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1. 发明申请

US20220119552A1 COMPLEMENTARY RNA LINKED BISPECIFIC T-CELL ENGAGING ANTIBODIES 有权
公开(公告)号：US20220119552A1
公开(公告)日：2022-04-21
申请号：US17503132
申请日：2021-10-15
申请人： City of Hope
发明人： John E. Shively , Lin Li , Maciej Kujawski , Piotr Swiderski
IPC分类号： C07K16/42 , C07K16/28 , C07K16/46
摘要： The compositions and methods provide herein include, inter alia, antibodies attached to single-stranded oligoribonucleotides. Two antibodies are capable of forming complexes in vivo through hybridization of the respective complementary oligoribonucleotides they are bound to. For example, a first antibody bound to a first oligoribonucleotide through a first chemical linker may be administered to a subject, bind to a cell surface antigen in vivo and subsequently form an antibody complex in vivo with a second antibody bound to a second oligoribonucleotide through a second chemical linker, through complementary base-pairing between the first and the second oligoribonucleotide. The compositions and methods provided herein are, inter alia, useful for diagnostic and therapeutic purposes, for example, the treatment of cancer or autoimmune disease.

2. 发明授权

US12043673B2 Complementary RNA linked bispecific T-cell engaging antibodies 有权
公开(公告)号：US12043673B2
公开(公告)日：2024-07-23
申请号：US17503132
申请日：2021-10-15
申请人： City of Hope
发明人： John E. Shively , Lin Li , Maciej Kujawski , Piotr Swiderski
IPC分类号： C07K16/00 , C07K16/28 , C07K16/42 , C07K16/46 , C07K19/00
CPC分类号： C07K16/4283 , C07K16/283 , C07K16/2878 , C07K16/46 , C07K2317/24 , C07K2317/31 , C07K2317/52
摘要： The compositions and methods provide herein include, inter alia, antibodies attached to single-stranded oligoribonucleotides. Two antibodies are capable of forming complexes in vivo through hybridization of the respective complementary oligoribonucleotides they are bound to. For example, a first antibody bound to a first oligoribonucleotide through a first chemical linker may be administered to a subject, bind to a cell surface antigen in vivo and subsequently form an antibody complex in vivo with a second antibody bound to a second oligoribonucleotide through a second chemical linker, through complementary base-pairing between the first and the second oligoribonucleotide. The compositions and methods provided herein are, inter alia, useful for diagnostic and therapeutic purposes, for example, the treatment of cancer or autoimmune disease.

3. 发明授权

US11535847B2 Multivalent oligonucleotide assemblies 有权
公开(公告)号：US11535847B2
公开(公告)日：2022-12-27
申请号：US16702318
申请日：2019-12-03
申请人： City of Hope
发明人： Piotr Swiderski
IPC分类号： C12N15/11 , C12N15/113
摘要： Provided herein, inter alia, are double stranded oligonucleotide molecules and methods of making the molecules. The double stranded oligonucleotide molecules include a first oligonucleotide strand comprising a first nucleic acid sequence bound to a second nucleic acid sequence through a first spacer, wherein said second nucleic acid sequence is bound to a third nucleic acid sequence through a second spacer and a second oligonucleotide strand comprising a fourth nucleic acid sequence bound to a fifth nucleic acid sequence through a third spacer, wherein said fifth nucleic acid sequence is bound to a sixth nucleic acid sequence through a fourth spacer, wherein the second nucleic acid sequence and the fifth nucleic acid sequence are hybridized to form a double stranded nucleic acid core of said double stranded oligonucleotide.

4. 发明申请

US20200339984A1 MULTIVALENT OLIGONUCLEOTIDE ASSEMBLIES 审中-公开
公开(公告)号：US20200339984A1
公开(公告)日：2020-10-29
申请号：US16702318
申请日：2019-12-03
申请人： City of Hope
发明人： Piotr Swiderski
IPC分类号： C12N15/113 , C12N15/11
摘要： Provided herein, inter alia, are double stranded oligonucleotide molecules and methods of making the molecules. The double stranded oligonucleotide molecules include a first oligonucleotide strand comprising a first nucleic acid sequence bound to a second nucleic acid sequence through a first spacer, wherein said second nucleic acid sequence is bound to a third nucleic acid sequence through a second spacer and a second oligonucleotide strand comprising a fourth nucleic acid sequence bound to a fifth nucleic acid sequence through a third spacer, wherein said fifth nucleic acid sequence is bound to a sixth nucleic acid sequence through a fourth spacer, wherein the second nucleic acid sequence and the fifth nucleic acid sequence are hybridized to form a double stranded nucleic acid core of said double stranded oligonucleotide.

5. 发明授权

US10538761B2 Multivalent oligonucleotide assemblies 有权
公开(公告)号：US10538761B2
公开(公告)日：2020-01-21
申请号：US15209545
申请日：2016-07-13
申请人： City of Hope
发明人： Piotr Swiderski
IPC分类号： C12N15/113 , A61K47/61 , A61K31/7105 , A61K31/713 , C07H21/02 , C12N15/11
摘要： Provided herein, inter alia, are double stranded oligonucleotide molecules and methods of making the molecules. The double stranded oligonucleotide molecules include a first oligonucleotide strand comprising a first nucleic acid sequence bound to a second nucleic acid sequence through a first spacer, wherein said second nucleic acid sequence is bound to a third nucleic acid sequence through a second spacer and a second oligonucleotide strand comprising a fourth nucleic acid sequence bound to a fifth nucleic acid sequence through a third spacer, wherein said fifth nucleic acid sequence is bound to a sixth nucleic acid sequence through a fourth spacer, wherein the second nucleic acid sequence and the fifth nucleic acid sequence are hybridized to form a double stranded nucleic acid core of said double stranded oligonucleotide.

6. 发明申请

US20170029816A1 MULTIVALENT OLIGONUCLEOTIDE ASSEMBLIES 审中-公开
标题翻译：多功能寡核苷酸组装
公开(公告)号：US20170029816A1
公开(公告)日：2017-02-02
申请号：US15209545
申请日：2016-07-13
申请人： City of Hope
发明人： Piotr Swiderski
IPC分类号： C12N15/113 , C12N15/11
CPC分类号： C12N15/113 , C12N15/111 , C12N2310/11 , C12N2310/14 , C12N2310/351 , C12N2310/53 , C12N2320/30 , C12N2320/32 , C12N2330/00
摘要： Provided herein, inter alia, are double stranded oligonucleotide molecules and methods of making the molecules. The double stranded oligonucleotide molecules include a first oligonucleotide strand comprising a first nucleic acid sequence bound to a second nucleic acid sequence through a first spacer, wherein said second nucleic acid sequence is bound to a third nucleic acid sequence through a second spacer and a second oligonucleotide strand comprising a fourth nucleic acid sequence bound to a fifth nucleic acid sequence through a third spacer, wherein said fifth nucleic acid sequence is bound to a sixth nucleic acid sequence through a fourth spacer, wherein the second nucleic acid sequence and the fifth nucleic acid sequence are hybridized to form a double stranded nucleic acid core of said double stranded oligonucleotide.
摘要翻译：本文提供的是双链寡核苷酸分子和制备分子的方法。双链寡核苷酸分子包括第一寡核苷酸链，其包含通过第一间隔物与第二核酸序列结合的第一核酸序列，其中所述第二核酸序列通过第二间隔物与第三核酸序列结合，第二寡核苷酸链，其包含通过第三间隔基与第五核酸序列结合的第四核酸序列，其中所述第五核酸序列通过第四间隔子与第六核酸序列结合，其中第二核酸序列和第五核酸序列杂交以形成所述双链寡核苷酸的双链核酸核心。

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