会员体验
专利管家(专利管理)
工作空间(专利管理)
风险监控(情报监控)
数据分析(专利分析)
侵权分析(诉讼无效)
联系我们
交流群
官方交流:
QQ群: 891211   
微信请扫码    >>>
现在联系顾问~
热词
    • 1. 发明授权
    • Process for preparing pyrano- and thiopyranoindole derivatives
    • 吡喃并噻唑衍生物的制备方法
    • US4056538A
    • 1977-11-01
    • US733834
    • 1976-10-18
    • Christopher A. DemersonLeslie G. HumberAndre A. AsselinIvo JirkovskyThomas A. Dobson
    • Christopher A. DemersonLeslie G. HumberAndre A. AsselinIvo JirkovskyThomas A. Dobson
    • C07D491/04C07D491/052C07D495/04
    • C07D491/04C07D495/04
    • Pyranoindole and thiopyranoindole derivatives characterized by having an amino(lower)alkyl radical attached to either or both the 1 and 9 position of a pyrano[ 3,4-b]indole or thiopyrano[3,4-b]indole nucleus are disclosed. The amino position of the amino(lower)alkyl radical may be further substituted with one or two lower alkyl groups or incorporated into a heterocyclic amine radical. The derivatives having the amino(lower)alkyl radical only at position 1 are further substituted at position 1 and may be optionally substituted at positions 3, 4, 5, 6, 7, 8, and 9. The derivatives having the amino(lower)alkyl radical only at position 9 posses two substituents at position 1 and may be optionally substituted at position 3, 4, 5, 6, 7, and 8. The derivatives having an amino(lower)alkyl radical at both positions 1 and 9 are further substituted at position 1 and may be optionally substituted at positions 3, 4, 5, 6, 7 and 8. The pyrano- and thiopyranoindole derivatives of this invention are useful antidepressant and antiulcer agents. Methods for the preparation and use of these derivatives are also disclosed.
    • 公开了以吡喃并吲哚和噻喃并吲哚为衍生物,其特征在于具有连接于吡喃并[3,4-b]吲哚或噻喃并[3,4-b]吲哚核的1位和9位的氨基(低级)烷基。 氨基(低级)烷基的氨基位置可进一步被一个或两个低级烷基取代或并入杂环胺基中。 仅在位置1具有氨基(低级)烷基的衍生物在位置1处进一步被取代,并且可以在3,4,5,6,7,8和9位任意被取代。具有氨基(低级) 仅在位置9的烷基在位置1具有两个取代基,并且可以任选地在3,4,5,6,7和8位被取代。在位置1和9处具有氨基(低级)烷基的衍生物进一步 在位置1被取代,并且可以任选地在3,4,5,6,7和8位上被取代。本发明的吡喃和噻喃并吲哚衍生物是有用的抗抑郁剂和抗溃疡剂。 还公开了这些衍生物的制备和使用方法。
    • 2. 发明授权
    • Pyranoindole derivatives, compositions and method of use
    • 吡咯啉衍生物,组合物和使用方法
    • US4066779A
    • 1978-01-03
    • US736613
    • 1976-10-28
    • Christopher A. DemersonLeslie G. HumberAndre A. AsselinIvo JirkovskyThomas A. Dobson
    • Christopher A. DemersonLeslie G. HumberAndre A. AsselinIvo JirkovskyThomas A. Dobson
    • C07D209/08A61K31/40A61K31/445A61K31/495A61K31/535
    • C07D209/08Y10S514/925
    • Pyranolindole and thiopyranoindole derivatives characterized by having an amino(lower)alkyl radical attached to either or both the 1 and 9 position of a pyrano[3,4-b]indole or thiopyrano[3,4-b]indole nucleus or having said radical attached to the 1 position of pyrano[4,3-b]indole or thiopyrano[4,3-b]indole nucleus are disclosed. The amino portion of the amino(lower)alkyl radical may be further substituted with one or two lower alkyl groups or incorporated into a heterocyclic amine radical. The derivatives having the amino(lower)alkyl radical only at position 1 are further substituted at position 1 and may be optionally substituted at positions 3,4,5,6,7,8, and 9. The pyrano[3,4-b]indole or thiopyrano[3,4-b]indole derivatives having the amino(lower)alkyl radical only at position 9 possess two substituents at position 1 and may be optionally substituted at position 3,4,5,6,7, and 8; the derivatives having an amino-(lower)alkyl radical at both positions 1 and 9 are further substituted at position 1 and may be optionally substituted at positions 3,4,5,6,7 and 8. The pyrano- and thiopyranindole derivatives of this invention are useful antidepressant and antiulcer agents. Methods for the preparation and use of these derivatives are also disclosed.
    • 吡喃并吲哚和噻喃并吲哚衍生物,其特征在于具有连接于吡喃并[3,4-b]吲哚或噻喃并[3,4-b]吲哚核的1位和9位的氨基(低级)烷基,或具有所述基团 公开了吡喃并[4,3-b]吲哚或噻喃并[4,3-b]吲哚核的1位。 氨基(低级)烷基的氨基部分可进一步被一个或两个低级烷基取代或并入杂环胺基中。 仅在位置1具有氨基(低级)烷基的衍生物在位置1处进一步被取代,并且可以在3,4,5,6,7,8和9位任意被取代。吡喃并[3,4-b ]吲哚或噻喃并[3,4-b]吲哚衍生物,其仅在位置9具有氨基(低级)烷基,在位置1具有两个取代基,并且可以任选在3,4,5,6,7和8位上被取代 ; 具有位置1和9位置上的氨基 - (低级)烷基的衍生物在位置1进一步被取代,并且可以在3,4,5,6,7和8位任意取代。这种吡喃和噻喃衍生物 本发明是有用的抗抑郁药和抗溃疡剂。 还公开了这些衍生物的制备和使用方法。
    • 3. 发明授权
    • Pharmaceutical method for using pyrano-and thiopyranoindole derivatives
    • 吡喃并噻唑衍生物的制备方法
    • US4041169A
    • 1977-08-09
    • US736624
    • 1976-10-28
    • Christopher A. DemersonLeslie G. HumberAndre A. AsselinIvo JirkovskyThomas A. Dobson
    • Christopher A. DemersonLeslie G. HumberAndre A. AsselinIvo JirkovskyThomas A. Dobson
    • C07D209/08A61K31/40
    • C07D209/08Y10S514/925
    • Pyranoindole and thiopyranoindole derivatives characterized by having an amino(lower)alkyl radical attached to either or both the 1 and 9 position of a pyrano[3,4-b]indole or thiopyrano[3,4-b]indole nucleus or having said radical attached to the 1 position of a pyrano[4,3-b]indole or thiopyrano[4,3-b]indole nucleus are disclosed. The amino portion of the amino(lower)alkyl radical may be further substituted with one or two lower alkyl groups or incorporated into a heterocyclic amine radical. The derivatives having the amino(lower)alkyl radical only at position 1 are further substituted at position 1 and may be optionally substituted at positions 3,4,5,6,7,8, and 9. The pyrano[3,4-b]indole or thiopyrano[3,4-b]indole derivatives having the amino(lower)alkyl radical only at position 9 possess two substituents at position 1 and may be optionally substituted at position 3,4,5,6,7, and 8; the derivatives having an amino(lower)alkyl radical at both positions 1 and 9 are further substituted at position 1 and may be optionally substituted at positions 3,4,5,6,7 and 8. The pyrano- and thiopyranoindole derivatives of this invention are useful antidepressant and antiulcer agents. Methods for the preparation and use of these derivatives are also disclosed.
    • 吡喃并吲哚和噻喃并吲哚衍生物,其特征在于具有连接于吡喃并[3,4-b]吲哚或噻喃并[3,4-b]吲哚核的1位和9位的氨基(低级)烷基,或具有所述基团 公开了连接于吡喃并[4,3-b]吲哚或噻喃并[4,3-b]吲哚核的1位的化合物。 氨基(低级)烷基的氨基部分可进一步被一个或两个低级烷基取代或并入杂环胺基中。 仅在位置1具有氨基(低级)烷基的衍生物在位置1处进一步被取代,并且可以在3,4,5,6,7,8和9位任意被取代。吡喃并[3,4-b ]吲哚或噻喃并[3,4-b]吲哚衍生物,其仅在位置9具有氨基(低级)烷基,在位置1具有两个取代基,并且可以任选在3,4,5,6,7和8位上被取代 ; 具有位置1和9的氨基(低级)烷基的衍生物在1位进一步被取代,并且可以在3,4,5,6,7和8位任意被取代。本发明的吡喃和噻喃并吲哚衍生物 是有用的抗抑郁药和抗溃疡剂。 还公开了这些衍生物的制备和使用方法。
    • 4. 发明授权
    • Pyranoindole derivatives as antiulcer agents
    • 吡咯并吲哚衍生物作为抗溃疡剂
    • US4066780A
    • 1978-01-03
    • US736606
    • 1976-10-28
    • Christopher A. DemersonLeslie G. HumberAndre A. AsselinIvo JirkovskyThomas A. Dobson
    • Christopher A. DemersonLeslie G. HumberAndre A. AsselinIvo JirkovskyThomas A. Dobson
    • C07D209/08A61K31/40A61K31/445A61K31/495A61K31/535
    • C07D209/08Y10S514/925
    • Pyranoindole and thiopyranoindole derivatives characterized by having an amino(lower)alkyl radical attached to either or both the 1 and 9 position of a pyrano[3,4-b]indole or thiopyrano[3,4-b]indole nucleus or having said radical attached to the 1 position of a pyrano[4,3-b]indole or thiopyrano[4,3-b]indole nucleus are disclosed. The amino portion of the amino(lower)alkyl radical may be further substituted with one or two lower alkyl groups or incorporated into a heterocyclic amine radical. The derivatives having the amino(lower)alkyl radical only at position 1 are further substituted at position 1 and may be optionally substituted at positions 3,4,5,6,7,8, and 9. The pyrano[3,4-b]indole or thiopyrano[3,4-b]indole derivatives having the amino(lower)alkyl radical only at position 9 possess two substitutents at position 1 and may be optionally substituted at position 3,4,5,6,7, and 8; the derivatives having an amino(lower)alkyl radical at both positions 1 and 9 are further substituted at position 1 and may be optionally substituted at positions 3,4,5,6,7 and 8. The pyrano-and thiopyranoindole derivatives of this invention are useful antidepressant and antiulcer agents. Methods for the preparation and use of these derivatives are also disclosed.
    • 吡喃并吲哚和噻喃并吲哚衍生物,其特征在于具有连接于吡喃并[3,4-b]吲哚或噻喃并[3,4-b]吲哚核的1位和9位的氨基(低级)烷基,或具有所述基团 公开了连接于吡喃并[4,3-b]吲哚或噻喃并[4,3-b]吲哚核的1位的化合物。 氨基(低级)烷基的氨基部分可进一步被一个或两个低级烷基取代或并入杂环胺基中。 仅在位置1具有氨基(低级)烷基的衍生物在位置1处进一步被取代,并且可以在3,4,5,6,7,8和9位任意被取代。吡喃并[3,4-b ]吲哚或噻喃并[3,4-b]吲哚衍生物,其仅在位置9具有氨基(低级)烷基,在位置1具有两个取代基,并且可以在3,4,5,6,7和8位上任选被取代 ; 具有位置1和9位置上的氨基(低级)烷基的衍生物在位置1处进一步被取代,并且可以在3,4,5,6,7和8位任意被取代。本发明的吡喃和噻喃并吲哚衍生物 是有用的抗抑郁药和抗溃疡剂。 还公开了这些衍生物的制备和使用方法。
    • 5. 发明授权
    • Pyrano- and thiopyranoindole derivatives
    • 吡喃和噻喃并吲哚衍生物
    • US4118394A
    • 1978-10-03
    • US822456
    • 1977-08-08
    • Christopher A. DemersonLeslie G. HumberAndre A. AsselinIvo JirkovskyThomas A. Dobson
    • Christopher A. DemersonLeslie G. HumberAndre A. AsselinIvo JirkovskyThomas A. Dobson
    • C07D491/04C07D491/052C07D495/04C07D513/04
    • C07D491/04C07D495/04Y10S514/925
    • Pyranoindole and thiopyranoindole derivatives characterized by having an amino(lower)alkyl radical attached to either or both the 1 and 9 position of a pyrano[3,4-b]indole or thiopyrano[3,4-b]indone nucleus are disclosed. The amino portion of the amino(lower)alkyl radical may be further substituted with one or two lower alkyl groups or incorporated into a heterocyclic amine radical. The derivatives having the amino(lower)alkyl radical only at position 1 are further substituted at position 1 and may be optionally substituted at positions 3, 4, 5, 6, 7, 8, and 9. The derivatives having the amino(lower)alkyl radical only at position 9 possess two substituents at position 1 and may be optionally substituted at position 3, 4, 5, 6, 7, and 8. The derivatives having an amino(lower)alkyl radical at both positions 1 and 9 are further substituted at position 1 and may be optionally substituted at positions 3, 4, 5, 6, 7 and 8. The pyrano- and thiopyranoindole derivatives of this invention are useful antidepressant and antiulcer agents. Methods for the preparation and use of these derivatives are also disclosed.
    • 披露了具有连接于吡喃并[3,4-b]吲哚或噻喃并[3,4-b]吲哚核的1位和9位的氨基(低级)烷基的吡喃并吲哚和噻喃并吲哚衍生物。 氨基(低级)烷基的氨基部分可进一步被一个或两个低级烷基取代或并入杂环胺基中。 仅在位置1具有氨基(低级)烷基的衍生物在位置1处进一步被取代,并且可以在3,4,5,6,7,8和9位任意被取代。具有氨基(低级) 仅在位置9的烷基基团在位置1具有两个取代基,并且可以任选地在3,4,5,6,7和8位被取代。在位置1和9位置具有氨基(低级)烷基的衍生物进一步 在位置1被取代,并且可以任选地在3,4,5,6,7和8位上被取代。本发明的吡喃和噻喃并吲哚衍生物是有用的抗抑郁剂和抗溃疡剂。 还公开了这些衍生物的制备和使用方法。
    • 6. 发明授权
    • Process for making pyrano- and thiopyranoindole derivatives
    • 制备吡喃和噻喃并吲哚衍生物的方法
    • US4056537A
    • 1977-11-01
    • US733829
    • 1976-10-18
    • Christopher A. DemersonLeslie G. HumberAndre A. AsselinIvo JirkovskyThomas A. Dobson
    • Christopher A. DemersonLeslie G. HumberAndre A. AsselinIvo JirkovskyThomas A. Dobson
    • C07D491/04C07D491/052C07D495/04
    • C07D491/04C07D495/04
    • Pyranoindole and thiopyranoindole derivatives characterized by having an amino(lower)alkyl radical attached to either or both the 1 and 9 position of a pyrano[3,4-b]indole or thiopyrano[3,4-b]indole nucleus are disclosed. The amino portion of the amino(lower)alkyl radical may be further substituted with one or two lower alkyl groups or incorporated into a heterocyclic amine radical. The derivatives having the amino(lower)alkyl radical only at position 1 are further substituted at position 1 and may be optionally substituted at positions 3, 4, 5, 6, 7, 8, and 9. The derivatives having the amino(lower)alkyl radical only at position 9 possess two substituents at position 1 and may be optionally substituted at position 3, 4, 5, 6, 7, and 8. The derivatives having an amino(lower)alkyl radical at both positions 1 and 9 are further substituted at position 1 and may be optionally substituted at positions 3, 4, 5, 6, 7 and 8. The pyrano- and thiopyranoindole derivatives of this invention are useful antidepressant and antiulcer agents. Methods for the preparation and use of these derivatives are also disclosed.
    • 公开了以吡喃并吲哚和噻喃并吲哚衍生物为特征的具有连接于吡喃并[3,4-b]吲哚或噻喃并[3,4-b]吲哚核的1位和9位的氨基(低级)烷基。 氨基(低级)烷基的氨基部分可进一步被一个或两个低级烷基取代或并入杂环胺基中。 仅在位置1具有氨基(低级)烷基的衍生物在位置1处进一步被取代,并且可以在3,4,5,6,7,8和9位任意被取代。具有氨基(低级) 仅在位置9的烷基基团在位置1具有两个取代基,并且可以任选地在3,4,5,6,7和8位被取代。在位置1和9位置具有氨基(低级)烷基的衍生物进一步 在位置1被取代,并且可以任选地在3,4,5,6,7和8位上被取代。本发明的吡喃和噻喃并吲哚衍生物是有用的抗抑郁剂和抗溃疡剂。 还公开了这些衍生物的制备和使用方法。
    • 7. 发明授权
    • Pyrano- and thiopyranoindole derivatives, compositions and methods of use
    • 吡喃和噻喃并吲哚衍生物,组合物和使用方法
    • US4003913A
    • 1977-01-18
    • US555906
    • 1975-03-05
    • Christopher A. DemersonLesie G. HumberAndre A. AsselinIvo JirkovskyThomas A. Dobson
    • Christopher A. DemersonLesie G. HumberAndre A. AsselinIvo JirkovskyThomas A. Dobson
    • C07D209/08C07D495/04
    • C07D209/08Y10S514/925
    • Pyranoindole and thiopyranoindole derivatives characterized by having an amino(lower)alkyl radical attached to either or both the 1 and 9 position of a pyrano[3,4-b]indole or thiopyrano[3,4-b]indole nucleus or having said radical attached to the 1 position of a pyrano[4,3-b]indole or thiopyrano[4,3-b]indole nucleus are disclosed. The amino portion of the amino(lower)alkyl radical may be further substituted with one or two lower alkyl groups or incorporated into a heterocyclic amine radical. The derivatives having the amino(lower)alkyl radical only at position 1 are further substituted at position 1 and may be optionally substituted at positions 3,4,5,6,7,8, and 9. The pyrano[3,4-b]indole or thiopyrano[3,4-b]indole derivatives having the amino(lower)alkyl radical only at position 9 possess two substituents at position 1 and may be optionally substituted at position 3,4,5,6,7, and 8; the derivatives having an amino(lower)alkyl radical at both positions 1 and 9 are further substituted at position 1 and may be optionally substituted at positions 3,4,5,6,7 and 8. The pyrano-and thiopyranoindole derivatives of this invention are useful antidepressant and antiulcer agents. Methods for the preparation and use of these derivatives are also disclosed.
    • 吡喃并吲哚和噻喃并吲哚衍生物,其特征在于具有连接于吡喃并[3,4-b]吲哚或噻喃并[3,4-b]吲哚核的1位和9位的氨基(低级)烷基,或具有所述基团 公开了连接于吡喃并[4,3-b]吲哚或噻喃并[4,3-b]吲哚核的1位的化合物。 氨基(低级)烷基的氨基部分可进一步被一个或两个低级烷基取代或并入杂环胺基中。 仅在位置1具有氨基(低级)烷基的衍生物在位置1处进一步被取代,并且可以在3,4,5,6,7,8和9位任意被取代。吡喃并[3,4-b ]吲哚或噻喃并[3,4-b]吲哚衍生物,其仅在位置9具有氨基(低级)烷基,在位置1具有两个取代基,并且可以任选在3,4,5,6,7和8位上被取代 ; 具有位置1和9位置上的氨基(低级)烷基的衍生物在位置1处进一步被取代,并且可以在3,4,5,6,7和8位任意被取代。本发明的吡喃和噻喃并吲哚衍生物 是有用的抗抑郁药和抗溃疡剂。 还公开了这些衍生物的制备和使用方法。