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1. 发明申请

US20050075310A1 Gangliosides with a modified acyl function 失效
标题翻译：具有改性酰基功能的神经节苷脂
公开(公告)号：US20050075310A1
公开(公告)日：2005-04-07
申请号：US10497173
申请日：2003-05-27
申请人： Christopher Beermann , Lars Bode , Gunther Boehm
发明人： Christopher Beermann , Lars Bode , Gunther Boehm
IPC分类号： A23L1/29 , A23L1/30 , A61K31/7004 , A61K31/7028 , A61P3/02 , C07H15/10 , A61K31/739 , C08B37/00
CPC分类号： C07H15/10 , A23L33/105 , A23L33/40 , A61K31/7028 , A61K2300/00
摘要： The invention relates to a ganglioside mixture, consisting of gangliosides, of the following general formula: (sugar)-OCH2—CH(—NH—CO—R1)—CH(OH)—CH=CH-R2, wherein (sugar) represents a sugar radical, the group —CO—R1 represents an acyl-fatty acid which is bonded to the radical of the molecule in the form of an amide, R1 represents a straight saturated alkyl radical having at least 10 C-atoms and R2 represents a straight, saturated alkyl radical having at least 10 C-atoms or a straight alkenyl radical having at least 10 C-atoms and one, two or three double bond(s). Said mixture is characterised in that at least 10 wt. % of the gangliosides of the general formula I are of the group —CO—R1 and the acyl-fatty acids are a C20:0 fatty acid. Said mixtures exhibit an improved biological activity.
摘要翻译：本发明涉及神经节苷脂混合物，由神经节苷脂组成，具有以下通式：（糖）-OCH 2 -CH（-NH-CO-R 1）-CH（OH）-CH = CH-R 2 ，其中（糖）表示糖基，基团-CO-R 1表示与酰基形式的分子基团结合的酰基脂肪酸，R 1表示直链饱和烷基具有至少10个C原子的基团和R 2表示具有至少10个C原子的直链饱和烷基或具有至少10个C原子和一个，两个或三个双键的直链烯基，。所述混合物的特征在于，至少10wt。通式I的神经节苷脂的％为-CO-R 1基团，酰基脂肪酸为C20：0脂肪酸。所述混合物表现出改善的生物活性。

2. 发明授权

US07851450B2 Gangliosides with a modified acyl function 失效
标题翻译：具有改性酰基功能的神经节苷脂
公开(公告)号：US07851450B2
公开(公告)日：2010-12-14
申请号：US10497173
申请日：2003-05-27
申请人： Christopher Beerman , Lars Bode , Gunther Boehm
发明人： Christopher Beerman , Lars Bode , Gunther Boehm
IPC分类号： A61K31/702 , A61K31/7028 , A61K31/7032 , C07H15/04 , C07H15/10
CPC分类号： C07H15/10 , A23L33/105 , A23L33/40 , A61K31/7028 , A61K2300/00
摘要： The invention relates to a ganglioside mixture, consisting of gangliosides, of the following general formula: (sugar)-OCH2—CH(—NH—CO—R1)—CH(OH)—CH═CH—R2, wherein (sugar) represents a sugar radical, the group —CO—R1 represents an acyl-fatty acid which is bonded to the radical of the molecule in the form of an amide, R1 represents a straight saturated alkyl radical having at least 10 C-atoms and R2 represents a straight, saturated alkyl radical having at least 10 C-atoms or a straight alkenyl radical having at least 10 C-atoms and one, two or three double bond(s). Said mixture is characterised in that at least 10 wt. % of the gangliosides of the general formula I are of the group —CO—R1 and the acyl-fatty acids are a C20:0 fatty acid. Said mixtures exhibit an improved biological activity.
摘要翻译：本发明涉及神经节苷脂混合物，由神经节苷脂组成，具有以下通式：（糖）-OCH 2 -CH（-NH-CO-R 1）-CH（OH）-CH = CH-R 2，其中（糖）代表糖基，基团-CO-R 1表示酰基脂肪酸，其与酰胺基分子的基团键合，R 1表示具有至少10个C原子的直链饱和烷基，R 2表示具有至少10个C原子的直链饱和烷基或具有至少10个C原子和一个，两个或三个双键的直链烯基。所述混合物的特征在于，至少10wt。通式I的神经节苷脂的％为-CO-R1基团，酰基脂肪酸为C20：0脂肪酸。所述混合物表现出改善的生物活性。

3. 发明授权

US09675649B2 Disialyllacto-N-tetraose (DSLNT) or variants, isomers, analogs and derivatives thereof to prevent or inhibit bowel disease 有权
公开(公告)号：US09675649B2
公开(公告)日：2017-06-13
申请号：US13983624
申请日：2012-02-03
申请人： Lars Bode
发明人： Lars Bode
IPC分类号： A61K31/702 , A61K35/74 , A61K35/742 , A61K35/741 , G01N33/50 , A23K40/10 , A23K10/18 , A23K20/163 , A23K50/00 , A23P10/28 , A23L29/30 , A23L33/00 , A23L33/135
CPC分类号： A61K35/742 , A23K10/18 , A23K20/163 , A23K40/10 , A23K50/00 , A23L5/00 , A23L29/30 , A23L33/125 , A23L33/135 , A23L33/40 , A23P10/28 , A61K31/702 , A61K35/741 , G01N33/50 , G01N2400/00 , G01N2800/065 , G01N2800/067 , G01N2800/38 , G01N2800/7095
摘要： The invention provides formulations comprising isolated Disialyllacto-N-tetraose (DSLNT) or variants, isomers, analogs and derivatives thereof.

4. 发明申请

US20130315990A1 DISIALYLLACTO-N-TETRAOSE (DSLNT) OR VARIANTS, ISOMERS, ANALOGS AND DERIVATIVES THEREOF TO PREVENT OR INHIBIT BOWEL DISEASE 有权
标题翻译：异噻唑烷酮（DSLNT）或其变体，异构体，模拟物及其衍生物，以防止或抑制BOWEL疾病
公开(公告)号：US20130315990A1
公开(公告)日：2013-11-28
申请号：US13983624
申请日：2012-02-03
申请人： Lars Bode
发明人： Lars Bode
IPC分类号： A61K31/702 , A23L1/29 , A23K1/16 , A61K35/74
CPC分类号： A61K35/742 , A23K10/18 , A23K20/163 , A23K40/10 , A23K50/00 , A23L5/00 , A23L29/30 , A23L33/125 , A23L33/135 , A23L33/40 , A23P10/28 , A61K31/702 , A61K35/741 , G01N33/50 , G01N2400/00 , G01N2800/065 , G01N2800/067 , G01N2800/38 , G01N2800/7095
摘要： The invention provides formulations comprising isolated Disialyllacto-N-tetraose (DSLNT) or variants, isomers, analogs and derivatives thereof.
摘要翻译：本发明提供了包含分离的二唾液乳糖-N-四糖（DSLNT）或其变体，异构体，类似物和衍生物的制剂。

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