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1. 发明申请

US20060205808A1 Anti-inflammatory and cure for ageing, Alzheimer's disease on phloroglucinol derivatives 审中-公开
标题翻译：消炎和治愈老化，阿尔茨海默病对间苯三酚衍生物
公开(公告)号：US20060205808A1
公开(公告)日：2006-09-14
申请号：US11078194
申请日：2005-03-10
申请人： Chun-Nan Lin , Jih-Pyang Wang , Jing-Ru Weng
发明人： Chun-Nan Lin , Jih-Pyang Wang , Jing-Ru Weng
IPC分类号： A61K31/343 , C07C49/105 , C07D307/92 , A61K31/12
CPC分类号： C07D307/92 , C07C49/743 , C07D307/80
摘要： The fresh seeds obtained from the fresh fruits of Garcinia subelliptica, were extracted with chloroform at room temperature. The CHCl3 extract was concentrated under reduced pressure to afford a brown residue. This residue was subjected to column chromatography (silica gel) and eluted with appropriate solvent system to give two phloroglucinol derivatives (Compounds 1 and 4). Compound 1 exhibited potent inhibitory effects on the release of β-glucuronidase and lysozyme from rat neutrophils stimulated with formyl-Met-Leu-Phe(fMLP)/cyto-chalasin B (CB). Compound 1 also exhibited potent inhibitory effect on the superoxide anion generation in rat neutrophils stimulated with fMLP/CB. Compound 4 exhibited potent inhibitory effect on NO production in lipopolysaccharide (LPS)/interferon-γ (IFN-γ)-activation in N9 cells. These Compounds may be developed as anti-inflammatory, anti-cancer agent, cure for ageing, and Alzheimer's disease treatment drugs.
摘要翻译：从藤黄新鲜果实中获得的新鲜种子在室温下用氯仿萃取。将CHCl 3萃取物在减压下浓缩，得到棕色残余物。将该残余物进行柱色谱法（硅胶），并用合适的溶剂系统洗脱，得到两种间苯三酚衍生物（化合物1和4）。化合物1对用甲酰-Mly-Leu-Phe（fMLP）/细胞色素B（CB）刺激的大鼠嗜中性粒细胞释放β-葡糖苷酸酶和溶菌酶具有有效的抑制作用。化合物1还对用fMLP / CB刺激的大鼠嗜中性粒细胞中的超氧阴离子产生表现出有效的抑制作用。化合物4对N9细胞中脂多糖（LPS）/干扰素-γ（IFN-γ）活化的NO产生表现出有效的抑制作用。这些化合物可以被开发为抗炎，抗癌剂，治愈老化和阿尔茨海默病治疗药物。

2. 发明授权

US08329940B2 18β-glycyrrhetinic acid derivatives and synthetic method thereof 有权
标题翻译： 18＆ - 甘草次酸衍生物及其合成方法
公开(公告)号：US08329940B2
公开(公告)日：2012-12-11
申请号：US12649437
申请日：2009-12-30
申请人： Chun-Nan Lin , Dravidum Maitraie , Jih-Pyang Wang , Chi-Feng Hung , Huang-Yao Tu , Ya-Ting Liou , Bai-Luh Wei , Shyh-Chyun Yang
发明人： Chun-Nan Lin , Dravidum Maitraie , Jih-Pyang Wang , Chi-Feng Hung , Huang-Yao Tu , Ya-Ting Liou , Bai-Luh Wei , Shyh-Chyun Yang
IPC分类号： C07C61/12 , C07C69/74 , C07D313/06
CPC分类号： C07D313/06 , A61K31/19 , A61K31/215 , A61K31/335 , C07C231/02 , C07C231/12 , C07D313/08 , C07J63/008 , C07J73/003
摘要： The present invention provides a chemical compound having the structure being one selected from a group consisting of wherein R1 is one selected from a group consisting of COOCH3, COOCH2Ph, CONHCH(CH3)2 and CONHC6H5, R2 is one selected from a group consisting of H, CH3 and CH(CH3)2, R3 is one selected from a group consisting of H, CH3, CH(CH3)2 and CH2Ph, and R4 is one of CH(CH3)2 and C6H5.
摘要翻译：本发明提供一种具有以下结构的化合物：其中R 1为选自COOCH 3，COOCH 2 Ph，CONHCH（CH 3）2和CONHC 6 H 5中的一个，R 2为选自H ，CH 3和CH（CH 3）2，R 3是选自H，CH 3，CH（CH 3）2和CH 2 Ph的一个，R 4是CH（CH 3）2和C 6 H 5之一。

3. 发明申请

US20110039922A1 18beta-GLYCYRRHETINIC ACID DERIVATIVES AND SYNTHETIC METHOD THEREOF 有权
标题翻译： 18beta-GLYCYRRHETINIC酸衍生物及其合成方法
公开(公告)号：US20110039922A1
公开(公告)日：2011-02-17
申请号：US12649437
申请日：2009-12-30
申请人： Chun-Nan Lin , Dravidum Maitraie , Jih-Pyang Wang , Chi-Feng Hung , Huang-Yao Tu , Ya-Ting Liou , Bai-Luh Wei , Shyh-Chyun Yang
发明人： Chun-Nan Lin , Dravidum Maitraie , Jih-Pyang Wang , Chi-Feng Hung , Huang-Yao Tu , Ya-Ting Liou , Bai-Luh Wei , Shyh-Chyun Yang
IPC分类号： A61K31/335 , C07D313/06 , C07C69/74 , C07C61/16 , A61K31/215 , A61K31/19 , A61P29/00
CPC分类号： C07D313/06 , A61K31/19 , A61K31/215 , A61K31/335 , C07C231/02 , C07C231/12 , C07D313/08 , C07J63/008 , C07J73/003
摘要： The present invention provides a chemical compound having the structure being one selected from a group consisting of wherein R1 is one selected from a group consisting of COOCH3, COOCH2Ph, CONHCH(CH3)2 and CONHC6H5, R2 is one selected from a group consisting of H, CH3 and CH(CH3)2, R3 is one selected from a group consisting of H, CH3, CH(CH3)2 and CH2Ph, and R4 is one of CH(CH3)2 and C6H5.
摘要翻译：本发明提供一种具有以下结构的化合物：其中R 1为选自COOCH 3，COOCH 2 Ph，CONHCH（CH 3）2和CONHC 6 H 5中的一个，R 2为选自H ，CH 3和CH（CH 3）2，R 3是选自H，CH 3，CH（CH 3）2和CH 2 Ph的一个，R 4是CH（CH 3）2和C 6 H 5之一。

4. 发明授权

US5563167A Abruquinone derivatives and their uses 失效
标题翻译：阿布奎醌衍生物及其用途
公开(公告)号：US5563167A
公开(公告)日：1996-10-08
申请号：US237090
申请日：1994-05-03
申请人： Sheng-Chu Kuo , Sheng-Chih Chen , Jin-Bin Wu , Che-Ming Teng , Jih-Pyang Wang
发明人： Sheng-Chu Kuo , Sheng-Chih Chen , Jin-Bin Wu , Che-Ming Teng , Jih-Pyang Wang
IPC分类号： A61K31/353 , C07D311/64 , A61K31/35 , A61K35/78
CPC分类号： A61K31/353 , C07D311/64
摘要： Disclosed are methods of isolation and purification of active constituents from Hsian-ssu-tsu (Abrus precatorius L.), and the therapeutical applications of the purified compounds. From the cloroform fraction of the methanolic extract of the roots of Abrus precatorius L., Abruquinones A, B, D, E, F, which are shown as Compounds I through V, respectively, as follows: ##STR1## were isolated and identified Pharmacological evaluations showed that these compounds possess an activity to inhibit platelet aggregation, as well as antiinflammatory, and antiallergic activities.
摘要翻译：公开了分离和纯化茜草（Abrus precatorius L.）的活性成分的方法，以及纯化的化合物的治疗应用。从Abrus precatorius L.，Abruquinones A，B，D，E，F的根的甲醇提取物的cloroform分数分别表示为化合物I至V，如下所示：药理学评估表明，这些化合物具有抑制血小板聚集的活性，以及抗炎和抗过敏活性。

5. 发明授权

US5856352A Abruquinone derivatives useful in the treatment of inflammation and allergic reactions 失效
标题翻译：用于治疗炎症和过敏反应的Abruquinone衍生物
公开(公告)号：US5856352A
公开(公告)日：1999-01-05
申请号：US841729
申请日：1997-04-29
申请人： Sheng-Chu Kuo , Sheng-Chih Chen , Jin-Bin Wu , Che-Hing Teng , Jih-Pyang Wang
发明人： Sheng-Chu Kuo , Sheng-Chih Chen , Jin-Bin Wu , Che-Hing Teng , Jih-Pyang Wang
IPC分类号： A61K31/35
CPC分类号： A61K31/35
摘要： Disclosed are methods of providing antiinflammatory activity and inhibiting allergic reaction by administering Abruquinones A, B, D, E, or F to a subject in need thereof.
摘要翻译：公开了通过将阿布奎醌A，B，D，E或F给予有需要的受试者来提供抗炎活性和抑制过敏反应的方法。

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