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1. 发明申请

US20220016267A1 NANOPARTICLES FOR CANCER DETECTION 有权
公开(公告)号：US20220016267A1
公开(公告)日：2022-01-20
申请号：US17408972
申请日：2021-08-23
申请人： CITY OF HOPE
发明人： Tom HABER , Pengpeng CAO , Jacob BERLIN , Karen ABOODY
IPC分类号： A61K49/00
摘要： Disclosed herein, inter alia, are methods for detecting cancer using nanoparticles.

2. 发明申请

US20220341059A1 Chemically Encoded Spatially Addressed Library Screening Platforms 有权
公开(公告)号：US20220341059A1
公开(公告)日：2022-10-27
申请号：US17845949
申请日：2022-06-21
申请人： City of Hope
发明人： Jacob BERLIN , Gregory Copeland , Kathleen Elison , Hurik Muradyan
IPC分类号： C40B50/16 , G01N33/543 , C12N15/10 , C40B40/10 , C40B70/00
摘要： Provided herein are encoded split pool libraries useful, inter alia, for forming highly diverse and dense arrays for screening and detection of a variety of molecules.

3. 发明申请

US20210324538A1 Chemically Encoded Spatially Addressed Library Screening Platforms 有权
公开(公告)号：US20210324538A1
公开(公告)日：2021-10-21
申请号：US17238150
申请日：2021-04-22
申请人： City of Hope
发明人： Jacob BERLIN , Gregory COPELAND , Kathleen ELISON , Hurik MURADYAN
IPC分类号： C40B50/16 , G01N33/543 , C12N15/10 , C40B40/10 , C40B70/00
摘要： Provided herein are encoded split pool libraries useful, inter alia, for forming highly diverse and dense arrays for screening and detection of a variety of molecules.

4. 发明申请

US20190390367A1 Chemically Encoded Spatially Addressed Library Screening Platforms 审中-公开
公开(公告)号：US20190390367A1
公开(公告)日：2019-12-26
申请号：US16555531
申请日：2019-08-29
申请人： City of Hope
发明人： Jacob BERLIN , Gregory Copeland , Kathleen Elison , Hurik Muradyan
IPC分类号： C40B40/10 , G01N33/543 , C40B70/00
摘要： Provided herein are encoded split pool libraries useful, inter alia, for forming highly diverse and dense arrays for screening and detection of a variety of molecules.

5. 发明申请

US20180369422A1 NANOPARTICLES FOR CANCER DETECTION 审中-公开
公开(公告)号：US20180369422A1
公开(公告)日：2018-12-27
申请号：US16066626
申请日：2016-12-28
申请人： City of Hope
发明人： Tom HABER , Pengpeng CAO , Jacob BERLIN , Karen ABOODY
IPC分类号： A61K49/00
摘要： Disclosed herein, inter alia, are methods for detecting cancer using nanoparticles.

6. 发明申请

US20130210896A1 Immunotheraphy of Brain Tumors Using a Nanoparticle CpG Delivery System 审中-公开
标题翻译：使用纳米颗粒CpG递送系统对脑肿瘤的免疫疗法
公开(公告)号：US20130210896A1
公开(公告)日：2013-08-15
申请号：US13673973
申请日：2012-11-09
申请人： CITY OF HOPE
发明人： Behnam BADIE , Leying ZHANG , Darya ALIZADEH , Dongchang ZHAO , Jacob BERLIN
IPC分类号： A61K47/48
CPC分类号： A61K47/6929
摘要： One aspect of the invention relates to a nanoparticle conjugated CpG (NANO-CpG) composition and pharmaceutical composition thereof, and the preparation methods thereof. Another aspect of the invention relates to a method for using the NANO-CpG to improve CpG delivery into brain tumor associated inflammatory cells in a subject. Another aspect of the invention relates to a method for treating or preventing a method for treating and/or preventing a brain tumor in a subject comprising administering a therapeutically effective amount of the NANO-CpG or a pharmaceutical composition thereof to the subject. In one embodiment, a subject treated with the NANO-CpG composition disclosed herein or a pharmaceutical composition thereof developed immunity to brain tumor.
摘要翻译：本发明的一个方面涉及一种纳米颗粒缀合的CpG（NANO-CpG）组合物及其药物组合物及其制备方法。本发明的另一方面涉及使用NANO-CpG来改善受试者中与脑肿瘤相关的炎症细胞中CpG递送的方法。本发明的另一方面涉及用于治疗或预防受治疗和/或预防受试者脑肿瘤的方法的方法，其包括向受试者施用治疗有效量的NANO-CpG或其药物组合物。在一个实施方案中，用本文公开的NANO-CpG组合物或其药物组合物治疗的受试者开发了对脑肿瘤的免疫。

7. 发明申请

US20200378031A1 Chemically Encoded Spatially Addressed Library Screening Platforms 审中-公开
公开(公告)号：US20200378031A1
公开(公告)日：2020-12-03
申请号：US16940499
申请日：2020-07-28
申请人： City of Hope
发明人： Jacob BERLIN , Gregory COPELAND , Kathleen ELISON , Hurik MURADYAN
IPC分类号： C40B50/16 , G01N33/543 , C12N15/10 , C40B40/10 , C40B70/00
摘要： Provided herein are encoded split pool libraries useful, inter alia, for forming highly diverse and dense arrays for screening and detection of a variety of molecules.

8. 发明申请

US20200316010A1 SILICA NANOPARTICLE WITH AN INSOLUBLE DRUG 审中-公开
公开(公告)号：US20200316010A1
公开(公告)日：2020-10-08
申请号：US16483212
申请日：2018-02-02
申请人： CITY OF HOPE
发明人： Pamela TIET , Jacob BERLIN
IPC分类号： A61K31/337 , A61K47/24 , A61K9/14
摘要： Disclosed herein, inter alia, are nanoparticle compositions (e.g., silica nanoparticles) including insoluble drug nanocrystals and methods of using the same for treating cancer.

9. 发明申请

US20190388474A1 ENCAPSULATED DIAGNOSTICS AND THERAPEUTICS IN NANOPARTICLES - CONJUGATED TO TROPIC CELLS AND METHODS FOR THEIR USE 审中-公开
公开(公告)号：US20190388474A1
公开(公告)日：2019-12-26
申请号：US16534925
申请日：2019-08-07
申请人： CITY OF HOPE
发明人： Karen ABOODY , Alexander ANNALA , Rachael MOONEY , Jacob BERLIN , Yiming WENG
IPC分类号： A61K35/30 , A61K31/4188 , A61K49/08
摘要： A therapeutic or diagnostic delivery vehicle is provided. The delivery vehicle may include one or more particles, such as microparticles, nanoparticles and stimuli-responsive particles, conjugated to a tropic cell that targets at least one pathological entity or site. In addition. a pharmaceutical composition is provided. The pharmaceutical composition may include, among other things, a particle conjugated to a tropic cell such as those discussed above and at least one diagnostic or therapeutic agent, such as those described herein. In some aspects, the tropic cell may target at least one pathological entity or site. Further, methods for diagnosing, monitoring or treating a pathological condition in a subject are provided. Such methods may include administering a therapeutically effective amount of the pharmaceutical composition to a subject.

10. 发明申请

US20190022246A1 SILICON NANOPARTICLE WITH PLATINUM ANTI-CANCER AGENT 审中-公开
公开(公告)号：US20190022246A1
公开(公告)日：2019-01-24
申请号：US16066628
申请日：2016-12-28
申请人： CITY OF HOPE
发明人： Pengpeng CAO , Jacob BERLIN , Karen ABOODY , Rachael MOONEY , Wafa ABIDI
IPC分类号： A61K47/69 , A61K9/00 , A61P35/00
摘要： Disclosed herein, inter alia, are compositions and methods of using the same for treating cancer.

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