专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US3971793A Certain 6-(dialkylamino, pyrrolidino and piperidino)ethoxy-4,7-dimethoxy-5-(3-phenyl-1-hydroxypropyl)2,3-dihydrob enzofurans 失效
标题翻译：某些6-（二烷基氨基，吡咯烷子基和哌啶子基）乙氧基-4,7-二甲氧基-5-（3-苯基-1-羟丙基）2,3-二氢苯并呋喃
公开(公告)号：US3971793A
公开(公告)日：1976-07-27
申请号：US438744
申请日：1974-02-01
申请人： Claude P. Fauran , Jeannine A. Eberle , Guy R. Bourgery , Guy M. Raynaud , Bernard M. Pourrias
发明人： Claude P. Fauran , Jeannine A. Eberle , Guy R. Bourgery , Guy M. Raynaud , Bernard M. Pourrias
IPC分类号： C07D307/86 , C07D211/22
CPC分类号： C07D307/86 , Y10S514/821 , Y10S514/869 , Y10S514/929
摘要： A compound of the formula ##SPC1##In which R is hydrogen, hydroxy, halogen or alkoxy containing up to 3 carbon atoms, and ##EQU1## is dialkylamino in which the alkyls contain up to 3 carbon atoms, or pyrrolidino, piperidino, morpholino or hexamethyleneimino, and n is 2 or 3. The compounds are prepared by reacting R substituted benzaldehyde with a 2,3-dihydrobenzofuran derivative and then reducing that reaction product. The compounds possess antihypertensive, hypotensive, vasodilatatory, spasmolytic, diuretic, sedative, anti-arythmic and anti-inflammatory properties.
摘要翻译：式中R为氢，羟基，卤素或至多3个碳原子的烷氧基的化合物，R 1 -N ANGLE R 2为烷基含有最多3个碳原子的二烷基氨基，或吡咯烷基，哌啶子基，吗啉代或六亚甲基亚氨基，n为2或3.通过使R取代的苯甲醛与2,3-二氢苯并呋喃衍生物反应然后还原该反应产物来制备化合物。该化合物具有抗高血压，降血压，血管扩张，解痉，利尿，镇静，抗胂和抗炎等功能。

2. 发明授权

US4013768A Pyrimidin-6-yl acethydroxamic acids, their therapeutic application and their process of preparation 失效
标题翻译：吡咯烷-6-YL乙酰氧基酸，其治疗应用及其制备方法
公开(公告)号：US4013768A
公开(公告)日：1977-03-22
申请号：US554532
申请日：1975-03-03
申请人： Claude P. Fauran , Jeannine A. Eberle , Guy R. Bourgery , Guy M. Raynaud , Claude J. Gouret
发明人： Claude P. Fauran , Jeannine A. Eberle , Guy R. Bourgery , Guy M. Raynaud , Claude J. Gouret
IPC分类号： C07D239/28 , A61K31/505 , C07D239/42 , C07D413/12 , C07D239/26
CPC分类号： C07D239/42 , C07D413/12
摘要： Compounds of the formula ##STR1## in which R is aminocarbonylphenyl in which amino is --NH.sub.2, pyrrolidino, piperidino or morpholino, and Ar is phenyl substituted with chloro, fluoro, trifluoromethyl, methylenedioxy or one or more methoxy.The compounds are prepared by 2-Ar-4-chloro-pyrimidin-6-yl ethylacetate with ##STR2## and then reacting that reaction product with hydroxylamine hydrochloride. The compounds possess vasodilatatory, anti-ulcerous, respiratory analeptic, hypotensive, diuretic, anti-depressive, analgesic, anti-inflammatory and neurotropic properties.

3. 发明授权

US3962256A 2-Aminomethyl benzimidazole derivatives 失效
标题翻译： 2-氨基乙基苯并咪唑衍生物
公开(公告)号：US3962256A
公开(公告)日：1976-06-08
申请号：US481273
申请日：1974-06-20
申请人： Claude P. Fauran , Jeannine A. Eberle , Guy M. Raynaud , Nicole A. M. Dorme
发明人： Claude P. Fauran , Jeannine A. Eberle , Guy M. Raynaud , Nicole A. M. Dorme
IPC分类号： C07D233/04 , C07D235/10 , C07D235/14 , C07D401/06
CPC分类号： C07D235/10 , C07D235/14 , Y10S514/821 , Y10S514/826 , Y10S514/869 , Y10S514/929
摘要： Compounds having the formula ##EQU1## WHEREIN Ar is phenyl optionally substituted by one or more halogens, alkyl having 1 to 4 carbons or alkoxy containing up to 4 carbons, and R.sub.1 and R.sub.2 each is alkyl having one to 4 carbons or ##EQU2## is piperidino, pyrrolidino, morpholino and hexamethyleneimino. The compounds are prepared by reacting the corresponding 2-chloromethyl benzimidazole with ##EQU3## The compounds possess analgesic, antihypertensive, gastric antisecretory, antiinflammatory, antibronchoconstrictive, anticholinergic, spasmolytic, sedative, antiulcerous, vasodilatatory, central nervous system stimulant, antiarythmic, diuretic and antihistaminic properties.

4. 发明授权

US4041030A Arylamino pyrimidinic derivatives 失效
标题翻译：芳基嘧啶衍生物
公开(公告)号：US4041030A
公开(公告)日：1977-08-09
申请号：US714473
申请日：1976-08-16
申请人： Claude P. Fauran , Guy R. Bourgery , Guy M. Raynaud , Claude J. Gouret
发明人： Claude P. Fauran , Guy R. Bourgery , Guy M. Raynaud , Claude J. Gouret
IPC分类号： C07D239/42 , C07D401/12 , C07D413/12
CPC分类号： C07D401/12 , C07D239/42 , Y10S514/869 , Y10S514/906 , Y10S514/927
摘要： Compounds of the formula ##STR1## WHEREIN Ar is phenyl or phenyl substituted by one or more halogens, a trifluoromethyl, a methylenedioxy, one or more methoxy, an alkyl having one to 4 carbon atoms or a dimethylamino,And R is ##STR2## wherein R.sub.1 and R.sub.2 each are hydrogen or alkyl of 1 to 4 carbon atoms, or ##STR3## PYRROLIDINO, MORPHOLINO, PIPERIDINO OR PIPERAZINO N'-substituted by alkyl of 1 to 4 carbon atoms, or phenyl, or R is para-2-morpholino ethylamino carbonyl, and R.sub.3 is hydrogen or methyl.The compounds are obtained by reacting 2-Ar-2-chloro-6-methyl pyrimidine, with ##STR4## The compounds possess sedative, antiulcerous, antibronchoconstrictive, anticholinergic, diuretic, analgesic myorelaxant and antianoximia properties.
摘要翻译：下式的化合物Ar是苯基或被一个或多个卤素，三氟甲基，亚甲二氧基，一个或多个甲氧基，具有1至4个碳原子的烷基或二甲基氨基取代的苯基，AND R是其中 R 1和R 2各自为氢或1至4个碳原子的烷基，或由1-4个碳原子的烷基或苯基取代的吡咯烷基，吗啉，哌啶或哌嗪，或R为对位-2-吗啉代乙氨基羰基，R 3为氢或甲基。

5. 发明授权

US3951968A (2-6-Oxymethylene) morpholino (4,3a) benzimidazoles 失效
标题翻译：（2-6-氧亚甲基）吗啉代（4,3a）苯并咪唑
公开(公告)号：US3951968A
公开(公告)日：1976-04-20
申请号：US506825
申请日：1974-09-17
申请人： Claude P. Fauran , Jeannine A. Eberle , Michel J. Turin , Guy M. Raynaud , Claude J. Gouret
发明人： Claude P. Fauran , Jeannine A. Eberle , Michel J. Turin , Guy M. Raynaud , Claude J. Gouret
IPC分类号： C07D498/12 , C07D235/12 , C07D498/18 , C07D265/00 , C07D273/00 , C07D295/00
CPC分类号： C07D235/12 , Y10S148/067 , Y10S514/869 , Y10S514/87 , Y10S514/927
摘要： Compounds having the formula ##SPC1##Wherein Y is an aliphatic radical having up to 4 carbon atoms, phenyl, or phenyl substituted by one or more halogens, aliphatic radical having up to 4 carbon atoms, methoxy or trifluoromethyl.The compounds are prepared by reacting epichlorohydrin with benzimidazole substituted at the 2 position by ##EQU1## The compounds possess diuretic, sedative, antiulcerous, analgesic, antiinflammatory and cardiac analeptic properties.
摘要翻译：具有式WHEREIN Y的化合物是具有至多4个碳原子的脂族基团，苯基或被一个或多个卤素取代的苯基，具有至多4个碳原子的脂族基团，甲氧基或三氟甲基。

6. 发明授权

US4025514A Arylamino pyrimidinic derivatives 失效
标题翻译：芳基嘧啶衍生物
公开(公告)号：US4025514A
公开(公告)日：1977-05-24
申请号：US714472
申请日：1976-08-16
申请人： Claude P. Fauran , Guy R. Bourgery , Guy M. Raynaud , Claude J. Gouret
发明人： Claude P. Fauran , Guy R. Bourgery , Guy M. Raynaud , Claude J. Gouret
IPC分类号： C07D239/42 , C07D401/12
CPC分类号： C07D401/12 , C07D239/42
摘要： Compounds of the formula ##STR1## wherein Ar is phenyl or phenyl substituted by one or more halogens, a trifluoromethyl, a methylenedioxy, one or more methoxy, an alkyl having one to 4 carbon atoms or a dimethylamino,And R is ##STR2## and R.sub.5 is alkyl of 1 to 4 carbon atoms, 2,3-dihydroxypropyl or 2,2-dimethyl dioxolan-4-yl methyl or hydroxycarbonylmethyl.The compounds are obtained by reacting 2-Ar-4-chloro-6-methyl pyrimidine, with ##STR3## The compounds possess sedative, antiinflammatory, antiulcerous, and anti-anoxemia properties.
摘要翻译：其中Ar是苯基或被一个或多个卤素取代的苯基，三氟甲基，亚甲二氧基，一个或多个甲氧基，具有1-4个碳原子的烷基或二甲基氨基的化合物，和R是＆lt; IMAGE＆gt;和 R5是1-4个碳原子的烷基，2,3-二羟基丙基或2,2-二甲基二氧戊环-4-基甲基或羟基羰基甲基。

7. 发明授权

US4031089A Furo (2,3d) pyrimidines 失效
标题翻译：呋喃（2,3d）嘧啶
公开(公告)号：US4031089A
公开(公告)日：1977-06-21
申请号：US715377
申请日：1976-08-18
申请人： Claude P. Fauran , Guy R. Bourgery , Guy M. Raynaud , Nicole A. M. Dorme
发明人： Claude P. Fauran , Guy R. Bourgery , Guy M. Raynaud , Nicole A. M. Dorme
IPC分类号： C07D491/04 , C07D491/048
CPC分类号： C07D491/04 , Y10S514/869 , Y10S514/927
摘要： Compounds of the formula ##STR1## wherein R is alkyl of 1-4 carbon atoms, phenyl, or phenyl substituted by one or more halogen or trifluoromethyl, and Z is ##STR2## wherein R.sub.1 is hydrogen, alkyl of 1-4C, 2,2-dimethyldioxolan-4-yl methyl, or 2,3-dihydroxy prop-1-yl, R.sub.2 is ##STR3## wherein ##STR4## is morpholino, pyrrolidino, piperidino or hexamethyleneimino, and n is an integer from 4 to 7.The compounds are prepared by reacting R-substituted 4-chloro-2-methyl furo (2,3d) pyrimidine with HZ. The compounds possess antiulcerous, antibronchoconstrictive and anticholinergic, analgesic, antihistamine, diuretic, cardiovascular analeptic, antiinflammatory and hypertensive properties.
摘要翻译：其中R是1-4个碳原子的烷基，苯基或被一个或多个卤素或三氟甲基取代的苯基，Z是下式的化合物，其中R 1是氢，1-4C的烷基，2,2-二甲基二氧杂环戊烷-4-基甲基或2,3-二羟基丙-1-基，其中，作为吗啉，吡咯烷子基，哌啶子基或哌啶子基，六亚甲基亚氨基，n为4〜7的整数。

8. 发明授权

US4007187A Furo (2,3d) pyrimidines 失效
标题翻译：呋喃（2,3d）嘧啶
公开(公告)号：US4007187A
公开(公告)日：1977-02-08
申请号：US506826
申请日：1974-09-17
申请人： Claude P. Fauran , Guy R. Bourgery , Guy M. Raynaud , Nicole A. M. Dorme
发明人： Claude P. Fauran , Guy R. Bourgery , Guy M. Raynaud , Nicole A. M. Dorme
IPC分类号： A61K31/519 , C07D491/04 , C07D491/048 , C07D239/00
CPC分类号： C07D491/04
摘要： Compounds of the formula ##STR1## wherein R is alkyl of 1-4 carbon atoms, phenyl, or phenyl substituted by one or more halogen or trifluoromethyl, and Z is ##STR2## wherein R.sub.1 is hydrogen, alkyl of 1-4C, 2,2-dimethyldioxolan-4-yl methyl, or 2,3-dihydroxy prop-1-yl, R.sub.2 is ##STR3## wherein ##STR4## is morpholino, pyrrolidino, piperidino or hexamethyleneimino, and n is an integer from 4 to 7. The compounds are prepared by reacting R-substituted 4-chloro-2-methyl furo (2,3d) pyrimidine with HZ. The compounds possess antiulcerous, antibronchoconstrictive and anticholinergic, analgesic, antihistamine, diuretic, cardiovascular analeptic, antiinflammatory and hypertensive properties.
摘要翻译：其中R是1-4个碳原子的烷基，苯基或被一个或多个卤素或三氟甲基取代的苯基，Z是下式的化合物，其中R 1是氢，1-4C的烷基，2,2-二甲基二氧杂环戊烷-4-基甲基或2,3-二羟基丙-1-基，其中，作为吗啉，吡咯烷子基，哌啶子基或哌啶子基，六亚甲基亚氨基，n为4〜7的整数。该化合物通过R-取代的4-氯-2-甲基呋喃（2,3d）嘧啶与HZ反应来制备。该化合物具有抗溃疡，抗纤维蛋白胆固醇和抗胆碱能药，止痛药，抗组胺药，利尿剂，心血管镇痛药，抗炎和高血压药物。

9. 发明授权

US4029650A Novel derivatives of N-(3,4,5-trimethoxy cinnamoyl)piperazine and the process for preparing them 失效
标题翻译： N-（3,4,5-三甲氧基肉桂酰）哌嗪的新衍生物及其制备方法
公开(公告)号：US4029650A
公开(公告)日：1977-06-14
申请号：US633932
申请日：1975-11-20
申请人： Guy M. Raynaud , Bernard M. Pourrias , Claude P. Fauran , Michel J. Turin
发明人： Guy M. Raynaud , Bernard M. Pourrias , Claude P. Fauran , Michel J. Turin
IPC分类号： C07D295/18 , A61K31/47 , A61K31/472 , A61K31/495 , A61K31/496 , A61K31/55 , A61P9/08 , A61P9/10 , A61P9/12 , C07D217/06 , C07D295/185 , C07D241/02 , C07D403/06
CPC分类号： C07D295/185
摘要： Compounds having the formula ##STR1## in which R.sub.1 is alkyl having no more than 4 carbon atoms and R.sub.2 is dimethoxyphenylethyl or ##STR2## is piperidino, heptamethyleneimino or 1,2,3,4-tetrahydroisoquinolino. The compounds are prepared by condensing N-(3,4,5-trimethoxy cinnamoyl)N'-(carboxymethyl) piperazine with ##STR3## The compounds possess peripheral, coronary and cerebral vasodilatory properties and an antihypertensive property.
摘要翻译：其中R1是不多于4个碳原子的烷基，R2是二甲氧基苯基乙基或者“IMAGE”的化合物是哌啶子基，七亚甲基亚氨基或1,2,3,4-四氢异喹啉。通过将N-（3,4,5-三甲氧基肉桂酰基）N' - （羧甲基）哌嗪与“IMAGE”

10. 再颁专利

USRE29934E Derivatives of 5-carbamoyloxymethyl-3-substituted-2-oxazolidinones, process of preparation thereof and therapeutic application 失效
标题翻译： 5-氨基甲酰氧基甲基-3-取代-2-恶唑烷酮的衍生物，其制备方法和治疗应用
公开(公告)号：USRE29934E
公开(公告)日：1979-03-13
申请号：US663563
申请日：1976-03-03
申请人： Claude P. Fauran , Guy M. Raynaud , Rene A. Oliver , Colette A. Douzon
发明人： Claude P. Fauran , Guy M. Raynaud , Rene A. Oliver , Colette A. Douzon
IPC分类号： C07D263/24
CPC分类号： C07D263/24
摘要： A compound of the formula ##STR1## .[.in which R is H, halogen, alkyl having 1 to 4 carbon atoms or trifluoromethyl, and R.sub.1 and R.sub.2 each is H or dialkylaminoalkyl or together with N comprise methylpiperazino..]. .Iadd.in which (1) .Iadd. ##STR2##.Iaddend. is -NH.sub.2 and R is H, m-CH.sub.3, o-CF.sub.3, m-Cl, p-Cl, m-Br, m-F, p-F, o-F, p-CH.sub.3 or m-CH.sub.3, or .Iadd. ##STR3##.Iaddend. and R is H, m-CF.sub.3 or m-F, or .Iadd. ##STR4##.Iaddend. and R is H, m-CF.sub.3 or m-F.The compound is prepared by treating the corresponding 5-hydroxymethyl compound with ammonia or an amine in the presence of phosgene.The compounds possess anti-depressive, myorelaxing, tranquilizing, sedative, analgesic, anti-convulsive, anti-pyretic, anti-inflammatory and uricosuric activities.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式