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1. 发明授权

US09422589B2 Assay for histidinyl hydroxylase activity 有权
标题翻译：测定组氨酸羟化酶活性
公开(公告)号：US09422589B2
公开(公告)日：2016-08-23
申请号：US14235217
申请日：2012-07-25
申请人： Christopher Joseph Schofield , Wei Ge , Matthew Edward Cockman , Peter John Ratcliffe , Mathew Louis Coleman
发明人： Christopher Joseph Schofield , Wei Ge , Matthew Edward Cockman , Peter John Ratcliffe , Mathew Louis Coleman
IPC分类号： C12Q1/26 , G01N33/50 , G01N33/573
CPC分类号： C12Q1/26 , G01N33/5023 , G01N33/573 , G01N2333/90245
摘要： The present invention relates to assays for monitoring activity of Mina53 and NO66 activities, in particular, to assays for identifying modulators of Mina53 and NO66 activities. The invention also relates to assays to monitor the histidinyl hydroxylase activity of Mina53 and NO66 on their substrates, the human ribosomal protein Rpl27a and Rpl8 respectively. The invention also enables the introduction of S-3-hydroxyhistidinyl residues into peptides and proteins.
摘要翻译：本发明涉及用于监测Mina53和NO66活性的活性的测定法，特别涉及鉴定Mina53和NO66活性的调节剂的测定。本发明还涉及分别监测Mina53和NO66对其底物，人核糖体蛋白Rpl27a和Rpl8的组氨酸羟化酶活性的测定。本发明还能够将S-3-羟基组氨酸残基引入肽和蛋白质。

2. 发明申请

US20140248636A1 ASSAY FOR HISTIDINYL HYDROXYLASE ACTIVITY 有权
标题翻译：测定羟脯氨酸羟化酶活性
公开(公告)号：US20140248636A1
公开(公告)日：2014-09-04
申请号：US14235217
申请日：2012-07-25
申请人： Christopher Joseph Schofield , Wei Ge , Matthew Edward Cockman , Peter John Ratcliffe , Mathew Louis Coleman
发明人： Christopher Joseph Schofield , Wei Ge , Matthew Edward Cockman , Peter John Ratcliffe , Mathew Louis Coleman
IPC分类号： C12Q1/26 , G01N33/573
CPC分类号： C12Q1/26 , G01N33/5023 , G01N33/573 , G01N2333/90245
摘要： The present invention relates to assays for monitoring activity of Mina53 and NO66 activities, in particular, to assays for identifying modulators of Mina53 and NO66 activities. The invention also relates to assays to monitor the histidinyl hydroxylase activity of Mina53 and NO66 on their substrates, the human ribosomal protein Rpl27a and Rpl8 respectively. The invention also enables the introduction of S-3-hydroxyhistidinyl residues into peptides and proteins.
摘要翻译：本发明涉及用于监测Mina53和NO66活性的活性的测定法，特别涉及鉴定Mina53和NO66活性的调节剂的测定。本发明还涉及分别监测Mina53和NO66对其底物，人核糖体蛋白Rpl27a和Rpl8的组氨酸羟化酶活性的测定。本发明还能够将S-3-羟基组氨酸残基引入肽和蛋白质。

3. 发明申请

US20140051106A1 METHOD FOR ASSAYING OGFOD1 ACTIVITY 有权
标题翻译：测定OGFOD1活性的方法
公开(公告)号：US20140051106A1
公开(公告)日：2014-02-20
申请号：US13985243
申请日：2012-02-10
申请人： Christopher Joseph Schofield , Alexander Wolf , Wei Ge , Armin Thalhammer , Christoph Loenarz , Peter John Ratcliffe , Matthew Edward Cockman
发明人： Christopher Joseph Schofield , Alexander Wolf , Wei Ge , Armin Thalhammer , Christoph Loenarz , Peter John Ratcliffe , Matthew Edward Cockman
IPC分类号： C12Q1/26
CPC分类号： C12Q1/26 , G01N2333/90245
摘要： The present invention relates to assays for monitoring activity of OGFOD1 activity, in particular, to assays for identifying modulators of OGFOD1 activity. The invention also relates to assays to monitor the prolyl hydroxylase activity of OGFOD1 on its substrate, the human ribosomal protein RPS23. The invention also enables the introduction of 3-hydroxyprolyl residues into peptides and proteins.
摘要翻译：本发明涉及用于监测OGFOD1活性的活性的测定法，特别是用于鉴定OGFOD1活性调节剂的测定法。本发明还涉及监测OGFOD1在其底物，人核糖体蛋白RPS23上的脯氨酰羟化酶活性的测定。本发明还能够将3-羟基脯氨酸残基引入肽和蛋白质。

4. 发明授权

US09228224B2 Method for assaying OGFOD1 activity 有权
标题翻译： OGFOD1活性测定方法
公开(公告)号：US09228224B2
公开(公告)日：2016-01-05
申请号：US13985243
申请日：2012-02-10
申请人： Christopher Joseph Schofield , Alexander Wolf , Wei Ge , Armin Thalhammer , Christoph Loenarz , Peter John Ratcliffe , Matthew Edward Cockman
发明人： Christopher Joseph Schofield , Alexander Wolf , Wei Ge , Armin Thalhammer , Christoph Loenarz , Peter John Ratcliffe , Matthew Edward Cockman
IPC分类号： C12Q1/26
CPC分类号： C12Q1/26 , G01N2333/90245
摘要： The present invention relates to assays for monitoring activity of OGFOD1 activity, in particular, to assays for identifying modulators of OGFOD1 activity. The invention also relates to assays to monitor the prolyl hydroxylase activity of OGFOD1 on its substrate, the human ribosomal protein RPS23. The invention also enables the introduction of 3-hydroxyprolyl residues into peptides and proteins.
摘要翻译：本发明涉及用于监测OGFOD1活性的活性的测定法，特别是用于鉴定OGFOD1活性调节剂的测定法。本发明还涉及监测OGFOD1在其底物，人核糖体蛋白RPS23上的脯氨酰羟化酶活性的测定。本发明还能够将3-羟基脯氨酸残基引入肽和蛋白质。

5. 发明申请

US20140045930A1 ASSAY FOR ARGINYL HYDROXYLASE ACTIVITY 审中-公开
标题翻译：测定ARGINYL羟化酶活性
公开(公告)号：US20140045930A1
公开(公告)日：2014-02-13
申请号：US13982639
申请日：2012-01-30
申请人： Christopher Joseph Schofield , Chia-Hua Ho , Alexander Wolf , Wei Ge
发明人： Christopher Joseph Schofield , Chia-Hua Ho , Alexander Wolf , Wei Ge
IPC分类号： C12Q1/26 , C12P21/00 , A61K45/00
CPC分类号： C12Q1/26 , A61K45/00 , C12P21/00 , G01N2333/90245
摘要： The present invention relates to assays for monitoring activity of YcfD activity, in particular, to assays for identifying modulators of YcfD activity. The present invention also relates to the use of YcfD inhibitors as antibiotics. The invention also relates to methods for introducing hydroxyarginine residues into proteins.
摘要翻译：本发明涉及用于监测YcfD活性的活性的测定法，特别是用于鉴定YcfD活性调节剂的测定法。本发明还涉及YcfD抑制剂作为抗生素的用途。本发明还涉及将精氨酸残基引入蛋白质的方法。

6. 发明申请

US20110250591A1 METHOD OF DESIGNING siRNAS FOR GENE SILENCING 有权
标题翻译：设计用于基因沉默的siRNA的方法
公开(公告)号：US20110250591A1
公开(公告)日：2011-10-13
申请号：US13100836
申请日：2011-05-04
申请人： Aimee L. Jackson , Steven R. Bartz , Julja Burchard , Peter S. Linsley , Wei Ge , Guy L. Cavet
发明人： Aimee L. Jackson , Steven R. Bartz , Julja Burchard , Peter S. Linsley , Wei Ge , Guy L. Cavet
IPC分类号： C12Q1/68
CPC分类号： C12N15/111 , C12N2310/14 , C12N2320/11 , C12N2330/31 , G06F19/18 , G06F19/22
摘要： The present invention provides a method for identifying siRNA target motifs in a transcript using a position-specific score matrix approach. The invention also provides a method for identifying off-target genes of an siRNA using a position-specific score matrix approach. The invention further provides a method for designing siRNAs with higher silencing efficacy and specificity. The invention also provides a library of siRNAs comprising siRNAs with high silencing efficacy and specificity.
摘要翻译：本发明提供使用位置特异性评分矩阵法来鉴定转录物中的siRNA靶基序的方法。本发明还提供了一种使用位置特异性评分矩阵方法鉴定siRNA的靶外基因的方法。本发明还提供了设计具有较高沉默功效和特异性的siRNA的方法。本发明还提供了包含具有高沉默功效和特异性的siRNA的siRNA文库。

7. 发明申请

US20130192952A1 PROFILE TRACK INTEGRATED DRIVE SYSTEM 审中-公开
标题翻译：配置跟踪集成驱动系统
公开(公告)号：US20130192952A1
公开(公告)日：2013-08-01
申请号：US13518511
申请日：2010-12-23
申请人： Guobin Lin , Zhaohui Lui , Ke Ye , Songjian He , Biao Li , Coliu Muke Wu , Yanying Anne Chen , Richard Qingdong Jiang , Ji An Wan , Yaoji Xu , Guojie Samuel Ye , De Wu , MingPing Jiang , JianGuo Li , Weifeng Shao , Wei Ge , Graham Worthington
发明人： Guobin Lin , Zhaohui Lui , Ke Ye , Songjian He , Biao Li , Coliu Muke Wu , Yanying Anne Chen , Richard Qingdong Jiang , Ji An Wan , Yaoji Xu , Guojie Samuel Ye , De Wu , MingPing Jiang , JianGuo Li , Weifeng Shao , Wei Ge , Graham Worthington
IPC分类号： B66B23/02
CPC分类号： B66B23/02 , B66B23/00 , Y10T29/49826 , Y10T29/49947
摘要： A method for assembling a drive system for an escalator system includes securing one or more track sets extending along a path of the escalator to one or more support members extending at least partially across a width of the escalator system. A drive member is secured to the one or more support members such that the drive member is operably connected to the one or more track sets. The one or more track sets, the one or more support members and the drive member are installed into the escalator system as a unit.
摘要翻译：用于组装用于自动扶梯系统的驱动系统的方法包括将沿着自动扶梯的路径延伸的一个或多个轨道组固定到至少部分地横跨自动扶梯系统的宽度延伸的一个或多个支撑构件。驱动构件固定到一个或多个支撑构件，使得驱动构件可操作地连接到一个或多个轨道组。一个或多个轨道组，一个或多个支撑构件和驱动构件作为一个单元安装到自动扶梯系统中。

8. 外观设计

USD583489S1 Fluorescent lamp tube 有权
标题翻译：荧光灯管
公开(公告)号：USD583489S1
公开(公告)日：2008-12-23
申请号：US29301737
申请日：2008-03-13
申请人： Baogui Ge , Wei Ge
设计人： Baogui Ge , Wei Ge

9. 发明授权

US09056750B2 Escalator handrail chain 有权
标题翻译：自动扶梯扶手链
公开(公告)号：US09056750B2
公开(公告)日：2015-06-16
申请号：US13516809
申请日：2011-01-13
申请人： Wei Ge , Weifeng Shao , MingPing Jiang , Jun Li
发明人： Wei Ge , Weifeng Shao , MingPing Jiang , Jun Li
IPC分类号： B66B23/04 , B66B23/24
CPC分类号： B66B23/04 , B66B23/24
摘要： A handrail assembly for an escalator system includes a handrail movable along a length of the escalator and a handrail guide assembly defining a travel path for the handrail. The handrail guide assembly includes a handrail guide and a plurality of sliding bearing supports interconnected to form a handrail chain and secured to the handrail guide. One or more sliding bearings extend at least partially through each sliding bearing support of the handrail chain. A shaft extends through each sliding bearing support and is in sliding contact with the one or more sliding bearings. One or more rollers are secured to at least one end of the shaft and is in rolling contact with the handrail.
摘要翻译：用于自动扶梯系统的扶手组件包括沿着自动扶梯的长度移动的扶手和限定用于扶手的行进路径的扶手引导组件。扶栏引导组件包括扶手引导件和互连的多个滑动轴承支撑件，以形成扶手链并固定在扶手导轨上。一个或多个滑动轴承至少部分延伸穿过扶手链的每个滑动轴承支撑件。轴延伸穿过每个滑动轴承支撑件并与一个或多个滑动轴承滑动接触。一个或多个辊固定到轴的至少一端并与扶手滚动接触。

10. 发明授权

US09934914B2 Heart-shaped self-locking button 有权
公开(公告)号：US09934914B2
公开(公告)日：2018-04-03
申请号：US14890609
申请日：2013-09-24
申请人： Zhong Hui Chen , Wei Ge , Ling Li , Song Liu , Lei Tao
发明人： Zhong Hui Chen , Wei Ge , Ling Li , Song Liu , Lei Tao
IPC分类号： H01H13/56 , H01H13/04 , H01H13/14
CPC分类号： H01H13/562 , H01H13/04 , H01H13/14 , H01H2221/036 , H01H2235/01 , H01H2235/028
摘要： A heart-shaped self-locking button includes one housing and one push rod. The push rod is slidably arranged within the housing. A heart-shaped structure is formed on the push rod. The button includes one pin and one flexible element. One end of the pin is fixed on the housing, while the other end is fitted with the heart-shaped structure. The flexible element is arranged between the housing and the push rod and presses the pin towards the heart-shaped structure to allow the pin to be in constant contact with the heart-shaped structure. The heart-shaped structure is arranged on the push rod. Also, the flexible element between the housing and the push rod is utilized to press the pin towards the heart-shaped structure on the push rod to allow the pin to be in constant contact with the heart-shaped structure when moving.

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