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1. 发明授权

US4840895A Monoclonal antibodies reactive with immune complexes 失效
标题翻译：与免疫复合物反应的单克隆抗体
公开(公告)号：US4840895A
公开(公告)日：1989-06-20
申请号：US803137
申请日：1985-11-18
申请人： Colin H. Self
发明人： Colin H. Self
IPC分类号： G01N33/543 , A61K39/00 , A61K39/395 , C07K14/005 , C07K14/195 , C07K16/00 , C07K16/42 , C07K19/00 , C12N15/00 , C12N15/02 , C12P21/00 , C12P21/08 , C12Q1/00 , C12R1/91 , G01N33/53 , G01N33/531 , G01N33/564 , G01N33/573 , G01N33/577
CPC分类号： G01N33/564 , C07K16/42 , G01N33/531 , Y10S436/80 , Y10S436/804 , Y10S436/805 , Y10S436/808 , Y10S530/808 , Y10S530/866
摘要： A secondary monoclonal antibody against a complex of a molecule of molecular weight less than 5000 and a binding protein against said molecule which secondary monoclonal antibody is not an antibody against molecule or against its binding protein.
摘要翻译： PCT No.PCT / GB85 / 00120 Sec。 371日期：1985年11月18日 102（e）1985年11月18日PCT PCT Fils 3月29日，PCT PCT。第WO85 / 04422号公报 1985年10月10日。针对分子量小于5000的分子的复合物的二级单克隆抗体和针对所述分子的结合蛋白，该次级单克隆抗体不是针对分子或其结合蛋白的抗体。

2. 发明授权

US5616503A Determination of haptens 失效
标题翻译：半抗原的测定
公开(公告)号：US5616503A
公开(公告)日：1997-04-01
申请号：US256525
申请日：1994-07-15
申请人： Colin H. Self
发明人： Colin H. Self
IPC分类号： G01N33/543 , G01N33/577 , G01N33/74
CPC分类号： G01N33/54306 , G01N33/577 , G01N33/743 , Y10S436/817 , Y10S436/822 , Y10S436/824 , Y10S436/825
摘要： A method of determining a hapten which comprises: (1) contacting the sample which contains or may contain the hapten with a first binding partner which binds the hapten; (2) separating the hapten bound to the first binding partner from material which is not bound by the first binding partner; (3) contacting the hapten bound to the first binding partner with a second binding partner which binds the hapten; and (4) assaying the hapten bound to a binding partner as is described. Kits are also described.
摘要翻译： PCT No.PCT / GB93 / 00100 Sec。 371日期1994年7月15日 102（e）日期1994年7月15日PCT提交1993年1月15日PCT公布。公开号WO93 / 14404 日期：1993年7月22日一种测定半抗原的方法，包括：（1）将含有或可含有半抗原的样品与结合半抗原的第一结合配偶体接触; （2）将与第一结合配偶体结合的半抗原与不受第一结合配偶体结合的材料分离; （3）使与第一结合伴侣结合的半抗原与结合半抗原的第二结合配偶体接触; 和（4）如所述，测定与结合配偶体结合的半抗原。还描述了套件。

3. 发明授权

US4446231A Immunoassay using an amplified cyclic detection system 失效
标题翻译：免疫测定使用放大循环检测系统
公开(公告)号：US4446231A
公开(公告)日：1984-05-01
申请号：US307600
申请日：1981-10-01
申请人： Colin H. Self
发明人： Colin H. Self
IPC分类号： C12Q1/48 , C12Q1/50 , G01N33/53 , G01N33/58 , G01N33/54
CPC分类号： C12Q1/48 , C12Q1/50 , G01N33/53 , G01N33/581 , Y10S435/81 , Y10S435/966
摘要： An immunoassay is disclosed where the label is an enzyme which converts a precursor into a cycling factor which in turn is interconverted in a cycling detection system. The detection system is amplified by the enzyme label constantly increasing the amount of cycling factors in the system. The system of NADP to NAD with NAD cycling to NADH and back is preferred.
摘要翻译：公开了免疫测定，其中标记是将前体转化为循环因子的酶，循环因子又循环在循环检测系统中。检测系统通过酶标标扩增，不断增加系统中循环因子的数量。 NADP与NAD循环至NADH和后退的NADP体系是优选的。

4. 发明授权

US4769321A Assay method and reagent therefor 失效
标题翻译：测定方法和试剂
公开(公告)号：US4769321A
公开(公告)日：1988-09-06
申请号：US853916
申请日：1986-04-21
申请人： Colin H. Self
发明人： Colin H. Self
IPC分类号： G01N33/53 , G01N33/58 , G01N33/54 , C12Q1/32 , C12Q1/42
CPC分类号： G01N33/581 , Y10S435/81 , Y10S435/966 , Y10S435/975
摘要： Enzymatic assays are described which enable the detection of inter alia enzymes, cofactors and substrates in small quantity with the ability to produce a visually detectable change.

5. 发明授权

US4595655A Assay method and reagent therefor 失效
标题翻译：测定方法和试剂
公开(公告)号：US4595655A
公开(公告)日：1986-06-17
申请号：US448369
申请日：1982-12-09
申请人： Colin H. Self
发明人： Colin H. Self
IPC分类号： C12Q1/48 , C12Q1/50 , G01N33/53 , G01N33/58
CPC分类号： C12Q1/48 , C12Q1/50 , G01N33/53 , G01N33/581 , Y10S435/81 , Y10S435/966
摘要： The present invention provides a method for determining a ligand or receptor which comprises carrying out an assay for the ligand or receptor, the assay requiring a labelled component, wherein the labelled component is a conjugate between a ligand or a receptor and a primary enzyme that is itself capable of producing or removing a modulator for a secondary system or that is the first enzyme in an enzyme system that is capable of producing or removing a modulator for a secondary system, and determining that portion of labelled component to be determined by allowing the primary enzyme and any other enzymes in the enzyme system, to produce or remove the modulator for the secondary system, allowing the secondary system to function in the presence or absence as appropriate of the modulator, and determining a product of the secondary system.
摘要翻译：本发明提供了一种用于测定配体或受体的方法，其包括对配体或受体进行测定，所述测定需要标记的组分，其中标记的组分是配体或受体与主要酶之间的缀合物，其为本身能够产生或除去二级体系的调节剂，或者是能够产生或除去二级体系的调节剂的酶体系中的第一种酶，并且通过允许一级酶和酶系统中的任何其它酶，以产生或除去用于二次系统的调节剂，允许二级体系在调节剂存在或不存在的情况下起作用，并确定次级体系的产物。

6. 发明授权

US5468651A Method for determining haptens, use of method and components useful in method 失效
标题翻译：用于确定半抗原的方法，方法和组分的使用在方法中有用
公开(公告)号：US5468651A
公开(公告)日：1995-11-21
申请号：US276766
申请日：1994-07-18
申请人： Colin H. Self
发明人： Colin H. Self
IPC分类号： G01N33/53 , G01N33/543
CPC分类号： G01N33/54306 , G01N33/53 , Y10S435/965 , Y10S435/971 , Y10S436/822
摘要： A method is described for determining a hapten which method comprises (i) contacting the hapten with a binding partner of the hapten, whereby the hapten becomes bound to some of the binding partner, (ii) contacting the unbound binding partner with a secondary binding partner therefor, (iii) contacting the binding partner with an antibody which binds the binding partner which has bound thereto the hapten but which does not bind the binding partner which has bound thereto its secondary binding partner; and (iv) determining the amount of antibody bound to the binding partner. Kits for use in the method are also described.
摘要翻译：描述了用于确定半抗原的方法，该方法包括（i）使半抗原与半抗原的结合配偶体接触，由此半抗原结合到一些结合配偶体，（ii）使未结合的结合配偶体与次级结合配偶体（iii）使结合配偶体与结合结合配偶体的抗体接触，所述结合配偶体与所述半抗原结合，但不结合结合配偶体与其结合配偶体结合; 和（iv）测定与结合配偶体结合的抗体的量。还描述了用于该方法的试剂盒。

7. 发明授权

US4956303A Secondary antibodies against complexes of small molecules and binding partners therefor, their preparation, and their use in diagnostic methods 失效
标题翻译：针对小分子及其结合配偶体的复合物的二抗，其制备及其在诊断方法中的应用
公开(公告)号：US4956303A
公开(公告)日：1990-09-11
申请号：US43377
申请日：1987-04-28
申请人： Colin H. Self
发明人： Colin H. Self
IPC分类号： C07K16/42 , G01N33/53
CPC分类号： G01N33/53 , C07K16/4208 , Y10S530/866
摘要： A secondary antibody capable of stabilizing the binding of a small molecule to its binding protein is described which secondary antibody is capable of binding said binding protein in the presence of an in the absence of the small molecule but is not capable of binding said small molecule in the absence of binding protein. Such antibodies may be obtained by forming a complex between a small molecule and its binding protein, using the complex to raise antibodies and selecting the antibodies. The antibodies may be used in competitive assays in which it is desired to improve the binding of a small molecule or labelled small molecule to its binding protein.
摘要翻译：描述了能够稳定小分子与其结合蛋白的结合的二级抗体，其中二抗能够在不存在小分子但不能结合所述小分子的情况下结合所述结合蛋白没有结合蛋白。这样的抗体可以通过在小分子与其结合蛋白之间形成复合物，使用复合物来产生抗体并选择抗体来获得。抗体可以用于需要改进小分子或标记的小分子与其结合蛋白的结合的竞争性测定中。

8. 发明授权

US4828985A Antibodies against the complex of a small molecule and its binding protein, their preparation and their use in diagnostic methods 失效
标题翻译：针对小分子及其结合蛋白的复合物的抗体及其制备及其在诊断方法中的应用
公开(公告)号：US4828985A
公开(公告)日：1989-05-09
申请号：US832710
申请日：1986-02-07
申请人： Colin H. Self
发明人： Colin H. Self
IPC分类号： A61K39/00 , G01N33/53 , G01N33/531 , G01N33/532
CPC分类号： G01N33/53 , G01N33/531 , Y10S435/81 , Y10S436/805 , Y10S436/808 , Y10S530/866
摘要： The invention involves polyclonal antibodies reactive with a complex of a hapten and its binding protein, wherein the antibodies are unreactive with the free hapten or free binding protein. The antibodies are useful in assays of the hapten or the binding protein.
摘要翻译： PCT No.PCT / GB85 / 00255 Sec。 371日期1986年2月7日第 102（e）日期1986年2月7日PCT提交1985年6月11日PCT公布。第WO86 / 00140号公报日期1986年1月3日。本发明涉及与半抗原及其结合蛋白的复合体反应的多克隆抗体，其中抗体与游离半抗原或游离结合蛋白不反应。该抗体可用于半抗原或结合蛋白的测定。

9. 发明授权

US4598042A Immunoassay with an increasing cyclic detection system 失效
标题翻译：免疫测定与循环检测系统不断增加
公开(公告)号：US4598042A
公开(公告)日：1986-07-01
申请号：US559489
申请日：1983-12-08
申请人： Colin H. Self
发明人： Colin H. Self
IPC分类号： G01N33/53 , G01N33/58 , C12Q1/32 , C12Q1/42 , G01N33/543
CPC分类号： G01N33/581 , Y10S435/81 , Y10S435/966 , Y10S435/975
摘要： An immunoassay uses an antibody or antigen -enzyme conjugate which converts a precursor to a cycling agent used in a cycling detection system. The amount of cycling agent is continually increased permitting amplification. The prefered system converts NADP to NAD using the conjugate label and the cycling system interconverts NAD and NADH.
摘要翻译：免疫测定使用将前体转化为循环检测系统中使用的循环剂的抗体或抗原 - 酶联结物。循环剂的量不断增加，允许扩增。优选的系统使用共轭标记将NADP转化为NAD，循环系统将NAD和NADH相互转化。

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