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1. 发明申请

US20100198020A1 System And Method For Computer-Implemented Method For Actively Managing Increased Insulin Resistance In Type 2 Diabetes Mellitus 审中-公开
标题翻译：计算机实施方法的系统和方法，用于积极管理2型糖尿病中增加的胰岛素抵抗
公开(公告)号：US20100198020A1
公开(公告)日：2010-08-05
申请号：US12757920
申请日：2010-04-09
申请人： Clifton A. Alferness , Gust H. Bardy
发明人： Clifton A. Alferness , Gust H. Bardy
IPC分类号： A61B5/00
CPC分类号： G06F19/3475 , G06F19/3456 , G06F19/3481 , G16H15/00 , G16H50/50
摘要： A computer-implemented method for actively managing increased insulin resistance in Type 2 diabetes mellitus is provided. A computer-generated model of glycemic effect for a Type 2 diabetic patient for digestive response is established on a computer workstation. A rise in postprandial blood glucose from a meal planned for ingestion by the patients estimated as displayed through the digestive response model. A coefficient applied to the digestive response model for an initial degree of insulin resistance experienced by the patient is adjusted. Following a physiologic increase in insulin resistance, a rise in postprandial blood glucose from a subsequent meal planned for ingestion by the patient is estimated as displayed through the digestive response model. The coefficient applied to the digestive response model for a subsequent degree of insulin resistance experienced by the patient is adjusted.
摘要翻译：提供了一种主动管理2型糖尿病胰岛素抵抗增加的计算机实现方法。在计算机工作站上建立了计算机生成的2型糖尿病患者消化反应的血糖效应模型。膳食中餐后血糖升高，计划由通过消化反应模型显示的患者进行摄入。调整用于患者经历的初始胰岛素抵抗程度的消化反应模型的系数。在胰岛素抵抗的生理上升后，通过消化反应模型估计出计划由患者摄取的随后的膳食中餐后血糖的升高。调整用于患者经历的随后的胰岛素抵抗程度的消化反应模型的系数。

2. 发明申请

US20100138453A1 SYSTEM AND METHOD FOR GENERATING A PERSONALIZED DIABETES MANAGEMENT TOOL FOR DIABETES MELLITUS 审中-公开
标题翻译：用于产生糖尿病患者的个体化糖尿病管理工具的系统和方法
公开(公告)号：US20100138453A1
公开(公告)日：2010-06-03
申请号：US12030104
申请日：2008-02-12
申请人： Clifton A. Alferness , Gust H. Bardy
发明人： Clifton A. Alferness , Gust H. Bardy
IPC分类号： G06F17/30 , G06Q99/00 , G06F7/00
CPC分类号： G06Q50/22 , G06F19/3456 , G16H50/50
摘要： A system and method for generating a personalized diabetes management tool for diabetes mellitus is provided. An insulin activity curve for a patient population for an insulin preparation for diabetes mellitus treatment is identified. A personal insulin activity model for the patient is generated. An insulin sensitivity is determined by taking a derivative of the rate of change of blood glucose over time for the insulin preparation. An insulin sensitivity coefficient for the insulin preparation for a patient of diabetes mellitus is established. The insulin sensitivity coefficient is applied to the patient population insulin activity curve over a duration of action of the insulin preparation.
摘要翻译：提供了一种用于产生用于糖尿病的个性化糖尿病管理工具的系统和方法。鉴定用于糖尿病治疗的胰岛素制剂的患者群体的胰岛素活性曲线。产生患者的个人胰岛素活性模型。胰岛素敏感性是通过取胰岛素制剂随时间变化的血糖变化率来确定的。建立糖尿病患者胰岛素制剂的胰岛素敏感性系数。在胰岛素制剂的作用持续时间内，将胰岛素敏感性系数应用于患者群体胰岛素活性曲线。

3. 发明申请

US20100198021A1 COMPUTER-IMPLEMENTED METHOD FOR PROVIDING A TUNABLE PERSONALIZED TOOL FOR ESTIMATING GLYCATED HEMOGLOBIN 审中-公开
标题翻译：用于提供用于估计糖化血红蛋白的可调式个性化工具的计算机实现方法
公开(公告)号：US20100198021A1
公开(公告)日：2010-08-05
申请号：US12760497
申请日：2010-04-14
申请人： Clifton A. Alferness , Gust H. Bardy
发明人： Clifton A. Alferness , Gust H. Bardy
IPC分类号： A61B5/00
CPC分类号： G06F19/3456 , G06F19/3475 , G06F19/3481 , G16H15/00 , G16H50/50
摘要： A computer-implemented method for providing a tunable personalized tool for estimating glycated hemoglobin is provided. An electronically-stored history of empirically measured glucose levels is maintained for a patient over a set period of time in order of increasing age. A predictive model of estimated glycated hemoglobin is built on a computer workstation. A decay factor is designated particularized to the patient. The decay factor is applied to each of the measured glucose levels. The measured glucose levels is scaled by a scaling coefficient. The measured glucose levels are aggregated and scaled as decayed and scaled into an estimate of glycated hemoglobin for the time period. The glycated hemoglobin estimate is displayed to the patient on the computer workstation.
摘要翻译：提供了一种用于提供用于估计糖化血红蛋白的可调谐个性化工具的计算机实现的方法。根据年龄的增加，在一段时间内为患者维持经验测量的葡萄糖水平的电子存储历史。估计糖化血红蛋白的预测模型建立在计算机工作站上。衰减因子被指定为患者特定的。衰减因子被应用于每个测量的葡萄糖水平。测量的葡萄糖水平通过缩放系数缩放。测量的葡萄糖水平被聚集并按比例衰变并且缩放到糖化血红蛋白的时间期间的估计值。糖化血红蛋白估计显示给计算机工作站上的患者。

4. 发明申请

US20100145725A1 SYSTEM AND METHOD FOR MANAGING TYPE 1 DIABETES MELLITUS THROUGH A PERSONAL PREDICTIVE MANAGEMENT TOOL 审中-公开
标题翻译：通过个人预测管理工具管理1型糖尿病的系统和方法
公开(公告)号：US20100145725A1
公开(公告)日：2010-06-10
申请号：US12030120
申请日：2008-02-12
申请人： Clifton A. Alferness , Gust H. Bardy
发明人： Clifton A. Alferness , Gust H. Bardy
IPC分类号： A61B5/00 , G06F19/00
CPC分类号： G06F19/3475 , G06F19/3456 , G06F19/3481 , G06Q50/24 , G16H15/00 , G16H50/50
摘要： A system and method for managing Type 1 diabetes mellitus through a personal predictive management tool is provided. A personal insulin response profile for a patient of Type 1 diabetes mellitus is referenced for a type of insulin preparation. A time course curve is maintained for a patient population including, expected blood glucose levels for a type of human-consumable food. The blood glucose levels are estimated following consumption of the food by evaluating an interaction between the personal insulin response profile and the time course curve over a duration of action of the insulin preparation.
摘要翻译：提供了一种通过个人预测管理工具管理1型糖尿病的系统和方法。对于1型糖尿病患者的个人胰岛素反应特征参考一种胰岛素制剂。对于患者群体维持时间过程曲线，包括一种人类可食用食物的预期血糖水平。通过在胰岛素制剂的作用持续时间内评估个人胰岛素反应曲线和时间过程曲线之间的相互作用，在消费食物后估计血糖水平。

5. 发明申请

US20100137786A1 SYSTEM AND METHOD FOR ACTIVELY MANAGING TYPE 1 DIABETES MELLITUS ON A PERSONALIZED BASIS 审中-公开
标题翻译：一种基于个人化基础的1型糖尿病患者的系统和方法
公开(公告)号：US20100137786A1
公开(公告)日：2010-06-03
申请号：US12030087
申请日：2008-02-12
申请人： Clifton A. Alferness , Gust H. Bardy
发明人： Clifton A. Alferness , Gust H. Bardy
IPC分类号： A61M31/00 , G06G7/48 , A61B5/00
CPC分类号： G06F19/3475 , G06F19/3456 , G06F19/3481 , G16H15/00 , G16H50/50
摘要： A system and method for actively managing Type 1 diabetes mellitus on a personalized basis is provided. Models of glycemic effect for a Type 1 diabetic patient are established for both insulin time course and digestive response. A rise in postprandial blood glucose is estimated through food ingestion of a planned meal in proportion to the digestive response model. An amount of insulin necessary and timing of delivery to mediate transport of blood glucose into cells in proportion to the postprandial blood glucose rise is determined through the insulin time course model.
摘要翻译：提供了一种以个性化方式主动管理1型糖尿病的系统和方法。为胰岛素时间过程和消化反应建立1型糖尿病患者的血糖效应模型。餐后血糖升高通过与消化反应模型成比例的食物摄取计划的膳食来估计。通过胰岛素时间过程模型确定必需的胰岛素量和输送时间，以调节与餐后血糖升高成比例的血糖转运到细胞中。

6. 发明申请

US20110077930A1 COMPUTER-IMPLEMENTED METHOD FOR PROVIDING A PERSONALIZED TOOL FOR ESTIMATING 1,5-ANHYDROGLUCITOL 审中-公开
标题翻译：用于提供个体化工具的计算机实现方法，用于估算1,5-ANHYDROGLUCITOL
公开(公告)号：US20110077930A1
公开(公告)日：2011-03-31
申请号：US12894031
申请日：2010-09-29
申请人： Clifton A. Alferness , Gust H. Bardy
发明人： Clifton A. Alferness , Gust H. Bardy
IPC分类号： G06G7/60 , G01N33/48 , G06F19/00
CPC分类号： G06F19/3456 , G16H15/00 , G16H50/50
摘要： A computer-implemented method for providing a personalized tool for estimating 1,5-anhydroglucitol is provided. An electronically-stored history of empirically measured glucose levels is maintained for a patient over a set period of time in order of increasing age. A predictive model of estimated glycated hemoglobin is built on a computer workstation. A decay factor is designated particularized to the patient. The decay factor is applied to each of the measured glucose levels. The measured glucose levels is scaled by a scaling coefficient. The measured glucose levels are aggregated and scaled as decayed and scaled into an estimate of glycated hemoglobin for the time period. The glycated hemoglobin estimate is displayed to the patient on the computer workstation.
摘要翻译：提供了一种用于提供用于估计1,5-脱水葡萄糖醇的个性化工具的计算机实现的方法。根据年龄的增加，在一段时间内为患者维持经验测量的葡萄糖水平的电子存储历史。估计糖化血红蛋白的预测模型建立在计算机工作站上。衰减因子被指定为患者特定的。衰减因子被应用于每个测量的葡萄糖水平。测量的葡萄糖水平通过缩放系数缩放。测量的葡萄糖水平被聚集并按比例衰变并且缩放到糖化血红蛋白的时间期间的估计值。糖化血红蛋白估计显示给计算机工作站上的患者。

7. 发明申请

US20100138203A1 SYSTEM AND METHOD FOR ACTIVELY MANAGING TYPE 2 DIABETES MELLITUS ON A PERSONALIZED BASIS 审中-公开
标题翻译：在个人化基础上进行2型糖尿病管理的系统与方法
公开(公告)号：US20100138203A1
公开(公告)日：2010-06-03
申请号：US12030097
申请日：2008-02-12
申请人： Clifton A. Alferness , Gust H. Bardy
发明人： Clifton A. Alferness , Gust H. Bardy
IPC分类号： G06G7/48 , A61B5/00
CPC分类号： G06F19/3456 , G06F19/3475 , G06F19/3481 , G16H15/00 , G16H50/50
摘要： A system and method for actively managing Type 2 diabetes mellitus on a personalized basis is provided. A model of glycemic effect for a Type 2 diabetic patient for digestive response is established. The digestive response model is adjusted for a degree of insulin resistance experienced by the patient. A rise in postprandial blood glucose through food ingestion of a planned meal is estimated in proportion to the adjusted digestive response model. The tool also allows for the avoidance of hypoglycemic episodes by medications.
摘要翻译：提供了一种以个性化方式主动管理2型糖尿病的系统和方法。建立了2型糖尿病患者消化反应的血糖效应模型。消化反应模型根据患者经历的胰岛素抵抗程度进行调整。通过食物摄入计划用餐，餐后血糖升高与调整后的消化反应模型成比例。该工具还允许通过药物避免低血糖发作。

8. 发明申请

US20100145174A1 System And Method For Providing A Personalized Tool For Estimating Glycated Hemoglobin 审中-公开
标题翻译：提供用于估计糖化血红蛋白的个性化工具的系统和方法
公开(公告)号：US20100145174A1
公开(公告)日：2010-06-10
申请号：US12372662
申请日：2009-02-17
申请人： Clifton A. Alferness , Gust H. Bardy
发明人： Clifton A. Alferness , Gust H. Bardy
IPC分类号： A61B5/00
CPC分类号： G06F19/3475 , A61B5/14532 , G01N33/723 , G06F19/3456 , G06F19/3481 , G16H10/60 , G16H15/00 , G16H50/50
摘要： A system and method for providing a personalized tool for estimating glycated hemoglobin is provided. An electronically-stored history of empirically measured glucose levels for a patient is maintained over a set period of time in order of increasing age. A decay factor is applied to each of the measured glucose levels. The measured glucose levels are aggregated and scaled as decayed into an estimate of glycated hemoglobin for the time period. The glycated hemoglobin estimate is displayed to the patient.
摘要翻译：提供了一种用于提供用于估计糖化血红蛋白的个性化工具的系统和方法。电子存储病历经验测量的葡萄糖水平的历史在一定时间段内按照年龄的增加来维持。对每个测量的葡萄糖水平应用衰减因子。测量的葡萄糖水平被聚合并按比例衰变为糖化血红蛋白的估计时间段。糖尿病血红蛋白估计显示给患者。

9. 发明申请

US20100145173A1 SYSTEM AND METHOD FOR CREATING A PERSONALIZED TOOL PREDICTING A TIME COURSE OF BLOOD GLUCOSE AFFECT IN DIABETES MELLITUS 审中-公开
标题翻译：创造个性化工具的系统和方法预测糖尿病患者血糖葡萄糖时间过程的影响
公开(公告)号：US20100145173A1
公开(公告)日：2010-06-10
申请号：US12030071
申请日：2008-02-12
申请人： Clifton A. Alferness , Gust H. Bardy
发明人： Clifton A. Alferness , Gust H. Bardy
IPC分类号： A61B5/00
CPC分类号： G06F19/3475 , G06F19/3456 , G06F19/3481 , G16H50/50
摘要： A system and method for establishing a tool of blood glucose change for diabetes mellitus management in an individual patient is provided. Factors specific to a diabetic patient are determined. An insulin sensitivity for an insulin preparation for treatment of diabetes mellitus is identified. A carbohydrate sensitivity for a known quantity of carbohydrate is identified, which is measured postprandial after a fixed time period. A management tool for the diabetic patient is generated. A time course for a dose of the insulin preparation with an amplitude of change proportioned to the insulin sensitivity is mapped. A time course for an amount of carbohydrate with an amplitude of change proportioned to the carbohydrate sensitivity is mapped. The management tool is calibrated by aggregating feedback from testing of blood glucose into at least one of the insulin and the carbohydrate sensitivities.
摘要翻译：提供了一种在个体患者中建立用于糖尿病管理的血糖变化工具的系统和方法。确定糖尿病患者特异性因素。确定了用于治疗糖尿病的胰岛素制剂的胰岛素敏感性。确定已知量的碳水化合物的碳水化合物敏感性，其在固定时间段后餐后测定。生成糖尿病患者的管理工具。映射胰岛素制剂剂量与胰岛素敏感性成正比变化幅度的时间过程。绘制了与碳水化合物灵敏度成比例的具有变化幅度的碳水化合物量的时间过程。管理工具通过将从血糖测试到至少一种胰岛素和碳水化合物敏感性的反馈进行聚合来校准。

10. 发明授权

US10064615B2 Tissue fixation devices and a transoral endoscopic gastroesophageal flap valve restoration device and assembly using same 有权
公开(公告)号：US10064615B2
公开(公告)日：2018-09-04
申请号：US13604276
申请日：2012-09-05
申请人： Steve G. Baker , Brett J. Carter , Stefan J. M. Kraemer , Clifton A. Alferness , John M. Adams
发明人： Steve G. Baker , Brett J. Carter , Stefan J. M. Kraemer , Clifton A. Alferness , John M. Adams
IPC分类号： A61B17/04 , A61B17/064 , A61B17/068 , A61B17/00
CPC分类号： A61B17/0401 , A61B17/0469 , A61B17/064 , A61B17/068 , A61B2017/00827 , A61B2017/0409 , A61B2017/0414 , A61B2017/0419
摘要： Tissue fasteners carried on a tissue piercing deployment wire fasten tissue layers of a mammalian body together. The fasteners include a first member, a second member, and a connecting member extending between the first and second members. The first and second members are substantially parallel to each other. The fasteners may be deployed in limited spaces and in various applications including the restoration of a gastroesophageal flap valve.

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