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    • 4. 发明授权
    • Quinoline-3-carboxamides, their manufacture and use
    • 喹啉-3-甲酰胺,其制造和使用
    • US5798451A
    • 1998-08-25
    • US794572
    • 1997-02-03
    • Wolfgang von DeynHans TheobaldChristoph NueblingUwe KardorffHelmut WalterKarl-Otto WestphalenThomas KappeMatthias Gerber
    • Wolfgang von DeynHans TheobaldChristoph NueblingUwe KardorffHelmut WalterKarl-Otto WestphalenThomas KappeMatthias Gerber
    • A01N43/42C07D215/56
    • A01N43/42C07D215/56
    • Quinoline-3-carboxamides I ##STR1## where R.sup.1 is hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, and the organic radicals may be substituted or unsubstituted; R.sup.2 is hydrogen, hydroxyl, alkoxy, alkenyloxy, dialkylamino, alkyl, alkenyl, alkynyl, cycloalkyl, and the organic radicals may be substituted or unsubstituted; or R.sup.1, R.sup.2 together denote an alkylene chain of 4 to 7 members and which may be interrupted by oxygen, sulfur or N-methyl; R.sup.3 -R.sup.6 are hydrogen, alkyl, alkoxy, haloalkyl, haloalkoxy, alkylthio, haloalkylthio, halogen, cyano or nitro; X is oxygen or sulfur; with the proviso that R.sup.2 is not hydrogen, C.sub.1 -C.sub.3 -alkyl, n-butyl, 3-methylbutyl, cyclohexyl, hexyl, heptyl, octyl, 2-chlorobenzyl, 3-(dimethylamino)propyl, 3-(diethylamino)propyl, 2-morpholinoethyl or 2-(3,4-dimethoxyphenyl)ethyl when R.sup.1 and R.sup.3 to R.sup.6 are hydrogen and X is oxygen, and that R.sup.2 is not benzyl when R.sup.1 is methyl, R.sup.3 to R.sup.6 are hydrogen and X is oxygen, and that R.sup.1 and R.sup.2 do not jointly denote morpholino when R.sup.3 to R.sup.6 are hydrogen and X is oxygen.
    • 喹啉-3-甲酰胺其中R 1是氢,烷基,烯基,炔基,环烷基和有机基团可以是取代或未取代的(I) R2是氢,羟基,烷氧基,烯氧基,二烷基氨基,烷基,烯基,炔基,环烷基,有机基可以是取代或未取代的; 或R 1,R 2一起表示4至7个成员的亚烷基链,并且可被氧,硫或N-甲基中断; R3-R6是氢,烷基,烷氧基,卤代烷基,卤代烷氧基,烷硫基,卤代烷硫基,卤素,氰基或硝基; X是氧或硫; 条件是R2不是氢,C1-C3-烷基,正丁基,3-甲基丁基,环己基,己基,庚基,辛基,2-氯苄基,3-(二甲基氨基)丙基,3-(二乙基氨基)丙基, 当R 1和R 3至R 6为氢且X为氧时,R 2为苄基,R 3为R 6为氢,X为氧时,R 2为苄基, 当R 3至R 6为氢且X为氧时,R 2不共同表示吗啉代。
    • 8. 发明授权
    • Quinoline-3-carboxamides, their manufacture and use
    • 喹啉-3-甲酰胺,其制造和使用
    • US5972841A
    • 1999-10-26
    • US988765
    • 1997-12-11
    • Wolfgang von DeynHans TheobaldChristoph NueblingUwe KardorffHelmut WalterKarl-Otto WestphalenThomas KappeMatthias Gerber
    • Wolfgang von DeynHans TheobaldChristoph NueblingUwe KardorffHelmut WalterKarl-Otto WestphalenThomas KappeMatthias Gerber
    • A01N43/42C07D215/56
    • A01N43/42C07D215/56
    • Quinoline-3-carboxamides I ##STR1## where R.sup.1 is hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, and the organic radicals may be substituted or unsubstituted;R.sup.2 is hydrogen, hydroxyl, alkoxy, alkenyloxy, dialkylamino, alkyl, alkenyl, alkynyl, cycloalkyl, and the organic radicals may be substituted or unsubstituted;orR.sup.1, R.sup.2 together denote an alkylene chain of 4 to 7 members and which may be interrupted by oxygen, sulfur or N-methyl;R.sup.3 -R.sup.6 are hydrogen, alkyl, alkoxy, haloalkyl, haloalkoxy, alkylthio, haloalkylthio, halogen, cyano or nitro;X is oxygen or sulfur;with the proviso that R.sup.2 is not hydrogen, C.sub.1 -C.sub.3 -alkyl, n-butyl, 3-methylbutyl, cyclohexyl, hexyl, heptyl, octyl, 2-chlorobenzyl, 3-(dimethylamino)propyl, 3-(diethylamino)propyl, 2-morpholinoethyl or 2-(3,4-dimethoxyphenyl)ethyl when R.sup.1 and R.sup.3 to R.sup.6 are hydrogen and X is oxygen, and that R.sup.2 is not benzyl when R.sup.1 is methyl, R.sup.3 to R.sup.6 are hydrogen and X is oxygen, and that R.sup.1 and R.sup.2 do not jointly denote morpholino when R.sup.3 to R.sup.6 are hydrogen and X is oxygen.
    • 其中R 1是氢,烷基,烯基,炔基,环烷基和有机基团的喹啉-3-甲酰胺I可以是取代或未取代的; R2是氢,羟基,烷氧基,烯氧基,二烷基氨基,烷基,烯基,炔基,环烷基,有机基可以是取代或未取代的; 或R 1,R 2一起表示4至7个成员的亚烷基链,并且可被氧,硫或N-甲基中断; R3-R6是氢,烷基,烷氧基,卤代烷基,卤代烷氧基,烷硫基,卤代烷硫基,卤素,氰基或硝基; X是氧或硫; 条件是R2不是氢,C1-C3-烷基,正丁基,3-甲基丁基,环己基,己基,庚基,辛基,2-氯苄基,3-(二甲基氨基)丙基,3-(二乙基氨基)丙基, 当R 1和R 3至R 6为氢且X为氧时,R 2为苄基,R 3为R 6为氢,X为氧时,R 2为苄基, 当R 3至R 6为氢且X为氧时,R 2不共同表示吗啉代。