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1. 发明授权

US5523321A Prostacyclins, their analogs or prostaglandins and thromboxane antagonists for treatment of thrombotic and thromboembolic syndromes 失效
标题翻译：前列环素，其类似物或前列腺素和血栓素拮抗剂用于治疗血栓形成和血栓栓塞综合征
公开(公告)号：US5523321A
公开(公告)日：1996-06-04
申请号：US504071
申请日：1990-04-02
申请人： Claus-Steffen Stuerzebecher , Werner Witt , Bernd Raduechel , Werner Skuballa , Helmut Vorbrueggen
发明人： Claus-Steffen Stuerzebecher , Werner Witt , Bernd Raduechel , Werner Skuballa , Helmut Vorbrueggen
IPC分类号： A61K31/557 , A61K31/355 , A61K31/19 , A61K31/34
CPC分类号： A61K31/557
摘要： Combination products containing a prostaglandin (PG), prostacyclin (PC) or a prostacyclin analog (PCA) and a thromboxane receptor antagonist (TXAA) are suitable for joint application to thrombotic and thromboembolic syndromes.
摘要翻译：包含前列腺素（PG），前列环素（PC）或前列环素类似物（PCA）和血栓素受体拮抗剂（TXAA）的组合产品适用于联合应用于血栓形成和血栓栓塞综合征。

2. 发明授权

US4721729A Novel carbacyclins, process for the preparation thereof, and their use as medicinal agents 失效
标题翻译：新型碳环霉素，其制备方法及其作为药剂的用途
公开(公告)号：US4721729A
公开(公告)日：1988-01-26
申请号：US702092
申请日：1985-02-08
申请人： Werner Skuballa , Bernd Raduechel , Helmut Vorbrueggen , Robert Nickolson , Martin Haberey , Olaf Loge , Claus-Steffen Stuerzebecher
发明人： Werner Skuballa , Bernd Raduechel , Helmut Vorbrueggen , Robert Nickolson , Martin Haberey , Olaf Loge , Claus-Steffen Stuerzebecher
IPC分类号： C07C43/14 , A61K31/557 , A61P43/00 , C07C27/00 , C07C35/31 , C07C35/52 , C07C41/00 , C07C45/00 , C07C49/24 , C07C49/255 , C07C49/76 , C07C67/00 , C07C405/00 , C07C177/00
CPC分类号： C07C405/0083 , Y10S514/829
摘要： Carbacyclins of Formula I ##STR1## wherein R.sub.1 is an alkyl, cycloalkyl, aryl, aralkyl, or heterocyclic group,Y is a keto group or a hydroxymethylene group,X is a --CH.sub.2 -- group or an oxygen atom,A is a --CH.sub.2 --CH.sub.2 --, a trans--CH.dbd.CH-- or a --C.tbd.C-- group,W is a hydroxymethylene group or a ##STR2## D is the group ##STR3## a straight-chain or branched, saturated alkylene group or unsaturated alkylene group of up to 5 carbon atoms which can optionally be substituted by 1-2 fluorine atoms,n is 1, 2 or 3,E is a direct bond, a --C.tbd.C-- group or a --CR.sub.4 .dbd.CR.sub.5 -- group wherein R.sub.4 is hydrogen or an alkyl group and R.sub.5 is hydrogen, halogen or an alkyl group,R.sub.2 is an alkyl, cycloalkyl, aryl, or heterocyclic group, andR.sub.3 is a hydroxy group,are valuable, e.g., as cytoprotective agents.
摘要翻译：式I的卡巴菌素其中R 1是烷基，环烷基，芳基，芳烷基或杂环基，Y是酮基或羟亚甲基，X是-CH 2 - 基或氧原子，A是 -CH 2 -CH 2 - ，反式-CH = CH-或-C 3 C C基团，W是羟基亚甲基基团，或者D是基团，即直链或支链饱和亚烷基或至多5个碳原子的不饱和亚烷基，其可任选被1-2个氟原子取代，n为1,2或3，E为直接键，-C 3位C基团或-CR 4 = CR 5 - 基团，其中R 4是氢或烷基，R 5是氢，卤素或烷基，R 2是烷基，环烷基，芳基或杂环基，并且R 3是羟基，是有价值的，例如作为细胞保护剂。

3. 发明授权

US4827017A Novel carbacyclins, processes for their production and their use as medicinal agents 失效
标题翻译：新型碳霉素，其生产工艺及其作为药剂的使用
公开(公告)号：US4827017A
公开(公告)日：1989-05-02
申请号：US21102
申请日：1987-03-03
申请人： Werner Skuballa , Bernd Raduechel , Helmut Vorbrueggen , Ekkehard Schillinger , Claus-Steffen Stuerzebecher
发明人： Werner Skuballa , Bernd Raduechel , Helmut Vorbrueggen , Ekkehard Schillinger , Claus-Steffen Stuerzebecher
IPC分类号： C07D309/12 , A61K31/557 , A61P1/04 , A61P7/02 , A61P9/08 , A61P9/12 , A61P11/08 , A61P43/00 , C07C45/00 , C07C49/835 , C07C51/00 , C07C65/19 , C07C67/00 , C07C69/76 , C07C69/773 , C07C405/00 , C07C177/00
CPC分类号： C07C405/0083
摘要： Carbacyclin derivatives of Formula I ##STR1## wherein R.sub.1 is OR.sub.2 wherein R.sub.2 is hydrogen, C.sub.1 -C.sub.10 -alkyl, C.sub.3 -C.sub.10 -cycloalkyl, C.sub.6 -C.sub.10 -aryl, ##STR2## or a heterocyclic residue, or R.sub.1 is R.sub.3 wherein R.sub.3 is C.sub.1 -C.sub.10 -alkyl, C.sub.3 -C.sub.10 -cycloalkyl, C.sub.6 -C.sub.10 -aryl, C.sub.7 -C.sub.14 -aralkyl or a heterocyclic residue,A is --CH.sub.2 --CH.sub.2 --, trans--CH.dbd.CH-- or --C.tbd.C--,W is a free or functionally modified hydroxymethylene group or a free or functionally modified ##STR3## wherein the OH-group can be in the .alpha.- or .beta.-position, D is ##STR4## a straight-chain, saturated alkylene group of 1-10 carbon atoms, or a branched, saturated or a straight-chain or branched, unsaturated alkylene group of 2-10 carbon atoms, each of which can optionally by substituted by fluorine atoms,n is the number 1, 2 or 3,E is --C.tbd.C-- or --CR.sub.6 .dbd.CR.sub.7 -- wherein R.sub.6 and R.sub.7 differ from each other and one is hydrogen and the other alkyl of 1-5 carbon atoms, or one is hydrogen and the other is halogen, orE can also be --CH.sub.2 CH.sub.2 -- when R.sub.1 is R.sub.3,R.sub.4 is C.sub.1-10 -alkyl, C.sub.3 -C.sub.10 -cycloalkyl, optionally substituted C.sub.6 -C.sub.10 -aryl or a heterocyclic group,R.sub.5 is a free or functionally modified hydroxy group and, when R.sub.2 is hydrogen, the salts thereof with physiologically compatible bases;are useful as medicinal agents.
摘要翻译：式I的卡巴环素衍生物其中R 1是OR 2，其中R 2是氢，C 1 -C 10 - 烷基，C 3 -C 10 - 环烷基，C 6 -C 10 - 芳基，或者杂环残基，或者R 1是R 3 其中R 3是C 1 -C 10 - 烷基，C 3 -C 10 - 环烷基，C 6 -C 10 - 芳基，C 7 -C 14 - 芳烷基或杂环残基，A是-CH 2 -CH 2 - ，反式-CH = CH-或-C - ，W是游离或官能改性的羟基亚甲基或游离的或功能上被修饰的“IMAGE”，其中OH基可以是α或β-位，D是直链，饱和的亚烷基 1-10个碳原子，或2-10个碳原子的支链，饱和或直链或支链不饱和的亚烷基，其各自可任选被氟原子取代，n为数1,2或3， E是-C 3位C或-CR 6 = CR 7 - ，其中R 6和R 7彼此不同，一个是氢，1-5个碳原子的另一个烷基，或一个是氢，另一个是卤素，或者也可以是当R 1为R 3，R 4为C 1-10时为-CH 2 CH 2 - 烷基，C 3 -C 10 - 环烷基，任选取代的C 6 -C 10 - 芳基或杂环基，R 5是游离或官能改性的羟基，并且当R 2是氢时，其与生理上相容的碱的盐; 作为药剂有用。

4. 发明授权

US06225347B1 9-halogen-(Z)-prostaglandin derivatives, process for their production and their use as pharmaceutical agents 失效
标题翻译： 9-卤素 - （Z） - 前列腺素衍生物，其制备方法及其作为药剂的用途
公开(公告)号：US06225347B1
公开(公告)日：2001-05-01
申请号：US08313667
申请日：1994-09-27
申请人： Bernd Buchmann , Werner Skuballa , Helmut Vorbrueggen , Bernd Raduechel , Olaf Loge , Walter Elger , Claus-Steffen Stuerzebecher , Karl-Heinz Thierauch
发明人： Bernd Buchmann , Werner Skuballa , Helmut Vorbrueggen , Bernd Raduechel , Olaf Loge , Walter Elger , Claus-Steffen Stuerzebecher , Karl-Heinz Thierauch
IPC分类号： C07C40500
CPC分类号： C07C405/0016 , C07C405/00 , C07C405/0025
摘要： The invention relates to 9-halogen-(Z) prostane derivatives of formula I in which Z represents the radicals Hal represents a chlorine or fluorine atom in the alpha or beta position, R1 represents the radical with R2 meaning a hydrogen atom, an alkyl, cycloalkyl, aryl or heterocyclic radical or R1 represents the radical with R3 meaning an acid radical or the radical R2 and A represents a —CH2—CH2—, a trans-CH═CH or —C≡C group, W represents a free or a functionally modified group, and the respective OH groups can be in the alpha or beta position, D and E together represent a direct bond or D represents a straight-chain alkylene group with 1-10 C atoms, a branched-chain alkylene group with 2-10 C atoms or an annular alkylene group with 3-10 C atoms, which optionally can be substituted by fluorine atoms, and E represents an oxygen or sulfur atom, a direct bond, a C≡C bond or a —CR6═CR7 group, and R6 and R7 are different and mean a hydrogen atom, a chlorine atom or a C1-C4 alkyl group, R4 resents a free or functionally modified hydroxy group, R5 means a hydrogen atom, an alkyl, a halogen-substituted alkyl, a cycloalkyl or an optionally substituted aryl or a heterocyclic group, and if R2 means a hydrogen atom, its salts with physiologically compatible bases or its cyclodextrin chlathrates, process for their production and their pharmaceutical use.
摘要翻译：本发明涉及式Iin的9-卤素 - （Z）前列腺衍生物，其中Z代表基团.Hal表示α或β位上的氯或氟原子，R 1表示R 2表示氢原子，烷基，环烷基，芳基或杂环基或R 1表示基团，其中R 3表示酸基或基团R 2且A表示-CH 2 -CH 2 - ，反式-CH = CH或-C = C基团，W表示游离或功能修饰基团， OH基可以是α或β位，D和E一起代表直接键或D表示具有1-10个C原子的直链亚烷基，具有2-10个C原子的支链亚烷基或环状亚烷基具有3-10个C原子的基团，其任选地可以被氟原子取代，E表示氧或硫原子，直接键合，C = C键或-CR 6 = CR 7基团，并且R 6和R 7不同，一个氢原子，一个氯原子或一个C 1 -C 4烷基，R 4是一个游离的或官能改性的羟基，R 5表示氢原子，烷基，卤素取代的烷基，环烷基或任选取代的芳基或杂环基，如果R 2表示氢原子，则其与生理上相容的碱或其环糊精的盐 chlathrates，生产过程及其药物用途。

5. 发明授权

US5891910A 9-halogen-(Z) prostaglandin derivatives, process for their production and their use as pharmaceutical agents 失效
标题翻译： 9-卤素 - （Z）前列腺素衍生物，其制备方法及其作为药剂的用途
公开(公告)号：US5891910A
公开(公告)日：1999-04-06
申请号：US467888
申请日：1995-06-06
申请人： Bernd Buchmann , Werner Skuballa , Helmut Vorbrueggen , Bernd Raduechel , Olaf Loge , Walter Elger , Claus-Steffen Stuerzebecher , Karl-Heinz Thierauch
发明人： Bernd Buchmann , Werner Skuballa , Helmut Vorbrueggen , Bernd Raduechel , Olaf Loge , Walter Elger , Claus-Steffen Stuerzebecher , Karl-Heinz Thierauch
IPC分类号： C07C405/00 , A61K31/557
CPC分类号： C07C405/00 , C07C405/0016 , C07C405/0025
摘要： The invention relates to 9-halogen-(Z) prostane derivatives of formula I ##STR1## in which ##STR2## Z represents the radicals Hal represents a chlorine or fluorine atom,R.sub.1 represents ##STR3## A represents a --CH.sub.2 --CH.sub.2 --, a trans--CH=CH or --C.ident.C, W represents a free or a functionally modified ##STR4## group, D and E together represent a direct bond orD represents a straight-chain alkylene group with 1-10 C atoms, a branched-chain alkylene group with 2-10 C atoms or an annular alkylene group with 3-10 C atoms, which optionally can be substituted by fluorine atoms, andE represents an oxygen or sulfur atom, a direct bond, a C.ident.C bond or a --CR.sub.6 =CR.sub.7 group, and R.sub.6 and R.sub.7 are different and mean a hydrogen atom, a chlorine atom or a C.sub.1 -C.sub.4 alkyl group,R.sub.4 represents a free or functionally modified hydroxy,R.sub.5 means a hydrogen atom, an alkyl, a halogen-substituted alkyl, a cycloalkyl or an optionally substituted aryl or a heterocyclic group.
摘要翻译：本发明涉及式I的9-卤代 - （Z）前列腺衍生物，其中，Z表示基团，Hal表示氯或氟原子，R1表示A表示 -CH 2 -CH 2 - ，反式-CH = CH或-C = C，W表示游离或官能改性的基团，D和E一起表示直接键或D表示直链亚烷基，其中1 -10个C原子，具有2-10个碳原子的支链亚烷基或具有3-10个C原子的环状亚烷基，其任选可以被氟原子取代，E表示氧或硫原子，直接键，C = C键或-CR6 = CR7基，R6和R7不同，表示氢原子，氯原子或C1-C4烷基，R4表示游离或官能改性的羟基，R5表示氢原子，烷基，卤素取代的烷基，环烷基或任选取代的芳基或杂环基。

6. 发明授权

US5013758A Novel carbacyclins, processes for their preparation and their use as medicinal agents 失效
标题翻译：新型碳霉素，其制备方法及其用作药物
公开(公告)号：US5013758A
公开(公告)日：1991-05-07
申请号：US434561
申请日：1989-11-13
申请人： Werner Skuballa , Bernd Raduechel , Helmut Vorbrueggen , Claus-Steffen Stuerzebecher , Martin Haberey , Ekkehard Schillinger , Michael H. Town
发明人： Werner Skuballa , Bernd Raduechel , Helmut Vorbrueggen , Claus-Steffen Stuerzebecher , Martin Haberey , Ekkehard Schillinger , Michael H. Town
IPC分类号： A61K31/557 , A61P9/12 , C07C51/00 , C07C51/367 , C07C59/125 , C07C67/00 , C07C405/00 , C07D309/12
CPC分类号： C07C405/0083 , C07D309/12
摘要： (5E)-13,14,18,18,19,19-hexadehydro-3-oxa-6a-carbaprostaglandin I.sub.2 derivatives of Formula I ##STR1## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4 are hydrogen or alkyl of 1-5 carbon atoms, andR.sub.5 is an alkyl group of 1-5 carbon atoms, as well as the physiologically compatible salts thereof;have pharmacologically valuable activity.
摘要翻译：（I）的（5E）-13,14,18,18,19,19-六氢-3-氧杂-10-碳前列腺素I 2衍生物其中R 1，R 2，R 3，R 4为氢或烷基， -5个碳原子，R5是1-5个碳原子的烷基，以及其生理上相容的盐; 具有药理学有价值的活动。

7. 发明授权

US4806668A Process for the production of 9beta-chloroprostaglandins 失效
标题翻译：生产9beta-氯前列腺素的方法
公开(公告)号：US4806668A
公开(公告)日：1989-02-21
申请号：US110745
申请日：1987-08-07
申请人： Bernd Raduechel , Werner Skuballa , Helmut Vorbrueggen
发明人： Bernd Raduechel , Werner Skuballa , Helmut Vorbrueggen
IPC分类号： C07C47/198 , C07C45/00 , C07C45/59 , C07C45/60 , C07C47/277 , C07C49/753 , C07C67/00 , C07C405/00 , C07F7/18 , C07F7/08
CPC分类号： C07C405/00 , C07C45/59 , C07C45/60 , C07C47/277 , C07C49/753
摘要： The invention relates to a process for the production of (5-chloro-3-hydroxycyclopentyl) acetaldehydes of formula II ##STR1## in which R signifies a benzyl radical, a tert-butyldimethylsilyl radical or a tert-butyldiphenylsilyl radical, characterized in that a compound of formula I ##STR2## in which R has the meanings already mentioned, is reduced in the presence of a reduction agent.
摘要翻译： PCT No.PCT / DE86 / 00483 Sec。 371日期1987年8月7日 102（e）日期1987年8月7日PCT公布1986年11月28日PCT公布。公开号WO87 / 03582 日期：1987年6月18日。本发明涉及制备式II的（5-氯-3-羟基环戊基）乙醛的方法，其中R表示苄基，叔丁基二甲基甲硅烷基或叔丁基二甲基甲硅烷基丁基二苯基甲硅烷基，其特征在于其中R具有上述含义的式I的化合物在还原剂的存在下还原。

8. 发明授权

US4618626A Novel carbacyclin esters, process for the preparation thereof, and their use as medicinal agents 失效
标题翻译：新型卡巴环素酯，其制备方法及其作为药剂的用途
公开(公告)号：US4618626A
公开(公告)日：1986-10-21
申请号：US777535
申请日：1985-09-16
申请人： Werner Skuballa , Bernd Raduechel , Helmut Vorbrueggen , Gerda Mannesmann , Bob Nieuweboer , Michael-Harold Town
发明人： Werner Skuballa , Bernd Raduechel , Helmut Vorbrueggen , Gerda Mannesmann , Bob Nieuweboer , Michael-Harold Town
IPC分类号： C07C69/708 , A61K31/557 , A61P1/04 , A61P9/08 , A61P9/12 , A61P11/08 , C07C67/10 , C07C69/732 , C07C405/00 , C07C177/00
CPC分类号： C07C405/0083
摘要： Carbacyclin esters of Formula I ##STR1## wherein R.sub.1 is an unsubstituted or substituted aromatic residue,R.sub.2 is a free or functionally modified hydroxy group,R.sub.3 is an alkyl or cycloalkyl group, or an optionally substituted aryl group, or a heterocyclic group,X is an oxygen atom or the group --CH.sub.2 --,A is a --CH.sub.2 --CH.sub.2 --, trans--CH.dbd.CH--, or --C.tbd.C--group,W is a free or functionally modified hydroxymethylene group or a free or functionally modified ##STR2## wherein the OH-group can be in the .alpha.- or .beta.-position D is the group ##STR3## a straight-chain saturated alkylene group of 1-5 carbon atoms, a branched, saturated or a straight-chain or branched, unsaturated alkylene group of 2-5 carbon atoms, which groups can optionally be substituted by fluorine atoms,E is a direct bond, a --C.tbd.C--group, or a --CR.sub.4 .dbd.CR.sub.5 -- group wherein R.sub.2 and R.sub.5 mean a hydrogen atom or an alkyl group of 1-5 carbon atoms;are useful as blood-pressure-lowering agents, inter alia.
摘要翻译：式I的卡巴环素酯其中R 1是未取代或取代的芳族残基，R 2是游离或官能改性的羟基，R 3是烷基或环烷基，或任选取代的芳基或杂环基，X是氧原子或基团-CH 2 - ，A是-CH 2 -CH 2 - ，反式-CH = CH-或-C 3 C C基，W是游离或官能改性的羟基亚甲基，功能修饰的“IMAGE”，其中OH基可以在α或β位D是基团，即1-5个碳原子的直链饱和亚烷基，支链，饱和或直链或2-5个碳原子的支链不饱和亚烷基，该基团可任选被氟原子取代，E是直接键，-C 3 C C基或-CR 4 = CR 5 - 基，其中R 2和R 5表示氢原子或1-5个碳原子的烷基; 作为降血压剂特别有用。

9. 发明授权

US5157042A 3-oxa-5-fluoro-carbacyclins, their preparation and use as medicinal agents 失效
标题翻译： 3-OXA-5-FLOORO-CARBACYCLINS，其制备和用作药物代理
公开(公告)号：US5157042A
公开(公告)日：1992-10-20
申请号：US713002
申请日：1991-06-10
申请人： Werner Skuballa , Bernd Raduechel , Helmut Vorbrueggen , Jorge Casals-Stenzel , Gerda Mannesmann , Michael H. Town
发明人： Werner Skuballa , Bernd Raduechel , Helmut Vorbrueggen , Jorge Casals-Stenzel , Gerda Mannesmann , Michael H. Town
IPC分类号： C07C69/708 , A61K31/225 , A61K31/35 , A61K31/351 , A61K31/557 , A61P7/02 , A61P9/12 , A61P11/08 , C07C51/00 , C07C51/367 , C07C59/125 , C07C59/62 , C07C67/00 , C07C67/31 , C07C231/00 , C07C231/02 , C07C231/12 , C07C235/06 , C07C235/08 , C07C235/88 , C07C405/00 , C07D309/12 , C07D317/72
CPC分类号： C07D317/72 , C07C405/0083
摘要： Carbacyclin derivatives of Formula I ##STR1## wherein R.sub.1 is OR.sub.2, wherein R.sub.2 is hydrogen, alkyl, cycloalkyl, aryl, ##STR2## or a heterocyclic residue; or R.sub.1 is NHR.sub.3 wherein R.sub.3 is an acid residue (acyl) or R.sub.2 ;A is --CH.sub.2 --CH.sub.2 --, trans--CH.dbd.CH--, or --C.tbd.C--;W is a free or functionally modified hydroxymethylene group or a free or functionally modified ##STR3## wherein the OH-group can be in the .alpha.- or .beta.-position; D is ##STR4## a straight-chain, saturated aliphatic group of 1-10 carbon atoms; or a branched, saturated or straight-chain or branched, unsaturated aliphatic group of 2-10 carbon atoms; all of which are substituted by fluorine atoms;n is 1, 2, or 3;E is a direct bond, --C.tbd.C--, or --CR.sub.6 .dbd.CR.sub.7 --, wherein R.sub.6 is hydrogen or alkyl of 1-5 carbon atoms and R.sub.7 is hydrogen, halogen or alkyl of 1-5 carbon atoms;R.sub.4 is an aliphatic group, cycloalkyl, optionally substituted aryl, or a heterocyclic group; andR.sub.5 is a free or functionally modified hydroxy group; andwhen R.sub.1 is OH, the salts thereof with physiologically compatible bases,are valuable pharmacological agents.
摘要翻译：式I的卡巴环素衍生物其中R 1是OR 2，其中R 2是氢，烷基，环烷基，芳基，杂芳基或杂环残基; 或R1是NHR3，其中R3是酸残基（酰基）或R2; A是-CH 2 -CH 2 - ，反式-CH = CH-或-C 3位C; W是游离或官能改性的羟基亚甲基或游离或官能改性的“IMAGE”，其中OH基可以是α-或β-位; D是1-10个碳原子的直链饱和脂族基团; 或2-10个碳原子的支链，饱和或直链或支链的不饱和脂族基团; 所有这些都被氟原子取代; n为1,2或3; E是直接键，-C 3 D或-CR 6 = CR 7 - ，其中R 6是氢或1-5个碳原子的烷基，R 7是氢，卤素或1-5个碳原子的烷基; R4是脂族基团，环烷基，任选取代的芳基或杂环基; R5是游离或官能改性的羟基; 当R1是OH时，其与生理上相容的碱的盐是有价值的药剂。

10. 发明授权

US5079259A Pharmaceutically active 9-chloroprostaglandins 失效
标题翻译：药物活性9氯罗丹明
公开(公告)号：US5079259A
公开(公告)日：1992-01-07
申请号：US96232
申请日：1987-09-08
申请人： Werner Skuballa , Bernd Raduechel , Helmut Vorbrueggen , Walter Elger , Olaf Loge , Ekkehard Schillinger
发明人： Werner Skuballa , Bernd Raduechel , Helmut Vorbrueggen , Walter Elger , Olaf Loge , Ekkehard Schillinger
IPC分类号： A61K31/557 , A61K31/5575 , A61P43/00 , C07C67/00 , C07C401/00 , C07C405/00
CPC分类号： C07C405/00 , C07C405/0041
摘要： A 9-chloroprostane of the formula ##STR1## wherein the 9-chlorine atom can be in the .alpha. or .beta.-position and R.sub.1, R.sub.4, R.sub.5, A, B, W, D and E are as described hereinafter which are useful as medical agents.

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