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1. 发明授权

US07052837B2 Histoplasma capsulatum catalase sequences and their use in the detection of Histoplamsa capsulatum and histoplasmosis 有权
标题翻译：组织胞浆过氧化氢酶序列及其在检测组织胞浆菌和组织胞浆菌病中的应用
公开(公告)号：US07052837B2
公开(公告)日：2006-05-30
申请号：US10099352
申请日：2002-03-13
申请人： Clayton H. Johnson , J. Lyndal York , Joan E. McEwen
发明人： Clayton H. Johnson , J. Lyndal York , Joan E. McEwen
IPC分类号： C12Q1/68 , C12P19/34 , C07H21/04
CPC分类号： C12N9/0065 , C12Q1/6895 , C12Q2600/158 , G01N33/56961 , G01N33/573
摘要： The present invention describes Histoplasmosis capsulatum catalase A and catalase P nucleic acid and protein sequences as reagents for the detection of H. capsulatum infection. Specifically, the invention describes intron sequences from the H. capsulatum catalase A (CATA) and catalase P (CATP) genes which can be used for hybridization and PCR based detection of H. capsulatum infection. In another embodiment, assays for H. capsulatum catalase P or catalase A polypeptides are used as diagnostic tests for H. capsulatum infection and histoplasmosis, respectively. Also described is the differentiation of H. capsulatum from Blastomyces dermititidis based on a H. capsulatum catalase P PCR based assay.
摘要翻译：本发明描述了组织胞浆菌过氧化氢酶A和过氧化氢酶P核酸和蛋白质序列作为检测荚膜梭菌感染的试剂。具体地，本发明描述了可用于杂交和PCR检测荚膜梭菌感染的H. capsulatum过氧化氢酶A（CATA）和过氧化氢酶P（CATP）基因的内含子序列。在另一个实施方案中，分别用于H. capsulatum过氧化氢酶P或过氧化氢酶A多肽的测定作为荚膜梭菌感染和组织胞浆菌病的诊断试验。还描述了基于基于H. capsulatum过氧化氢酶基于PCR的测定法，来自真皮酵母菌的H. capsulatum的分化。

2. 发明授权

US07217519B1 Histoplasma capsulatum chitin synthase sequences and their use for detection of Histoplasma capsulatum and histoplasmosis 有权
标题翻译：组织胞浆壳聚糖合酶序列及其用于检测组织胞浆菌和组织胞浆菌病的用途
公开(公告)号：US07217519B1
公开(公告)日：2007-05-15
申请号：US10718955
申请日：2003-11-21
申请人： Clayton H. Johnson , Joan E. McEwen
发明人： Clayton H. Johnson , Joan E. McEwen
IPC分类号： C12Q1/68 , C12P19/34 , C07H21/04
CPC分类号： C12Q1/6895 , C12Q2600/158
摘要： The present invention describes Histoplasmosis capsulatum chitin synthase nucleic acid and protein sequences as reagents for the detection of H. capsulatum infection. Specifically, the invention describes intron sequences from the H. capsulatum chitin synthase gene which can be used for hybridization-based and PCR-based detection of H. capsulatum infection. In another embodiment, assays for H. capsulatum chitin synthase 2 polypeptide and/or mRNA used as a diagnostic test for H. capsulatum infection and/or histoplasmosis. Also described is the differentiation of H. capsulatum from Blastomyces dermititidis based on detection of intron 1 sequences specific to H. capsulatum chitin synthase 2. The present invention also comprises the production of H. capsulatum strains lacking functional chitin synthase 2 as a means to produce H. capsulatum having reduced pathogenicity.
摘要翻译：本发明描述了组织胞浆菌壳聚糖几丁质合酶核酸和蛋白质序列作为检测荚膜梭菌感染的试剂。具体地，本发明描述了可用于基于杂交和基于PCR的荚膜梭菌感染检测的荚膜梭菌几丁质合酶基因的内含子序列。在另一个实施方案中，用于幽门螺杆菌壳聚糖合酶2多肽和/或mRNA的测定用作幽门螺杆菌感染和/或组织胞浆菌病的诊断试验。还描述了基于检测对H. capsulatum几丁质合酶2特异性的内含子1序列的幽门螺杆菌的分离。本发明还包括生产缺乏功能性甲壳质合酶2的荚膜梭菌菌株作为生产手段 H. capsulatum具有降低的致病性。

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