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1. 发明授权

US08349839B2 Inhibitors of HIV replication 有权
标题翻译： HIV复制抑制剂
公开(公告)号：US08349839B2
公开(公告)日：2013-01-08
申请号：US12756276
申请日：2010-04-08
申请人： Claudio Sturino , Patrick Deroy , Martin Duplessis , Paul J. Edwards , Anne-Marie Faucher , Teddy Halmos , Clint James , Jean-Eric Lacoste , Eric Malenfant , Joannie Minville , Louis Morency , Sebastien Morin , Martin Tremblay , Christiane Yoakim
发明人： Claudio Sturino , Patrick Deroy , Martin Duplessis , Paul J. Edwards , Anne-Marie Faucher , Teddy Halmos , Clint James , Jean-Eric Lacoste , Eric Malenfant , Joannie Minville , Louis Morency , Sebastien Morin , Martin Tremblay , Christiane Yoakim
IPC分类号： A61K31/501 , A61K31/34 , C07D237/36 , C07D307/92
CPC分类号： C07D491/048 , C07D487/04 , C07D491/147 , C07D513/04 , C07D519/00
摘要： Compounds of formula (I): wherein R1, R2, A1, A2, A3, A4, X and Y are as defined herein, are useful as inhibitors of HIV replication.
摘要翻译：式（I）化合物：其中R1，R2，A1，A2，A3，A4，X和Y如本文所定义，可用作HIV复制的抑制剂。

2. 发明授权

US06806265B2 Non-nucleoside reverse transcriptase inhibitors 有权
标题翻译：非核苷逆转录酶抑制剂
公开(公告)号：US06806265B2
公开(公告)日：2004-10-19
申请号：US10430116
申请日：2003-05-06
申请人： Bruno Simoneau , Serge Landry , Eric Malenfant , Julie Naud , Jeffrey O'Meara , Bounkham Thavonekham , Christiane Yoakim
发明人： Bruno Simoneau , Serge Landry , Eric Malenfant , Julie Naud , Jeffrey O'Meara , Bounkham Thavonekham , Christiane Yoakim
IPC分类号： C07D47114
CPC分类号： C07D471/14
摘要： Compounds represented by formula I: wherein R2 is selected from the group consisting of H, (C1-4)alkyl, halo, haloalkyl, OH, (C1-6)alkoxy, NH(C1-4alkyl) or N(C1-4alkyl)2; R4 is H or Me; R5 is H or Me; R11 is H, (C1-4)alkyl, (C3-4)cycloalkyl and (C1-4)alkyl-(C3-4)cycloalkyl; A is a connecting chain of (C1-3)alkyl; B is O or S; n is 0 or 1; wherein when n is 0: Ring C is 6- or 10-membered aryl or 5- or 6-membered heterocycle having from 1 to 4 heteroatoms selected from the group consisting of O, N, and S, said aryl and said heterocycle being optionally substituted; and E is CONR12R13; CONHNR14R15; NR16COR17; NR18SO2(C1-6)alkyl; SO2NR19R20; or SO2R21; or when n is 1: Ring C is as defined above and E is a single bond or a connecting group; and Ring D is 6- or 10-membered aryl or 5- or 6-membered heterocycle having from 1 to 4 heteroatoms selected from the group consisting of O, N, and S, said aryl and said heterocycle being optionally substituted with from 1 to 5 substituents; or a salt or a prodrug thereof are provided as inhibitors of HIV reverse transcriptase.
摘要翻译：由式I表示的化合物：其中R 2选自H，（C 1-4）烷基，卤素，卤代烷基，OH，（C 1-6）烷氧基，NH（C 1-4烷基）或N（C1- 4烷基）2; R 4是H或Me; R 5是H或Me; R 11是H，（C 1-4）烷基，（C 3-4）环烷基和（C 1-4）烷基 - （C 3-4）环烷基; A是（C 1-3）烷基的连接链; B是O或S; n为0或1; 其中当n为0时：环C为具有1至4个选自O，N和S的杂原子的6-元或10元芳基或5-或6-元杂环，所述芳基和所述杂环任选地并且E是CONR 12 R 13; CONHNR 14 R 15; NR 16 COR 17; NR 18（C 1-6）烷基; SO 2 NR 19 R 20; 或SO2R 21; 或者n为1时：环C如上所定义，E为单键或连接基团; 且R D为具有1至4个选自O，N和S的杂原子的6-或10-元芳基或5-或6-元杂环，所述芳基和所述杂环任选被1至5个取代基;或其盐或前药作为HIV逆转录酶的抑制剂提供。

3. 发明授权

US07105510B2 Non-nucleoside reverse transcriptase inhibitors 有权
标题翻译：非核苷逆转录酶抑制剂
公开(公告)号：US07105510B2
公开(公告)日：2006-09-12
申请号：US10662856
申请日：2003-09-15
申请人： Christiane Yoakim , Eric Malenfant , Bounkham Thavonekham , William Ogilvie , Robert Déziel
发明人： Christiane Yoakim , Eric Malenfant , Bounkham Thavonekham , William Ogilvie , Robert Déziel
IPC分类号： C07D471/14 , A61K31/55 , A61P31/18
CPC分类号： C07D471/14
摘要： Compounds represented by formula I: wherein R1 is H, halogen, (C1-4)alkyl, O(C1-4)alkyl, and haloalkyl; R2 is H or (C1-4)alkyl; R3 is H or (C1-4)alkyl; R4 is (C1-4)alkyl, (C1-4)alkyl(C3-7)cycloalkyl, or (C3-7)cycloalkyl; and Q is a fused phenyl-5 or 6-membered saturated heterocycle having one to two heteroatoms selected from O and N, said Q being optionally substituted with hydroxy, or (C1-4)alkyl which in turn maybe optionally substituted with pyridinyl-N-oxide or C(O)OR wherein R is H or (C1-4)alkyl; or a salt thereof. The compounds have inhibitory activity against Wild Type, and single and double mutants strains, of HIV.
摘要翻译：由式I表示的化合物：其中R 1是H，卤素，（C 1-4烷基）烷基，O（C 1-4 - ） - 烷基和卤代烷基; R 2是H或（C 1-4 - ）烷基; R 3是H或（C 1-4 - ）烷基; R 4是（C 1-4烷基）烷基，（C 1-4 - ）烷基（C 1-3 - >）环烷基，或（C 3-7）环烷基; 并且Q是具有一个到两个选自O和N的杂原子的稠合苯基-5或6元饱和杂环，所述Q任选被羟基或（C 1-4烷基）烷基取代，可以任选地被吡啶基-N-氧化物或C（O）OR取代，其中R是H或（C 1-4）烷基; 或其盐。该化合物对野生型具有抑制活性，并具有HIV和HIV的单和双突变株。

4. 发明申请

US20120144475A1 SCALABLE NAT TRAVERSAL 审中-公开
标题翻译：可伸缩的NAT TRAVERSAL
公开(公告)号：US20120144475A1
公开(公告)日：2012-06-07
申请号：US13147922
申请日：2010-02-05
申请人： Sebastien Boire-Lavigne , Richard Colette , Sebastien Lalonde , Eric Malenfant
发明人： Sebastien Boire-Lavigne , Richard Colette , Sebastien Lalonde , Eric Malenfant
IPC分类号： G06F21/00
CPC分类号： H04L61/2567 , H04L29/125 , H04L29/12528 , H04L45/72 , H04L61/2564 , H04L61/2575 , H04L61/2589 , H04L63/029 , H04L65/1006 , H04L65/1069
摘要： A system and method for traversing a firewall for a voice-over-IP session or other communication session uses four main components: a relay agent, and NAT 30A gent, a SIP proxy and a application server. The SIP proxy is located in the public network and SIP signaling messages are routed through the SIP proxy. The sever opens ports in the firewall for signaling between the SIP proxy and the relay agent behind the firewall. The application server also opens ports in the firewall for media traffic. The NAT 30A gent disposed in the path from the firewall to the Internet filters media packets and changes the public source address of the media packets to a predetermined address associated with the open media port.
摘要翻译：用于遍历IP语音IP会话或其他通信会话的防火墙的系统和方法使用四个主要组件：中继代理和NAT 30A连接，SIP代理和应用服务器。 SIP代理位于公共网络中，SIP信令消息通过SIP代理路由。服务器打开防火墙中的端口，在SIP代理和防火墙后面的中继代理之间进行信令通信。应用服务器还在防火墙中为媒体流量打开端口。设置在从防火墙到互联网的路径中的NAT 30A通过过滤媒体分组，并将媒体分组的公共源地址改变为与打开的媒体端口相关联的预定地址。

5. 发明授权

US08825822B2 Scalable NAT traversal 有权
标题翻译：可扩展NAT穿越
公开(公告)号：US08825822B2
公开(公告)日：2014-09-02
申请号：US12701147
申请日：2010-02-05
申请人： Sébastien Boire-Lavigne , Richard Collette , Sebastien Lalonde , Eric Malenfant
发明人： Sébastien Boire-Lavigne , Richard Collette , Sebastien Lalonde , Eric Malenfant
IPC分类号： G06F15/173
CPC分类号： H04L61/2567 , H04L29/125 , H04L29/12528 , H04L45/72 , H04L61/2564 , H04L61/2575 , H04L61/2589 , H04L63/029 , H04L65/1006 , H04L65/1069
摘要： A system and method for traversing a firewall for a voice-over-IP session or other communication session uses four main components: a relay agent, and NAT 30Agent, a SIP proxy and a application server. The SIP proxy is located in the public network and SIP signaling messages are routed through the SIP proxy. The sever opens ports in the firewall for signaling between the SIP proxy and the relay agent behind the firewall. The application server also opens ports in the firewall for media traffic. The NAT 30Agent disposed in the path from the firewall to the Internet filters media packets and changes the public source address of the media packets to a predetermined address associated with the open media port.
摘要翻译：用于遍历IP语音会话或其他通信会话的防火墙的系统和方法使用四个主要组件：中继代理和NAT 30Agent，SIP代理和应用服务器。 SIP代理位于公共网络中，SIP信令消息通过SIP代理路由。服务器打开防火墙中的端口，在SIP代理和防火墙后面的中继代理之间进行信令通信。应用服务器还在防火墙中为媒体流量打开端口。设置在从防火墙到因特网的路径中的NAT 30Agent过滤媒体分组，并将媒体分组的公共源地址改变为与打开的媒体端口相关联的预定地址。

6. 发明授权

US07939545B2 Inhibitors of human immunodeficiency virus replication 有权
标题翻译：人体免疫缺陷病毒复制抑制剂
公开(公告)号：US07939545B2
公开(公告)日：2011-05-10
申请号：US11746303
申请日：2007-05-09
申请人： Youla S. Tsantrizos , Michael Boes , Christian Brochu , Craig Fenwick , Stephen Mason , Marc Pesant , Eric Malenfant
发明人： Youla S. Tsantrizos , Michael Boes , Christian Brochu , Craig Fenwick , Stephen Mason , Marc Pesant , Eric Malenfant
IPC分类号： A61K31/04 , C07D215/38
CPC分类号： C07D215/22 , C07D215/14 , C07D215/18 , C07D215/227 , C07D311/08 , C07D311/12 , C07D311/14 , C07D401/04 , C07D401/12 , C07D405/04 , C07D409/04 , C07D413/12
摘要： Compounds of formula I: wherein a, b, c, X, R2, R3, R4, R6 and R7 are defined herein, are useful as inhibitors of HIV replication.
摘要翻译：式I化合物：其中a，b，c，X，R2，R3，R4，R6和R7如本文所定义，可用作HIV复制的抑制剂。

7. 发明申请

US20050193646A1 Parapet wall 审中-公开
标题翻译：护墙墙
公开(公告)号：US20050193646A1
公开(公告)日：2005-09-08
申请号：US11068231
申请日：2005-03-01
申请人： Jean-Claude Malenfant , Eric Malenfant , Yves Malenfant
发明人： Jean-Claude Malenfant , Eric Malenfant , Yves Malenfant
IPC分类号： E04D13/12 , E04G21/32 , E04H12/20
CPC分类号： E04G21/3223
摘要： A parapet wall comprising posts, each post being fastened to a siding of a building by a post fastening means, and heddles connected between the posts, the post fastening means being fastened to the siding of the building on the one hand and to an edge of a roof of the building on the other hand, along a direction generally perpendicular to the siding of the building, by a mounting plate including a first part fastened to the edge of the roof and a second part accommodating a foot of the post.
摘要翻译：一种护栏墙，其包括柱，每个柱通过柱固定装置固定到建筑物的侧板上，以及连接在柱之间的综丝，所述柱固定装置一方面固定在建筑物的侧板上，另一方面，建筑物的屋顶沿着大致垂直于建筑物的侧板的方向，通过安装板，该安装板包括固定到屋顶的边缘的第一部分和容纳柱的脚的第二部分。

8. 发明授权

US5948935A Process and intermediates for (s)-.alpha.-amino-1-carboxycyclopentaneacetic acid 失效
标题翻译：（s）-α-氨基-1-羧基环戊烷乙酸的方法和中间体
公开(公告)号：US5948935A
公开(公告)日：1999-09-07
申请号：US12237
申请日：1998-01-23
申请人： Jean-Marie Ferland , Ingrid Guse , Eric Malenfant
发明人： Jean-Marie Ferland , Ingrid Guse , Eric Malenfant
IPC分类号： C07C227/18 , C07C229/46 , C07C237/14 , C07C255/31 , C07C69/74 , C07C61/06
CPC分类号： C07C237/14 , C07C227/18 , C07C255/31 , C07B2200/07 , C07C2101/08
摘要： Disclosed herein is a process for preparing (S)-.alpha.-amino-1-carboxycyclopentaneacetic acid which is a useful intermediate for preparing peptidomimetic inhibitors of herpes viral ribonucleotide reductase. The process comprises the preparation of the key intermediate ##STR1## and its subsequent conversion to the desired product.
摘要翻译：本文公开了一种制备（S）-α-氨基-1-羧基环戊烷乙酸的方法，其是制备疱疹病毒核糖核苷酸还原酶的拟肽抑制剂的有用中间体。该方法包括制备关键中间体及其随后转化成所需产物。

9. 发明授权

US07178695B1 Dispenser for a liquid or semi-solid material 失效
标题翻译：液体或半固体材料的分配器
公开(公告)号：US07178695B1
公开(公告)日：2007-02-20
申请号：US11237738
申请日：2005-09-29
申请人： Jean-Claude Malenfant , Eric Malenfant , Yves Malenfant
发明人： Jean-Claude Malenfant , Eric Malenfant , Yves Malenfant
IPC分类号： B67D5/64
CPC分类号： E01C23/20
摘要： A dispenser for depositing at least one of lines and stripes of at least one material, comprising a trolley having front and back wheels and securing at least one container on a platform thereof, the trolley being movable between an in-use position, wherein the trolley is straighten up on the front wheels thereof allowing a content of the at least one container to be out from at least one aperture on a bottom part of the at least one container, and an out-of use position, wherein the trolley rests on rear wheels thereof and the content of the at least one container is stopped from flowing out from the at least one aperture.
摘要翻译：一种用于沉积至少一种材料的线条和条纹中的至少一种的分配器，包括具有前轮和后轮的手推车并将至少一个容器固定在其平台上，所述手推车可在使用中的位置之间移动，其中所述手推车在其前轮上被拉直，允许至少一个容器的内容物从至少一个容器的底部上的至少一个孔排出，以及一个不在使用位置，其中手推车搁置在后部其轮子和至少一个容器的内容物被停止从至少一个孔流出。

10. 发明授权

US06239125B1 Azetidinone derivatives for the treatment of HCMV infections 有权
标题翻译：氮杂环丁酮衍生物用于治疗HCMV感染
公开(公告)号：US06239125B1
公开(公告)日：2001-05-29
申请号：US09167142
申请日：1998-10-06
申请人： Eric Malenfant , Jeffrey O'Meara , Robert Déziel , William W. Ogilvie
发明人： Eric Malenfant , Jeffrey O'Meara , Robert Déziel , William W. Ogilvie
IPC分类号： C07D20508
CPC分类号： C07D401/12 , A61K31/395 , A61K31/70 , A61K45/06 , C07D205/08 , C07D205/09
摘要： A compound of formula 1: wherein Y is S or O; R1 is C1-6 alkyl; (C0-6 alkyl)aryl; (C0-6 alkyl)Het; or R1 is an amino acid analog or dipeptide analog of the formula: wherein R2 is H, C1-10 alkyl; or an amide or ester group; A is C6-10 aryl, Het or CH—R3 wherein R3 is C1-6 alkyl or (C0-4 alkyl)aryl; and Z is H, C1-6 alkyl, or an acyl; R4 is hydrogen, lower alkyl, methoxy, ethoxy, or benzyloxy; and R5 is alkyl, cycloalkyl, carboxyl group; an aryl; Het or Het(lower alkyl); or R4 and R5 together with the nitrogen atom to which they are attached form a nitrogen containing ring optionally substituted with phenyl or C(O)OCH2-phenyl, said phenyl ring optionally mono- or di-substituted with among others C(O)OR7 wherein R7 is lower alkyl or phenyl(lower alkyl); or a therapeutically acceptable acid addition salt thereof which compounds are useful in the treatment of HCMV infections.
摘要翻译：式1的化合物：其中Y是S或O; R 1是C 1-6烷基; （C0-6烷基）芳基; （C0-6烷基）Het; 或R 1是下式的氨基酸类似物或二肽类似物：其中R 2是H，C 1-10烷基; 或酰胺或酯基; A为C 6-10芳基，Het或CH-R 3，其中R 3为C 1-6烷基或（C 0-4烷基）芳基; 和Z是H，C 1-6烷基或酰基; R 4是氢，低级烷基，甲氧基，乙氧基或苄氧基; 和R 5是烷基，环烷基，羧基; 芳基; Het或Het（低级烷基）; 或R 4和R 5与它们所连接的氮原子一起形成任选被苯基或C（O）OCH 2 - 苯基取代的含氮环，所述苯环任选地被C（O）OR 7单取代，其中 R7是低级烷基或苯基（低级烷基）; 或其治疗上可接受的酸加成盐，其化合物可用于治疗HCMV感染。

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