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1. 发明申请

US20100312079A1 OXIMETRY WITH REMOTE DISPLAY 有权
标题翻译：带远程显示的OXIMETRY
公开(公告)号：US20100312079A1
公开(公告)日：2010-12-09
申请号：US12794097
申请日：2010-06-04
申请人： Christopher Larsen , Timothy L. Johnson , Scott Everett Blomberg , Charles U. Smith , Jayant Parthasarathy
发明人： Christopher Larsen , Timothy L. Johnson , Scott Everett Blomberg , Charles U. Smith , Jayant Parthasarathy
IPC分类号： A61B5/1455
CPC分类号： A61B5/14552 , A61B5/0002 , A61B5/14551 , A61B5/742
摘要： A device includes a first sensor coupler that is configured to receive a first input signal from a first sensor. The first input signal corresponds to a first physiological parameter and is based on optical excitation of a tissue. The device includes a processor coupled to the first sensor coupler. The processor is configured to generate an output signal based on the first input signal. The first physiological parameter is encoded in the output signal. The output signal differs from the first input signal. The device includes an output coupler configured to communicate the output signal to a remote device.
摘要翻译：一种设备包括被配置为从第一传感器接收第一输入信号的第一传感器耦合器。第一输入信号对应于第一生理参数，并且基于组织的光学激发。该设备包括耦合到第一传感器耦合器的处理器。处理器被配置为基于第一输入信号产生输出信号。第一个生理参数被编码在输出信号中。输出信号与第一输入信号不同。该设备包括被配置为将输出信号传送到远程设备的输出耦合器。

2. 发明授权

US08792950B2 Oximetry with remote display 有权
标题翻译：血氧饱和度与远程显示
公开(公告)号：US08792950B2
公开(公告)日：2014-07-29
申请号：US12794097
申请日：2010-06-04
申请人： Christopher Larsen , Timothy L. Johnson , Scott Everett Blomberg , Charles U. Smith , Jayant Parthasarathy
发明人： Christopher Larsen , Timothy L. Johnson , Scott Everett Blomberg , Charles U. Smith , Jayant Parthasarathy
IPC分类号： A61B5/00
CPC分类号： A61B5/14552 , A61B5/0002 , A61B5/14551 , A61B5/742
摘要： A device includes a first sensor coupler that is configured to receive a first input signal from a first sensor. The first input signal corresponds to a first physiological parameter and is based on optical excitation of a tissue. The device includes a processor coupled to the first sensor coupler. The processor is configured to generate an output signal based on the first input signal. The first physiological parameter is encoded in the output signal. The output signal differs from the first input signal. The device includes an output coupler configured to communicate the output signal to a remote device.
摘要翻译：一种设备包括被配置为从第一传感器接收第一输入信号的第一传感器耦合器。第一输入信号对应于第一生理参数，并且基于组织的光学激发。该设备包括耦合到第一传感器耦合器的处理器。处理器被配置为基于第一输入信号产生输出信号。第一个生理参数被编码在输出信号中。输出信号与第一输入信号不同。该设备包括被配置为将输出信号传送到远程设备的输出耦合器。

3. 发明授权

US5405363A Implantable cardioverter defibrillator having a smaller displacement volume 失效
标题翻译：具有较小排量的植入式心律转复除颤器
公开(公告)号：US5405363A
公开(公告)日：1995-04-11
申请号：US263257
申请日：1994-06-21
申请人： Mark W. Kroll , Theodore P. Adams , Kenneth M. Anderson , Charles U. Smith
发明人： Mark W. Kroll , Theodore P. Adams , Kenneth M. Anderson , Charles U. Smith
IPC分类号： A61N1/375 , A61N1/378 , A61N1/39 , H01M2/10 , H01M6/50 , H01M16/00
CPC分类号： A61N1/375 , A61N1/3787 , A61N1/3931 , A61N1/3956 , A61N1/3975 , H01M16/00 , A61N1/3758 , A61N1/3906 , A61N1/3912 , H01M2/1066 , H01M6/5016
摘要： A capacitor-discharge implantable cardioverter defibrillator (ICD) has a relatively smaller displacement volume of less than about 90 cc. The smaller volume of the ICD is achieved by selecting and arranging the internal components of the ICD to deliver a maximum defibrillation countershock optimized in terms of a minimum physiologically effective current (I.sub.pe), rather than a minimum defibrillation threshold energy (DFT). As a result of the optimization in terms of a minimum effective current I.sub.pe, there is a significant decrease in the maximum electrical charge energy (E.sub.c) that must be stored by the capacitor of the ICD to less than about 30 Joules, even though a higher safety margin is provided for by the device. Due to this decrease in the maximum E.sub.c, as well as corollary decreases in the effective capacitance value required for the capacitor and the net energy storage required of the battery, the overall displacement volume of the ICD is reduced to the point where subcutaneous implantation of the device in the pectoral region of human patients is practical. The size of the capacitor is reduced because the effective capacitance required can be less than about 125 .mu. F. By optimizing both the charging time and the countershock duration for the smaller maximum E.sub.c, the size of the battery is reduced because the total energy storage capacity can be less than about 1.0 Amp-hours. In the preferred embodiment, the charging time for each defibrillation countershock is reduced to less than about 10 seconds and the pulse duration of the countershock is reduced to less than about 6 milliseconds.
摘要翻译：电容放电可植入式心律转复除颤器（ICD）具有小于约90cc的相对较小的置换体积。通过选择和布置ICD的内部部件来实现ICD的体积较小，以提供根据最小生理有效电流（Ipe）而不是最小除颤阈值能量（DFT）优化的最大除颤反相。作为最小有效电流Ipe优化的结果，ICD的电容器必须存储的最大电荷能量（Ec）显着降低到小于约30焦耳，即使较高的设备提供安全余量。由于最大Ec的这种减小以及电容器所需的有效电容值和电池所需的净能量存储的必然减小，ICD的总位移体积减少到皮下植入在人类胸腔的器官是实用的。电容器的尺寸减小，因为所需的有效电容可以小于约125μF。通过优化较小的最大Ec的充电时间和反冲时间，电池的尺寸减小，因为总能量存储容量可以小于约1.0安培小时。在优选实施例中，每个去纤维颤动反射的充电时间减少到小于约10秒，并且该反冲的脉冲持续时间减小到小于约6毫秒。

4. 发明授权

US5697953A Implantable cardioverter defibrillator having a smaller displacement volume 失效
标题翻译：具有较小排量的植入式心律转复除颤器
公开(公告)号：US5697953A
公开(公告)日：1997-12-16
申请号：US582529
申请日：1996-01-11
申请人： Mark W. Kroll , Theodore P. Adams , Kenneth M. Anderson , Charles U. Smith
发明人： Mark W. Kroll , Theodore P. Adams , Kenneth M. Anderson , Charles U. Smith
IPC分类号： A61N1/375 , A61N1/39 , H01M2/10 , H01M6/50 , H01M16/00
CPC分类号： A61N1/375 , A61N1/3956 , A61N1/3758 , H01M16/00 , H01M2/1066 , H01M6/5016
摘要： A capacitor-discharge implantable cardioverter defibrillator (ICD) has a relatively longer device life of greater that 5 years. The longer life of the ICD is achieved by selecting and arranging the internal components of the ICD to deliver a maximum defibrillation countershock optimized in terms of a minimum physiologically effective current (I.sub.pe), rather than a minimum defibrillation threshold energy (DFT). As a result of the optimization in terms of a minimum effective current I.sub.pe, there is a significant decrease in the maximum electrical charge energy (E.sub.c) that must be stored by the capacitor of the ICD to less than about 30 Joules, even though a higher safety margin is provided for by the device. Due to this decrease in the maximum E.sub.c, as well as corollary decreases in the effective capacitance value required for the capacitor and the net energy storage required of the battery, the overall displacement volume of the ICD is reduced to the point where subcutaneous implantation of the device in the pectoral region of human patients is practical. The size of the capacitor is reduced because the effective capacitance required can be less than about 125 .mu.F. By optimizing both the charging time and the countershock duration for the smaller maximum E.sub.c, the size of the battery is reduced because the total energy storage capacity can be less than about 1.0 Amp-hours. In the preferred embodiment, the charging time for each defibrillation countershock is reduced to less than about 10 seconds and the pulse duration of the countershock is reduced to less than about 6 milliseconds.
摘要翻译：电容放电可植入式心律转复除颤器（ICD）具有相对较长的器件寿命，大于5年。通过选择和布置ICD的内部组件来实现ICD的更长寿命，以提供根据最小生理有效电流（Ipe）而不是最小除颤阈值能量（DFT）优化的最大除颤抗倒伏。作为最小有效电流Ipe优化的结果，ICD的电容器必须存储的最大电荷能量（Ec）显着降低到小于约30焦耳，即使较高的设备提供安全余量。由于最大Ec的这种减小以及电容器所需的有效电容值和电池所需的净能量存储的必然减小，ICD的总位移体积减少到皮下植入在人类胸腔的器官是实用的。电容器的尺寸减小，因为所需的有效电容可以小于约125μF。通过优化较小的最大Ec的充电时间和反冲时间，电池的尺寸减小，因为总能量存储容量可以小于约1.0安培小时。在优选实施例中，每个去纤维颤动反射的充电时间减少到小于约10秒，并且该反冲的脉冲持续时间减小到小于约6毫秒。

5. 发明授权

US5645573A Optimal pulse defibrillator 失效
标题翻译：最佳脉搏除颤器
公开(公告)号：US5645573A
公开(公告)日：1997-07-08
申请号：US478001
申请日：1995-06-07
申请人： Mark W. Kroll , Charles U. Smith
发明人： Mark W. Kroll , Charles U. Smith
IPC分类号： A61N1/39
CPC分类号： A61N1/3956 , A61N1/3906 , A61N1/3912
摘要： The model that is developed in the present invention is based upon the pioneering neurophysiological models of Lapicque and Weiss. The present model determines mathematically the optimum pulse duration, d.sub.p, for a truncated capacitor-discharge waveform employed for defibrillation. The model comprehends the system time constant, RC, where R is tissue resistance and C is the value of the capacitor being discharged, and also the chronaxie time, d.sub.c, defined by Lapicque, which is a characteristic time associated with the heart. The present model and analysis find the optimum pulse duration to be d.sub.p =(0.58)(RC+d.sub.c). Taking the best estimate of the chronaxie value from the literature to be 2.7 ms, permits one to rewrite the optimum pulse duration as d.sub.p =(0.58)RC+1.6 ms. The present invention makes use of the mathematical definition of optimum pulse duration by storing in the control circuitry of the defibrillation system the actual measured value of the particular capacitor incorporated in the system. The optimized-pulse prescription of this invention can be applied to a monophasic waveform, or to either or both of the phases of a biphasic waveform.
摘要翻译：本发明开发的模型是基于Lapicque和Weiss的开创性神经生理学模型。本模型在数学上确定了用于除颤的截断电容放电波形的最佳脉冲持续时间dp。该模型包括系统时间常数RC，其中R是组织电阻，C是正在放电的电容器的值，以及由与心脏相关联的特征时间Lapicque定义的时间曲线dc。目前的模型和分析发现最佳脉冲持续时间为dp =（0.58）（RC + dc）。将文献中的时代值的最佳估计值设为2.7 ms，可以将最优脉冲持续时间重写为dp =（0.58）RC + 1.6 ms。本发明通过在除颤系统的控制电路中存储包含在系统中的特定电容器的实际测量值来利用最佳脉冲持续时间的数学定义。本发明的优化脉冲处方可以应用于单相波形，也可以应用于双相波形的任一相或两相。

6. 发明授权

US5957956A Implantable cardioverter defibrillator having a smaller mass 失效
标题翻译：植入式心律转复除颤器质量较小
公开(公告)号：US5957956A
公开(公告)日：1999-09-28
申请号：US963154
申请日：1997-11-03
申请人： Mark W. Kroll , Theodore P. Adams , Kenneth M. Anderson , Charles U. Smith
发明人： Mark W. Kroll , Theodore P. Adams , Kenneth M. Anderson , Charles U. Smith
IPC分类号： A61N1/375 , A61N1/39 , H01M2/10 , H01M6/50 , H01M16/00 , A61N1/18
CPC分类号： A61N1/375 , A61N1/3956 , A61N1/3758 , H01M16/00 , H01M2/1066 , H01M6/5016
摘要： A capacitor-discharge implantable cardioverter defibrillator (ICD) has a relatively smaller mass of less than about 120 grams. The smaller mass of the ICD is achieved by selecting and arranging the internal components of the ICD to deliver a maximum defibrillation countershock optimized in terms of a minimum physiologically effective current (I.sub.pe), rather than a minimum defibrillation threshold energy (DFT). As a result of the optimization in terms of a minimum effective current I.sub.pe, there is a significant decrease in the maximum electrical charge energy (E.sub.c) that must be stored by the capacitor of the ICD to less than about 30 Joules, even though a higher safety margin is provided for by the device. Due to this decrease in the maximum E.sub.c, as well as corollary decreases in the effective capacitance value required for the capacitor and the net energy storage required of the battery, the overall displacement volume of the ICD is reduced to the point where subcutaneous implantation of the device in the pectoral region of human patients is practical. The size of the capacitor is reduced because the effective capacitance required can be less than about 125 .mu.F. By optimizing both the charging time and the countershock duration for the smaller maximum E.sub.c, the size of the battery is reduced because the total energy storage capacity can be less than about 1.0 Amp-hours. In the preferred embodiment, the charging time for each defibrillation countershock is reduced to less than about 10 seconds and the pulse duration of the countershock is reduced to less than about 6 milliseconds.
摘要翻译：电容放电植入式心律转复除颤器（ICD）的质量相对较小，小于约120克。通过选择和布置ICD的内部部件来实现ICD的较小质量，以提供根据最小生理有效电流（Ipe）而不是最小除颤阈值能量（DFT）优化的最大除颤抗倒伏。作为最小有效电流Ipe优化的结果，ICD的电容器必须存储的最大电荷能量（Ec）显着降低到小于约30焦耳，即使较高的设备提供安全余量。由于最大Ec的这种减小以及电容器所需的有效电容值和电池所需的净能量存储的必然减小，ICD的总位移体积减少到皮下植入在人类胸腔的器官是实用的。电容器的尺寸减小，因为所需的有效电容可以小于约125μF。通过优化较小的最大Ec的充电时间和反冲时间，电池的尺寸减小，因为总能量存储容量可以小于约1.0安培小时。在优选实施例中，每个去纤维颤动反射的充电时间减少到小于约10秒，并且该反冲的脉冲持续时间减小到小于约6毫秒。

7. 发明授权

US5827326A Implantable cardioverter defibrillator having a smaller energy storage capacity 失效
标题翻译：具有较小能量储存能力的植入式心律转复除颤器
公开(公告)号：US5827326A
公开(公告)日：1998-10-27
申请号：US412920
申请日：1995-03-29
申请人： Mark W. Kroll , Theodore P. Adams , Kenneth M. Anderson , Charles U. Smith
发明人： Mark W. Kroll , Theodore P. Adams , Kenneth M. Anderson , Charles U. Smith
IPC分类号： A61N1/375 , A61N1/378 , A61N1/39 , H01M2/10 , H01M6/50 , H01M16/00
CPC分类号： A61N1/375 , A61N1/3787 , A61N1/3931 , A61N1/3956 , A61N1/3975 , H01M16/00 , A61N1/3758 , A61N1/3906 , A61N1/3912 , H01M2/1066 , H01M6/5016
摘要： A capacitor-discharge implantable cardioverter defibrillator (ICD) has a relatively smaller energy storage capacity of less than about 1.0 Amp-hours. The smaller energy storage capacity of the ICD is achieved by selecting and arranging the internal components of the ICD to deliver a maximum defibrillation countershock optimized in terms of a minimum physiologically effective current (I.sub.pe) rather than a minimum defibrillation threshold energy (DFT). As a result of the optimization in terms of a minimum effective current I.sub.pe, there is a significant decrease in the maximum electrical charge energy (E.sub.c) that must be stored by the capacitor of the ICD to less than about 30 Joules, even though a higher safety margin is provided for by the device. Due to this decrease in the maximum E.sub.c, as well as corollary decreases in the effective capacitance value required for the capacitor and the net energy storage required of the battery, the overall displacement volume of the ICD is reduced to the point where subcutaneous implantation of the device in the pectoral region of human patients is practical. The size of the capacitor is reduced because the effective capacitance required can be less than about 125 .mu.F. By optimizing both the charging time and the countershock duration for the smaller maximum E.sub.c, the size of the battery is reduced because the total energy storage capacity can be less than about 1.0 Amp-hours. In the preferred embodiment, the charging time for each defibrillation countershock is reduced to less than about 10 seconds and the pulse duration of the countershock is reduced to less than about 6 milliseconds.
摘要翻译：电容放电植入式心律转复除颤器（ICD）具有小于约1.0安培小时的相对较小的储能能力。通过选择和布置ICD的内部部件来实现ICD的较小的能量存储容量，以提供根据最小生理有效电流（Ipe）而不是最小除颤阈值能量（DFT）优化的最大除颤反相。作为最小有效电流Ipe优化的结果，ICD的电容器必须存储的最大电荷能量（Ec）显着降低到小于约30焦耳，即使较高的设备提供安全余量。由于最大Ec的这种减小以及电容器所需的有效电容值和电池所需的净能量存储的必然减小，ICD的总位移体积减少到皮下植入在人类胸腔的器官是实用的。电容器的尺寸减小，因为所需的有效电容可以小于约125μF。通过优化较小的最大Ec的充电时间和反冲时间，电池的尺寸减小，因为总能量存储容量可以小于约1.0安培小时。在优选实施例中，每个去纤维颤动反射的充电时间减少到小于约10秒，并且该反冲的脉冲持续时间减小到小于约6毫秒。

8. 发明授权

US5549643A Optimal pulse defibrillator 失效
标题翻译：最佳脉搏除颤器
公开(公告)号：US5549643A
公开(公告)日：1996-08-27
申请号：US322189
申请日：1994-10-12
申请人： Mark W. Kroll , Charles U. Smith
发明人： Mark W. Kroll , Charles U. Smith
IPC分类号： A61N1/39 , H01M2/10 , H01M16/00
CPC分类号： A61N1/3956 , A61N1/3906 , A61N1/3912 , H01M16/00 , H01M2/1066
摘要： The model that is developed in the invention is based upon the pioneering neurophysiological models of Lapicque and Weiss. The present model determines mathematically the optimum pulse duration, d.sub.p, for a truncated capacitor-discharge waveform employed for defibrillation. The model comprehends the system time constant, RC, where R is tissue resistance and C is the value of the capacitor being discharged, and also the chronaxie time, d.sub.c, defined by Lapicque, which is a characteristic time associated with the heart. The present model and analysis find the optimum pulse duration to be d.sub.p =(0.58)(RC+d.sub.c). Taking the best estimate of the chronaxie value from the literature to be 2.7 ms, permits one to rewrite the optimum pulse duration as d.sub.p =(0.58)RC+1.6 ms. The apparatus makes use of the mathematical definition of optimum pulse duration by storing in the control circuitry of the defibrillation system the actual measured value of the particular capacitor incorporated in the system. The optimized-pulse prescription of this invention can be applied to a monophasic waveform, or to either or both of the phases of a biphasic waveform.
摘要翻译：本发明开发的模型是基于Lapicque和Weiss的开创性神经生理学模型。本模型在数学上确定了用于除颤的截断电容放电波形的最佳脉冲持续时间dp。该模型包括系统时间常数RC，其中R是组织电阻，C是正在放电的电容器的值，以及由与心脏相关联的特征时间Lapicque定义的时间曲线dc。目前的模型和分析发现最佳脉冲持续时间为dp =（0.58）（RC + dc）。将文献中的时代值的最佳估计值设为2.7 ms，可以将最优脉冲持续时间重写为dp =（0.58）RC + 1.6 ms。该装置通过在除颤系统的控制电路中存储包含在系统中的特定电容器的实际测量值来利用最佳脉冲持续时间的数学定义。本发明的优化脉冲处方可以应用于单相波形，也可以应用于双相波形的任一相或两相。

9. 发明授权

US5431686A Method for optimal pulse defibrillation using an implantable defibrillator 失效
标题翻译：使用可植入除颤器进行最佳脉搏除颤的方法
公开(公告)号：US5431686A
公开(公告)日：1995-07-11
申请号：US835836
申请日：1992-02-18
申请人： Mark W. Kroll , Charles U. Smith
发明人： Mark W. Kroll , Charles U. Smith
IPC分类号： A61N1/39 , H01M2/10 , H01M16/00 , A61N1/00
CPC分类号： A61N1/3956 , A61N1/3906 , A61N1/3912 , H01M16/00 , H01M2/1066
摘要： The model that is developed in the present invention is based upon the pioneering neurophysiological models of Lapicque and Weiss. The present model determines mathematically the optimum pulse duration, d.sub.p, for a truncated capacitor-discharge waveform employed for defibrillation. The model comprehends the system time constant, RC, where R is tissue resistance and C is the value of the capacitor being discharged, and also the chronaxie time, d.sub.c, defined by Lapicque, which is a characteristic time associated with the heart. The present model and analysis find the optimum pulse duration to be d.sub.p =(0.58)(RC+d.sub.c). Taking the best estimate of the chronaxie value from the literature to be 2.7 ms, permits one to rewrite the optimum pulse duration as d.sub.p =(0.58)RC+1.6 ms. The present invention makes use of the mathematical definition of optimum pulse duration by storing in the control circuitry of the defibrillation system the actual measured value of the particular capacitor incorporated in the system. The optimized-pulse prescription of this invention can be applied to a monophasic waveform, or to either or both of the phases of a biphasic waveform.
摘要翻译：本发明开发的模型是基于Lapicque和Weiss的开创性神经生理学模型。本模型在数学上确定了用于除颤的截断电容放电波形的最佳脉冲持续时间dp。该模型包括系统时间常数RC，其中R是组织电阻，C是正在放电的电容器的值，以及由与心脏相关联的特征时间Lapicque定义的时间曲线dc。目前的模型和分析发现最佳脉冲持续时间为dp =（0.58）（RC + dc）。将文献中的时代值的最佳估计值设为2.7 ms，可以将最优脉冲持续时间重写为dp =（0.58）RC + 1.6 ms。本发明通过在除颤系统的控制电路中存储包含在系统中的特定电容器的实际测量值来利用最佳脉冲持续时间的数学定义。本发明的优化脉冲处方可以应用于单相波形，也可以应用于双相波形的任一相或两相。

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