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1. 发明申请

US20060240001A1 P-cadherin antibodies 有权
公开(公告)号：US20060240001A1
公开(公告)日：2006-10-26
申请号：US11410610
申请日：2006-04-25
申请人： Christopher Bauer , Maureen Bourner , Melanie Boyle , Gerald Casperson , David Griggs , Richard Head , William Joy , Richard Mazzarella , Ralph Minter , Mark Moffat , Barrett Thiele , Todd Vanarsdale
发明人： Christopher Bauer , Maureen Bourner , Melanie Boyle , Gerald Casperson , David Griggs , Richard Head , William Joy , Richard Mazzarella , Ralph Minter , Mark Moffat , Barrett Thiele , Todd Vanarsdale
IPC分类号： A61K39/395 , C07K16/30
CPC分类号： C07K16/28 , C07K2317/21 , C07K2317/565 , C07K2317/622 , C07K2317/76 , C07K2317/92 , Y02P20/582
摘要： The present invention relates to antibodies including human antibodies and antigen-binding portions thereof that bind to P-cadherin, and that function to inhibit P-cadherin. The invention also relates to heavy and light chain immunoglobulins derived from human P-cadherin antibodies and nucleic acid molecules encoding such immunoglobulins. The present invention also relates to methods of making human P-cadherin antibodies, compositions comprising these antibodies and methods of using the antibodies and compositions. The invention also relates to transgenic animals or plants comprising nucleic acid molecules of the present invention.

2. 发明授权

US6035228A Frameless stereotactic arm apparatus and method of using same 失效
标题翻译：无框立体定向手臂装置及其使用方法
公开(公告)号：US6035228A
公开(公告)日：2000-03-07
申请号：US980443
申请日：1997-11-28
申请人： Jeffrey H. Yanof , Ronald B. Sharpless , David Jeri , Christopher Bauer , Daniel S. Furst
发明人： Jeffrey H. Yanof , Ronald B. Sharpless , David Jeri , Christopher Bauer , Daniel S. Furst
IPC分类号： G01B7/00 , A61B5/055 , A61B6/03 , A61B8/14 , A61B19/00 , B25J19/04 , A61B5/00
CPC分类号： A61B90/11 , A61B34/70
摘要： An imaging apparatus (18) includes a frameless stereotactic arm apparatus (30) including a first base portion (42) mounted in a fixed relationship to the imaging device. A second free end (40) of the arm assembly is adapted to move into varied positions near a specimen disposed on the imaging apparatus. At least one pivot joint (44, 48, 52, 56, 60) is provided between the first base portion and the free end of the arm for permitting selective relevant movement between the arm members. Electro-mechanical and electro-magnetic brake devices are provided at respective joints to selectively lock the free end of the arm assembly to the base portion. The brakes are responsive to a brake command signal (210) generated by the imaging device. A low pass filter (240) conditions the brake command signal to substantially eliminate high frequency electromagnetic switching noise in the stereotactic arm. So that the arm is movable in emergency situations, the brakes are adapted to rebase in response to application of a force in excess of a predetermined breakaway threshold force.
摘要翻译：成像装置（18）包括无架立体定向臂装置（30），该装置包括与成像装置成固定关系的第一基部（42）。臂组件的第二自由端（40）适于移动到设置在成像装置上的样本附近的不同位置。至少一个枢转接头（44,48,52,56,60）设置在第一基座部分和臂的自由端之间，以允许臂部件之间的选择性相关的运动。机电和电磁制动装置设置在各个接头处以选择性地将臂组件的自由端锁定到基部。制动器响应于由成像装置产生的制动指令信号（210）。低通滤波器（240）调节制动指令信号，以基本上消除立体定向臂中的高频电磁开关噪声。因此，臂在紧急情况下是可移动的，所以制动器响应于施加超过预定的分离阈值力的力而被适应。

3. 发明授权

US5957933A Interchangeable guidance devices for C.T. assisted surgery and method of using same 失效
标题翻译： C.T.可互换导向装置辅助手术及其使用方法
公开(公告)号：US5957933A
公开(公告)日：1999-09-28
申请号：US980253
申请日：1997-11-28
申请人： Jeffrey H. Yanof , Laura L. Goldstein , Fred C. Jensen , James C. Foster , Christopher Bauer
发明人： Jeffrey H. Yanof , Laura L. Goldstein , Fred C. Jensen , James C. Foster , Christopher Bauer
IPC分类号： A61B10/02 , A61B5/055 , A61B6/03 , A61B6/12 , A61B19/00
CPC分类号： A61B90/13 , A61B90/11 , A61B6/584
摘要： A stereotactic guide apparatus 100 is provided for use with a CT scanner device 18 for guiding the entry of a probe into a patient's body. The CT scanner device is provided with a stereotactic arm member 30 having a first base end 42 connected to the CT scanner device 18 and a second free end 40 movable relative to the CT scanner device. The stereotactic surgical instrument guide apparatus includes a first end effector member 106 including a guide channel 152 defining a probe insertion path 150. The surgical instrument guidance device further includes a second end effector member 104 on the free end of the stereotactic arm member and including a laser light source 108 generating a light guide beam along the probe insertion path 150. Each of the first and second end effector members are selectively releasably attached to the free end of the stereotactic arm member and, further, are adapted to provide respective first and second device identification signals to the CT scanner device through the stereotactic arm member. The top end effector member 104 is preferably stationary in use during interventional procedures and the bottom end effector member 106 is selectively retractable into a hollow support tube 142. Alternatively, the first and second end effector members are selectively pivotally attached to the free end of the stereotactic arm member.
摘要翻译：提供了立体定向引导装置100，用于与CT扫描器装置18一起用于将探针进入患者体内。 CT扫描器装置设置有立体定向臂构件30，其具有连接到CT扫描器装置18的第一基端42和相对于CT扫描器装置可移动的第二自由端40。立体定向手术器械引导装置包括第一端部执行器构件106，其包括限定探针插入路径150的引导通道152.外科器械引导装置还包括在立体定向臂构件的自由端上的第二端部执行器构件104，激光光源108沿着探针插入路径150产生光导光束。第一和第二端部执行器部件中的每一个选择性地可释放地附接到立体定向臂部件的自由端，并且还适于提供相应的第一和第二通过立体定向臂构件将装置识别信号传送到CT扫描装置。顶部执行器构件104在介入操作期间优选地是静止的，并且底端执行器构件106选择性地可缩回到中空支撑管142中。或者，第一和第二端部执行器构件选择性地枢转地附接到立体定向臂构件。

4. 发明申请

US20070167806A1 MULTI-MODALITY IMAGING AND TREATMENT 审中-公开
标题翻译：多模态成像与治疗
公开(公告)号：US20070167806A1
公开(公告)日：2007-07-19
申请号：US11563713
申请日：2006-11-28
申请人： Bradford Wood , King Li , Jeffrey Yanof , Jochen Kruecker , Christopher Bauer
发明人： Bradford Wood , King Li , Jeffrey Yanof , Jochen Kruecker , Christopher Bauer
IPC分类号： A61B8/14
CPC分类号： A61B6/032 , A61B6/4417 , A61B6/5247 , A61B8/13 , A61B8/4218 , A61B8/4281 , A61B8/4416
摘要： A probe includes an ultrasound imaging transducer and a high intensity focused ultrasound (HIFU) transducer. The probe is operatively connected to a localizer which provides information indicative of the position and orientation of the probe in relation to a CT scanner. Information from the ultrasound imaging transducer and the CT scanner is used to assist in planning and performing a HIFU treatment.
摘要翻译：探针包括超声成像换能器和高强度聚焦超声（HIFU）换能器。探针可操作地连接到定位器，该定位器提供指示探针相对于CT扫描仪的位置和取向的信息。来自超声成像传感器和CT扫描仪的信息用于协助规划和执行HIFU治疗。

5. 发明授权

US06853856B2 Diagnostic imaging interventional apparatus 有权
标题翻译：诊断成像介入仪
公开(公告)号：US06853856B2
公开(公告)日：2005-02-08
申请号：US09990127
申请日：2001-11-21
申请人： Jeffrey H. Yanof , Uri Shreter , Christopher Bauer
发明人： Jeffrey H. Yanof , Uri Shreter , Christopher Bauer
IPC分类号： A61B5/055 , A61B6/03 , A61B6/08 , A61B6/12 , A61B18/20 , A61B19/00 , A61B5/05
CPC分类号： A61B6/08 , A61B34/10 , A61B34/70 , A61B90/50 , A61B2018/2025 , A61B2090/376
摘要： A medical imaging system for conducting an image-guided medical procedure on a subject and a method for performing the same is provided. The system includes a medical imaging apparatus, such as a CT scanner, magnetic resonance imaging system, or ultrasonic imaging system, etc., for obtaining volumetric images of the subject. Through intervention planning techniques, an interventional procedure on a subject using the volumetric images is determined. A mechanical arm assembly disposed in proximity to the medical imaging apparatus carries out the interventional procedure. The mechanical arm assembly includes a base support, a distal end, a plurality of arm segments, and a plurality of joints between the arm segments for carrying out the interventional procedure. An end-effector is disposed at the distal end of the mechanical arm assembly. The end-effector includes gripping means for selectively gripping and releasing a surgical instrument during the interventional procedure.
摘要翻译：提供了一种用于对被摄体进行图像引导医疗程序的医疗成像系统及其执行方法。该系统包括用于获得受试者的体积图像的医学成像装置，例如CT扫描仪，磁共振成像系统或超声成像系统等。通过干预计划技术，确定使用体积图像的受试者的介入程序。设置在医疗成像设备附近的机械臂组件执行介入过程。机械臂组件包括基座支撑件，远端，多个臂段以及用于执行介入过程的臂段之间的多个接头。末端执行器设置在机械臂组件的远端。末端执行器包括用于在介入手术期间选择性地夹持和释放外科器械的夹持装置。

6. 发明授权

US06785572B2 Tactile feedback and display in a CT image guided robotic system for interventional procedures 有权
标题翻译：触觉反馈和显示在CT图像引导机器人系统的介入程序
公开(公告)号：US06785572B2
公开(公告)日：2004-08-31
申请号：US09990122
申请日：2001-11-21
申请人： Jeffrey Harold Yanof , Karl J. West , Christopher Bauer , David Morgan Kwartowitz
发明人： Jeffrey Harold Yanof , Karl J. West , Christopher Bauer , David Morgan Kwartowitz
IPC分类号： A61B505
CPC分类号： A61B34/70 , A61B10/0233 , A61B34/76 , A61B34/77 , A61B2017/3405 , A61B2090/376
摘要： A system (10) for conducting an image-guided medical procedure on a subject (20) includes a medical imaging apparatus (100) which intermittently during the procedure obtains, upon demand, real-time medical images of the actual procedure. A robotic arm (200) hold a medical instrument (e.g., a biopsy needle (210)) that is used to perform the procedure. The robotic arm (200) manipulates the medical instrument in response to drive signals from a haptic control (400). A detector (e.g., a strain gauge (230)) measures forces experienced by the medical instrument during the procedure. The haptic control (400) generates the drive signals in response to manipulations of an input device (e.g., a knob (404) or an auxiliary instrument, such as, in the case of a biopsy, a remote needle (500)) by an operator, and the operator receives tactile feedback from the haptic control (400) in accordance with the measured forces experienced by the medical instrument. A display (e.g., a video monitor (152)) shows a virtual planning view of the procedure. The virtual planning view depicts a pre-procedure image (310) of the subject (20) with a virtual medical instrument (e.g., a virtual needle (300)) corresponding to the medical instrument held by the robotic arm (200) superimposed therein. In response to the drive signals from the haptic control (400), the virtual medical instrument has its position and orientation updated relative to the pre-procedure image (310).
摘要翻译：用于对被摄体（20）进行图像引导的医疗程序的系统（10）包括医疗成像设备（100），其在所述过程期间间歇地获得根据需要的实际过程的实时医学图像。机器臂（200）保持用于执行该过程的医疗器械（例如，活检针（210））。机器人臂（200）响应于来自触觉控制器（400）的驱动信号来操纵医疗器械。检测器（例如，应变仪（230））测量在该过程期间医疗器械所经历的力。触觉控制（400）响应于输入装置（例如，旋钮（404）或辅助仪器（例如活检的情况下的远程针（500））的操纵，产生驱动信号操作员，并且操作者根据所测量的医疗器械的力量从触觉控制器（400）接收触觉反馈。显示器（例如，视频监视器（152））示出了该过程的虚拟规划视图。虚拟规划视图描绘了与由机器人手臂（200）重叠的医疗器械相对应的虚拟医疗器械（例如，虚拟针（300））的对象（20）的预过程图像（310）。响应于来自触觉控制（400）的驱动信号，虚拟医疗器械相对于前处理图像（310）更新其位置和方位。

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