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1. 发明授权

US10350309B2 Methods of preparing ophthalmic formulations and uses of same 有权
公开(公告)号：US10350309B2
公开(公告)日：2019-07-16
申请号：US15864679
申请日：2018-01-08
申请人： Cognoptix, Inc.
发明人： Haresh Bhagat , Gerald D. Cagle , Francis X. Smith , Paul D. Hartung
IPC分类号： A61K49/00 , A61K9/00 , A61K47/06
摘要： The present invention relates to a process for preparing an ointment comprising subjecting a mixture of a fluorescent molecular rotor compound, mineral oil, and grinding media to ball milling agitation and combining this mixture with a hydrophobic vehicle for an ointment. The invention also relates to an ophthalmic formulation comprising a pharmaceutically acceptable carrier and a compound of the following structural Formula (I), or a pharmaceutically acceptable salt thereof: Values and preferred values of the variables in structural Formula (I) are described herein.

2. 发明申请

US20130114042A1 Ocular Imaging 审中-公开
标题翻译：眼睛成像
公开(公告)号：US20130114042A1
公开(公告)日：2013-05-09
申请号：US13732940
申请日：2013-01-02
申请人： COGNOPTIX, INC.
发明人： Lee E. Goldstein , Norman C. Ford , Leo T. Chylack, Jr. , Paul D. Hartung , Marc D. Friedman , Evan A. Sherr , Stephen D. Fantone
IPC分类号： A61B3/14
CPC分类号： A61B3/14 , A61B3/117
摘要： A system for performing quasi-elastic light scattering and fluorescent ligand scanning on a subject's eye includes a light source configured to transmit light toward the subject's eye, a lens configured to focus light sent from the source and scattered by the subject's eye, a measurement reflector disposed to receive at least a portion of the focused light and configured to reflect a first portion of the received light, a camera configured and disposed to receive the first portion of the received light and configured to provide indicia of an image corresponding to the first portion of the received light, and a processor coupled to the camera and configured to analyze intensities of light in the image to determine a location of a reference point corresponding to an interface of a portion of the eye.
摘要翻译：用于在受试者的眼睛上执行准弹性光散射和荧光配体扫描的系统包括：被配置为朝向被检者的眼睛透射光的光源;被配置为聚焦从源发射并被受检者眼睛散射的光的透镜;测量反射器被配置为接收聚焦光的至少一部分并且被配置为反射接收到的光的第一部分;配置和设置成接收所接收的光的第一部分并被配置为提供对应于第一部分的图像的标记的照相机以及耦合到相机并被配置为分析图像中的光的强度以确定与眼睛的一部分的界面相对应的参考点的位置的处理器。

3. 发明授权

US09451909B2 System and method for detecting amyloid proteins 有权
公开(公告)号：US09451909B2
公开(公告)日：2016-09-27
申请号：US14955853
申请日：2015-12-01
申请人： Cognoptix, Inc.
发明人： Paul D. Hartung , Vincent Valvo , Charles Kerbage , Gerald D. Cagle , Dennis J. Nilan
IPC分类号： A61B3/10 , A61B3/00 , A61B3/14 , A61B5/145 , A61B5/1455 , A61B5/00 , A61B3/107
CPC分类号： A61B5/14546 , A61B3/0008 , A61B3/1005 , A61B3/107 , A61B3/111 , A61B3/117 , A61B3/1173 , A61B3/135 , A61B5/0068 , A61B5/0071 , A61B5/1455 , A61B5/4088 , A61B5/6821 , A61B2562/0238 , A61B2562/0242
摘要： In accordance with an embodiment of the invention, there is provided a device and method for detecting an amyloid protein in an eye of a mammal. A method comprises illuminating the eye with a light source having at least one of a wavelength property, a polarization property or a combination thereof, each appropriate to produce fluorescence in at least an amyloid-binding compound when the amyloid-binding compound is bound to the amyloid protein, the amyloid-binding compound having been introduced to the eye and specifically binding to the amyloid protein indicative of the amyloidogenic disorder; and determining a time decay rate of fluorescence for at least the fluorescence produced by the amyloid-binding compound bound to the amyloid protein, the determining permitting distinguishing of the presence of the amyloid-binding compound bound to the amyloid protein in the eye based on at least the time decay rate.

4. 发明申请

US20150118163A1 Methods of Preparing Ophthalmic Formulations and Uses of Same 审中-公开
标题翻译：制备眼用配方及其用途的方法
公开(公告)号：US20150118163A1
公开(公告)日：2015-04-30
申请号：US14528077
申请日：2014-10-30
申请人： Cognoptix, Inc.
发明人： Haresh Bhagat , Gerald D. Cagle , Francis X. Smith , Paul D. Hartung
IPC分类号： A61K49/00
CPC分类号： A61K49/0021 , A61K9/0048 , A61K47/06
摘要： The present invention relates to a process for preparing an ointment comprising subjecting a mixture of a fluorescent molecular rotor compound, mineral oil, and grinding media to ball milling agitation and combining this mixture with a hydrophobic vehicle for an ointment. The invention also relates to an ophthalmic formulation comprising a pharmaceutically acceptable carrier and a compound of the following structural Formula (I), or a pharmaceutically acceptable salt thereof: Values and preferred values of the variables in structural Formula (I) are described herein.
摘要翻译：本发明涉及一种制备软膏的方法，包括使荧光分子转子化合物，矿物油和研磨介质的混合物进行球磨搅拌，并将该混合物与用于软膏的疏水性载体组合。本发明还涉及包含药学上可接受的载体和以下结构式（I）的化合物或其药学上可接受的盐的眼用制剂：本文描述了结构式（I）中变量的值和优选值。

5. 发明申请

US20180126008A1 Methods Of Preparing Ophthalmic Formulations And Uses Of Same 审中-公开
公开(公告)号：US20180126008A1
公开(公告)日：2018-05-10
申请号：US15864679
申请日：2018-01-08
申请人： Cognoptix, Inc.
发明人： Haresh Bhagat , Gerald D. Cagle , Francis X. Smith , Paul D. Hartung
IPC分类号： A61K49/00 , A61K47/06 , A61K9/00
CPC分类号： A61K49/0021 , A61K9/0048 , A61K47/06
摘要： The present invention relates to a process for preparing an ointment comprising subjecting a mixture of a fluorescent molecular rotor compound, mineral oil, and grinding media to ball milling agitation and combining this mixture with a hydrophobic vehicle for an ointment. The invention also relates to an ophthalmic formulation comprising a pharmaceutically acceptable carrier and a compound of the following structural Formula (I), or a pharmaceutically acceptable salt thereof: Values and preferred values of the variables in structural Formula (I) are described herein.

6. 发明申请

US20160278677A1 Method for Measuring Fluorescence in Ocular Tissue 审中-公开
标题翻译：测量眼组织荧光的方法
公开(公告)号：US20160278677A1
公开(公告)日：2016-09-29
申请号：US15035549
申请日：2013-11-12
申请人： COGNOPTIX, INC.
发明人： Charles Kerbage , Paul D. Hartung
IPC分类号： A61B5/1455 , A61K49/00 , A61B5/145 , A61B3/14 , A61B5/00
CPC分类号： A61B5/14555 , A61B3/1173 , A61B3/14 , A61B5/0071 , A61B5/0082 , A61B5/14546 , A61B5/4082 , A61B5/4088 , A61K47/60 , A61K49/0021
摘要： A method is provided for ophthalmic measurements, wherein the amount of a fluorophore is detected in ocular tissue and the obtained fluorescence signals are normalized by per-forming a ratio.
摘要翻译：提供了一种用于眼科测量的方法，其中在眼组织中检测到荧光团的量，并且通过逐个形成比例对所获得的荧光信号进行归一化。

7. 发明申请

US20160183859A1 SYSTEM AND METHOD FOR DETECTING AMYLOID PROTEINS 有权
标题翻译：用于检测淀粉样蛋白的系统和方法
公开(公告)号：US20160183859A1
公开(公告)日：2016-06-30
申请号：US14955853
申请日：2015-12-01
申请人： Cognoptix, Inc.
发明人： Paul D. Hartung , Vincent Valvo , Charles Kerbage , Gerald D. Cagle , Dennis J. Nilan
IPC分类号： A61B5/145 , A61B3/107 , A61B3/00 , A61B3/10 , A61B5/1455 , A61B5/00
CPC分类号： A61B5/14546 , A61B3/0008 , A61B3/1005 , A61B3/107 , A61B3/111 , A61B3/117 , A61B3/1173 , A61B3/135 , A61B5/0068 , A61B5/0071 , A61B5/1455 , A61B5/4088 , A61B5/6821 , A61B2562/0238 , A61B2562/0242
摘要： In accordance with an embodiment of the invention, there is provided a device and method for detecting an amyloid protein in an eye of a mammal. A method comprises illuminating the eye with a light source having at least one of a wavelength property, a polarization property or a combination thereof, each appropriate to produce fluorescence in at least an amyloid-binding compound when the amyloid-binding compound is bound to the amyloid protein, the amyloid-binding compound having been introduced to the eye and specifically binding to the amyloid protein indicative of the amyloidogenic disorder; and determining a time decay rate of fluorescence for at least the fluorescence produced by the amyloid-binding compound bound to the amyloid protein, the determining permitting distinguishing of the presence of the amyloid-binding compound bound to the amyloid protein in the eye based on at least the time decay rate.
摘要翻译：根据本发明的一个实施方案，提供了用于检测哺乳动物眼睛中淀粉样蛋白质的装置和方法。一种方法包括用具有波长特性，极化性质或其组合中的至少一种的光源照射眼睛，当淀粉样蛋白结合化合物与淀粉样蛋白，已经引入到眼睛中的淀粉样蛋白结合化合物与指示淀粉样变性疾病的淀粉样蛋白特异性结合; 以及确定至少由与淀粉样蛋白结合的淀粉样蛋白结合化合物产生的荧光的荧光的时间衰减速率，所述确定允许基于在...的区别在眼睛中结合到淀粉样蛋白的淀粉样蛋白结合化合物的存在时间衰减率最小。

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