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1. 发明授权

US09675595B2 Synergistic combinations of PI3K- and MEK-inhibitors 有权
公开(公告)号：US09675595B2
公开(公告)日：2017-06-13
申请号：US14240499
申请日：2012-08-30
申请人： Christine Fritsch , Xizhong Huang , Markus Boehm , Emmanuelle di Tomaso , Jan Cosaert
发明人： Christine Fritsch , Xizhong Huang , Markus Boehm , Emmanuelle di Tomaso , Jan Cosaert
IPC分类号： A61K31/44 , A61K31/415 , A61K31/4439 , A61K45/06 , A61K31/4184 , A61K31/4412
CPC分类号： A61K31/4439 , A61K31/4184 , A61K31/4412 , A61K45/06 , A61K2300/00
摘要： A pharmaceutical combination comprising (a) the phosphatidylinositol 3-kinase (PI3K) inhibitor compound (S)-pyrrolidine-1,2-dicarboxylic acid 2-amide 1-({4-methyl-5-[2-(2,2,2-trifluoro-1,1-dimethyl-ethyl)-pyridin-4-yl]thiazol-2-yl}-amide) or a pharmaceutically acceptable salt thereof, and (b) at least one mitogen activated protein kinase (MEK) inhibitor or a pharmaceutically acceptable salt, and optionally at least one pharmaceutically acceptable carrier, for simultaneous, separate or sequential administration; the uses of such combination in the treatment of proliferative diseases; and methods of treating a subject suffering from a proliferative disease comprising administering a therapeutically effective amount of such combination.

2. 发明申请

US20140179744A1 SYNERGISTIC COMBINATIONS OF PI3K- AND MEK-INHIBITORS 有权
标题翻译： PI3K和MEK-INHIBITORS的协同组合
公开(公告)号：US20140179744A1
公开(公告)日：2014-06-26
申请号：US14240499
申请日：2012-08-30
申请人： Fritsch Christine , Xizhong Huang , Markus Boehm , Emmanuelle di Tomaso , Jan Cosaert
发明人： Fritsch Christine , Xizhong Huang , Markus Boehm , Emmanuelle di Tomaso , Jan Cosaert
IPC分类号： A61K31/4439 , A61K31/4412 , A61K31/4184
CPC分类号： A61K31/4439 , A61K31/4184 , A61K31/4412 , A61K45/06 , A61K2300/00
摘要： A pharmaceutical combination comprising (a) the phosphatidylinositol 3-kinase (PI3K) inhibitor compound (S)-pyrrolidine-1,2-dicarboxylic acid 2-amide 1-({4-methyl-5-[2-(2,2,2-trifluoro-1,1-dimethyl-ethyl)-pyridin-4-yl]-thiazol-2-yl}-amide) or a pharmaceutically acceptable salt thereof, and (b) at least one mitogen activated protein kinase (MEK) inhibitor or a pharmaceutically acceptable salt, and optionally at least one pharmaceutically acceptable carrier, for simultaneous, separate or sequential administration; the uses of such combination in the treatment of proliferative diseases; and methods of treating a subject suffering from a proliferative disease comprising administering a therapeutically effective amount of such combination.
摘要翻译：一种药物组合，其包含（a）磷脂酰肌醇3-激酶（PI3K）抑制剂化合物（S） - 吡咯烷-1,2-二羧酸2-酰胺1 - （{4-甲基-5- [2- 2-三氟-1,1-二甲基 - 乙基） - 吡啶-4-基] - 噻唑-2-基} - 酰胺）或其药学上可接受的盐，和（b）至少一种丝裂原活化蛋白激酶（MEK）抑制剂或药学上可接受的盐，以及任选的至少一种药学上可接受的载体，用于同时，分开或顺序施用; 这种组合在增殖性疾病治疗中的应用; 以及治疗患有增殖性疾病的受试者的方法，包括施用治疗有效量的这种组合。

3. 发明授权

US08438190B2 Generating web services from business intelligence queries 有权
标题翻译：从商业智能查询生成Web服务
公开(公告)号：US08438190B2
公开(公告)日：2013-05-07
申请号：US12684228
申请日：2010-01-08
申请人： Michael Jung , Christian Klensch , Richard Putz , Markus Heluut Kahn , Hartmut Koerner , Andreas Paul , Joachim Brechtel , Stefan-Claudius Mueller , Markus Boehm
发明人： Michael Jung , Christian Klensch , Richard Putz , Markus Heluut Kahn , Hartmut Koerner , Andreas Paul , Joachim Brechtel , Stefan-Claudius Mueller , Markus Boehm
IPC分类号： G06F17/30 , G06Q30/00
CPC分类号： G06Q10/06
摘要： In an embodiment of the invention, analytical data may be extracted from a business intelligence (BI) system on criteria specified in metadata of a business intelligence query. Once the data is extracted from the BI system, the extracted content may be provided in the context of semantic identifiers. In an embodiment, the semantic identifiers may provide a description of the extracted content associated with the identifier. In one embodiment, the semantic identifiers may be obtained from the criteria specified in the query. In another embodiment, the semantic identifiers may be defined in and obtained from a separate enterprise service repository. In an embodiment, a proposed mapping between query elements and semantic identifiers may be suggested by a processor.
摘要翻译：在本发明的实施例中，可以从商业智能（BI）系统中提取商业智能查询的元数据中指定的标准的解析数据。一旦从BI系统提取数据，可以在语义标识符的上下文中提供所提取的内容。在一个实施例中，语义标识符可以提供与标识符相关联的提取的内容的描述。在一个实施例中，语义标识符可以从查询中指定的标准获得。在另一个实施例中，可以在单独的企业服务存储库中定义语义标识符并从其中获得语义标识符。在一个实施例中，提出的查询元素和语义标识符之间的映射可由处理器建议。

4. 发明授权

US11023487B2 Data replication for cloud based in-memory databases 有权
公开(公告)号：US11023487B2
公开(公告)日：2021-06-01
申请号：US13783763
申请日：2013-03-04
申请人： Jens Odenheimer , Markus Boehm
发明人： Jens Odenheimer , Markus Boehm
IPC分类号： G06F16/27
摘要： System, method, and computer program product embodiments enable configuration of a recommended data replication strategy for cloud based in-memory databases. An embodiment operates by requesting, by a first computing device, configuration of an on-demand cloud-based in-memory database, assessing, at the first computing device, database system components, and transmitting database system component information from the first computing device to a second computing device over a network. The first computing device receives from the second computing device an evaluation of the database system components and a recommended replication strategy responsive to a replication rule set. The database system components at the first computing device are then configured to use the recommended replication strategy.

5. 发明申请

US20110173220A1 GENERATING WEB SERVICES FROM BUSINESS INTELLIGENCE QUERIES 有权
标题翻译：从业务智能查询生成WEB服务
公开(公告)号：US20110173220A1
公开(公告)日：2011-07-14
申请号：US12684228
申请日：2010-01-08
申请人： Michael JUNG , Christian KLENSCH , Richard PUTZ , Markus Heluut KAHN , Hartmut KOERNER , Andreas PAUL , Joachim BRECHTEL , Stefan-Claudius MUELLER , Markus Boehm
发明人： Michael JUNG , Christian KLENSCH , Richard PUTZ , Markus Heluut KAHN , Hartmut KOERNER , Andreas PAUL , Joachim BRECHTEL , Stefan-Claudius MUELLER , Markus Boehm
IPC分类号： G06F17/30
CPC分类号： G06Q10/06
摘要： In an embodiment of the invention, analytical data may be extracted from a business intelligence (BI) system on criteria specified in metadata of a business intelligence query. Once the data is extracted from the BI system, the extracted content may be provided in the context of semantic identifiers. In an embodiment, the semantic identifiers may provide a description of the extracted content associated with the identifier. In one embodiment, the semantic identifiers may be obtained from the criteria specified in the query. In another embodiment, the semantic identifiers may be defined in and obtained from a separate enterprise service repository. In an embodiment, a proposed mapping between query elements and semantic identifiers may be suggested by a processor.
摘要翻译：在本发明的实施例中，可以从商业智能（BI）系统中提取商业智能查询的元数据中指定的标准的解析数据。一旦从BI系统提取数据，可以在语义标识符的上下文中提供所提取的内容。在一个实施例中，语义标识符可以提供与标识符相关联的提取的内容的描述。在一个实施例中，语义标识符可以从查询中指定的标准获得。在另一个实施例中，可以在单独的企业服务存储库中定义语义标识符并从其中获得语义标识符。在一个实施例中，提出的查询元素和语义标识符之间的映射可由处理器建议。

6. 发明申请

US20100104659A1 BENZOPYRANOPYRAZOLES 审中-公开
标题翻译：苯并二恶唑
公开(公告)号：US20100104659A1
公开(公告)日：2010-04-29
申请号：US12373433
申请日：2007-07-12
申请人： Matthias Vennemann , Thomas Bär , Thomas Maier , Andreas Lindenmaier , Jürgen Braunger , Markus Boehm , Astrid Zimmermann , Volker Gekeler
发明人： Matthias Vennemann , Thomas Bär , Thomas Maier , Andreas Lindenmaier , Jürgen Braunger , Markus Boehm , Astrid Zimmermann , Volker Gekeler
IPC分类号： A61K31/4162 , C07D491/04 , C07D471/02 , C07D401/14 , C07D403/14 , A61K31/4738 , A61K31/454 , A61K31/496 , A61K33/24 , A61P35/00 , A61K31/397
CPC分类号： C07D491/04
摘要： Compounds of a certain formula I, in which Ra, Rb and Rc have the meanings indicated in the description, are effective compounds with anti-proliferative and/or apoptosis inducing activity.
摘要翻译：其中Ra，Rb和Rc具有说明书中所示含义的某种式I化合物是具有抗增殖和/或凋亡诱导活性的有效化合物。

7. 发明申请

US20140250070A1 Data Replication for Cloud Based In-Memory Databases 审中-公开
标题翻译：基于云的内存数据库的数据复制
公开(公告)号：US20140250070A1
公开(公告)日：2014-09-04
申请号：US13783763
申请日：2013-03-04
申请人： Jens ODENHEIMER , Markus Boehm
发明人： Jens ODENHEIMER , Markus Boehm
IPC分类号： G06F17/30
CPC分类号： G06F16/27
摘要： Disclosed herein are system, method, and computer program product embodiments for data replication for cloud based in-memory databases. An embodiment operates by requesting, by a first computing device, configuration of an on-demand cloud-based in-memory database, assessing, at the first computing device, database system components, and transmitting database system component information from the first computing device to a second computing device over a network. The first computing device receives from the second computing device an evaluation of the database system components and a recommended replication strategy responsive to a replication rule set. The database system components at the first computing device are then configured to use the recommended replication strategy.
摘要翻译：本文公开了用于基于云的存储器内数据库的数据复制的系统，方法和计算机程序产品实施例。实施例通过由第一计算设备请求配置基于需求的基于云的存储器内数据库，在第一计算设备处评估数据库系统组件并将数据库系统组件信息从第一计算设备传送到网络上的第二计算设备。第一计算设备从第二计算设备接收对数据库系统组件的评估以及响应于复制规则集的推荐复制策略。然后将第一计算设备上的数据库系统组件配置为使用推荐的复制策略。

8. 发明授权

US07185947B2 Wall structure and method for the production thereof 失效
标题翻译：墙体结构及其制造方法
公开(公告)号：US07185947B2
公开(公告)日：2007-03-06
申请号：US10538429
申请日：2003-12-11
申请人： Markus Boehm
发明人： Markus Boehm
IPC分类号： B60J7/00
CPC分类号： B60H1/00564 , B60H1/0055 , B60K37/00 , B60K2350/401
摘要： Described is a wall structure used, for example, in the form of an instrument panel in a motor vehicle interior. The wall structure is embodied in the form of a laminated material consisting of a top layer, a hollow layer and a lower layer. The top layer is oriented towards the interior of the motor vehicle, and the hollow layer is arranged near a ventilation system of the motor vehicle so that a heat energy is removed from the top layer or is supplied thereto using an airflow. Described is also a method for producing the wall structure which allows to air-conditioning the interior of the motor vehicle or control the temperature of the surface layers inside thereof with low energy consumption and in a quick manner.
摘要翻译：描述了例如以汽车内部的仪表板的形式使用的壁结构。壁结构以由顶层，中空层和下层组成的层压材料的形式实施。顶层朝向机动车辆的内部，并且中空层布置在机动车辆的通风系统附近，使得热能从顶层移除或者使用气流被供应到其上。还有一种用于制造壁结构的方法，该壁结构允许对机动车辆的内部进行空调或者以低能量和快速的方式控制其内部的表面层的温度。

9. 发明授权

US07027584B2 Method for signaling and processing incoming calls for a call center 失效
标题翻译：用于信令和处理呼叫中心的来电的方法
公开(公告)号：US07027584B2
公开(公告)日：2006-04-11
申请号：US10149717
申请日：2000-12-12
申请人： Markus Boehm
发明人： Markus Boehm
IPC分类号： H04M3/00
CPC分类号： H04M3/523 , H04M3/42068 , H04M7/0093 , H04M2207/203
摘要： The invention relates to a method for signaling and processing incoming calls for a call center. The invention further relates to a corresponding exchange and corresponding call center. According to the invention, incoming calls for the call center and the subscriber numbers of the callers are signaled to the call center by the exchange via an internet protocol link between the exchange and the call center.
摘要翻译：本发明涉及用于信令和处理呼叫中心的呼入的方法。本发明还涉及相应的交换机和相应的呼叫中心。根据本发明，通过交换机和呼叫中心之间的因特网协议链路，通过交换机将呼叫中心的呼入呼叫和呼叫者的用户号码发信号通知呼叫中心。

10. 发明授权

US09156881B2 Tripeptide KDPT for antiapoptotic treatment 有权
标题翻译：用于抗细胞凋亡治疗的三肽KDPT
公开(公告)号：US09156881B2
公开(公告)日：2015-10-13
申请号：US14344398
申请日：2012-09-24
申请人： Dominik Bettenworth , Markus Boehm , Andreas Luegering
发明人： Dominik Bettenworth , Markus Boehm , Andreas Luegering
IPC分类号： A61K38/06 , A61K38/34 , C07K5/08 , C07K5/09
CPC分类号： C07K5/0815 , A61K38/06 , A61K38/34
摘要： The present invention is related to the tripeptide (I)Lys-(d)Pro-(I)Thr (KdPT) or pharmaceutically acceptable salts thereof for therapeutic, prophylactic therapeutic or cosmetic treatment of a disease with increased apoptosis, wherein the treatment has an anti-apoptotic effect. The present invention is also related to the use of KdPT or pharmaceutically acceptable salts thereof for the manufacture of a pharmaceutical or cosmetic composition for an anti-apoptotic treatment of disorders that are related with increased apoptosis.
摘要翻译：本发明涉及三肽（I）Lys-（d）Pro-（I）Thr（KdPT）或其药学上可接受的盐，用于治疗，预防性治疗或美容治疗具有增加的细胞凋亡的疾病，其中治疗具有抗凋亡作用。本发明还涉及KdPT或其药学上可接受的盐在制备用于与凋亡增加相关的疾病的抗凋亡治疗的药物或化妆品组合物中的用途。

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