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1. 发明授权

US08843630B1 Decentralized request routing 有权
标题翻译：分散请求路由
公开(公告)号：US08843630B1
公开(公告)日：2014-09-23
申请号：US12544517
申请日：2009-08-20
申请人： Christopher C. Thomas , Christopher Kommareddy , Preetha Chatterjee , Nan Zhong , Mitchell Sundt , Vivek Rai
发明人： Christopher C. Thomas , Christopher Kommareddy , Preetha Chatterjee , Nan Zhong , Mitchell Sundt , Vivek Rai
IPC分类号： G06F15/16 , G06F15/173 , H04L29/08 , H04L12/803
CPC分类号： H04L67/1008 , H04L47/125 , H04L67/1025 , H04L67/42
摘要： Systems and methods provide logic for decentralized request routing. In one implementation, a computer-implemented method routes a request. The method includes receiving, by a client server, the request. The client server evaluates feedback information received by the client server from at least one of a plurality of host servers. The client server selects one of the plurality of host servers to process the request, based on the evaluation, and transmits the request to the selected one of the plurality of host servers.
摘要翻译：系统和方法为分散式请求路由提供逻辑。在一个实现中，计算机实现的方法路由请求。该方法包括由客户端服务器接收该请求。客户机服务器从多个主机服务器中的至少一个评估由客户端服务器接收的反馈信息。客户服务器基于评估，选择多个主机服务器之一来处理该请求，并将该请求发送给多个主机服务器中的所选主机服务器。

2. 发明申请

US20160263125A1 AMINO, AMIDO AND HETEROCYCLIC COMPOUNDS AS MODULATORS OF RAGE ACTIVITY AND USES THEREOF 审中-公开
公开(公告)号：US20160263125A1
公开(公告)日：2016-09-15
申请号：US15164324
申请日：2016-05-25
申请人： Ann Marie Schmidt , Ravichandran Ramasamy , Alexander Shekhtman , Vivek Rai , Michaele B. Manigrasso
发明人： Ann Marie Schmidt , Ravichandran Ramasamy , Alexander Shekhtman , Vivek Rai , Michaele B. Manigrasso
IPC分类号： A61K31/5377 , A61K31/426 , A61K31/357 , A61K31/167 , A61K31/137 , A61K31/505 , A61K31/506 , A61K31/4439 , A61K31/427 , A61K31/454 , A61K31/353 , A61K31/4184 , A61K31/185 , A61K31/4985 , A61K31/47 , A61K31/52 , A61K31/4045 , A61K31/403 , A61K31/44
CPC分类号： A61K31/5377 , A61K31/137 , A61K31/167 , A61K31/185 , A61K31/353 , A61K31/357 , A61K31/403 , A61K31/4045 , A61K31/4184 , A61K31/426 , A61K31/427 , A61K31/44 , A61K31/4439 , A61K31/454 , A61K31/47 , A61K31/4985 , A61K31/505 , A61K31/506 , A61K31/52 , C07D213/75 , C07D239/42 , C07D277/28 , C07D319/20
摘要： Amino, amido, and heterocyclic compounds are disclosed. The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, diabetes complications, inflammation, and neurodegeneration, obesity, cancer, ischemia/reperfusion injury, cardiovascular disease and other diseases related to RAGE activity.

3. 发明授权

US09364472B2 Amino, Amido and heterocyclic compounds as modulators of RAGE activity and uses thereof 有权
标题翻译：氨基，酰氨基和杂环化合物作为RAGE活性的调节剂及其用途
公开(公告)号：US09364472B2
公开(公告)日：2016-06-14
申请号：US14819535
申请日：2015-08-06
申请人： Ann Marie Schmidt , Ravichandran Ramasamy , Alexander Shekhtman , Vivek Rai , Michaele B. Manigrasso
发明人： Ann Marie Schmidt , Ravichandran Ramasamy , Alexander Shekhtman , Vivek Rai , Michaele B. Manigrasso
IPC分类号： A61K31/44 , A61K31/47
CPC分类号： A61K31/5377 , A61K31/137 , A61K31/167 , A61K31/185 , A61K31/353 , A61K31/357 , A61K31/403 , A61K31/4045 , A61K31/4184 , A61K31/426 , A61K31/427 , A61K31/44 , A61K31/4439 , A61K31/454 , A61K31/47 , A61K31/4985 , A61K31/505 , A61K31/506 , A61K31/52 , C07D213/75 , C07D239/42 , C07D277/28 , C07D319/20
摘要： Amino, amido, and heterocyclic compounds are disclosed. The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, diabetes complications, inflammation, and neurodegeneration, obesity, cancer, ischemia/reperfusion injury, cardiovascular disease and other diseases related to RAGE activity.
摘要翻译：公开了氨基，酰氨基和杂环化合物。该化合物可以制备成药物组合物，并且可以用于预防和治疗包括人在内的哺乳动物中的多种病症，包括非限制性实例，糖尿病并发症，炎症和神经变性，肥胖症，癌症，局部缺血 /再灌注损伤，心血管疾病等与RAGE活动相关的疾病。

4. 发明申请

US20150094307A1 AMINO, AMIDO AND HETEROCYCLIC COMPOUNDS AS MODULATORS OF RAGE ACTIVITY AND USES THEREOF 有权
标题翻译： AMINO，AMIDO和杂环化合物作为RAGE活性的调节剂及其用途
公开(公告)号：US20150094307A1
公开(公告)日：2015-04-02
申请号：US14503919
申请日：2014-10-01
申请人： Ann Marie Schmidt , Ravichandran Ramasamy , Alexander Shekhtman , Vivek Rai , Michaele B. Manigrasso
发明人： Ann Marie Schmidt , Ravichandran Ramasamy , Alexander Shekhtman , Vivek Rai , Michaele B. Manigrasso
IPC分类号： C07D319/20 , C07D277/28 , C07D239/42 , C07D213/75
CPC分类号： A61K31/5377 , A61K31/137 , A61K31/167 , A61K31/185 , A61K31/353 , A61K31/357 , A61K31/403 , A61K31/4045 , A61K31/4184 , A61K31/426 , A61K31/427 , A61K31/44 , A61K31/4439 , A61K31/454 , A61K31/47 , A61K31/4985 , A61K31/505 , A61K31/506 , A61K31/52 , C07D213/75 , C07D239/42 , C07D277/28 , C07D319/20
摘要： Amino, amido, and heterocyclic compounds are disclosed. The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, diabetes complications, inflammation, and neurodegeneration, obesity, cancer, ischemia/reperfusion injury, cardiovascular disease and other diseases related to RAGE activity.
摘要翻译：公开了氨基，酰氨基和杂环化合物。该化合物可以制备成药物组合物，并且可以用于预防和治疗包括人在内的哺乳动物中的多种病症，包括非限制性实例，糖尿病并发症，炎症和神经变性，肥胖症，癌症，局部缺血 /再灌注损伤，心血管疾病等与RAGE活动相关的疾病。

5. 发明授权

US08159961B1 Load balancing utilizing adaptive thresholding 有权
标题翻译：利用自适应阈值进行负载平衡
公开(公告)号：US08159961B1
公开(公告)日：2012-04-17
申请号：US11694667
申请日：2007-03-30
申请人： Vivek Rai , Dan Mihai Dumitriu , Swaminathan Sivasubramanian
发明人： Vivek Rai , Dan Mihai Dumitriu , Swaminathan Sivasubramanian
IPC分类号： H04L12/56
CPC分类号： H04L67/42 , H04L67/02 , H04L67/1002
摘要： A method and a system for processing data requests in a client-server computing environment, such as the Web, are disclosed. A client device initially transmits a data request to a randomly selected first server device. The first server device may reject the data request if its request queue threshold is exceeded. The client device retransmits the data request, including the request queue threshold, to a randomly selected second server device. The second server device may reject the data request if the request queue threshold of the first server device is smaller than a request queue threshold of the second server device. The client device transmits the data request back to the first server device, including the request queue threshold of the second server device. The first server device processes the data request and adjusts its request queue threshold based on the request queue thresholds of the first and the second server devices.
摘要翻译：公开了一种用于处理诸如Web的客户端 - 服务器计算环境中的数据请求的方法和系统。客户机设备最初向随机选择的第一服务器设备发送数据请求。如果超过了其请求队列阈值，则第一个服务器设备可以拒绝数据请求。客户端设备向随机选择的第二服务器设备重传包括请求队列阈值的数据请求。如果第一服务器设备的请求队列阈值小于第二服务器设备的请求队列阈值，则第二服务器设备可拒绝该数据请求。客户端设备将数据请求发送回第一服务器设备，包括第二服务器设备的请求队列阈值。第一服务器设备处理数据请求并根据第一和第二服务器设备的请求队列阈值调整其请求队列阈值。

6. 发明授权

US10265320B2 Amino, amido and heterocyclic compounds as modulators of rage activity and uses thereof 有权
公开(公告)号：US10265320B2
公开(公告)日：2019-04-23
申请号：US15164324
申请日：2016-05-25
申请人： Ann Marie Schmidt , Ravichandran Ramasamy , Alexander Shekhtman , Vivek Rai , Michaele B. Manigrasso
发明人： Ann Marie Schmidt , Ravichandran Ramasamy , Alexander Shekhtman , Vivek Rai , Michaele B. Manigrasso
IPC分类号： A61K31/425 , A61K31/5377 , C07D319/20 , C07D213/75 , C07D277/28 , C07D239/42 , A61K31/47 , A61K31/137 , A61K31/167 , A61K31/185 , A61K31/353 , A61K31/357 , A61K31/403 , A61K31/4045 , A61K31/4184 , A61K31/426 , A61K31/427 , A61K31/44 , A61K31/4439 , A61K31/454 , A61K31/4985 , A61K31/505 , A61K31/506 , A61K31/52
摘要： Amino, amido, and heterocyclic compounds are disclosed. The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, diabetes complications, inflammation, and neurodegeneration, obesity, cancer, ischemia/reperfusion injury, cardiovascular disease and other diseases related to RAGE activity.

7. 发明授权

US08576710B2 Load balancing utilizing adaptive thresholding 有权
标题翻译：利用自适应阈值进行负载平衡
公开(公告)号：US08576710B2
公开(公告)日：2013-11-05
申请号：US13438734
申请日：2012-04-03
申请人： Vivek Rai , Dan Mihai Dumitriu , Swaminathan Sivasubramanian
发明人： Vivek Rai , Dan Mihai Dumitriu , Swaminathan Sivasubramanian
IPC分类号： H04B1/00
CPC分类号： H04L67/42 , H04L67/02 , H04L67/1002
摘要： Methods and systems for processing data requests in a client-server computing environment, such as the Web, are disclosed. A client device initially transmits a data request to a randomly selected first server device. The first server device may reject the data request if its request queue threshold is exceeded. The client device retransmits the data request, including the request queue threshold, to a randomly selected second server device. The second server device may reject the data request if the request queue threshold of the first server device is smaller than a request queue threshold of the second server device. The client device transmits the data request back to the first server device, including the request queue threshold of the second server device. The first server device processes the data request and adjusts its request queue threshold based on the request queue thresholds of the first and second server devices.
摘要翻译：公开了在诸如Web的客户端 - 服务器计算环境中处理数据请求的方法和系统。客户机设备最初向随机选择的第一服务器设备发送数据请求。如果超过了其请求队列阈值，则第一个服务器设备可以拒绝数据请求。客户端设备向随机选择的第二服务器设备重传包括请求队列阈值的数据请求。如果第一服务器设备的请求队列阈值小于第二服务器设备的请求队列阈值，则第二服务器设备可拒绝该数据请求。客户端设备将数据请求发送回第一服务器设备，包括第二服务器设备的请求队列阈值。第一服务器设备处理数据请求并根据第一和第二服务器设备的请求队列阈值调整其请求队列阈值。

8. 发明申请

US20120254300A1 LOAD BALANCING UTILIZING ADAPTIVE THRESHOLDING 有权
标题翻译：负载均衡利用自适应阈值
公开(公告)号：US20120254300A1
公开(公告)日：2012-10-04
申请号：US13438734
申请日：2012-04-03
申请人： Vivek Rai , Dan Mihai Dumitriu , Swaminathan Sivasubramanian
发明人： Vivek Rai , Dan Mihai Dumitriu , Swaminathan Sivasubramanian
IPC分类号： G06F15/16
CPC分类号： H04L67/42 , H04L67/02 , H04L67/1002
摘要： Methods and systems for processing data requests in a client-server computing environment, such as the Web, are disclosed. A client device initially transmits a data request to a randomly selected first server device. The first server device may reject the data request if its request queue threshold is exceeded. The client device retransmits the data request, including the request queue threshold, to a randomly selected second server device. The second server device may reject the data request if the request queue threshold of the first server device is smaller than a request queue threshold of the second server device. The client device transmits the data request back to the first server device, including the request queue threshold of the second server device. The first server device processes the data request and adjusts its request queue threshold based on the request queue thresholds of the first and second server devices.
摘要翻译：公开了在诸如Web的客户端 - 服务器计算环境中处理数据请求的方法和系统。客户机设备最初向随机选择的第一服务器设备发送数据请求。如果超过了其请求队列阈值，则第一个服务器设备可以拒绝数据请求。客户端设备向随机选择的第二服务器设备重传包括请求队列阈值的数据请求。如果第一服务器设备的请求队列阈值小于第二服务器设备的请求队列阈值，则第二服务器设备可拒绝该数据请求。客户端设备将数据请求发送回第一服务器设备，包括第二服务器设备的请求队列阈值。第一服务器设备处理数据请求并根据第一和第二服务器设备的请求队列阈值调整其请求队列阈值。

9. 发明授权

US10729695B2 Amino, amido and heterocyclic compounds as modulators of RAGE activity and uses thereof 有权
公开(公告)号：US10729695B2
公开(公告)日：2020-08-04
申请号：US16384293
申请日：2019-04-15
申请人： Ann Marie Schmidt , Ravichandran Ramasamy , Alexander Shekhtman , Vivek Rai , Michaele B. Manigrasso
发明人： Ann Marie Schmidt , Ravichandran Ramasamy , Alexander Shekhtman , Vivek Rai , Michaele B. Manigrasso
IPC分类号： A61K31/5377 , C07D319/20 , C07D213/75 , C07D277/28 , C07D239/42 , C07D403/04 , C07D403/06 , C07D487/14 , C07D417/04 , C07D277/42 , A61K31/4178 , A61K31/47 , A61K31/137 , A61K31/167 , A61K31/185 , A61K31/353 , A61K31/357 , A61K31/403 , A61K31/4045 , A61K31/4184 , A61K31/426 , A61K31/427 , A61K31/44 , A61K31/4439 , A61K31/454 , A61K31/4985 , A61K31/505 , A61K31/506 , A61K31/52
摘要： Amino, amido, and heterocyclic compounds are disclosed. The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, diabetes complications, inflammation, and neurodegeneration, obesity, cancer, ischemia/reperfusion injury, cardiovascular disease and other diseases related to RAGE activity.

10. 发明申请

US20190374548A1 AMINO, AMIDO AND HETEROCYCLIC COMPOUNDS AS MODULATORS OF RAGE ACTIVITY AND USES THEREOF 审中-公开
公开(公告)号：US20190374548A1
公开(公告)日：2019-12-12
申请号：US16384293
申请日：2019-04-15
申请人： Ann Marie Schmidt , Ravichandran Ramasamy , Alexander Shekhtman , Vivek Rai , Michaele B. Manigrasso
发明人： Ann Marie Schmidt , Ravichandran Ramasamy , Alexander Shekhtman , Vivek Rai , Michaele B. Manigrasso
IPC分类号： A61K31/5377 , C07D319/20 , C07D213/75 , C07D277/28 , C07D239/42 , A61K31/47 , A61K31/137 , A61K31/167 , A61K31/185 , A61K31/353 , A61K31/357 , A61K31/403 , A61K31/4045 , A61K31/4184 , A61K31/426 , A61K31/427 , A61K31/44 , A61K31/4439 , A61K31/454 , A61K31/4985 , A61K31/505 , A61K31/506 , A61K31/52
摘要： Amino, amido, and heterocyclic compounds are disclosed. The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, diabetes complications, inflammation, and neurodegeneration, obesity, cancer, ischemia/reperfusion injury, cardiovascular disease and other diseases related to RAGE activity.

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