation, and their use in membranes for medical treatments such as hemodialysis, hemodiafiltration and hemofiltration, in membranes for water purification, and in membranes for bioprocessing.
摘要翻译：疏水性聚合物和亲水性聚合物的接枝共聚物，其制备方法以及它们用于医疗处理如血液透析，血液透析滤过和血液滤过的膜，用于水净化的膜和用于生物处理的膜中的用途。

7. 发明申请

US20070296105A1 Continuous Method For Production Of A Regioselective Porous Hollow Fibre Membrane 有权
标题翻译：连续法制备区域选择性多孔中空纤维膜
公开(公告)号：US20070296105A1
公开(公告)日：2007-12-27
申请号：US11631786
申请日：2005-07-04
申请人： Bernd Krause , Hermann Gohl , Christoph Beck , Jurgen Dannenmaier , Michael Muller , Edmund Kurz , Heinrich Malthaner , Christian Oehr , Markus Storr
发明人： Bernd Krause , Hermann Gohl , Christoph Beck , Jurgen Dannenmaier , Michael Muller , Edmund Kurz , Heinrich Malthaner , Christian Oehr , Markus Storr
IPC分类号： B01D69/08 , B01D67/00
CPC分类号： B01D61/00 , B01D67/0093 , B01D69/02 , B01D69/08 , B01D71/68 , B01D2323/38 , B01J20/261 , B01J20/262 , B01J20/265 , B01J20/28004 , B01J20/28021 , B01J20/28023 , B01J20/28033 , B01J20/28069 , B01J20/28085 , B01J20/3085 , B01J20/321 , B01J20/3212 , B01J20/3217 , B01J20/3219 , B01J20/3248 , B01J20/3253 , B01J20/3274 , B01J2220/445
摘要： A continuous method for production of a porous hollow fibre membrane having regioselective affinity for compounds in blood or other biologically active fluids to be removed during purification of blood or said fluids is disclosed, as well as a porous hollow fibre membrane produced by said method, an adsorption device containing such a porous hollow fibre membrane, and use of such a porous hollow fibre membrane.
摘要翻译：公开了一种用于生产在血液或所述流体净化期间除去的血液或其它生物活性流体中的化合物的区域选择性亲和性的多孔中空纤维膜的连续方法，以及通过所述方法制备的多孔中空纤维膜，含有这种多孔中空纤维膜的吸附装置，以及这种多孔中空纤维膜的使用。

8. 发明授权

US11478757B2 High cut-off hemodialysis membrane for use in liver dialysis 有权
公开(公告)号：US11478757B2
公开(公告)日：2022-10-25
申请号：US13578161
申请日：2011-04-13
申请人： Markus Storr , Bernd Krause , Hermann Goehl , Thomas Ertl , Alexander Gekeler
发明人： Markus Storr , Bernd Krause , Hermann Goehl , Thomas Ertl , Alexander Gekeler
IPC分类号： B01D69/08 , A61M1/16 , B01D67/00 , B01D71/68
摘要： A system for liver dialysis makes use of a high cut-off hemodialysis membrane for removing water-soluble and protein-bound toxins from the blood of a person in need. A high cut-off hollow fiber hemodialysis membrane has improved potential to remove albumin-bound toxins and inflammatory mediators.

9. 发明授权

US08748538B2 Graft copolymers 有权
标题翻译：接枝共聚物
公开(公告)号：US08748538B2
公开(公告)日：2014-06-10
申请号：US13583827
申请日：2011-03-09
申请人： Bernd Krause , Hermann Goehl , Markus Storr , Ralf Menda , Hans-Georg Herz , Joerg Williardt
发明人： Bernd Krause , Hermann Goehl , Markus Storr , Ralf Menda , Hans-Georg Herz , Joerg Williardt
IPC分类号： B01D71/68 , C08F271/02
CPC分类号： C08F271/02 , B01D67/0011 , B01D67/0016 , B01D71/44 , B01D71/68 , B01D71/78 , B01D2323/08 , B01D2323/38 , C08G81/024 , C08L39/06 , C08L81/06 , C08L2666/04
摘要： Graft copolymers of hydrophobic polymers and hydrophilic polymers, a method for their preparation, and their use in membranes for medical treatments such as hemodialysis, hemodiafiltration and hemofiltration, in membranes for water purification, and in membranes for bioprocessing.
摘要翻译：疏水性聚合物和亲水性聚合物的接枝共聚物，其制备方法以及它们用于医疗处理如血液透析，血液透析滤过和血液滤过的膜，用于水净化的膜和用于生物处理的膜中的用途。

10. 发明申请

US20120305486A1 HIGH CUT-OFF HEMODIALYSIS MEMBRANE FOR USE IN LIVER DIALYSIS 审中-公开
标题翻译：高切割血液透析膜用于肝脏透析
公开(公告)号：US20120305486A1
公开(公告)日：2012-12-06
申请号：US13578161
申请日：2011-04-13
申请人： Markus Storr , Bernd Krause , Hermann Goehl , Thomas Ertl , Alexander Gekeler
发明人： Markus Storr , Bernd Krause , Hermann Goehl , Thomas Ertl , Alexander Gekeler
IPC分类号： A61M1/16 , B01D61/24 , B01D69/08 , B82Y30/00
CPC分类号： B01D67/0009 , A61M1/16 , A61M1/1696 , A61M2210/1071 , B01D69/08 , B01D69/087 , B01D71/68 , B01D2325/20
摘要： A system for liver dialysis makes use of a high cut-off hemodialysis membrane for removing water-soluble and protein-bound toxins from the blood of a person in need. A high cut-off hollow fiber hemodialysis membrane has improved potential to remove albumin-bound toxins and inflammatory mediators.
摘要翻译：用于肝透析的系统使用高截止血液透析膜来从需要的人的血液中除去水溶性和蛋白质结合的毒素。高截止的中空纤维血液透析膜具有改善去除白蛋白结合毒素和炎性介质的潜力。

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