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1. 发明授权

US06760679B1 Method and apparatus for positional calibration of a thermal analysis instrument 有权
标题翻译：热分析仪的位置校准方法和装置
公开(公告)号：US06760679B1
公开(公告)日：2004-07-06
申请号：US09796750
申请日：2001-03-02
申请人： Christopher F. Carney , Fred L. Ferguson , John R. Reader , Weidong Liu , Jay A. Crosby
发明人： Christopher F. Carney , Fred L. Ferguson , John R. Reader , Weidong Liu , Jay A. Crosby
IPC分类号： G01C1738
CPC分类号： G01N25/4866 , G01N25/4853 , G01N35/025 , G01N2035/0494
摘要： The present invention is directed to a technique for performing calibration of an automatic sampler device. According to an aspect, the automatic sampler device includes a cell with a sample platform and a reference platform; a sample arm; a sample tray, and a platen. The sample tray includes wells into which pans are inserted. The platen may include conductive and/or reflective areas for calibration. The sample arm has an electronic sensor and an optical sensor. The electrical sensor and the optical sensor are used to calibrate the positions of one or more of: the sample platform, the reference platform, and a well. According to another aspect, autocalibration is optimized by adjusting autocalibration results with a set of stored offset coefficients. The offset coefficients are generated by performing a manual calibration. The difference between the results of the manual calibration and an autocalibration are stored as offset coefficients. The offset coefficients can be applied to subsequent autocalibrations.
摘要翻译：本发明涉及一种用于执行自动取样器装置的校准的技术。根据一个方面，自动取样器装置包括具有样本平台和参考平台的单元; 样品臂样品托盘和压板。样品托盘包括插入平底锅的孔。压板可以包括用于校准的导电和/或反射区域。样品臂具有电子传感器和光学传感器。电传感器和光学传感器用于校准样品平台，参考平台和井中的一个或多个位置。根据另一方面，通过利用一组存储的偏移系数调整自动校准结果来优化自动校准。通过执行手动校准来产生偏移系数。手动校准和自动校准的结果之间的差异作为偏移系数存储。偏移系数可以应用于后续的自动校准。

2. 发明授权

US06846455B1 Automatic sampling device 有权
标题翻译：自动取样装置
公开(公告)号：US06846455B1
公开(公告)日：2005-01-25
申请号：US09796738
申请日：2001-03-02
申请人： Christopher F. Carney , Fred L. Ferguson , John R. Reader , Weidong Liu , Jay A. Crosby
发明人： Christopher F. Carney , Fred L. Ferguson , John R. Reader , Weidong Liu , Jay A. Crosby
IPC分类号： B25J15/00 , B25J15/12 , G01N25/20 , G01N35/00 , G01N35/02 , G05B19/04
CPC分类号： B25J15/12 , G01N25/20 , G01N35/0099 , G01N35/025 , G01N2035/00207 , G01N2035/00356
摘要： The invention relates to an automatic sampler device. According to one aspect, the automatic sampler includes a cell having a sample platform and a reference platform; a sample tray; and a sample arm. The sample tray has wells into which sample pans and reference pans are inserted. The geometry of the automatic sampler device permits the sample platform, the reference platform, and the wells in the sample tray to be accessed by the sample arm along a common arc. According to another aspect, the automatic sampler device includes a sample tray with wells, a sample arm, and a gripper device. The gripper device has gripping fingers. The gripping fingers open or close in a manner that tends to center objects grasped by the gripper device. According to another aspect, the automatic sampler device includes a sample tray with wells, a sample arm, and a gripper device. The sample arm has an optical sensor and an electrical sensor. The optical sensor and electrical sensor can be used to detect a pan grasped by the gripper device. According to another aspect, the automatic sampler device includes a sample tray with wells, a sample arm, and a gripper device. The gripper advice is capable of grasping pans of different sizes.
摘要翻译：本发明涉及一种自动取样装置。根据一个方面，自动采样器包括具有采样平台和参考平台的单元; 样品托盘和样品臂。样品盘具有插入样品平底锅和参考平底锅的孔。自动取样器装置的几何形状允许样品平台，参考平台和样品托盘中的孔沿着共同弧由样品臂进入。根据另一方面，自动取样器装置包括具有孔的样品盘，样品臂和夹持装置。夹持装置具有夹持指状物。夹持指状物以使夹持装置夹持的物体趋于中心的方式打开或关闭。根据另一方面，自动取样器装置包括具有孔的样品盘，样品臂和夹持装置。样品臂具有光学传感器和电传感器。光学传感器和电传感器可用于检测由夹具装置抓住的盘。根据另一方面，自动取样器装置包括具有孔的样品盘，样品臂和夹持装置。夹具建议能够抓住不同尺寸的平底锅。

3. 发明授权

US06652015B1 Gripper device 有权
标题翻译：夹爪装置
公开(公告)号：US06652015B1
公开(公告)日：2003-11-25
申请号：US09796748
申请日：2001-03-02
申请人： Christopher F. Carney , Fred L. Ferguson , John R. Reader , Weidong Liu
发明人： Christopher F. Carney , Fred L. Ferguson , John R. Reader , Weidong Liu
IPC分类号： B66C142
CPC分类号： B25J15/10 , Y10S294/902
摘要： The invention relates to a gripper device. According to one aspect, the gripper device includes fingers with grasping ends. The gripper device includes a mechanism to cause the grasping ends to open and close. When the mechanism is engaged, the grasping ends open and close to define a circumference. According to another aspect, the gripper device includes fingers, an upper flat member, and a lower flat member. The fingers have grasping ends. The fingers are inserted into the upper flat member and lower flat member. When the upper flat member is rotated relative to the lower flat member, the grasping ends of the fingers open and close. According to another aspect, a gripper assembly has a gripper device with fingers and a rotating member. The gripper assembly also has a motor and mechanism for rotating the rotating member. The gripper device opens or closes the grasping ends in response to the rotation of the rotating member. According to another aspect, a gripper finger has a top section, a middle section, a bottom section. The gripper finger has a plurality of balls located above the grasping end of the gripper finger.
摘要翻译：本发明涉及夹具装置。根据一个方面，夹持装置包括具有抓持端的手指。夹持装置包括使夹持端部打开和关闭的机构。当机构接合时，把持端部打开和关闭以限定圆周。根据另一方面，夹持装置包括指状物，上部平坦构件和下部平坦构件。手指抓住了一端。指状物插入上部平坦部件和下部扁平部件。当上部平板部件相对于下部平坦部件旋转时，手指的把持端部开闭。根据另一方面，夹具组件具有带指状物和旋转构件的夹持装置。夹具组件还具有用于旋转旋转构件的马达和机构。夹持装置响应于旋转构件的旋转而打开或关闭抓持端。根据另一方面，夹持器手指具有顶部，中间部分，底部部分。夹持器手指具有位于夹持器手指的夹持端上方的多个球。

4. 发明授权

US06644136B1 Sample tray for automatic sampler 有权
标题翻译：自动进样器的样品盘
公开(公告)号：US06644136B1
公开(公告)日：2003-11-11
申请号：US09796733
申请日：2001-03-02
申请人： Christopher F. Carney , Fred L. Ferguson , John R. Reader , Weidong Liu
发明人： Christopher F. Carney , Fred L. Ferguson , John R. Reader , Weidong Liu
IPC分类号： G01N100
CPC分类号： G01N25/4806 , G01N35/0099 , G01N35/025 , G01N2035/00356 , G01N2035/0465
摘要： The invention relates to a sample tray to be used by an automatic sampler having a sample arm. According to an aspect, the sample tray includes wells that can be accessed by a sample arm along a common arc of rotation, without moving the sample arm in and out. According to another aspect, the sample tray has several concentric rows of wells for holding sample pans and reference pans. Each row of wells lies along an inner circumference of the sample tray. The rows are placed so that when the sample tray is rotated, every well can be located on a common arc of rotation relative to a sample arm. According to another aspect, a well in a sample tray is configured with a pan receiving area and finger receiving areas. Gripper fingers can be extended into the finger receiving areas to access pans of different sizes.
摘要翻译：本发明涉及一种由具有样品臂的自动采样器使用的样品盘。根据一个方面，样品托盘包括可以沿着共同的旋转圆弧由样品臂访问的孔，而不移动样品臂进出。根据另一方面，样品托盘具有几个同心排的孔，用于保持样品盘和参考盘。每排井位于样品托盘的内圆周上。这些行被放置成使得当样品托盘旋转时，每个孔可以位于相对于样品臂的公共旋转弧上。根据另一方面，样品托盘中的孔配置有盘接收区域和手指接收区域。手指可以延伸到手指接收区域以访问不同尺寸的平底锅。

5. 发明授权

US06859271B1 Platen for automatic sampler 失效
标题翻译：压片机用于自动进样器
公开(公告)号：US06859271B1
公开(公告)日：2005-02-22
申请号：US09796751
申请日：2001-03-02
申请人： Christopher F. Carney , Fred L. Ferguson , John R. Reader , Weidong Liu
发明人： Christopher F. Carney , Fred L. Ferguson , John R. Reader , Weidong Liu
IPC分类号： G01N21/01 , G01N25/48 , G01N35/00 , G01N35/04
CPC分类号： G01N35/0099 , G01N25/4853 , G01N25/4866 , G01N2035/0441 , G01N2035/0493
摘要： The invention relates to a platen to be used with a sample tray of an automatic sampler. According to an aspect, the platen includes both electrically conductive and reflective areas that can be used to calibrate the sample tray. According to another aspect, calibration of the sample tray can be performed in all three dimensions. According to another aspect, the platen is used to calibrate the sample tray, including its height and the location of its wells. The platen may include electrically-responsive (i.e., conductive) and optically-responsive (i.e., reflective) areas that can be sensed by electrical sensors and optical sensors in order to compute the coordinates of representative wells.
摘要翻译：本发明涉及一种与自动采样器的样品盘一起使用的压板。根据一个方面，压板包括可用于校准样品盘的导电和反射区域。根据另一方面，可以在所有三个维度上执行样品盘的校准。根据另一方面，压板用于校准样品盘，包括其高度和其孔的位置。压板可以包括可由电传感器和光学传感器感测的电响应（即，导电）和光学响应（即，反射）区域，以计算代表性孔的坐标。

6. 发明授权

US06823278B1 Method and apparatus for positional calibration of a thermal analysis instrument 有权
公开(公告)号：US06823278B1
公开(公告)日：2004-11-23
申请号：US10730121
申请日：2003-12-09
申请人： Christopher F. Carney , Fred L. Ferguson , John R. Reader , Weidong Liu , Jay A. Crosby
发明人： Christopher F. Carney , Fred L. Ferguson , John R. Reader , Weidong Liu , Jay A. Crosby
IPC分类号： G01C1738
CPC分类号： G01N33/346
摘要： The present invention is directed to a technique for performing calibration of an automatic sampler device. According to an aspect, the automatic sampler device includes a cell with a sample platform and a reference platform; a sample arm; a sample tray, and a platen. The sample tray includes wells into which pans are inserted. The platen may include conductive and/or reflective areas for calibration. The sample arm has an electronic sensor and an optical sensor. The electrical sensor and the optical sensor are used to calibrate the positions of one or more of: the sample platform, the reference platform, and a well. According to another aspect, autocalibration is optimized by adjusting autocalibration results with a set of stored offset coefficients. The offset coefficients are generated by performing a manual calibration. The difference between the results of the manual calibration and an autocalibration are stored as offset coefficients. The offset coefficients can be applied to subsequent autocalibrations.

7. 发明授权

US10153273B1 Metal-semiconductor heterodimension field effect transistors (MESHFET) and high electron mobility transistor (HEMT) based device and method of making the same 有权
公开(公告)号：US10153273B1
公开(公告)日：2018-12-11
申请号：US15832377
申请日：2017-12-05
申请人： Roger S. Tsai , Weidong Liu , Yeong-Chang Chou
发明人： Roger S. Tsai , Weidong Liu , Yeong-Chang Chou
IPC分类号： H01L27/06 , H01L29/207 , H01L29/423 , H01L29/778 , H01L29/80 , H01L49/02 , H01L21/8252 , H01L29/66 , H01L21/764 , H01L21/74 , H01L21/285 , H01L21/3213 , H01L23/528 , H01L23/482 , H01L23/66 , H01L29/205
摘要： A semiconductor device is provided that comprises a base structure, a first channel layer overlying the base structure, a second channel layer overlying the first channel layer, and first, second, and third ohmic contacts overlying the second channel layer. The semiconductor device further comprises a metal-semiconductor heterodimension field effect transistor that is formed between the first and second ohmic contacts, the metal-semiconductor heterodimension field effect transistor including a first gate formed through the first and second channel layers. The semiconductor device yet further comprises a high electron mobility transistor formed between the second and third ohmic contacts, the high electron mobility transistor including a second gate formed through the second channel layer without extending through the first channel layer.

8. 发明授权

US08648087B2 N4-phenyl-quinazoline-4-amine derivatives and related compounds as ErbB type I receptor tyrosine kinase inhibitors for the treatment of hyperproliferative diseases 有权
标题翻译： N4-苯基 - 喹唑啉-4-胺衍生物和相关化合物作为用于治疗过度增殖性疾病的ErbB I型受体酪氨酸激酶抑制剂
公开(公告)号：US08648087B2
公开(公告)日：2014-02-11
申请号：US12085048
申请日：2006-11-15
申请人： Joseph P. Lyssikatos , Julie Marie Greschuk , Fredrik P. Marmsäter , Qian Zhao , D. David Hennings , Weidong Liu
发明人： Joseph P. Lyssikatos , Julie Marie Greschuk , Fredrik P. Marmsäter , Qian Zhao , D. David Hennings , Weidong Liu
IPC分类号： A01N43/54 , A61K31/517 , C07D239/72 , C07D401/00
CPC分类号： A61K31/337 , A61K31/513 , A61K31/517 , A61K39/3955 , C07D403/12 , C07D403/14 , C07D405/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04 , C07D495/04 , C07D519/00
摘要： This invention provides compounds of Formula I wherein B, G, A, E, R1, R2, R3, m and n are as defined herein, which are useful as type I receptor tyrosine kinase inhibitors, and methods of use thereof in the treatment of hyperproliferative disorders in mammals.
摘要翻译：本发明提供式I化合物，其中B，G，A，E，R 1，R 2，R 3，m和n如本文所定义，其可用作I型受体酪氨酸激酶抑制剂，及其用于治疗哺乳动物过度增生性疾病。

9. 发明申请

US20130337459A1 A METHOD OF ENHANCING MIR-185 EXPRESSION TO REDUCE LOW DENSITY LIPOPROTEIN/CHOLESTEROL ACCUMULATION IN A CELL 有权
标题翻译：一种增强MIR-185表达以减少细胞中低密度脂蛋白/胆固醇积累的方法
公开(公告)号：US20130337459A1
公开(公告)日：2013-12-19
申请号：US13919141
申请日：2013-06-17
申请人： Muhua Yang , Joseph T. Nickels, JR. , Weidong Liu , Christina Ann Pellicane
发明人： Muhua Yang , Joseph T. Nickels, JR. , Weidong Liu , Christina Ann Pellicane
IPC分类号： C12N15/113 , C12Q1/68
CPC分类号： C12N15/113 , C12N15/1137 , C12N15/1138 , C12N2310/141 , C12Q1/6883 , C12Q2600/158 , C12Q2600/178 , C12Y101/01034 , C12Y205/01021
摘要： The present invention provides a method of quantifying miR-185 as a potential biomarker in lipid disorder or cardiovascular diseases in human. The present invention also provides a method of modulating miR-185 in regulating LDL and cholesterol metabolism in cells. The present invention has therapeutic potential in the treatment of cholesterol/LDL related cardiovascular diseases in humans.
摘要翻译：本发明提供了定量miR-185作为人类脂质障碍或心血管疾病的潜在生物标志物的方法。本发明还提供调节miR-185调节细胞中LDL和胆固醇代谢的方法。本发明在治疗人类胆固醇/低密度脂蛋白相关心血管疾病方面具有治疗潜力。

10. 外观设计

USD671866S1 Frame of a stroller 有权
标题翻译：婴儿车的框架
公开(公告)号：USD671866S1
公开(公告)日：2012-12-04
申请号：US29371635
申请日：2011-06-15
申请人： Weidong Liu , Er-xue Wang
设计人： Weidong Liu , Er-xue Wang

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