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1. 发明申请

US20090162321A1 METHODS FOR PACKAGING PROPAGATION-DEFECTIVE VESICULAR STOMATITIS VIRUS VECTORS USING A STABLE CELL LINE THAT EXPRESSES G PROTEIN 审中-公开
标题翻译：使用表达G蛋白的稳定细胞系包装传播性缺陷性病毒性血管病毒载体的方法
公开(公告)号：US20090162321A1
公开(公告)日：2009-06-25
申请号：US12335778
申请日：2008-12-16
申请人： Christopher L. Parks , Susan E. Witko , Maninder K. Sidhu , J. Erik Johnson , Roger Michael Hendry
发明人： Christopher L. Parks , Susan E. Witko , Maninder K. Sidhu , J. Erik Johnson , Roger Michael Hendry
IPC分类号： A61K35/76 , C12N7/02 , C07H21/04 , A61P37/00
CPC分类号： C12N7/00 , C12N2510/02 , C12N2760/20251 , C12N2760/20252
摘要： A method of producing propagation-defective Vesicular Stomatitis Virus (VSV) is provided. The method involves providing a cell that includes an optimized VSV G gene, wherein expression of VSV G protein from the optimized VSV G gene is inducible; and inducing the cell to express VSV G protein from the optimized VSV G gene. The method also involves infecting the induced cell with an attenuated VSV; growing the infected cells in culture; and recovering attenuated VSV from the culture.
摘要翻译：提供了产生增生性水泡性口炎病毒（VSV）的方法。该方法包括提供包含优化的VSV G基因的细胞，其中来自优化的VSV G基因的VSV G蛋白的表达是诱导型的; 并诱导细胞从优化的VSV G基因中表达VSV G蛋白。该方法还涉及用减毒的VSV感染诱导的细胞; 培养受感染的细胞; 并从培养物中恢复减弱的VSV。

2. 发明申请

US20090175900A1 METHODS FOR PACKAGING PROPAGATION-DEFECTIVE VESICULAR STOMATITIS VIRUS VECTORS 审中-公开
标题翻译：用于包装传播性缺陷性病毒性STOMATITIV病毒载体的方法
公开(公告)号：US20090175900A1
公开(公告)日：2009-07-09
申请号：US12335763
申请日：2008-12-16
申请人： Christopher L. Parks , Susan E. Witko , Maninder K. Sidhu , J. Erik Johnson , Roger Michael Hendry
发明人： Christopher L. Parks , Susan E. Witko , Maninder K. Sidhu , J. Erik Johnson , Roger Michael Hendry
IPC分类号： A61K39/12 , C12N15/09 , C12N15/87 , C12N15/63
CPC分类号： C12N7/00 , C07K14/005 , C12N2760/20222 , C12N2760/20252 , C12N2760/20261
摘要： A method of producing propagation-defective Vesicular Stomatitis Virus (VSV) in a cell culture is provided. The method involves introducing a plasmid vector encoding an optimized VSV G gene into a cell; expressing VSV G protein from the optimized VSV G gene; and introducing a propagation-defective VSV into the cell expressing the VSV G protein encoded by the optimized VSV G gene. The method further includes growing the cells in culture; and recovering the propagation-defective VSV from the culture.
摘要翻译：提供了一种在细胞培养物中产生增生性水泡性口炎病毒（VSV）的方法。该方法包括将编码优化的VSV G基因的质粒载体导入细胞; 从优化的VSV G基因中表达VSV G蛋白; 并将增殖缺陷VSV引入表达由优化的VSV G基因编码的VSV G蛋白的细胞中。该方法还包括培养培养细胞; 并从培养物中回收传播缺陷VSV。

3. 发明申请

US20170258890A1 GENETICALLY STABLE REPLICATION COMPETENT SENDAI VIRUS VECTOR(S) CONTAINING AND EXPRESSING OPTIMIZED HIV GENES 审中-公开
公开(公告)号：US20170258890A1
公开(公告)日：2017-09-14
申请号：US15498554
申请日：2017-04-27
申请人： John Coleman , Josephine Helena Cox , Arban Domi , Hiroto Hara , Takashi Hironaka , Makoto Inoue , Dagna Skoog Laufer , Angela Grazia Lombardo , Christopher L. Parks , Eddy Sayeed , Maoli Yuan , Xinsheng Zhang
发明人： John Coleman , Josephine Helena Cox , Arban Domi , Hiroto Hara , Takashi Hironaka , Makoto Inoue , Dagna Skoog Laufer , Angela Grazia Lombardo , Christopher L. Parks , Eddy Sayeed , Maoli Yuan , Xinsheng Zhang
IPC分类号： A61K39/21 , C07K14/005 , C12N15/86 , C12N7/00
CPC分类号： A61K39/21 , A61K39/12 , A61K2039/5256 , A61K2039/53 , A61K2039/543 , A61K2039/545 , A61K2039/55511 , A61K2039/55555 , A61K2039/57 , A61K2039/575 , A61K2039/70 , C07K14/005 , C12N7/00 , C12N15/86 , C12N2740/16034 , C12N2740/16134 , C12N2740/16234 , C12N2740/16271 , C12N2740/16334 , C12N2760/18443 , C12N2760/18843 , C12N2760/18871 , C12N2760/20243
摘要： The present invention relates to genetically stable replication competent Sendai virus vector(s) containing optimized HIV genes, methods for making the same and cell substrates qualified for vaccine production which may comprise genetically stable replication competent Sendai virus vector(s) containing optimized HIV genes.

4. 发明授权

US06664066B2 Modified Morbillivirus V proteins 失效
标题翻译：改良的Morbillivirus V蛋白
公开(公告)号：US06664066B2
公开(公告)日：2003-12-16
申请号：US10311582
申请日：2002-12-16
申请人： Christopher L. Parks
发明人： Christopher L. Parks
IPC分类号： C12Q168
CPC分类号： C07K14/005 , A61K39/00 , A61K39/12 , A61K39/165 , A61K2039/525 , A61K2039/5254 , C07K2319/00 , C12N7/00 , C12N2760/18422 , C12N2760/18434 , C12N2760/18461
摘要： Modified Morbilliviruses having at least one mutation in the region corresponding to amino acids 112-134 of the measles virus V protein are described, wherein one or both of amino acids 113 or 114 is mutated. Such modified Morbilliviruses exhibit reduced repression of gene expression. Additional mutations or deletions in other regions of the genome may be included, including in the carboxy-terminal region.
摘要翻译：描述了在对应于麻疹病毒V蛋白的氨基酸112-134的区域中具有至少一个突变的修饰的转录病毒病毒，其中氨基酸113或114中的一个或两个突变。这种修饰的Morbilliviruses表现出减少的基因表达抑制。可以包括在基因组的其它区域中的其它突变或缺失，包括在羧基末端区域。

5. 发明授权

US06673572B2 Methods for rescue of RNA viruses 失效
标题翻译：拯救RNA病毒的方法
公开(公告)号：US06673572B2
公开(公告)日：2004-01-06
申请号：US10261961
申请日：2002-10-01
申请人： Christopher L. Parks , Mohinderjit S. Sidhu , Stephen A. Udem , Gerald R. Kovacs
发明人： Christopher L. Parks , Mohinderjit S. Sidhu , Stephen A. Udem , Gerald R. Kovacs
IPC分类号： C12P2106
CPC分类号： C07K14/005 , A61K2039/525 , C12N7/00 , C12N2760/18422 , C12N2760/18451 , C12N2760/18622 , C12N2760/18651
摘要： This invention relates to improved methods for producing nonsegmented, negative-sense, single-stranded RNA viruses of the Order designated Mononegavirales virus, including embodiments relating to methods of producing such viruses as attenuated and/or infectious viruses, such as Measles virus (MV) and respiratory syncytial virus (RSV). One method for producing a recombinant virus from the Order Mononegavirales comprises (a) in at least one host cell, conducting transfection of a rescue composition which comprises (i) a transcription vector comprising an isolated nucleic acid molecule which comprises polynucleotide sequence encoding a genome or antigenome of a nonsegmented, negative-sense, single stranded RNA virus of the Order Mononegavirales and (ii) at least one expression vector which comprises at least one isolated nucleic acid molecule encoding the trans-acting proteins necessary for encapsidation, transcription and replication; in a host cell under conditions sufficient to permit the co-expression of these vectors and the production of the recombinant virus; (b) heating the transfected rescue composition to an effective heat shock temperature under conditions sufficient to increase the recovery of the recombinant virus; and optionally, (c) harvesting the resulting recombinant virus.
摘要翻译：本发明涉及用于产生命名为单细胞病毒（Mononegavirales）病毒的非分段，负义的单链RNA病毒的改进方法，其包括与诸如麻疹病毒（MV）等减毒和/或感染性病毒一起生产此类病毒的方法，和呼吸道合胞病毒（RSV）。从单顺序单克隆抗体制备重组病毒的一种方法包括（a）在至少一个宿主细胞中，进行拯救组合物的转染，其包含（i）包含分离的核酸分子的转录载体，其包含编码基因组或单核苷酸单克隆的非分段的，负义的单链RNA病毒的抗原组成单元和（ii）至少一种表达载体，其包含至少一个分离的核酸分子，所述核酸分子编码壳化，转录和复制所必需的反式作用蛋白; 在足以允许这些载体的共表达和重组病毒的产生的条件下在宿主细胞中; （b）在足以增加重组病毒的恢复的条件下将转染的救援组合物加热至有效的热休克温度; 和（c）收获所得的重组病毒。

6. 发明申请

US20170258891A1 OPTIMIZED HIV ENVELOPE GENE AND EXPRESSION THEREOF 审中-公开
公开(公告)号：US20170258891A1
公开(公告)日：2017-09-14
申请号：US15498556
申请日：2017-04-27
申请人： Christopher L. Parks , Maoli Yuan , Xinsheng Zhang , Aaron Wilson , Angela Grazia Lombardo , Eddy Sayeed , Josephine Helena Cox , Takashi Hironaka , Makoto Inoue , Hiroto Hara
发明人： Christopher L. Parks , Maoli Yuan , Xinsheng Zhang , Aaron Wilson , Angela Grazia Lombardo , Eddy Sayeed , Josephine Helena Cox , Takashi Hironaka , Makoto Inoue , Hiroto Hara
IPC分类号： A61K39/21 , C12N15/86 , C12N7/00
CPC分类号： A61K39/21 , A61K39/12 , A61K2039/5256 , A61K2039/53 , A61K2039/543 , A61K2039/545 , A61K2039/55511 , A61K2039/55555 , A61K2039/57 , A61K2039/575 , A61K2039/70 , C07K14/005 , C12N7/00 , C12N15/86 , C12N2740/16034 , C12N2740/16134 , C12N2740/16234 , C12N2740/16271 , C12N2740/16334 , C12N2760/18443 , C12N2760/18843 , C12N2760/18871 , C12N2760/20243
摘要： The present invention relates to a vector(s) containing and expressing an optimized HIV EnvF gene, methods for making the same and cell substrates qualified for vaccine production which may comprise vector(s) containing optimized HIV genes.

7. 发明申请

US20130266611A1 RECOMBINANT VIRAL VECTORS 有权
标题翻译：重组病毒载体
公开(公告)号：US20130266611A1
公开(公告)日：2013-10-10
申请号：US13792106
申请日：2013-03-10
申请人： Svetlana Rabinovich , Maoli Yuan , Aaron J. Wilson , Sanjay Phogat , Ross W. B. Lindsay , Maria J. Chiuchiolo , Christopher L. Parks
发明人： Svetlana Rabinovich , Maoli Yuan , Aaron J. Wilson , Sanjay Phogat , Ross W. B. Lindsay , Maria J. Chiuchiolo , Christopher L. Parks
IPC分类号： A61K39/21
CPC分类号： A61K39/21 , A61K39/12 , A61K2039/5256 , A61K2039/53 , C12N2740/16134 , C12N2760/20243
摘要： The present relation relates to recombinant vesicular stomatitis virus for use as prophylactic and therapeutic vaccines for infectious diseases of AIDS. The present invention encompasses the preparation and purification of immunogenic compositions which are formulated into the vaccines of the present invention.
摘要翻译：本发明涉及重组水泡性口炎病毒，用作艾滋病感染性疾病的预防和治疗疫苗。本发明包括配制成本发明疫苗的免疫原性组合物的制备和纯化。

8. 发明申请

US20130189754A1 IMMUNOSELECTION OF RECOMBINANT VESICULAR STOMATITIS VIRUS EXPRESSING HIV-1 PROTEINS BY BROADLY NEUTRALIZING ANTIBODIES 审中-公开
标题翻译：通过广泛中和抗体免疫选择表达HIV-1蛋白的重组病毒性STOMATITIV病毒
公开(公告)号：US20130189754A1
公开(公告)日：2013-07-25
申请号：US13612001
申请日：2012-09-12
申请人： Christopher L. Parks , Christy Jurgens , Perry J. Tiberio , Simon Hoffenberg
发明人： Christopher L. Parks , Christy Jurgens , Perry J. Tiberio , Simon Hoffenberg
IPC分类号： A61K35/76
CPC分类号： A61K35/766 , G01N33/56983
摘要： The present relation relates to recombinant vesicular stomatitis virus for use as prophylactic and therapeutic vaccines for infectious diseases of AIDS. The present invention encompasses the preparation and purification of immunogenic compositions which are formulated into the vaccines of the present invention.
摘要翻译：本发明涉及重组水泡性口炎病毒，用作艾滋病感染性疾病的预防和治疗疫苗。本发明包括配制成本发明疫苗的免疫原性组合物的制备和纯化。

9. 发明申请

US20130266989A1 METHODS TO IMPROVE VECTOR EXPRESSION AND GENETIC STABILITY 有权
标题翻译：提高矢量表达和遗传稳定性的方法
公开(公告)号：US20130266989A1
公开(公告)日：2013-10-10
申请号：US13792103
申请日：2013-03-10
申请人： Christopher L. Parks , Kevin J. Wright , Maoli Yuan , Christy K. Jurgens , Xinsheng Zhang , Arban Domi , Simon Hoffenberg , Maria J. Chiuchiolo , Svetlana Rabinovich , Aaron J. Wilson , Ivo C. Lorenz
发明人： Christopher L. Parks , Kevin J. Wright , Maoli Yuan , Christy K. Jurgens , Xinsheng Zhang , Arban Domi , Simon Hoffenberg , Maria J. Chiuchiolo , Svetlana Rabinovich , Aaron J. Wilson , Ivo C. Lorenz
IPC分类号： C12N15/68
CPC分类号： C12N15/68 , A61K39/12 , A61K39/21 , A61K2039/5254 , A61K2039/5256 , C07K14/005 , C12N7/00 , C12N15/67 , C12N15/86 , C12N2740/16122 , C12N2740/16134 , C12N2760/16034 , C12N2760/18443 , C12N2760/20243
摘要： The present invention relates to methods of developing gene inserts that are more compatible with the host vectors by modifying a protein sequence to lessen potential interference with vector propagation while ensuring that the protein is expressed and processed efficiently and maintains desired structural features, and designing a gene with a nucleotide sequence that resembles the base composition of the host vector genome.
摘要翻译：本发明涉及通过修饰蛋白质序列来改变与宿主载体更相容的基因插入物的方法，以减少对载体繁殖的潜在干扰，同时确保蛋白质被有效地表达和加工并保持所需的结构特征，并设计基因其核苷酸序列类似于宿主载体基因组的基本组成。

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