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1. 发明申请

US20060063931A1 Compounds, methods and compositions useful for the treatment of bovine viral diarrhea virus (BVDV) infection and hepatitis C virus (HCV) infection 失效
公开(公告)号：US20060063931A1
公开(公告)日：2006-03-23
申请号：US11262427
申请日：2005-10-28
申请人： Christine Dykstra , Maurice Givens , David Stringfellow , Kenny Brock , David Boykin , Arvind Kumar , W. David Wilson , Richard Tidwell , Chad Stephens
发明人： Christine Dykstra , Maurice Givens , David Stringfellow , Kenny Brock , David Boykin , Arvind Kumar , W. David Wilson , Richard Tidwell , Chad Stephens
IPC分类号： C07D405/14
CPC分类号： C07D405/14 , A61K31/341 , A61K31/381 , A61K31/401 , A61K31/4178 , A61K31/4184 , A61K31/423 , A61K31/426 , A61K31/428 , A61K31/506 , C07D207/08 , C07D207/09 , C07D277/28 , C07D307/14 , C07D333/20 , C07D405/04 , C07D405/10
摘要： The present invention relates to novel compounds and methods that are useful in treating members of the Flaviviridae family of viruses. Compounds of the present invention will have a structure according to Formulas (I)-(VI) as recited throughout the application.

2. 发明申请

US20070010533A1 COMPOUNDS, METHODS AND COMPOSITIONS USEFUL FOR THE TREATMENT OF BOVINE VIRAL DIARRHEA VIRUS (BVDV) INFECTION AND HEPATITIS C VIRUS (HCV) INFECTION 失效
标题翻译：用于治疗牛病毒性乙型肝炎病毒（BVDV）感染和丙型肝炎病毒（HCV）感染的化合物，方法和组合物
公开(公告)号：US20070010533A1
公开(公告)日：2007-01-11
申请号：US10796657
申请日：2004-03-09
申请人： Christine Dykstra , Maurice Givens , David Stringfellow , Kenny Brock , David Boykin , Arvind Kumar , W. Wilson , Richard Tidwell , Chad Stephens
发明人： Christine Dykstra , Maurice Givens , David Stringfellow , Kenny Brock , David Boykin , Arvind Kumar , W. Wilson , Richard Tidwell , Chad Stephens
IPC分类号： A61K31/506 , A61K31/428 , A61K31/423 , A61K31/4184 , C07D417/14 , C07D413/02 , C07D403/14
CPC分类号： C07D207/08 , A61K31/341 , A61K31/381 , A61K31/401 , A61K31/4178 , A61K31/4184 , A61K31/426 , C07D207/09 , C07D277/28 , C07D307/14 , C07D307/52 , C07D307/54 , C07D333/20 , C07D405/04 , C07D405/10 , C07D405/14
摘要： The present invention relates to novel compounds and methods that are useful in treating members of the Flaviviridae family of viruses. Compounds of the present invention will have a structure according to Formulas (I)-(VI) as recited throughout the application.
摘要翻译：本发明涉及可用于治疗黄病毒科病毒家族的新化合物和方法。本发明的化合物将具有根据本申请所述的式（I） - （VI）的结构。

3. 发明申请

US20070072878A1 Compounds, methods and compositions useful for the treatment of bovine viral diarrhea virus (BVDV) infection and hepatitis C virus (HCV) infection 失效
公开(公告)号：US20070072878A1
公开(公告)日：2007-03-29
申请号：US11602031
申请日：2006-11-20
申请人： Christine Dykstra , Maurice Givens , David Stringfellow , Kenny Brock , David Boykin , Arvind Kumar , W. Wilson , Richard Tidwell , Chad Stephens
发明人： Christine Dykstra , Maurice Givens , David Stringfellow , Kenny Brock , David Boykin , Arvind Kumar , W. Wilson , Richard Tidwell , Chad Stephens
IPC分类号： A61K31/506 , A61K31/428 , A61K31/423 , A61K31/4184 , C07D417/14 , C07D413/14 , C07D403/14
CPC分类号： C07D405/14 , A61K31/341 , A61K31/381 , A61K31/401 , A61K31/4178 , A61K31/4184 , A61K31/423 , A61K31/426 , A61K31/428 , A61K31/506 , C07D207/08 , C07D207/09 , C07D277/28 , C07D307/14 , C07D333/20 , C07D405/04 , C07D405/10
摘要： The present invention relates to novel compounds and methods that are useful in treating members of the Flaviviridae family of viruses. Compounds of the present invention will have a structure according to Formulas (I)-(VI) as recited throughout the application.

4. 发明申请

US20070072877A1 Compounds, methods and compositions useful for the treatment of bovine viral diarrhea virus (BVDV) infection and hepatitis C virus (HCV) infection 失效
标题翻译：用于治疗牛病毒性腹泻病毒（BVDV）感染和丙型肝炎病毒（HCV）感染的化合物，方法和组合物
公开(公告)号：US20070072877A1
公开(公告)日：2007-03-29
申请号：US11601889
申请日：2006-11-20
申请人： Christine Dykstra , Maurice Givens , David Stringfellow , Kenny Brock , David Boykin , Arvind Kumar , W. Wilson , Richard Tidwell , Chad Stephens
发明人： Christine Dykstra , Maurice Givens , David Stringfellow , Kenny Brock , David Boykin , Arvind Kumar , W. Wilson , Richard Tidwell , Chad Stephens
IPC分类号： A61K31/506 , A61K31/428 , A61K31/423 , A61K31/4184 , C07D417/14 , C07D413/14 , C07D403/14
CPC分类号： C07D405/14 , A61K31/341 , A61K31/381 , A61K31/401 , A61K31/4178 , A61K31/4184 , A61K31/423 , A61K31/426 , A61K31/428 , A61K31/506 , C07D207/08 , C07D207/09 , C07D277/28 , C07D307/14 , C07D333/20 , C07D405/04 , C07D405/10
摘要： The present invention relates to novel compounds and methods that are useful in treating members of the Flaviviridae family of viruses. Compounds of the present invention will have a structure according to Formulas (I)-(VI) as recited throughout the application.
摘要翻译：本发明涉及可用于治疗黄病毒科病毒家族的新化合物和方法。本发明的化合物将具有根据本申请所述的式（I） - （VI）的结构。

5. 发明授权

US07603258B2 Noise reduction and estimation of pipeline signals 失效
标题翻译：管道信号的降噪和估计
公开(公告)号：US07603258B2
公开(公告)日：2009-10-13
申请号：US11265973
申请日：2005-11-03
申请人： Maurice Givens
发明人： Maurice Givens
IPC分类号： G06F15/00
CPC分类号： F16L55/0333
摘要： A method and apparatus for sensor output signal noise reduction in which at least one sensor output signal is introduced into an LMS-based adaptive noise cancellation mechanism and the resulting noise cancellation mechanism output signal is processed using a sub-band spectral subtractive mechanism, producing a reduced noise signal.
摘要翻译：一种用于传感器输出信号噪声降低的方法和装置，其中至少一个传感器输出信号被引入到基于LMS的自适应噪声消除机制中，并且使用子带频谱减法机构处理所得到的噪声消除机制输出信号，降噪信号。

6. 发明申请

US20110146407A1 METHOD FOR IDENTIFYING DEFECTIVE HEAT FUSION JOINTS 有权
标题翻译：识别缺陷热熔接头的方法
公开(公告)号：US20110146407A1
公开(公告)日：2011-06-23
申请号：US12644056
申请日：2009-12-22
申请人： James Emerson Huebler , Maurice Givens
发明人： James Emerson Huebler , Maurice Givens
IPC分类号： G01N29/04
CPC分类号： G01N29/07 , G01N29/0645 , G01N29/265 , G01N2291/0289
摘要： A method for characterizing a defect of a defective heat fusion joint connecting two pipe segments in which the time of flight of an ultrasonic waveform reflected off an exterior surface of a heat fusion joint fitting connecting the two pipe segments or reflected off an interior wall of one of the pipe segments at a plurality of locations around the circumference of the heat fusion joint fitting is measured to determine the minimum and maximum times of flight, which correspond to the maximum and minimum combined wall thicknesses of the heat fusion joint fitting connecting the pipe segments and the pipe segment wall. If the difference between the minimum and maximum combined wall thicknesses as determined from the measured times of flight is equal to or greater than a predetermined amount, then the heat fusion joint is defective and possibly unacceptable for use, requiring a second set of time-of-flight measurements to characterize the nature of the defect.
摘要翻译：一种用于表征连接两个管段的缺陷热熔接头的缺陷的方法，其中超声波波形的飞行时间从连接两个管段的热熔接头配件的外表面反射出或从一个内壁反射出来测量在热熔接头配件的圆周周围的多个位置处的管段的最小和最大次数，其对应于连接管段的热熔接头配件的最大和最小组合壁厚度和管段壁。如果从测量的飞行时间确定的最小和最大组合壁厚之间的差异等于或大于预定量，则热熔接头是有缺陷的并且可能不可接受使用，需要第二组时间 -flight测量来表征缺陷的性质。

7. 发明申请

US20070100587A1 Noise reduction and estimation of pipeline signals 失效
标题翻译：管道信号的降噪和估计
公开(公告)号：US20070100587A1
公开(公告)日：2007-05-03
申请号：US11265973
申请日：2005-11-03
申请人： Maurice Givens
发明人： Maurice Givens
IPC分类号： G06F15/00
CPC分类号： F16L55/0333
摘要： A method and apparatus for sensor output signal noise reduction in which at least one sensor output signal is introduced into an LMS-based adaptive noise cancellation mechanism and the resulting noise cancellation mechanism output signal is processed using a sub-band spectral subtractive mechanism, producing a reduced noise signal.
摘要翻译：一种用于传感器输出信号噪声降低的方法和装置，其中至少一个传感器输出信号被引入到基于LMS的自适应噪声消除机制中，并且使用子带频谱减法机构处理所得到的噪声消除机制输出信号，降噪信号。

8. 发明授权

US08014517B2 Method and apparatus for enhanced convergence of the normalized LMS algorithm 有权
标题翻译：用于增强归一化LMS算法收敛的方法和装置
公开(公告)号：US08014517B2
公开(公告)日：2011-09-06
申请号：US11787858
申请日：2007-04-18
申请人： Maurice Givens
发明人： Maurice Givens
IPC分类号： H04M9/08
CPC分类号： H04M9/082 , H03H2021/0089
摘要： Adaptive filters employing a normalized time domain least mean square algorithm having enhanced convergence rates by virtue of the use of an update gain greater than 2 λ max ⁢ ⁢ or ⁢ ⁢ 2 3 ⁢ ⁢ tr ⁡ [ R ] .
摘要翻译：采用归一化时域最小均方算法的自适应滤波器，通过使用大于2的最大增益增益收敛速度λmax ud或呃2 3 um tr⁡[R]。

9. 发明授权

US06947551B2 Apparatus and method of time delay estimation 有权
标题翻译：时间延迟估计的装置和方法
公开(公告)号：US06947551B2
公开(公告)日：2005-09-20
申请号：US09821707
申请日：2001-03-26
申请人： Maurice Givens
发明人： Maurice Givens
IPC分类号： H04B3/23 , H04M1/00
CPC分类号： H04B3/23
摘要： An apparatus and method for estimating a time delay between two signals are provided. An original signal and a delayed signal are provided to an average magnitude difference processor for determining an average magnitude difference for a sum of samples representing an envelope of each of the respective original and delayed signals, each for a series of sample delays. The time delay between the two signals is determined as the sample delay which minimizes the average magnitude difference.
摘要翻译：提供了用于估计两个信号之间的时间延迟的装置和方法。原始信号和延迟信号被提供给平均幅度差分处理器，用于确定表示每个相应原始信号和延迟信号的包络的样本的和的平均幅度差，每一个用于一系列采样延迟。两个信号之间的时间延迟被确定为最小化平均幅度差的采样延迟。

10. 发明授权

US08050414B2 Robust pipe-strike pulse detector 有权
标题翻译：坚固的打击脉冲探测器
公开(公告)号：US08050414B2
公开(公告)日：2011-11-01
申请号：US12252903
申请日：2008-10-16
申请人： Maurice Givens
发明人： Maurice Givens
IPC分类号： G01M7/00
CPC分类号： G01S15/88 , G01S7/527
摘要： A method for discriminating a noise pulse from a background noise in which a signal of interest is converted to an envelope signal using an entropy-based envelope generator, which envelope signal is then integrated over a plurality of consecutive integrative periods, producing an integrated envelope signal for each of the integration periods. The ratio of the envelope signal at the end of each of the integration periods corresponding to each corresponding said integrated envelope signal is determined and compared with a predetermined threshold signal for each of the integration periods, resulting in a comparison value. The integration period in which the comparison value exceeds the predetermined threshold signal and which is preceded by two integration periods in which the comparison value does not exceed the threshold value represents the point in time at which the noise pulse is detected.
摘要翻译：一种用于使用基于熵的包络发生器将感兴趣信号转换为包络信号的背景噪声区分噪声脉冲的方法，然后将该包络信号在多个连续积分周期上积分，产生积分包络信号对于每个整合期间。确定与每个对应的所述积分包络信号相对应的每个积分周期结束时的包络信号与每个积分周期的预定阈值信号的比率，得到比较值。比较值超过预定阈值信号并且比较值未超过阈值的两个积分周期之前的积分周期表示检测噪声脉冲的时间点。

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