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1. 发明授权

US07340083B2 Method and system for atherosclerosis risk scoring 有权
标题翻译：动脉粥样硬化风险评分方法与系统
公开(公告)号：US07340083B2
公开(公告)日：2008-03-04
申请号：US11172415
申请日：2005-06-29
申请人： Chun Yuan , Thomas S. Hatsukami , Renu Virmani , Jianming Cai , William S. Kerwin , Marina S. Ferguson
发明人： Chun Yuan , Thomas S. Hatsukami , Renu Virmani , Jianming Cai , William S. Kerwin , Marina S. Ferguson
IPC分类号： G06K9/00 , G06F7/60 , G06F17/10
CPC分类号： G06T7/0012 , A61B5/02007 , A61B5/055 , A61B5/7275 , A61B6/504 , A61B8/0833 , G06F19/00 , G06T2207/30101
摘要： A method for characterizing the risk associated with atherosclerosis is disclosed. The method uses one or more images of cross-sections of the artery or other vessel of interest to identify and locate components of the atherosclerotic deposit, including any hemorrhage, necrotic core, and calcification, and to determine the status and composition of the fibrous cap. In one embodiment, high resolution MRI images are utilized, although other imaging modalities may alternatively be used. A simple scoring system is applied that accounts for the presence of these components and more heavily weights the presence of these components in the juxtaluminal portion of the deposit. The status of the fibrous cap (intact or ruptured) and the composition of the fibrous cap (collagen or mixed tissue) are also incorporated into a final atherosclerosis risk score.
摘要翻译：公开了描述与动脉粥样硬化相关的风险的方法。该方法使用动脉或其他所需血管的横截面的一个或多个图像来识别和定位动脉粥样硬化沉积物的组分，包括任何出血，坏死核心和钙化，并确定纤维帽的状态和组成。在一个实施例中，利用了高分辨率MRI图像，但是也可以使用其它成像模式。应用一个简单的评分系统来解释这些组件的存在，并且更重地将这些组件的存在权重存放在存款的两个部分中。纤维帽（完整或破裂）的状态和纤维帽（胶原蛋白或混合组织）的组成也被纳入最终的动脉粥样硬化风险评分。

2. 发明申请

US20070003116A1 Method and system for atherosclerosis risk scoring 有权
标题翻译：动脉粥样硬化风险评分方法与系统
公开(公告)号：US20070003116A1
公开(公告)日：2007-01-04
申请号：US11172415
申请日：2005-06-29
申请人： Chun Yuan , Thomas Hatsukami , Renu Virmani , Jianming Cai , William Kerwin , Marina Ferguson
发明人： Chun Yuan , Thomas Hatsukami , Renu Virmani , Jianming Cai , William Kerwin , Marina Ferguson
IPC分类号： G06K9/00
CPC分类号： G06T7/0012 , A61B5/02007 , A61B5/055 , A61B5/7275 , A61B6/504 , A61B8/0833 , G06F19/00 , G06T2207/30101
摘要： A method for characterizing the risk associated with atherosclerosis is disclosed. The method uses one or more images of cross-sections of the artery or other vessel of interest to identify and locate components of the atherosclerotic deposit, including any hemorrhage, necrotic core, and calcification, and to determine the status and composition of the fibrous cap. In one embodiment, high resolution MRI images are utilized, although other imaging modalities may alternatively be used. A simple scoring system is applied that accounts for the presence of these components and more heavily weights the presence of these components in the juxtaluminal portion of the deposit. The status of the fibrous cap (intact or ruptured) and the composition of the fibrous cap (collagen or mixed tissue) are also incorporated into a final atherosclerosis risk score.
摘要翻译：公开了描述与动脉粥样硬化相关的风险的方法。该方法使用动脉或其他所需血管的横截面的一个或多个图像来识别和定位动脉粥样硬化沉积物的组分，包括任何出血，坏死核心和钙化，并确定纤维帽的状态和组成。在一个实施例中，利用了高分辨率MRI图像，但是也可以使用其它成像模式。应用一个简单的评分系统来解释这些组件的存在，并且更重地将这些组件的存在权重存放在存款的两个部分中。纤维帽（完整或破裂）的状态和纤维帽（胶原蛋白或混合组织）的组成也被纳入最终的动脉粥样硬化风险评分。

3. 发明授权

US07353117B2 Computation of wall thickness 有权
标题翻译：计算壁厚
公开(公告)号：US07353117B2
公开(公告)日：2008-04-01
申请号：US10804460
申请日：2004-03-19
申请人： Chun Yuan , Chao Han , Thomas S. Hatsukami
发明人： Chun Yuan , Chao Han , Thomas S. Hatsukami
IPC分类号： G06F19/00 , G06K9/34
CPC分类号： G06T7/0012 , A61B5/1075 , G06T7/62 , G06T7/66 , G06T17/20 , G06T2207/30101
摘要： A method for automatic vessel wall thickness measurement at any point along the perimeter of either luminal or outer vessel wall boundaries. The method employs both Delaunay triangulation and multiresolution tiling. The MaxMin angle property of the Delaunay triangulation is used to define the minimum energy function to calculate thickness. Multiresolution tiling is employed to enable the MaxMin angle lemma to be determined. The triangulation MaxMin angle lemma enables a minimal energy function to be defined based on triangulation angles, providing a stable and consistent geometrical computation. Additional morphological indexes can be assessed to achieve comprehensive quantification of vascular morphology. For example, based on the wall thickness, a set of vascular shape descriptors can be developed to distinguish different types of plaque morphology at different parts of a vessel wall.
摘要翻译：一种在管腔或外血管壁边界沿周边的任意点进行血管壁厚测量的方法。该方法采用Delaunay三角测量和多分辨率平铺。 Delaunay三角测量的MaxMin角度属性用于定义计算厚度的最小能量函数。采用多分辨率平铺来确定MaxMin角度引理。三角测量MaxMin角度引理使得能够基于三角测量角度定义最小能量函数，从而提供稳定和一致的几何计算。可以评估其他形态指标，以实现血管形态的全面定量。例如，基于壁厚，可以开发一组血管形状描述符，以区分血管壁不同部位的不同类型的斑块形态。

4. 发明申请

US20100312090A1 ATHEROSCLEROSIS RISK ASSESSMENT BY PROJECTED VOLUMES AND AREAS OF PLAQUE COMPONENTS 审中-公开
标题翻译：预计体积和面积组成部分的风险评估风险评估
公开(公告)号：US20100312090A1
公开(公告)日：2010-12-09
申请号：US12783327
申请日：2010-05-19
申请人： William S. Kerwin , Dongxiang Xu , Chun Yuan
发明人： William S. Kerwin , Dongxiang Xu , Chun Yuan
IPC分类号： A61B5/055 , A61B8/00 , A61B5/00 , G06K9/00
CPC分类号： G06T7/0012 , A61B5/02007 , A61B5/055 , A61B5/06 , A61B6/03 , A61B6/12 , A61B8/0833 , G06T2207/10072 , G06T2207/10132 , G06T2207/20068 , G06T2207/30101
摘要： A novel technique directed toward risk assessment of a patient's plaque vulnerability, wherein clinical events may be caused by internal plaque components affecting a lumen within an artery. A surface area projection or shadow of one or more plaque components onto a lumen can be measured and assessed. Optionally, a total volume projection onto the lumen can also be measured and assessed to refine the determination of risk to a patient and to monitor the progression of atherosclerosis over time.
摘要翻译：一种针对患者斑块脆弱性的风险评估的新技术，其中临床事件可能由影响动脉内腔的内部斑块成分引起。可以测量和评估一个或多个斑块组分到管腔上的表面积投影或阴影。任选地，还可以测量和评估对管腔的总体积投影，以便细化对患者的风险的确定并监测动脉粥样硬化随时间的进展。

5. 发明授权

US08131336B2 Automated in vivo plaque composition evaluation 有权
标题翻译：自动体内斑块组成评估
公开(公告)号：US08131336B2
公开(公告)日：2012-03-06
申请号：US11445510
申请日：2006-06-01
申请人： Fei Liu , William S Kerwin , Dongxiang Xu , Chun Yuan
发明人： Fei Liu , William S Kerwin , Dongxiang Xu , Chun Yuan
IPC分类号： A61B5/05
CPC分类号： A61B5/05 , A61B5/02007 , A61B5/7264 , G06T7/12 , G06T7/143 , G06T2207/10072 , G06T2207/30101
摘要： A method for the automated segmentation of in vivo image data is disclosed. A region of carotid artery in a number of patients was imaged using MRI. Histological data for each imaged region was then obtained, identifying various atherosclerotic plaque components in the imaged region. A portion of the histological data, and the image data, was used to generate PDFs based on image intensity, and on morphological data (local wall thickness and distance from lumen). The remaining data was used to validate the method. A plurality of MRI images were taken at various weightings, and the images were registered and normalized. The lumen and outer wall boundary were identified. The PDFs were combined in a Bayesian analysis with the intensity and morphological data to calculate the likelihood that each pixel corresponded to each of four plaque components. A contour algorithm was applied to generate contours segmenting the images by composition.
摘要翻译：公开了一种用于体内图像数据的自动分割的方法。使用MRI对许多患者的颈动脉区域进行成像。然后获得每个成像区域的组织学数据，鉴定成像区域中的各种动脉粥样硬化斑块组分。根据图像强度和形态学数据（局部壁厚和管腔距离），使用部分组织学资料和图像数据生成PDF。剩余的数据用于验证方法。以各种重量拍摄多个MRI图像，并对图像进行记录和归一化。确定了管腔和外壁边界。将PDF以贝叶斯分析与强度和形态数据组合，以计算每个像素对应于四个斑块组分中的每一个的可能性。应用轮廓算法，通过组合生成轮廓分割图像。

6. 发明申请

US20080009702A1 Automated in vivo plaque composition evaluation 有权
标题翻译：自动体内斑块组成评估
公开(公告)号：US20080009702A1
公开(公告)日：2008-01-10
申请号：US11445510
申请日：2006-06-01
申请人： Fei Liu , William S. Kerwin , Dongxiang Xu , Chun Yuan
发明人： Fei Liu , William S. Kerwin , Dongxiang Xu , Chun Yuan
IPC分类号： A61B5/05
CPC分类号： A61B5/05 , A61B5/02007 , A61B5/7264 , G06T7/12 , G06T7/143 , G06T2207/10072 , G06T2207/30101
摘要： A method for the automated segmentation of in vivo image data is disclosed. A region of carotid artery in a number of patients was imaged using MRI. Histological data for each imaged region was then obtained, identifying various atherosclerotic plaque components in the imaged region. A portion of the histological data, and the image data, was used to generate PDFs based on image intensity, and on morphological data (local wall thickness and distance from lumen). The remaining data was used to validate the method. A plurality of MRI images were taken at various weightings, and the images were registered and normalized. The lumen and outer wall boundary were identified. The PDFs were combined in a Bayesian analysis with the intensity and morphological data to calculate the likelihood that each pixel corresponded to each of four plaque components. A contour algorithm was applied to generate contours segmenting the images by composition.
摘要翻译：公开了一种用于体内图像数据的自动分割的方法。使用MRI对许多患者的颈动脉区域进行成像。然后获得每个成像区域的组织学数据，鉴定成像区域中的各种动脉粥样硬化斑块组分。根据图像强度和形态学数据（局部壁厚和管腔距离），使用部分组织学资料和图像数据生成PDF。剩余的数据用于验证方法。以各种重量拍摄多个MRI图像，并对图像进行记录和归一化。确定了管腔和外壁边界。将PDF以贝叶斯分析与强度和形态数据组合，以计算每个像素对应于四个斑块组分中的每一个的可能性。应用轮廓算法，通过组合生成轮廓分割图像。

7. 发明授权

US09529065B2 Interleaved black and bright blood dynamic contrast enhanced (DCE) MRI 有权
标题翻译：交错黑色和明亮的血液动态对比度增强（DCE）MRI
公开(公告)号：US09529065B2
公开(公告)日：2016-12-27
申请号：US14112135
申请日：2012-04-12
申请人： Jinnan Wang , Huijun Chen , Peter Börnert , Chun Yuan
发明人： Jinnan Wang , Huijun Chen , Peter Börnert , Chun Yuan
IPC分类号： G01V3/00 , G01R33/48 , G01R33/563
CPC分类号： G01R33/48 , G01R33/56316 , G01R33/5635
摘要： Interleaved black/bright imaging (IBBI) is performed using a magnetic resonance (MR) scanner wherein the black blood module of the IBBI includes: applying a first flow sensitization gradient; applying a spoiler gradient after applying the first flow sensitization gradient; applying a second flow sensitization gradient after applying the spoiler gradient wherein the second flow sensitization gradient has area equal to the first flow sensitization gradient but of opposite polarity; applying a slice selective radio frequency excitation pulse after applying the spoiler gradient; and performing a MR readout after applying the second flow sensitization gradient and after applying the slice selective radio frequency excitation wherein the readout acquires MR imaging data having blood signal suppression in the region excited by the slice selective radio frequency excitation pulse. The MR imaging data having blood signal suppression is reconstructed to generate black blood images, and MR imaging data generated by bright blood modules of the IBBI is reconstructed to generate bright blood images.
摘要翻译：使用磁共振（MR）扫描器进行交错黑/亮成像（IBBI），其中IBBI的黑血模块包括：施加第一流感敏化梯度; 在应用第一流感敏化梯度后应用扰流板梯度; 在施加扰流板梯度之后施加第二流动增感梯度，其中第二流动增感梯度具有等于第一流动增感梯度但具有相反极性的面积; 应用扰流板梯度后应用切片选择性射频激励脉冲; 以及在应用所述第二流敏增强梯度之后并且在施加所述切片选择性射频激发之后执行MR读出，其中所述读出器获取在由所述切片选择性射频激励脉冲激发的区域中具有血液信号抑制的MR成像数据。重建具有血液信号抑制的MR成像数据以产生黑血图像，并且重建由IBBI的亮血模块产生的MR成像数据以产生明亮的血液图像。

8. 发明申请

US20140010237A1 REORDERING DEVICE AND METHOD FOR ETHERNET TRANSMISSION 审中-公开
标题翻译：用于以太网传输的后续设备和方法
公开(公告)号：US20140010237A1
公开(公告)日：2014-01-09
申请号：US14005728
申请日：2012-02-03
申请人： Chun Yuan , Zhonglin Miao , Xiaoming Wang , Hengqi Liu
发明人： Chun Yuan , Zhonglin Miao , Xiaoming Wang , Hengqi Liu
IPC分类号： H04L12/801
CPC分类号： H04L47/34 , H04L5/1423
摘要： The disclosure discloses a reordering device and method for Ethernet transmission configured to solve a technical problem of large resource consumption and an the operating frequency failing to meet the requirement of a high-speed system in an existing reordering method. The reordering device provided by the disclosure includes a line sequence detecting module and a line sequence locking module, wherein the line sequence detecting module is configured to detect a line sequence corresponding to each channel, acquire a serial number of the channel and encode the serial number, and send the coded serial number to the line sequence locking module; and the line sequence locking module reorders input data according to the coded serial number received to obtain a reordered data stream, then sends out the reordered data stream, and at the same time, locks a sequence of the reordered data stream. By reordering and locking, the device and method provided by the disclosure can properly recover the sequence of data as soon as possible, thereby enhancing the operating frequency and lowering occupied resources.
摘要翻译：本发明公开了一种用于以太网传输的重新排序装置和方法，其被配置为解决大量资源消耗的技术问题，并且操作频率不能满足现有重新排序方法中的高速系统的要求。由本公开提供的重新排序装置包括线路序列检测模块和线路序列锁定模块，其中线路序列检测模块被配置为检测与每个频道相对应的线路序列，获取频道的序列号并对序列号进行编码并将编码序列号发送到行序锁定模块; 线路序列锁定模块根据接收到的编码序列号重新排序输入数据，以获得重新排序的数据流，然后发出重新排序的数据流，同时锁定重新排序的数据流的序列。通过重新排序和锁定，本公开提供的设备和方法可以尽可能地适当地恢复数据序列，从而增强操作频率并降低占用的资源。

9. 发明申请

US20080201337A1 METHOD AND SYSTEM FOR COLLECTING INFORMATION FROM COMPUTER SYSTEMS BASED ON A TRUSTED RELATIONSHIP 失效
标题翻译：基于信任关系从计算机系统收集信息的方法和系统
公开(公告)号：US20080201337A1
公开(公告)日：2008-08-21
申请号：US12044760
申请日：2008-03-07
申请人： Chun Yuan , Jiahe Helen Wang , Yi-Min Wang , Zheng Zhang
发明人： Chun Yuan , Jiahe Helen Wang , Yi-Min Wang , Zheng Zhang
IPC分类号： G06F17/30
CPC分类号： H04L41/0853
摘要： A method and system for retrieving data from devices in a way that seeks to preserve privacy and ensure the integrity of the retrieved data is provided. A retrieval system is implemented on a network of devices that communicate with each other via a secure communications link. Each device is directly connected to one or more “friend” devices that it trusts. The retrieval system operates by forwarding a request for data from one friend device to another friend device. Each friend device may optionally add data to the request until all the requested data is added. The request with the retrieved data is returned to the device that initiated the request.
摘要翻译：提供了以寻求保护隐私并确保检索的数据的完整性的方式从设备检索数据的方法和系统。在通过安全通信链路彼此通信的设备网络上实现检索系统。每个设备直接连接到它信任的一个或多个“朋友”设备。检索系统通过将数据的请求从一个朋友设备转发到另一个朋友设备来操作。每个朋友设备可以选择性地向请求中添加数据，直到添加所有请求的数据。具有检索到的数据的请求将返回给发起请求的设备。

10. 发明申请

US20070061623A1 Event-Based Automated Diagnosis of Known Problems 有权
标题翻译：基于事件的自动诊断已知问题
公开(公告)号：US20070061623A1
公开(公告)日：2007-03-15
申请号：US11556638
申请日：2006-11-03
申请人： Chun Yuan , Ji-Rong Wen , Wei-Ying Ma , Yi-Min Wang , Zheng Zhang
发明人： Chun Yuan , Ji-Rong Wen , Wei-Ying Ma , Yi-Min Wang , Zheng Zhang
IPC分类号： G06F11/00
CPC分类号： G06F11/079 , G06F11/0715
摘要： System events preceding occurrence of a problem are likely to be similar to events preceding occurrence of the same problem at other times or on other systems. Thus, the cause of a problem may be identified by comparing a trace of events preceding occurrence of the problem with previously diagnosed traces. Traces of events preceding occurrences of a problem arising from a known cause are reduced to a series of descriptive elements. These elements are aligned to correlate differently timed but otherwise similar traces of events, converted into symbolic representations, and archived. A trace of events leading to an undiagnosed a problem similarly is converted to a symbolic representation. The representation of the undiagnosed trace is then compared to the archived representations to identify a similar archived representation. The cause of the similar archived representation is presented as a diagnosis of the problem.
摘要翻译：发生问题之前的系统事件可能类似于在其他时间或其他系统上出现相同问题的事件。因此，可以通过将问题发生之前的事件跟踪与先前诊断的迹线进行比较来识别问题的原因。在已知原因引起的问题发生之前的事件跟踪被简化为一系列描述性元素。这些元素被对齐以将不同的定时但相似的事件轨迹相关联，转换成符号表示和归档。类似地导致未定义的问题的事件的轨迹被转换为符号表示。然后将未确定的跟踪的表示与归档表示进行比较，以识别类似的归档表示。类似归档表示的原因被提出作为问题的诊断。

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