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1. 发明授权

US5788984A Gestodene-containing agent for transdermal administration 失效
标题翻译：含Gestodene的透皮给药剂
公开(公告)号：US5788984A
公开(公告)日：1998-08-04
申请号：US403137
申请日：1995-03-13
申请人： Clemens Guenther , Ulrich Taeuber , Karin Schmidt-Gollwitzer , Jutta Riedl , Johannes Wilhelm Tack
发明人： Clemens Guenther , Ulrich Taeuber , Karin Schmidt-Gollwitzer , Jutta Riedl , Johannes Wilhelm Tack
IPC分类号： A61K9/58 , A61K9/70 , A61K31/565 , A61L15/00 , A61P3/00 , A61P5/30 , A61P5/34 , A61P13/02 , A61P15/00 , A61P15/12 , A61P19/10 , A61P35/00 , A61P43/00 , A61F13/00
CPC分类号： A61K9/7061 , A61K31/565 , A61K9/7069 , A61K9/7084
摘要： An agent for transdermal administration contains gestodene, optionally in combination with one or more estrogen(s).
摘要翻译：用于透皮给药的试剂含有任选与一种或多种雌激素组合的孕二烯酮。

2. 发明申请

US20120202841A1 Topical Compositions Comprising Ascomycins 有权
标题翻译：包含Ascomycins的专题组合
公开(公告)号：US20120202841A1
公开(公告)日：2012-08-09
申请号：US13204489
申请日：2011-08-05
申请人： Katrin Kriwet , Dorothea Ledergerber , Jutta Riedl
发明人： Katrin Kriwet , Dorothea Ledergerber , Jutta Riedl
IPC分类号： A61K31/436 , A61P17/00 , A61P37/00 , A61P29/00 , A61P35/00
CPC分类号： A61K9/0014 , A61K31/4353 , A61K31/436 , A61K47/02 , A61K47/06 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/16 , A61K47/44
摘要： The present invention relates to a composition for topical administration comprising an ascomycin and a carrier vehicle comprising means to retain water in the outer skin layer and means to hinder water evaporating from the skin.
摘要翻译：本发明涉及一种用于局部给药的组合物，包括一种含有子囊霉素和载体载体的载体载体，其包含在外皮层中保留水分的装置和阻止水从皮肤蒸发的装置。

3. 发明授权

US09402802B2 Topical compositions comprising ascomycins 有权
标题翻译：包含ascomycins的局部组合物
公开(公告)号：US09402802B2
公开(公告)日：2016-08-02
申请号：US13204489
申请日：2011-08-05
申请人： Katrin Kriwet , Dorothea Ledergerber , Jutta Riedl
发明人： Katrin Kriwet , Dorothea Ledergerber , Jutta Riedl
IPC分类号： A61K9/00 , A61K31/4353 , A61K31/436 , A61K47/02 , A61K47/06 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/16 , A61K47/44
CPC分类号： A61K9/0014 , A61K31/4353 , A61K31/436 , A61K47/02 , A61K47/06 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/16 , A61K47/44
摘要： The present invention relates to a composition for topical administration comprising an ascomycin and a carrier vehicle comprising means to retain water in the outer skin layer and means to hinder water evaporating from the skin.
摘要翻译：本发明涉及用于局部给药的组合物，其包含子囊霉素和载体载体，其包含在外皮层中保留水的装置和阻止水从皮肤蒸发的装置。

4. 发明授权

US6083528A Hormone replacement therapy method and hormone dispenser 失效
标题翻译：激素替代治疗方法和激素分配器
公开(公告)号：US6083528A
公开(公告)日：2000-07-04
申请号：US288225
申请日：1999-04-08
申请人： Jorg Elliesen , Jutta Riedl
发明人： Jorg Elliesen , Jutta Riedl
IPC分类号： A61K31/57 , A61F13/00
CPC分类号： A61K31/57
摘要： Varying the daily dose of either or both of the estrogen and the progestogen administered for hormone replacement therapy (HRT) is readily and inexpensively accomplished, without the necessity of the physician prescribing a new product each time the daily dose of the estrogen or progestogen is changed, by administering preferably transdermally the estrogen and the progestogen contained in separate extrudable pharmaceutical compositions from a dispenser which contains means, preferably adjustable only by the attending physician or dispensing pharmacist, for varying the volume of either or both of the respective compositions which is dispensed as a single dose from the dispenser in response to a defined digital dispensing manipulation of the dispenser thereby facilitating optimal compliance to a combination of HRT with individually adjusted dosages of the estrogen and progestogen.
摘要翻译：雌激素和孕激素替代疗法（HRT）中的一种或两种雌激素和孕激素的日剂量随着雌激素或孕激素每日剂量的变化而变化，不需要医生处方新产品通过优选经皮内施用包含在来自分配器的分开的可挤出药物组合物中的雌激素和孕激素，其包含优选仅由主治医师或分配药剂师调节以改变分配为相应组合物中的任一个或两者的体积的装置响应于分配器的定义的数字分配操作，来自分配器的单次剂量，从而促进最佳顺应HRT与雌激素和孕激素的单独调整剂量的组合。

5. 发明授权

US5676968A Transdermal therapeutic systems with crystallization inhibitors 无效
标题翻译：具有结晶抑制剂的透皮治疗系统
公开(公告)号：US5676968A
公开(公告)日：1997-10-14
申请号：US433557
申请日：1995-05-03
申请人： Ralph Lipp , Jutta Riedl , Johannes Tack
发明人： Ralph Lipp , Jutta Riedl , Johannes Tack
IPC分类号： A61K9/70 , A61F13/02
CPC分类号： A61K9/7053 , A61K9/7061
摘要： A transdermal therapeutic system is described, which is characterized in that it contains a crystallization inhibitor and optionally penetration enhancer in an active ingredient-containing adhesive matrix.
摘要翻译：描述了一种透皮治疗系统，其特征在于其在含活性成分的粘合剂基质中含有结晶抑制剂和任选的渗透增强剂。

6. 发明申请

US20060058279A1 Topical compositions comprising ascomycins 审中-公开
标题翻译：包含ascomycins的局部组合物
公开(公告)号：US20060058279A1
公开(公告)日：2006-03-16
申请号：US11266639
申请日：2005-11-03
申请人： Katrin Kriwet , Dorothea Ledergerber , Jutta Riedl
发明人： Katrin Kriwet , Dorothea Ledergerber , Jutta Riedl
IPC分类号： A61K31/44 , A61K31/33
CPC分类号： A61K9/0014 , A61K31/4353 , A61K31/436 , A61K47/02 , A61K47/06 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/16 , A61K47/44
摘要： The present invention relates to a composition for topical administration comprising an ascomycin and a carrier vehicle vehicle comprising means to retain water in the outer skin layer and means to hinder water evaporating from the skin.
摘要翻译：本发明涉及一种用于局部给药的组合物，其包含子囊霉素和载体载体载体，其包含在外皮层中保持水的装置和阻止水从皮肤蒸发的装置。

7. 发明授权

US06551611B2 Hormone replacement therapy method 失效
公开(公告)号：US06551611B2
公开(公告)日：2003-04-22
申请号：US09562316
申请日：2000-05-01
申请人： Jörg Elliesen , Jutta Riedl
发明人： Jörg Elliesen , Jutta Riedl
IPC分类号： A61F1300
CPC分类号： B65D83/0011 , A61K9/06 , A61K31/565 , A61K31/57 , B65D35/22 , B65D81/325 , B65D83/0005 , A61K2300/00
摘要： Varying the daily dose of either or both of the estrogen and the progestogen administered for hormone replacement therapy (HRT) is readily and inexpensively accomplished, without the necessity of the physician prescribing a new product each time the daily dose of the estrogen or progestogen is changed, by administering preferably transdermally the estrogen and the progestogen contained in separate extrudable pharmaceutical compositions from a dispenser which contains means, preferably adjustable only by the attending physician or dispensing pharmacist, for varying the volume of either or both of the respective compositions which is dispensed as a single dose from the dispenser in response to a defined digital dispensing manipulation of the dispenser thereby facilitating optimal compliance to a combination of HRT with individually adjusted dosages of the estrogen and progestogen.

8. 发明授权

US06534070B1 Composition with azelaic acid 有权
标题翻译：与壬二酸的组合
公开(公告)号：US06534070B1
公开(公告)日：2003-03-18
申请号：US09554738
申请日：2000-08-21
申请人： Patrick Franke , Clemens Günther , Jutta Riedl
发明人： Patrick Franke , Clemens Günther , Jutta Riedl
IPC分类号： A61K900
CPC分类号： A61K9/0014 , A61K31/23 , A61K47/10 , A61K47/14 , A61K47/24 , A61K47/26 , A61K47/32 , Y10S514/859
摘要： The invention relates to a pharmaceutical composition having the following constituents: azelaic acid, polyacrylic acid, triacylglyceride, propylene glycol, polysorbate, soya lecithin, water and salts. The composition is a hydrogel which is suited for the treatment of rosacea, presbyderma, melasma or skin irritations.
摘要翻译：本发明涉及具有以下成分的药物组合物：壬二酸，聚丙烯酸，三酰基甘油酯，丙二醇，聚山梨酯，大豆卵磷脂，水和盐。该组合物是适合于治疗酒渣鼻，皮疹，黑斑或皮肤刺激的水凝胶。

9. 发明授权

US5922349A Hormone replacement therapy method and hormone dispenser 失效
公开(公告)号：US5922349A
公开(公告)日：1999-07-13
申请号：US721968
申请日：1996-09-27
申请人： Jorg Elliesen , Jutta Riedl
发明人： Jorg Elliesen , Jutta Riedl
IPC分类号： A61K9/00 , A61K9/06 , A61K31/00 , A61K31/565 , A61K31/57 , A61M35/00 , A61P15/00 , A61P15/12 , B65D35/00 , B65D35/22 , B65D81/32 , B65D83/00 , B67D99/00 , A61F13/00
CPC分类号： B65D83/0011 , A61K31/565 , A61K31/57 , A61K9/06 , B65D35/22 , B65D81/325 , B65D83/0005
摘要： Varying the daily dose of either or both of the estrogen and the progestogen administered for hormone replacement therapy (HRT) is readily and inexpensively accomplished, without the necessity of the physician prescribing a new product each time the daily dose of the estrogen or progestogen is changed, by administering preferably transdermally the estrogen and the progestogen contained in separate extrudable pharmaceutical compositions from a dispenser which contains means, preferably adjustable only by the attending physician or dispensing pharmacist, for varying the volume of either or both of the respective compositions which is dispensed as a single dose from the dispenser in response to a defined digital dispensing manipulation of the dispenser thereby facilitating optimal compliance to a combination of HRT with individually adjusted dosages of the estrogen and progestogen.

10. 发明授权

US5904931A Transdermal therapeutic systems that contain sex steroids and dimethyl isosorbide 失效
标题翻译：含有性类固醇和二甲基异山梨醇的透皮治疗系统
公开(公告)号：US5904931A
公开(公告)日：1999-05-18
申请号：US693050
申请日：1996-11-08
申请人： Ralph Lipp , Clemens Gunther , Jutta Riedl , Ulrich Tauber
发明人： Ralph Lipp , Clemens Gunther , Jutta Riedl , Ulrich Tauber
IPC分类号： A61F13/02 , A61K9/70 , A61K31/565 , A61K31/57 , A61K47/26 , A61P5/30 , A61P13/02 , A61P15/00 , A61P25/04 , A61P43/00 , A61F13/00
CPC分类号： A61K9/7053 , A61K31/565 , A61K31/57 , A61K47/26 , A61K9/7061 , A61K9/7069
摘要： Transdermal therapeutic systems that contain sex steroids and optionally penetration-enhancers and crystallization inhibitors are described, which are characterized in that they contain dimethyl isosorbide, with the exception of systems that contain active ingredient-containing, non-free-flowing gel phases or 3-keto-desogestrel.
摘要翻译： PCT No.PCT / EP95 / 00483 Sec。 371日期：1996年11月8日 102（e）日期1996年11月8日PCT提交1995年2月9日PCT公布。第WO95 / 22322号公报日本1995年8月24日描述了含有性类固醇和任选的渗透增强剂和结晶抑制剂的经皮治疗系统，其特征在于它们含有二甲基异山梨醇，除了含有活性成分的非自由流动凝胶相或3-酮去氧孕烯。

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