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1. 发明申请

US20110062390A1 DERIVATIVES OF NANOMATERIALS AND RELATED DEVICES AND METHODS 审中-公开
标题翻译： NANOMATERIALS和相关设备和方法的衍生物
公开(公告)号：US20110062390A1
公开(公告)日：2011-03-17
申请号：US12743121
申请日：2008-11-17
申请人： Claudia Maria Cardona , Martin Drees , Brian Holloway
发明人： Claudia Maria Cardona , Martin Drees , Brian Holloway
IPC分类号： H01B1/12 , C07F3/00
CPC分类号： C07F5/00 , B82Y10/00 , B82Y30/00 , B82Y40/00 , C01B32/15 , C01B32/152 , H01L51/0036 , H01L51/0047 , H01L51/4253 , H01L51/426 , Y02E10/549
摘要： A functionalized trimetallic nitride endohedral fullerene based material can be represented according to the formula: A3-nXnN@Cm (R)o, wherein: where A and X are one or a combination of the following metal atoms: Sc, Y, La, Ce, Pr, Nd, Gd, Tb, Dy, Ho, Er, Tm, Lu; (n=0-3); N is nitrogen; Cm is a fullerene and m=about 60-about 200; and R is an organic, inorganic, or organometallic species. Related compositions, devices and methods are also described.
摘要翻译：可以根据下式表示官能化的三金属氮化物内面富勒烯材料：其中A和X是以下金属原子之一或其组合：Sc，Y，La，Ce ，Pr，Nd，Gd，Tb，Dy，Ho，Er，Tm，Lu; （n = 0-3）; N是氮; Cm是富勒烯，m =约60-约200; R是有机，无机或有机金属物质。还描述了相关的组合物，装置和方法。

2. 发明授权

US06235890B1 Methods and compositions for the detection of Candida spp. 有权
标题翻译：用于检测假丝酵母属的方法和组合物
公开(公告)号：US06235890B1
公开(公告)日：2001-05-22
申请号：US09269136
申请日：1999-07-12
申请人： Christine J. Morrison , Errol Reiss , Brian Holloway , Jong Hee Shin
发明人： Christine J. Morrison , Errol Reiss , Brian Holloway , Jong Hee Shin
IPC分类号： C07H2104
CPC分类号： C12Q1/6895
摘要： The present invention provides a rapid method for identifying species of Candida. Identification is through the use of a non-conserved regions of the ITS2 region flanked by highly conserved functional domains. Detection of members of the Candida and Aspergillus genera is enhanced by the detection of genus-specific regions of the 5.8S rRNA gene. The present invention provides isolated nucleic acids that selectively hybridize to the fungal genus-specific 5.8S rRNA region, and to the species-specific ITS2 region. The invention provides for nucleic acid sequences for use as selective probes for fungal genus-specific probes and as Candida species-specific probes. The present invention provides methods for the use of the Candida species-specific probes that allow the detection and identification of the individual species in biological samples.
摘要翻译：本发明提供了鉴定假丝酵母菌种的快速方法。鉴定是通过使用侧翼为高度保守的功能结构域的ITS2区域的非保守区域。通过检测5.8S rRNA基因的属特异性区域，可以增强念珠菌和曲霉属成员的检测。本发明提供了与真菌属特异性5.8S rRNA区域以及物种特异性ITS2区域选择性杂交的分离的核酸。本发明提供用作真菌属特异性探针和假丝酵母属特异性探针的选择性探针的核酸序列。本发明提供了使用允许在生物样品中检测和鉴定个体物种的假丝酵母属物种特异性探针的方法。

3. 发明申请

US20080248970A1 Compositions and Methods for the Detection of Candida Species 有权
标题翻译：用于检测假丝酵母属物种的组合物和方法
公开(公告)号：US20080248970A1
公开(公告)日：2008-10-09
申请号：US12088235
申请日：2006-09-26
申请人： Christine J. Morrison , Sanchita Das , Teresa Brown , Brian Holloway
发明人： Christine J. Morrison , Sanchita Das , Teresa Brown , Brian Holloway
IPC分类号： C40B40/06 , C07H21/04
CPC分类号： C12Q1/6895
摘要： Compositions and methods for detecting and/or differentiating among Candida organisms, including C. albicans and C. dubliniensis, are disclosed. Exemplary methods involve screening a sample suspected of containing at least one or more Candida sp. for the presence or absence of a nucleic acid sequence specific for each such fungal pathogen. Some disclosed methods permit the rapid and simultaneous detection and identification of several fungal pathogens (e.g., up to 100 fungi) in a single sample.
摘要翻译：公开了用于检测和/或区分假丝酵母属生物体的组合物和方法，包括白色念珠菌和C.都柏林。示例性方法包括筛选怀疑含有至少一种或多种念珠菌属的样品。对于每种这样的真菌病原体存在或不存在特异性的核酸序列。一些公开的方法允许在单个样品中快速和同时检测和鉴定几种真菌病原体（例如多达100个真菌）。

4. 发明申请

US20060213899A1 Heater and temperature measurement system 审中-公开
标题翻译：加热器和温度测量系统
公开(公告)号：US20060213899A1
公开(公告)日：2006-09-28
申请号：US11288678
申请日：2005-11-29
申请人： Ronald Outlaw , Brian Holloway
发明人： Ronald Outlaw , Brian Holloway
IPC分类号： F27B14/00
CPC分类号： F27D19/00 , B22D17/2038 , F27D11/02 , F27D21/0014
摘要： Current industrial and research applications that utilize resistance heating and temperature measurement require separate power and temperature connections, typically two for each. Such applications require separate assemblies and control. We describe herein a combined unit utilizing a thermocouple wire as one of its two leads. The resulting device requires only two connections and one control. An alternating cycle can be used to apply heating power, and temperature measurements are made during the power off portion of the cycle.
摘要翻译：利用电阻加热和温度测量的当前工业和研究应用需要单独的功率和温度连接，通常每个都有两个。这种应用需要单独的组件和控制。我们在这里描述了使用热电偶线作为其两个引线之一的组合单元。所产生的设备只需要两个连接和一个控制。可以使用交替循环来施加加热功率，并且在循环的断电部分期间进行温度测量。

5. 发明授权

US08119788B2 Compositions and methods for the detection of Candida species 有权
标题翻译：用于检测念珠菌物种的组合物和方法
公开(公告)号：US08119788B2
公开(公告)日：2012-02-21
申请号：US12088235
申请日：2006-09-26
申请人： Christine J. Morrison , Sanchita Das , Teresa Brown , Brian Holloway
发明人： Christine J. Morrison , Sanchita Das , Teresa Brown , Brian Holloway
IPC分类号： C40B40/06
CPC分类号： C12Q1/6895
摘要： Compositions and methods for detecting and/or differentiating among Candida organisms, including C. albicans and C. dubliniensis, are disclosed. Exemplary methods involve screening a sample suspected of containing at least one or more Candida sp. for the presence or absence of a nucleic acid sequence specific for each such fungal pathogen. Some disclosed methods permit the rapid and simultaneous detection and identification of several fungal pathogens (e.g., up to 100 fungi) in a single sample.
摘要翻译：公开了用于检测和/或区分假丝酵母属生物体的组合物和方法，包括白色念珠菌和C.都柏林。示例性方法包括筛选怀疑含有至少一种或多种念珠菌属的样品。对于每种这样的真菌病原体存在或不存在特异性的核酸序列。一些公开的方法允许在单个样品中快速和同时检测和鉴定几种真菌病原体（例如多达100个真菌）。

6. 发明申请

US20110020804A1 PHOTOINDUCED ELECTRON TRANSFER (PET) PRIMER FOR NUCLEIC ACID AMPLIFICATION 有权
标题翻译：用于核酸放大的光导电子转移（PET）预聚物
公开(公告)号：US20110020804A1
公开(公告)日：2011-01-27
申请号：US12743607
申请日：2008-11-21
申请人： Jothikumar Narayanan , Vincent Hill , Brian Holloway
发明人： Jothikumar Narayanan , Vincent Hill , Brian Holloway
IPC分类号： C12Q1/68 , C07H21/00
CPC分类号： C12Q1/6876 , C12Q1/6818 , C12Q1/6827 , C12Q1/6844 , C12Q2600/156 , C12Q2565/1015
摘要： This application provides photoinduced electron transfer (PET) nucleic acid molecules that can be used detect and amplify nucleic acid molecules, such as target nucleic acid molecules. These PET tags can be attached to the 5′-end of a target sequence-specific primer, thereby generating a PET primer. In particular examples, a PET tag includes a 5′-labeled nucleotide that can be quenched by at least two consecutive Gs within the tag sequence, and is unquenched when the PET tag hybridizes with its complementary nucleic acid molecule. Also disclosed are methods of using PET primers in nucleic acid amplification, such as real-time PCR.
摘要翻译：该应用提供可以用于检测和扩增核酸分子（例如靶核酸分子）的光诱导电子转移（PET）核酸分子。这些PET标签可以连接到靶序列特异性引物的5'端，从而产生PET引物。在具体实例中，PET标签包括可以在标签序列内由至少两个连续的Gs淬灭的5'标记的核苷酸，并且当PET标签与其互补的核酸分子杂交时，它们是不消失的。还公开了在核酸扩增中使用PET引物的方法，例如实时PCR。

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