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1. 发明授权

US07700355B2 Methods of producing a porous matrix for culturing and recovering cells 失效
标题翻译：生产用于培养和回收细胞的多孔基质的方法
公开(公告)号：US07700355B2
公开(公告)日：2010-04-20
申请号：US11030150
申请日：2005-01-07
申请人： Chun-Jen Liao , Jui-Hsiang Chen , Chen-Chi Tsai , Yung-Chih Wu , Shu-Fang Chiang , Yi-Jung Hsiang
发明人： Chun-Jen Liao , Jui-Hsiang Chen , Chen-Chi Tsai , Yung-Chih Wu , Shu-Fang Chiang , Yi-Jung Hsiang
IPC分类号： C12N5/00 , C12N5/06 , C12N5/08 , C12N11/10 , C12N11/12 , C12N1/02 , C12N5/02
CPC分类号： C12N5/0068 , A61L27/46 , A61L27/56 , C12N2533/18 , C08L5/04
摘要： A porous matrix, preparation thereof, and methods of using the same. The porous matrix of calcium alginate is prepared using a plurality of particles containing a multivalent cation, admixing the particles with ionic cross-linked polysaccharides and water to form a mixture, introducing a cross linker to solidify the mixture, dissolving the particles of the mixture in an acid to form a porous structure, and neutralizing and cross-linking the porous structure.
摘要翻译：多孔基体，其制备方法及其使用方法。藻酸钙的多孔基质是使用多个含有多价阳离子的颗粒制备的，将颗粒与离子交联的多糖和水混合以形成混合物，引入交联剂固化混合物，将混合物的颗粒溶解在酸形成多孔结构，中和并交联多孔结构。

2. 发明申请

US20060153814A1 Porous, matrix, preparation thereof, and methods of using the same 失效
标题翻译：多孔，基质，其制备方法及其使用方法
公开(公告)号：US20060153814A1
公开(公告)日：2006-07-13
申请号：US11030150
申请日：2005-01-07
申请人： Chun-Jen Liao , Jui-Hsiang Chen , Chen-Chi Tsai , Yung-Chih Wu , Shu-Fang Chiang , Yi-Jung Hsiang
发明人： Chun-Jen Liao , Jui-Hsiang Chen , Chen-Chi Tsai , Yung-Chih Wu , Shu-Fang Chiang , Yi-Jung Hsiang
IPC分类号： A61K35/12 , A61F2/00
CPC分类号： C12N5/0068 , A61L27/46 , A61L27/56 , C12N2533/18 , C08L5/04
摘要： A porous matrix, preparation thereof, and methods of using the same. The porous matrix of calcium alginate is prepared using a plurality of particles containing a multivalent cation, admixing the particles with ionic cross-linked polysaccharides and water to form a mixture, introducing a cross linker to solidify the mixture, dissolving the particles of the mixture in an acid to form a porous structure, and neutralizing and cross-linking the porous structure.
摘要翻译：多孔基体，其制备方法及其使用方法。藻酸钙的多孔基质是使用多个含有多价阳离子的颗粒制备的，将颗粒与离子交联的多糖和水混合以形成混合物，引入交联剂固化混合物，将混合物的颗粒溶解在酸形成多孔结构，中和并交联多孔结构。

3. 发明授权

US07906333B2 Surface modification of polysaccharide, the modified polysaccharide, and method of culturing and recovery cells using the same 有权
标题翻译：多糖的表面改性，改性多糖，以及使用该多糖的培养和回收细胞的方法
公开(公告)号：US07906333B2
公开(公告)日：2011-03-15
申请号：US11384386
申请日：2006-03-21
申请人： Chun-Jen Liao , Yung-chih Wu , Chen-Chi Tsai , Hsiang-Ming Huang , Yuan-Hua Hsu , Shu-Fang Chiang
发明人： Chun-Jen Liao , Yung-chih Wu , Chen-Chi Tsai , Hsiang-Ming Huang , Yuan-Hua Hsu , Shu-Fang Chiang
IPC分类号： C12N5/00 , A61K31/715
CPC分类号： C12N5/0068 , C12N2500/10 , C12N2533/50 , C12N2533/54 , C12N2533/70 , C12N2533/72 , C12N2533/74
摘要： A surface modification method of polysaccharide, the modified polysaccharide, and a method of culturing and recovery cells using the same are provided. The surface modification method of polysaccharide comprises (a) immersing a polysaccharide material in an acid, (b) immersing the polysaccharide material in an acidic solution containing a protein, and (c) immersing the polysaccharide material in an alkaline solution containing bivalent metal ions.
摘要翻译：提供了多糖，改性多糖的表面改性方法，以及使用其的培养和回收细胞的方法。多糖的表面改性方法包括（a）将多糖材料浸入酸中，（b）将多糖材料浸入含有蛋白质的酸性溶液中，（c）将多糖材料浸入含有二价金属离子的碱性溶液中。

4. 发明申请

US20070148768A1 Surface modification of polysaccharide, the modified polysaccharide, and method of culturing and recovery cells using the same 有权
标题翻译：多糖的表面改性，改性多糖，以及使用该多糖的培养和回收细胞的方法
公开(公告)号：US20070148768A1
公开(公告)日：2007-06-28
申请号：US11384386
申请日：2006-03-21
申请人： Chun-Jen Liao , Yung-chih Wu , Chen-Chi Tsai , Hsiang-Ming Huang , Yuan-Hua Hsu , Shu-Fang Chiang
发明人： Chun-Jen Liao , Yung-chih Wu , Chen-Chi Tsai , Hsiang-Ming Huang , Yuan-Hua Hsu , Shu-Fang Chiang
IPC分类号： C12P19/04 , C12N5/06 , C12N5/08
CPC分类号： C12N5/0068 , C12N2500/10 , C12N2533/50 , C12N2533/54 , C12N2533/70 , C12N2533/72 , C12N2533/74
摘要： A surface modification method of polysaccharide, the modified polysaccharide, and a method of culturing and recovery cells using the same are provided. The surface modification method of polysaccharide comprises (a) immersing a polysaccharide material in an acid, (b) immersing the polysaccharide material in an acidic solution containing a protein, and (c) immersing the polysaccharide material in an alkaline solution containing bivalent metal ions.
摘要翻译：提供了多糖，改性多糖的表面改性方法，以及使用其的培养和回收细胞的方法。多糖的表面改性方法包括（a）将多糖材料浸入酸中，（b）将多糖材料浸入含有蛋白质的酸性溶液中，（c）将多糖材料浸入含有二价金属离子的碱性溶液中。

5. 发明授权

US08062372B2 Spinal fusion device 有权
标题翻译：脊柱融合装置
公开(公告)号：US08062372B2
公开(公告)日：2011-11-22
申请号：US11611821
申请日：2006-12-15
申请人： Yang-Hwei Tsuang , Jui-Sheng Sun , Chun-Jen Liao , Chen-Chi Tsai , Shan-Chang Chueh , Yi-Hung Lin , Shian-Yih Wang , I-Fan Chiu
发明人： Yang-Hwei Tsuang , Jui-Sheng Sun , Chun-Jen Liao , Chen-Chi Tsai , Shan-Chang Chueh , Yi-Hung Lin , Shian-Yih Wang , I-Fan Chiu
IPC分类号： A61F2/44
CPC分类号： A61F2/4455 , A61F2/30771 , A61F2002/2835 , A61F2002/3008 , A61F2002/30153 , A61F2002/30163 , A61F2002/30171 , A61F2002/30772 , A61F2002/4629 , A61F2230/0019 , A61F2230/0028 , A61F2230/005 , A61F2250/0098 , A61F2310/00179 , A61F2310/00365
摘要： A spinal fusion device abutting and fixed between adjacent vertebrae. The spinal fusion device includes a support frame. The support frame has a plurality of extending bodies, each radially extending from a center of the support frame. A predetermined gap exists between every two adjacent extending bodies, receiving a bone graft.
摘要翻译：脊椎融合装置邻接并固定在相邻的椎骨之间。脊柱融合装置包括支撑框架。支撑框架具有多个延伸体，每个延伸体从支撑框架的中心径向延伸。在每两个相邻的延伸体之间存在预定的间隙，接收骨移植物。

6. 发明申请

US20070156240A1 SPINAL FUSION DEVICE 有权
标题翻译：脊柱融合装置
公开(公告)号：US20070156240A1
公开(公告)日：2007-07-05
申请号：US11611821
申请日：2006-12-15
申请人： Yang-Hwei Tsuang , Jui-Sheng Sun , Chun-Jen Liao , Chen-Chi Tsai , Shan-Chang Chueh , Yi-Hung Lin , Shian-Yih Wang , I-Fan Chiu
发明人： Yang-Hwei Tsuang , Jui-Sheng Sun , Chun-Jen Liao , Chen-Chi Tsai , Shan-Chang Chueh , Yi-Hung Lin , Shian-Yih Wang , I-Fan Chiu
IPC分类号： A61F2/44
CPC分类号： A61F2/4455 , A61F2/30771 , A61F2002/2835 , A61F2002/3008 , A61F2002/30153 , A61F2002/30163 , A61F2002/30171 , A61F2002/30772 , A61F2002/4629 , A61F2230/0019 , A61F2230/0028 , A61F2230/005 , A61F2250/0098 , A61F2310/00179 , A61F2310/00365
摘要： A spinal fusion device abutting and fixed between adjacent vertebrae. The spinal fusion device includes a support frame. The support frame has a plurality of extending bodies, each radially extending from a center of the support frame. A predetermined gap exists between every two adjacent extending bodies, receiving a bone graft.
摘要翻译：脊椎融合装置邻接并固定在相邻的椎骨之间。脊柱融合装置包括支撑框架。支撑框架具有多个延伸体，每个延伸体从支撑框架的中心径向延伸。在每两个相邻的延伸体之间存在预定的间隙，接收骨移植物。

7. 发明申请

US20060148072A1 Bioreactor system 审中-公开
标题翻译：生物反应器系统
公开(公告)号：US20060148072A1
公开(公告)日：2006-07-06
申请号：US11202020
申请日：2005-08-12
申请人： Chun-Jen Liao , Yung-Chin Wu , Ko-Chun Hsu , Hua-Chun Hsu , Chen-Chi Tsai , Da-Pan Chen
发明人： Chun-Jen Liao , Yung-Chin Wu , Ko-Chun Hsu , Hua-Chun Hsu , Chen-Chi Tsai , Da-Pan Chen
IPC分类号： C12M1/00
CPC分类号： C12M27/08 , C12M25/16
摘要： A bioreactor system. A supply container receives a cultivation solution. A bioreactor container is connected to the supply container and includes a porous carrier. The porous carrier carries a plurality of cells. The cultivation solution circulates between the supply container and the bioreactor container, providing needed nutrients to the cells.
摘要翻译：生物反应器系统。供应容器接收培养液。生物反应器容器连接到供应容器并且包括多孔载体。多孔载体携带多个单元。培养液在供应容器和生物反应器容器之间循环，向细胞提供所需的营养。

8. 发明申请

US20080110831A1 Apparatus for separating components from blood plasma 有权
标题翻译：用于将组分与血浆分离的装置
公开(公告)号：US20080110831A1
公开(公告)日：2008-05-15
申请号：US11976798
申请日：2007-10-29
申请人： Chen-Chi Tsai , Yung-Chih Wu
发明人： Chen-Chi Tsai , Yung-Chih Wu
IPC分类号： B01D61/00
CPC分类号： A61M1/02 , B01D61/18
摘要： The present invention relates to a process and apparatus for separating blood plasma, having a mixing unit in the form of a first injection having a first connecting tube and a first piston to provide a compartment for a mixture composed of plasma to be separated and the protein-precipitating agent; a separating unit composed of a filtering tube for separating and preserving a solid material after separation. The filtering tube includes a third connecting tube a filter and a third piston, the third connecting tube communicates with the fourth injection tube having a fourth piston for receiving a separated liquid; and a storage unit in the form of a fifth injection tube having a fifth connecting tube, a second connecting valve and a fifth piston.
摘要翻译：本发明涉及一种用于分离血浆的方法和装置，其具有第一注射形式的混合单元，其具有第一连接管和第一活塞，以提供由待分离血浆组成的混合物的隔室和蛋白质 - 沉淀剂; 分离单元，由分离后分离保存固体物质的过滤管构成。过滤管包括第三连接管，过滤器和第三活塞，第三连接管与第四注入管连通，具有用于接收分离液体的第四活塞; 以及具有第五连接管，第二连接阀和第五活塞的第五注入管形式的存储单元。

9. 发明申请

US20050133447A1 Process and apparatus for separating components from blood plasma 有权
标题翻译：用于从血浆中分离成分的方法和装置
公开(公告)号：US20050133447A1
公开(公告)日：2005-06-23
申请号：US10962609
申请日：2004-10-13
申请人： Chen-Chi Tsai , Yung-Chih Wu
发明人： Chen-Chi Tsai , Yung-Chih Wu
IPC分类号： A61M1/02 , B01D25/00 , B01D61/00 , B01D61/18
CPC分类号： A61M1/02 , B01D61/18
摘要： The present invention relates to a process and apparatus for separating blood plasma, having a mixing unit in the form of a first injection having a first connecting tube and a first piston to provide a compartment for a mixture composed of plasma to be separated and the protein-precipitating agent; a separating unit composed of a filtering tube for separating and preserving a solid material after separation. The filtering tube includes a third connecting tube a filter and a third piston, the third connecting tube communicates with the fourth injection tube having a fourth piston for receiving a separated liquid; and a storage unit in the form of a fifth injection tube having a fifth connecting tube, a second connecting valve and a fifth piston.
摘要翻译：本发明涉及一种用于分离血浆的方法和装置，其具有第一注射形式的混合单元，其具有第一连接管和第一活塞，以提供由待分离血浆组成的混合物的隔室和蛋白质 - 沉淀剂; 分离单元，由分离后分离保存固体物质的过滤管构成。过滤管包括第三连接管，过滤器和第三活塞，第三连接管与第四注入管连通，具有用于接收分离液体的第四活塞; 以及具有第五连接管，第二连接阀和第五活塞的第五注入管形式的存储单元。

10. 发明授权

US07481941B2 Method for separating components from blood plasma 有权
标题翻译：从血浆中分离成分的方法
公开(公告)号：US07481941B2
公开(公告)日：2009-01-27
申请号：US11976798
申请日：2007-10-29
申请人： Chen-Chi Tsai , Yung-Chih Wu
发明人： Chen-Chi Tsai , Yung-Chih Wu
IPC分类号： B01D61/14
CPC分类号： A61M1/02 , B01D61/18
摘要： The present invention relates to a process and apparatus for separating blood plasma, having a mixing unit in the form of a first injection having a first connecting tube and a first piston to provide a compartment for a mixture composed of plasma to be separated and the protein-precipitating agent; a separating unit composed of a filtering tube for separating and preserving a solid material after separation. The filtering tube includes a third connecting tube a filter and a third piston, the third connecting tube communicates with the fourth injection tube having a fourth piston for receiving a separated liquid; and a storage unit in the form of a fifth injection tube having a fifth connecting tube, a second connecting valve and a fifth piston.
摘要翻译：本发明涉及一种用于分离血浆的方法和装置，其具有第一注射形式的混合单元，其具有第一连接管和第一活塞，以提供由待分离血浆组成的混合物的隔室和蛋白质 - 沉淀剂; 分离单元，由分离后分离保存固体物质的过滤管构成。过滤管包括第三连接管，过滤器和第三活塞，第三连接管与第四注入管连通，具有用于接收分离液体的第四活塞; 以及具有第五连接管，第二连接阀和第五活塞的第五注入管形式的存储单元。

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