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1. 发明授权

US07741329B2 N-aroyl cyclic amines 失效
标题翻译： N-芳酰基环胺
公开(公告)号：US07741329B2
公开(公告)日：2010-06-22
申请号：US11926221
申请日：2007-10-29
申请人： Clive Leslie Branch , Steven Coulton , Amanda Johns , Christopher Norbert Johnson , Roderick Alan Porter , Geoffrey Stemp , Kevin Thewlis
发明人： Clive Leslie Branch , Steven Coulton , Amanda Johns , Christopher Norbert Johnson , Roderick Alan Porter , Geoffrey Stemp , Kevin Thewlis
IPC分类号： A61K31/506 , A61K31/4709 , A61K31/4725 , C07D401/14
CPC分类号： C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/06 , C07D405/14 , C07D409/14 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04
摘要： Disclosed are N-aroyl cyclic amine derivatives having the formula: wherein the substituent variables are as defined herein, and their use as pharmaceuticals.
摘要翻译：公开了具有下式的N-芳酰基环胺衍生物：其中取代基变量如本文所定义，及其作为药物的用途。

2. 发明授权

US07919507B2 N-aroyl cyclic amines 失效
标题翻译： N-芳酰基环胺
公开(公告)号：US07919507B2
公开(公告)日：2011-04-05
申请号：US11925129
申请日：2007-10-26
申请人： Clive Leslie Branch , Steven Coulton , Amanda Johns , Christopher Norbert Johnson , Roderick Alan Porter , Geoffrey Stemp , Kevin Thewlis
发明人： Clive Leslie Branch , Steven Coulton , Amanda Johns , Christopher Norbert Johnson , Roderick Alan Porter , Geoffrey Stemp , Kevin Thewlis
IPC分类号： A61K31/4545 , C07D401/12
CPC分类号： C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/06 , C07D405/14 , C07D409/14 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04
摘要： Disclosed are N-aroyl cyclic amine derivatives having the formula: wherein the substituent variables are as defined herein, and their use as pharmaceuticals.
摘要翻译：公开了具有下式的N-芳酰基环胺衍生物：其中取代基变量如本文所定义，及其作为药物的用途。

3. 发明授权

US07432270B2 N-aroyl cyclic amines 失效
标题翻译： N-芳酰基环胺
公开(公告)号：US07432270B2
公开(公告)日：2008-10-07
申请号：US10477008
申请日：2002-05-02
申请人： Clive Leslie Branch , Steven Coulton , Amanda Johns , Christopher Norbert Johnson , Roderick Alan Porter , Geoffrey Stemp , Kevin Thewlis
发明人： Clive Leslie Branch , Steven Coulton , Amanda Johns , Christopher Norbert Johnson , Roderick Alan Porter , Geoffrey Stemp , Kevin Thewlis
IPC分类号： A61K31/498 , C07D403/14 , C07D405/14 , C07D409/14 , C07D417/14
CPC分类号： C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/06 , C07D405/14 , C07D409/14 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04
摘要： This invention relates to N-aroyl cyclic amine derivatives and their use as orexin antagonists wherein: Y represents a bond, oxygen, or a group (CH2)n, wherein n represents 1, 2 or 3; m represents 1, 2, or 3; p represents ) or 1; X is NR, wherein R is H or (C1-4)alkyl; Ar1 is aryl, or a mono or bicyclic heteroaryl group containing up to 3 heteroatoms selected from N, O and S; any of which may be optionally substituted; A2 represents phenyl or a 5- or 6-membered heterocyclyl group containing up to 3 heteroatoms selected from N, O and S, wherein the phenyl or heterocyclyl group is substituted by R1 and further optional substituents; or Ar2 represents an optionally substituted bicyclic aromatic or bicyclic heteroaromatic group containing up to 3 heteroatoms selected from N, O and S; R1 represents hydrogen, optionally substituted (C1-4)alkoxy, halo, cyano, optionally substituted (C1-6)alkyl, optionally substituted phenyl, or an optionally substituted 5- or 6-membered heterocyclyl group containing up to 4 heteroatoms selected from N, O and S; when Ar1 is aryl p is not 1, or a pharmaceutical acceptable salt thereof.
摘要翻译：本发明涉及N-芳酰基环胺衍生物及其作为食欲素拮抗剂的用途，其中：Y表示键，氧或基团（CH 2）n，其中n 代表1,2或3; m表示1,2或3; p表示）或1; X是NR，其中R是H或（C 1-4 - ）烷基; Ar 1是芳基或含有至多3个选自N，O和S的杂原子的单或双环杂芳基; 任何一个可以任选地被取代; 代表苯基或含有至多3个选自N，O和S的杂原子的5或6元杂环基，其中苯基或杂环基被R 1取代， SUP>和另外任选的取代基; 或Ar 2表示含有至多3个选自N，O和S的杂原子的任选取代的双环芳族或双环杂芳族基团; R 1表示氢，任选取代的（C 1-4 - ）烷氧基，卤素，氰基，任选取代的（C 1-6 - ）烷基，或任选取代的苯基，或任选取代的含有至多4个选自N，O和S的杂原子的5或6元杂环基; 当Ar 1是芳基p不为1时，或其药学上可接受的盐。

4. 发明授权

US07470710B2 N-aroyl cyclic amine derivatives as orexin receptor antagonists 失效
标题翻译： N-芳酰基环胺衍生物作为食欲素受体拮抗剂
公开(公告)号：US07470710B2
公开(公告)日：2008-12-30
申请号：US10481133
申请日：2002-06-25
申请人： Clive Leslie Branch , Wai Ngor Chan , Amanda Johns , Christopher Norbert Johnson , David John Nash , Riccardo Novelli , Jean-Pierre Pilleux , Roderick Alan Porter , Rachel Elizabeth Anne Stead , Geoffrey Stemp
发明人： Clive Leslie Branch , Wai Ngor Chan , Amanda Johns , Christopher Norbert Johnson , David John Nash , Riccardo Novelli , Jean-Pierre Pilleux , Roderick Alan Porter , Rachel Elizabeth Anne Stead , Geoffrey Stemp
IPC分类号： A61K31/4525 , A61K31/4535 , A61K31/454 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D407/14
CPC分类号： C07D417/14 , C07D401/06 , C07D401/14 , C07D403/14 , C07D405/06 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/04 , C07D471/04 , C07D491/04
摘要： This invention relates to N-aroyl cyclic amine derivatives of formula (I), wherein X represents a bond, oxygen, NR3 or a group (CH2), wherein n represents 1, 2 or 3; Y represents CH2, CO, CH(OH), or CH2CH(OH); Het is an optionally substituted bicyclic heteroaryl group containing up to 4 heteroatoms selected from N, O and S; Ar2 represents an optionally substituted phenyl or a 5- or 6-membered heterocyclyl group containing up to 3 heteroatoms selected from N, O and S and their use as pharmaceuticals, specifically as orexin receptor antagonists.
摘要翻译：本发明涉及式（I）的N-芳酰基环胺衍生物，其中X表示键，氧，NR 3或基团（CH 2），其中n表示1,2或3; Y表示CH 2，CO，CH（OH）或CH 2 CH（OH）; Het是含有至多4个选自N，O和S的杂原子的任选取代的双环杂芳基; Ar2表示任选取代的苯基或含有至多3个选自N，O和S的杂原子的5-或6-元杂环基，以及它们作为药物的用途，特别是作为食欲素受体拮抗剂。

5. 发明授权

US07893090B2 N-aroyl cyclic amine derivatives as orexin receptor antagonists 失效
公开(公告)号：US07893090B2
公开(公告)日：2011-02-22
申请号：US11928072
申请日：2007-10-30
申请人： Clive Leslie Branch , Wai Ngor Chan , Amanda Johns , Christopher Norbert Johnson , David John Nash , Riccardo Novelli , Jean-Pierre Pilleux , Roderick Alan Porter , Rachel Elizabeth Anne Stead , Geoffrey Stemp
发明人： Clive Leslie Branch , Wai Ngor Chan , Amanda Johns , Christopher Norbert Johnson , David John Nash , Riccardo Novelli , Jean-Pierre Pilleux , Roderick Alan Porter , Rachel Elizabeth Anne Stead , Geoffrey Stemp
IPC分类号： A61K31/4525 , C07D401/06
CPC分类号： C07D417/14 , C07D401/06 , C07D401/14 , C07D403/14 , C07D405/06 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/04 , C07D471/04 , C07D491/04
摘要： Disclosed are N-aroyl cyclic amine derivatives having the formula: where the variables are as define herein, and their use as pharmaceuticals, specifically as orexin receptor antagonists.

6. 发明授权

US07928125B2 N-aroyl cyclic amine derivatives as orexin receptor antagonists 失效
标题翻译： N-芳酰基环胺衍生物作为食欲素受体拮抗剂
公开(公告)号：US07928125B2
公开(公告)日：2011-04-19
申请号：US11926409
申请日：2007-10-29
申请人： Clive Leslie Branch , Wai Ngor Chan , Amanda Johns , Christopher Norbert Johnson , David John Nash , Riccardo Novelli , Jean-Pierre Pilleux , Roderick Alan Porter , Rachel Elizabeth Anne Stead , Geoffrey Stemp
发明人： Clive Leslie Branch , Wai Ngor Chan , Amanda Johns , Christopher Norbert Johnson , David John Nash , Riccardo Novelli , Jean-Pierre Pilleux , Roderick Alan Porter , Rachel Elizabeth Anne Stead , Geoffrey Stemp
IPC分类号： A61K31/454 , A61K31/4525 , C07D401/14
CPC分类号： C07D417/14 , C07D401/06 , C07D401/14 , C07D403/14 , C07D405/06 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/04 , C07D471/04 , C07D491/04
摘要： Disclosed are N-aroyl cyclic amine derivatives having the formula: where the variables are as define herein, and their use as pharmaceuticals, specifically as orexin receptor antagonists.
摘要翻译：公开了具有下式的N-芳酰基环胺衍生物：其中变量如本文所定义，以及它们作为药物的用途，特别是作为食欲素受体拮抗剂。

7. 发明授权

US07928124B2 N-aroyl cyclic amine derivatives as orexin receptor antagonists 失效
公开(公告)号：US07928124B2
公开(公告)日：2011-04-19
申请号：US11926398
申请日：2007-10-29
申请人： Clive Leslie Branch , Wai Ngor Chan , Amanda Johns , Christopher Norbert Johnson , David John Nash , Riccardo Novelli , Jean-Pierre Pilleux , Roderick Alan Porter , Rachel Elizabeth Anne Stead , Geoffrey Stemp
发明人： Clive Leslie Branch , Wai Ngor Chan , Amanda Johns , Christopher Norbert Johnson , David John Nash , Riccardo Novelli , Jean-Pierre Pilleux , Roderick Alan Porter , Rachel Elizabeth Anne Stead , Geoffrey Stemp
IPC分类号： A61K31/4433 , A61K31/444 , C07D405/14
CPC分类号： C07D417/14 , C07D401/06 , C07D401/14 , C07D403/14 , C07D405/06 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/04 , C07D471/04 , C07D491/04
摘要： Disclosed are N-aroyl cyclic amine derivatives having the formula: where the variables are as define herein, and their use as pharmaceuticals, specifically as orexin receptor antagonists.

8. 发明授权

US07897618B2 N-aroyl cyclic amine derivatives as orexin receptor antagonists 失效
公开(公告)号：US07897618B2
公开(公告)日：2011-03-01
申请号：US11926375
申请日：2007-10-29
申请人： Clive Leslie Branch , Wai Ngor Chan , Amanda Johns , Christopher Norbert Johnson , David John Nash , Riccardo Novelli , Jean-Pierre Pilleux , Roderick Alan Porter , Rachel Elizabeth Anne Stead , Geoffrey Stemp
发明人： Clive Leslie Branch , Wai Ngor Chan , Amanda Johns , Christopher Norbert Johnson , David John Nash , Riccardo Novelli , Jean-Pierre Pilleux , Roderick Alan Porter , Rachel Elizabeth Anne Stead , Geoffrey Stemp
IPC分类号： A61K31/4545 , A61K31/4725 , C07D401/14 , C07D405/14
CPC分类号： C07D417/14 , C07D401/06 , C07D401/14 , C07D403/14 , C07D405/06 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/04 , C07D471/04 , C07D491/04
摘要： Disclosed are N-aroyl cyclic amine derivatives having the formula: where the variables are as define herein, and their use as pharmaceuticals, specifically as orexin receptor antagonists.

9. 发明授权

US06677354B2 Piperdines for use as orexin receptor antagonists 失效
标题翻译：用作食欲肽受体拮抗剂的Pi子
公开(公告)号：US06677354B2
公开(公告)日：2004-01-13
申请号：US10311445
申请日：2002-12-16
申请人： Clive Leslie Branch , Christopher Norbert Johnson , Geoffrey Stemp , Kevin Thewlis
发明人： Clive Leslie Branch , Christopher Norbert Johnson , Geoffrey Stemp , Kevin Thewlis
IPC分类号： A61K314545
CPC分类号： C07D401/06 , C07D211/26 , C07D401/10 , C07D405/06 , C07D405/10 , C07D405/14 , C07D409/14 , C07D413/10 , C07D413/14 , C07D417/06 , C07D417/14 , C07D471/04
摘要： Disclosed are compounds of formula (I): wherein: Y represents a group (CH2)n, wherein n represents 0, 1 or 2; R1 is phenyl, naphthyl, a mono or bicyclic heteroaryl group containing up to 3 heteroatoms selected from N, O and S; or a group NR3R4 wherein one of R3 and R4 is hydrogen or optionally substituted (C1-4)alkyl and the other is phenyl, naphthyl or a mono or bicyclic heteroaryl group containing up to 3 heteroatoms selected from N, O and S, or R3 and R4 together with the N atom to which they are attached form a 5 to 7-membered cyclic amine which has an optionally fused phenyl ring; any of which R1 groups may be optionally substituted; R2 represents phenyl or a 5- or 6-membered heteroaryl group containing up to 3 heteroatoms selected from N, O and S, wherein the phenyl or heteroaryl group is substituted by R5, and further optional substituents; or R2 represents an optionally substituted bicyclic aromatic or bicyclic heteroaromatic group containing up to 3 heteroatoms selected from N, O and S; R5 represents an optionally substituted (C1-4)alkoxy, halo, optionally substituted (C1-6)alkyl, optionally substituted phenyl, or an optionally substituted 5- or 6-membered heterocyclic ring containing up to 3 heteroatoms selected from N, O and S; or pharmaceutically acceptable salts thereof.
摘要翻译：公开了式（I）的化合物：其中：Y表示基团（CH 2）n，其中n表示0,1或2; R 1是苯基，萘基，含有至多3个选自杂原子的单或双环杂芳基来自N，O和S; 或NR 3或R 4基团，其中R 3和R 4中的一个是氢或任选取代的（C 1-4）烷基，另一个是苯基，萘基或含有上述的单或双环杂芳基至3个选自N，O和S的杂原子，或R 3和R 4与它们所连接的N原子一起形成具有任选稠合的苯环的5至7元环胺; 任何R 1可以任选被取代; R 2表示苯基或含有至多3个选自N，O和S的杂原子的5-或6-元杂芳基，其中苯基或杂芳基被取代 R 5和另外任选的取代基; 或R 2表示含有至多3个选自N，O和S的杂原子的任选取代的双环芳族或双环杂芳族基团; R 5表示任选取代的（C 1-4）烷氧基，卤素，任选取代的（C1- 6）烷基，任选取代的苯基或含有至多3个选自N，O和S的杂原子的任选取代的5或6元杂环; 或其药学上可接受的盐。

10. 发明授权

US06943160B2 Morpholine derivatives as antagonists of orexin receptors 失效
标题翻译：吗啉衍生物作为食欲素受体的拮抗剂
公开(公告)号：US06943160B2
公开(公告)日：2005-09-13
申请号：US10432421
申请日：2001-11-22
申请人： Clive Leslie Branch , Christopher Norbert Johnson , Alexander B. Smith , Geoffrey Stemp , Kevin Thewlis
发明人： Clive Leslie Branch , Christopher Norbert Johnson , Alexander B. Smith , Geoffrey Stemp , Kevin Thewlis
IPC分类号： C07D417/06 , A61K31/5377 , A61P3/04 , A61P3/10 , A61P9/00 , A61P9/10 , A61P15/00 , A61P25/00 , A61P25/02 , A61P25/06 , A61P25/18 , A61P25/20 , A61P25/22 , A61P25/24 , A61P25/30 , A61P43/00 , C07D417/12 , C07D417/14 , C07D413/06 , C07D413/12 , C07D413/14
CPC分类号： C07D417/12 , C07D417/14
摘要： This invention relates to morpholine derivatives of formula (I) and their use as antagonists of orexin receptors.
摘要翻译：本发明涉及式（I）的吗啉衍生物及其作为食欲素受体拮抗剂的用途。

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