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1. 发明授权

US5335663A Laparoscopic probes and probe sheaths useful in ultrasonic imaging applications 失效
标题翻译：腹腔镜探针和探针鞘可用于超声成像应用
公开(公告)号：US5335663A
公开(公告)日：1994-08-09
申请号：US989515
申请日：1992-12-11
申请人： Clyde G. Oakley , Lawrence J. Busse , Dennis R. Dietz , John E. Shishilla , Joseph V. Ranalletta
发明人： Clyde G. Oakley , Lawrence J. Busse , Dennis R. Dietz , John E. Shishilla , Joseph V. Ranalletta
IPC分类号： A61B8/12
CPC分类号： A61B8/12 , A61B8/445 , A61B8/4488
摘要： The invention relates to a medical ultrasonic imaging probe, such as may be used in laparoscopic surgery. A probe is provided having both forward viewing and side viewing ultrasonic capabilities. An apparatus is provided for manipulating and orienting video ultrasound images on a video monitor according to the position of the probe. A probe is also provided having both an ultrasonic device and a surgical tool, such as an electrocautery hook for excising and/or cauterizing tissue, that can be closely monitored by the ultrasonic device. Also provided is an ultrasonic probe having lumens for placing ultrasonically transmissive medium adjacent to ultrasonic transducers. A removable, rigid sheath is provided to fit over a laparoscopic probe. Removable sheath that includes a lumen for transmission of surgical tools and the like, an inner chamber containing ultrasonically transmissive medium and sealed with a breakable membrane, a balloon that can be inflated with ultrasonically transmissive medium, and lumens for injecting ultrasonically transmissive medium in the vicinity of a probe's ultrasonic device of a probe inserted into the sheath are disclosed.
摘要翻译：本发明涉及医用超声成像探针，例如可用于腹腔镜手术。提供具有前视观看和侧视超声功能的探针。提供一种装置，用于根据探针的位置在视频监视器上操纵和定向视频超声图像。还提供了一种探针，其具有可由超声波装置密切监测的超声波装置和外科手术工具，例如用于切除和/或烧灼组织的电烙铁钩。还提供了具有用于将超声波传播介质放置在超声换能器附近的腔的超声波探头。提供可移除的刚性护套以配合在腹腔镜探头上。可拆卸护套，其包括用于外科手术工具等的透射的内腔，包含超声波透射介质并用可破坏膜密封的内室，可以用超声波透射介质充气的气囊，以及用于在附近注射超声波透射介质的腔公开了探针插入护套中的探针的超声波装置。

2. 发明授权

US5503152A Ultrasonic transducer assembly and method for three-dimensional imaging 失效
标题翻译：超声波换能器组件及三维成像方法
公开(公告)号：US5503152A
公开(公告)日：1996-04-02
申请号：US314424
申请日：1994-09-28
申请人： Clyde G. Oakley , Lawrence J. Busse
发明人： Clyde G. Oakley , Lawrence J. Busse
IPC分类号： A61B8/08 , A61B8/12 , G01S7/52 , G01S15/89 , G10K11/26 , G10K11/35 , A61B8/00
CPC分类号： A61B8/483 , A61B8/08 , A61B8/12 , A61B8/145 , A61B8/4483 , A61B8/4494 , A61B8/462 , A61B8/466 , G01S15/8918 , G01S15/8938 , G01S15/8993 , G10K11/26 , G10K11/352 , A61B8/445 , G01S15/8925 , G01S7/52071 , Y10S128/916
摘要： Elongated arrays of individual ultrasonic transducer elements at spaced locations emit wedge-shaped beams of ultrasonic energy such that energy emitted by corresponding elements of the arrays travels into a common region of the object to be imaged. Energy emitted by the elements of both arrays is reflected by the same structure within the object. The relative distances of the reflecting structure from the corresponding elements of the arrays are compared to determine the elevation of the reflecting points with respect to an image plane, and a three-dimensional image of the reflectors is generated. A virtual image including information responsive to the elevation of the points can be derived, and used to recalculate the visible display corresponding to a user-selected image plane. The transducer may include a parallel pair of arrays.
摘要翻译：在间隔位置处的单个超声换能器元件的细长阵列发射超声波能量的楔形波束，使得阵列的相应元件发射的能量行进到待成像对象的公共区域。由两个阵列的元素发射的能量由对象内的相同结构反映。将反射结构与阵列的相应元件的相对距离进行比较以确定反射点相对于像平面的高度，并且产生反射器的三维图像。可以导出包括响应于点的高度的信息的虚像，并用于重新计算与用户选择的图像平面相对应的可见显示。换能器可以包括平行的阵列对。

3. 发明授权

US08323201B2 System and method for three-dimensional ultrasound imaging 有权
标题翻译：三维超声成像系统及方法
公开(公告)号：US08323201B2
公开(公告)日：2012-12-04
申请号：US12186967
申请日：2008-08-06
申请人： Farhad Towfiq , Lawrence J. Busse , Stephen J. Douglas
发明人： Farhad Towfiq , Lawrence J. Busse , Stephen J. Douglas
IPC分类号： A61B8/14 , A61B8/00
CPC分类号： A61B8/4494 , A61B5/7264 , A61B8/0825 , A61B8/13 , A61B8/145 , A61B8/406 , A61B8/4461 , A61B8/4483 , A61B8/483 , A61B8/5207 , A61B8/5253 , A61B2560/0475 , B06B1/0629 , G01S7/52046 , G01S7/52085 , G01S15/892 , G01S15/8925 , G01S15/894 , G01S15/8993 , G10K11/30
摘要： Under one aspect, an ultrasound system for producing a representation of an object includes: a concave transducer array configured to transmit ultrasonic pulses into the object and to receive ultrasonic pulses from the object, the ultrasonic pulses from the object containing structural information about the object, each transducer in the array generating an output signal representative of a portion of the structural information about the object; a multi-focal lens structure for focusing the transmitted ultrasonic pulses; a multiplexing structure in operable communication with the concave transducer array and including logic for coupling the output signals from at least one pair of transducers in the concave transducer array; and a beamformer in operable communication with the multiplexing structure and including logic for constructing a representation of structural information about the object based on the coupled output signals from the multiplexing structure.
摘要翻译：在一个方面，一种用于产生物体表示的超声系统包括：凹形换能器阵列，被配置为将超声波脉冲发射到物体中并从物体接收超声波脉冲，来自物体的超声波脉冲包含关于物体的结构信息，阵列中的每个换能器产生代表关于物体的结构信息的一部分的输出信号; 用于聚焦发射的超声波脉冲的多焦点透镜结构; 与所述凹形换能器阵列可操作地通信的多路复用结构，并且包括用于将来自所述凹形换能器阵列中的至少一对换能器的输出信号耦合的逻辑; 以及与多路复用结构可操作地通信的波束形成器，并且包括用于基于来自多路复用结构的耦合输出信号构建关于对象的结构信息的表示的逻辑。

4. 发明申请

US20090043206A1 SYSTEM AND METHOD FOR THREE-DIMENSIONAL ULTRASOUND IMAGING 有权
标题翻译：用于三维超声成像的系统和方法
公开(公告)号：US20090043206A1
公开(公告)日：2009-02-12
申请号：US12186967
申请日：2008-08-06
申请人： Farhad Towfiq , Lawrence J. Busse , Stephen J. Douglas
发明人： Farhad Towfiq , Lawrence J. Busse , Stephen J. Douglas
IPC分类号： A61B8/14
CPC分类号： A61B8/4494 , A61B5/7264 , A61B8/0825 , A61B8/13 , A61B8/145 , A61B8/406 , A61B8/4461 , A61B8/4483 , A61B8/483 , A61B8/5207 , A61B8/5253 , A61B2560/0475 , B06B1/0629 , G01S7/52046 , G01S7/52085 , G01S15/892 , G01S15/8925 , G01S15/894 , G01S15/8993 , G10K11/30
摘要： Under one aspect, an ultrasound system for producing a representation of an object includes: a concave transducer array configured to transmit ultrasonic pulses into the object and to receive ultrasonic pulses from the object, the ultrasonic pulses from the object containing structural information about the object, each transducer in the array generating an output signal representative of a portion of the structural information about the object; a multi-focal lens structure for focusing the transmitted ultrasonic pulses; a multiplexing structure in operable communication with the concave transducer array and including logic for coupling the output signals from at least one pair of transducers in the concave transducer array; and a beamformer in operable communication with the multiplexing structure and including logic for constructing a representation of structural information about the object based on the coupled output signals from the multiplexing structure.
摘要翻译：在一个方面，一种用于产生物体表示的超声系统包括：凹形换能器阵列，被配置为将超声波脉冲发射到物体中并从物体接收超声波脉冲，来自物体的超声波脉冲包含关于物体的结构信息，阵列中的每个换能器产生代表关于物体的结构信息的一部分的输出信号; 用于聚焦发射的超声波脉冲的多焦点透镜结构; 与所述凹形换能器阵列可操作地通信的多路复用结构，并且包括用于将来自所述凹形换能器阵列中的至少一对换能器的输出信号耦合的逻辑; 以及与多路复用结构可操作地通信的波束形成器，并且包括用于基于来自多路复用结构的耦合输出信号构建关于对象的结构信息的表示的逻辑。

5. 发明授权

US5038791A Heart imaging method 失效
标题翻译：心脏成像方法
公开(公告)号：US5038791A
公开(公告)日：1991-08-13
申请号：US536351
申请日：1990-06-11
申请人： H. Dale Collins , R. Parks Gribble , Lawrence J. Busse
发明人： H. Dale Collins , R. Parks Gribble , Lawrence J. Busse
IPC分类号： A61B5/0402 , A61B5/0408 , G03H5/00 , G06F17/00
CPC分类号： G03H5/00 , A61B5/0044 , A61B5/0402 , A61B5/04085
摘要： A method for providing an image of the human heart's electrical system derives time-of-flight data from an array of EKG electrodes and this data is transformed into phase information. The phase information, treated as a hologram, is reconstructed to provide an image in one or two dimensions of the electrical system of the functioning heart.
摘要翻译：用于提供人类心脏电气系统的图像的方法从EKG电极阵列导出飞行时间数据，并将该数据转换成相位信息。被视为全息图的相位信息被重建以在功能心脏的电气系统的一维或二维中提供图像。

6. 发明授权

US4531411A Acoustic emission linear pulse holography 失效
标题翻译：声发射线性脉冲全息术
公开(公告)号：US4531411A
公开(公告)日：1985-07-30
申请号：US545426
申请日：1983-10-25
申请人： H. Dale Collins , Lawrence J. Busse , Douglas K. Lemon
发明人： H. Dale Collins , Lawrence J. Busse , Douglas K. Lemon
IPC分类号： G01N29/06 , G01N29/14 , G01S5/22 , G01N29/04
CPC分类号： G01N29/0663 , G01N29/14 , G01S5/22
摘要： Defects in a structure are imaged as they propagate, using their emitted acoustic energy as a monitored source. Short bursts of acoustic energy propagate through the structure to a discrete element receiver array. A reference timing transducer located between the array and the inspection zone initiates a series of time-of-flight measurements. A resulting series of time-of-flight measurements are then treated as aperture data and are transferred to a computer for reconstruction of a synthetic linear holographic image. The images can be displayed and stored as a record of defect growth.
摘要翻译：结构中的缺陷在它们传播时被成像，使用其发射的声能作为监测的源。声能的短阵列通过结构传播到离散元件接收器阵列。位于阵列和检查区之间的参考定时换能器启动一系列飞行时间测量。然后将所得到的一系列飞行时间测量值视为孔径数据，并将其传送到计算机以重建合成的线性全息图像。可以将图像显示并存储为缺陷增长的记录。

7. 发明授权

US5363853A Ultrasound probe for use with transport catheter and method of making same 失效
标题翻译：用于运输导管的超声探头及其制作方法
公开(公告)号：US5363853A
公开(公告)日：1994-11-15
申请号：US80884
申请日：1993-06-22
申请人： Clement E. Lieber , Miriam H. Taimisto , David L. Swendson , Mark A. Konno , Lawrence J. Busse , Robert Skidmore
发明人： Clement E. Lieber , Miriam H. Taimisto , David L. Swendson , Mark A. Konno , Lawrence J. Busse , Robert Skidmore
IPC分类号： A61B8/06 , A61B8/12 , A61M25/00
CPC分类号： A61B8/06 , A61B8/12 , A61B8/445 , A61M25/0029 , A61M25/003 , A61M25/0032 , Y10T29/42
摘要： A probe for use within a catheter is disclosed. The probe transducer portion is constructed of a crystal hollow cylinder with an inside lead attached to the inner surface of the crystal cylinder. One end of the outside lead is positioned close to the outer surface, in a plane tangential to the outer surface, and is coupled to the outer surface of the crystal cylinder by a thin sputtered layer of conductive material. The probe transducer also includes a layer of acoustically absorbing material on the proximal end of the crystal, and layer of acoustically coupling material on the distal end of the crystal cylinder. The transducer element simultaneously generates an axially oriented signal beam at one frequency and a radially oriented signal beam at 2 different frequency. The signal beams are analyzed to calculate the blood flow area and the blood flow velocity, the product of which is the blood flow rate.
摘要翻译：公开了一种用于导管内的探针。探头传感器部分由结晶中空圆筒构成，其内部引线附接到晶体圆筒的内表面。外引线的一端在与外表面相切的平面中靠近外表面定位，并且通过导电材料的薄溅射层耦合到晶体筒的外表面。探针传感器还包括在晶体近端上的吸声材料层和在晶体圆筒的远端上的声耦合材料层。换能器元件同时产生一个频率的轴向取向的信号波束和两个不同频率的径向取向的信号波束。分析信号束以计算血流面积和血流速度，其乘积是血流速度。

8. 发明授权

US5359760A Method of manufacture of multiple-element piezoelectric transducer 失效
标题翻译：多元素压电换能器的制造方法
公开(公告)号：US5359760A
公开(公告)日：1994-11-01
申请号：US46965
申请日：1993-04-16
申请人： Lawrence J. Busse , Jeffry W. Stevenson , Wayne Huebner
发明人： Lawrence J. Busse , Jeffry W. Stevenson , Wayne Huebner
IPC分类号： B06B1/06 , H01L41/22 , H01L41/37 , H04R17/00
CPC分类号： B06B1/0622 , A61B8/4483 , H01L41/37 , Y10S310/80 , Y10T29/42
摘要： An improved method for fabrication of a multiple-element piezoelectric transducer and the transducer produced thereby. A green precursor tape is produced by doctor-blade tape-casting of a slurry containing lead zirconate-titanate (PZT) powder. After drying, individual strips of the tape are stacked between flat plates of previously sintered PZT, and sintered to form PZT strips; Pb from the previously sintered PZT plates makes up any Pb lost from the surfaces of the tape strips during sintering. The PZT strips are stacked interposed by layers of a thermoplastic polymer, and heated to a temperature above the melting point of the polymer, forming a laminate block. This block is then sliced perpendicular to the plane of the layers, forming slabs of alternate PZT and polymer layers; the slabs are then sliced perpendicular to the first slicing planes, forming strips of alternating PZT and polymer material. Electrodes are then added to complete the transducer assembly.
摘要翻译：一种用于制造多元素压电换能器和由此产生的换能器的改进方法。通过用包含锆钛酸铅（PZT）粉末的浆料的刮刀带铸造生产绿色前体胶带。干燥后，将各条条带堆叠在先前烧结的PZT的平板之间，并烧结形成PZT条带; 来自先前烧结的PZT板的Pb构成在烧结期间从带条表面损失的任何Pb。 PZT条由热塑性聚合物层层叠，并加热到高于聚合物熔点的温度，形成层压块。然后将该块垂直于层的平面切片，形成交替的PZT和聚合物层的板; 然后将板坯垂直于第一切割平面切片，形成交替的PZT和聚合物材料的条带。然后添加电极以完成换能器组件。

9. 发明授权

US5351693A Ultrasound probe for use with transport catheter and method of making same 失效
公开(公告)号：US5351693A
公开(公告)日：1994-10-04
申请号：US137381
申请日：1993-10-13
申请人： Miriam H. Taimisto , David L. Swendson , Lawrence J. Busse , Robert Skidmore
发明人： Miriam H. Taimisto , David L. Swendson , Lawrence J. Busse , Robert Skidmore
IPC分类号： A61B8/06 , A61B8/12 , A61M25/00
CPC分类号： A61B8/06 , A61B8/12 , A61B8/445 , A61M25/0029 , A61M25/003 , A61M25/0032 , Y10T29/42
摘要： A probe for use within a catheter is disclosed. The probe transducer portion is constructed of a crystal hollow cylinder with an inside lead attached to the inner surface of the crystal cylinder. One end of the outside lead is positioned close to the outer surface, in a plane tangential to the outer surface, and is coupled to the outer surface of the crystal cylinder by a thin sputtered layer of conductive material. The probe transducer also includes a layer of acoustically absorbing material on the proximal end of the crystal, and layer of acoustically coupling material on the distal end of the crystal cylinder. The transducer element simultaneously generates an axially oriented signal beam at one frequency and a radially oriented signal beam at 2 different frequency. The signal beams are analyzed to calculate the blood flow area and the blood flow velocity, the product of which is the blood flow rate.

10. 发明授权

US07300414B1 Transcranial ultrasound thrombolysis system and method of treating a stroke 有权
标题翻译：经颅超声溶栓系统及治疗中风的方法
公开(公告)号：US07300414B1
公开(公告)日：2007-11-27
申请号：US10111722
申请日：2000-11-01
申请人： Christy K. Holland , Daniel S. Kanter , Lawrence J. Busse , Kenneth R. Wagner
发明人： Christy K. Holland , Daniel S. Kanter , Lawrence J. Busse , Kenneth R. Wagner
IPC分类号： A61B17/20
CPC分类号： A61B17/2251 , A61B2017/22082
摘要： A method of transcranial ultrasound thrombolysis comprises the steps of providing a predetermined level of ultrasonic energy substantially throughout a primary treatment zone encompassing the M1 branch and M2 branches of the middle cerebral artery of an individual. A thrombolytic agent is also administered to the individual. A transcranial ultrasound thrombolysis system (10) is also provided that includes a transducer (20). The transducer is adapted to provide a predetermined level of ultrasonic energy substantially throughout a primary treatment zone encompassing at least a substantial portion of the M1 branch and the M2 branches of the middle cerebral artery in one hemisphere of a brain.
摘要翻译：经颅超声溶栓的方法包括以下步骤：基本上遍及包括个体的中脑动脉的M1分支和M2分支的整个治疗区域提供预定水平的超声波能量。也向个体施用血栓溶解剂。还提供了包括换能器（20）的经颅超声溶栓系统（10）。所述传感器适于基本上遍及包含至少大部分M1分支的主处理区域和大脑一个半球中的大脑中动脉的M2分支的预定水平的超声波能量。

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