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1. 发明授权

US06689884B1 Supramolecular pairing system, its preparation and use 有权
标题翻译：超分子配对体系，其制备和应用
公开(公告)号：US06689884B1
公开(公告)日：2004-02-10
申请号：US09509040
申请日：2000-08-03
申请人： Christian Miculka , Norbert Windhab , Albert Eschenmoser , Stefan Scherer , Gerhard Quinkert
发明人： Christian Miculka , Norbert Windhab , Albert Eschenmoser , Stefan Scherer , Gerhard Quinkert
IPC分类号： C07D23900
CPC分类号： C12Q1/68
摘要： The invention relates to a compound of formula (I), wherein R1 is NR3R4, OR3 or SR3 with R3 and R4 being H or CnH2n+1 independently of each other and being the same or different, n being a whole number from 1 to 12; R2 is equal to CmH2m—C(X)—Y with X being ═O, ═S or ═N, Y being equal to OR3, NR3R4 or SR3, R3 and R4 having the same meaning given above, and m being a whole number from 1 to 4; or R2 is equal to CmH2m—Z—Y′ with Z being a sulfonyl, phosphonyl, ether or amine group, Y′ being equal to H, CnH2n+1, OR3, NR3R4 or SR3 then Z is sulphonyl or phosphonyl group, n, R3 and R4 having the meaning given above, and Y′ being equal to CnH2n+1 when Z is an ether or an amine group; A, B, and D are the same or different and mean CR5R6, O, NR7 ou S independently of each other with R5, R6 and R7 being H or CnH2n+1, independently of each other, n having the meaning given above; and C is equal to CR8 or N with R8 having the meaning of R5 independently, A—B, B—C or C—D not being two identical heteroatoms; and nucleobase means thymine, uracile, adenine, cytosine, guanine, isocytosine, isoguanine, xanthine or hypoxanthine. The invention also relates to a method for producing these derivatives and to their use in pairing and/or testing systems.
摘要翻译：本发明涉及式（I）化合物，其中R 1为NR 3 R 4，OR 3或SR 3，R 3和R 4为H或C n H 2n +1彼此独立且相同或不同，n为1至12的整数; R 2等于CmH2m-C（X）-Y，其中X为= O，= S或= N，Y等于OR 3，NR 3 R 4或SR 3， R 3和R 4具有上述相同的含义，m为1至4的整数; 或R 2等于C m H 2 m-Z Y'，其中Z是磺酰基，膦酰基，醚或胺基，Y'等于H，C n H 2n + 1，OR 3，NR 3 R 4或当Z为醚或胺基时，Z为磺酰基或膦酰基，n，R 3和R 4具有上述含义，Y'等于C n H 2n + 1; A，B和D相同或不同，并且R 5，R 6和R 7独立地为CR 5，R 6和R 7独立地为CR 5 R 6，O，NR 7 H或C n H 2n + 1彼此独立地具有上述含义的n; 并且C等于CR 8或N，其中R 8独立地具有R 5的含义，A-B，B-C或C-D不是两个相同的杂原子; 核碱基是指胸腺嘧啶，尿嘧啶，腺嘌呤，胞嘧啶，鸟嘌呤，异胞嘧啶，异鸟嘌呤，黄嘌呤或次黄嘌呤。本发明还涉及一种制备这些衍生物的方法及其在配对和/或测试系统中的用途。

2. 发明授权

US07439345B2 Supramolecular pairing system, its preparation and use 失效
标题翻译：超分子配对体系，其制备和应用
公开(公告)号：US07439345B2
公开(公告)日：2008-10-21
申请号：US10746678
申请日：2003-12-23
申请人： Christian Miculka , Norbert Windhab , Albert Eschenmoser , Stefan Scherer , Gerhard Quinkert
发明人： Christian Miculka , Norbert Windhab , Albert Eschenmoser , Stefan Scherer , Gerhard Quinkert
IPC分类号： C07H21/00 , C07K5/00 , C07K7/00 , C07K15/00 , C07K17/00 , C07D487/00 , C07D230/00
CPC分类号： C12Q1/68
摘要： The invention relates to conjugates including at least one linker, a biomolecule coupled to the linker, and cyclohexane derivatives of the following formula: and oligomers thereof.
摘要翻译：本发明涉及包含至少一个接头，与接头连接的生物分子和下式的环己烷衍生物的缀合物：及其低聚物。

3. 发明授权

US06699978B1 Linker nucleoside, and production and use of the same 有权
标题翻译：连接核苷，生产和使用相同
公开(公告)号：US06699978B1
公开(公告)日：2004-03-02
申请号：US09509011
申请日：2000-07-11
申请人： Christian Miculka , Norbert Windhab , Tilmann Brandstetter , Stefan Scherer
发明人： Christian Miculka , Norbert Windhab , Tilmann Brandstetter , Stefan Scherer
IPC分类号： C07H1900
CPC分类号： G01N33/532 , A61K47/54 , A61K47/549 , B82Y10/00 , C07H19/04 , C07H21/00 , H01L51/0093 , Y02P20/55
摘要： The present invention relates to a linker nucleoside, its preparation and use for the covalent bonding of biomolecules to oligonucleotides, in particular p-RNA oligonucleotides.
摘要翻译：本发明涉及连接体核苷，其制备和用于将生物分子共价键合到寡核苷酸，特别是p-RNA寡核苷酸的用途。

4. 发明申请

US20050004356A1 Linker nucleoside, its preparation and use 审中-公开
标题翻译：连接核苷，其制备和应用
公开(公告)号：US20050004356A1
公开(公告)日：2005-01-06
申请号：US10792289
申请日：2004-03-02
申请人： Christian Miculka , Norbert Windhab , Tilmann Brandstetter , Stefan Scherer
发明人： Christian Miculka , Norbert Windhab , Tilmann Brandstetter , Stefan Scherer
IPC分类号： A61K31/7042 , A61K31/7052 , A61K31/7064 , A61K31/7076 , A61K31/712 , A61K47/48 , C07F9/6558 , C07H19/04 , C07H19/06 , C07H19/16 , C07H21/00 , G01N33/532 , H01L51/30 , C07H19/048 , C07H19/22
CPC分类号： G01N33/532 , A61K47/54 , A61K47/549 , B82Y10/00 , C07H19/04 , C07H21/00 , H01L51/0093 , Y02P20/55
摘要： The present invention relates to a linker nucleoside, its preparation and use for the covalent bonding of biomolecules to oligonucleotides, in particular p-RNA oligonucleotides.
摘要翻译：本发明涉及连接体核苷，其制备和用于将生物分子共价键合到寡核苷酸，特别是p-RNA寡核苷酸的用途。

5. 发明授权

US06696555B1 3'-Desoxypentopyranosyl nucleic acid, its production and its use 失效
标题翻译： 3'-脱氧吡喃糖基核酸，其生产及其用途
公开(公告)号：US06696555B1
公开(公告)日：2004-02-24
申请号：US09762977
申请日：2001-04-19
申请人： Christian Miculka , Thomas Wagner , Norbert Windhab
发明人： Christian Miculka , Thomas Wagner , Norbert Windhab
IPC分类号： C07H2100
CPC分类号： C07H21/02 , C07H19/04 , C07H21/00 , F16H15/42 , Y02P20/55
摘要： The invention relates to a 3′-deoxypentopyranosylnucleic acid consisting essentially of 3′-deoxypentopyranosylnucleosides of the formulae (I) or of the formulae (II) their preparation and use for the production of a therapeutic, diagnostic and/or electronic component.
摘要翻译：本发明涉及基本上由式（I）或式（II）的3'-脱氧吡喃半乳糖基核苷组成的3'-脱氧吡喃糖基核酸，其制备和用于制备治疗，诊断和/或电子成分的方法。

6. 发明授权

US07700761B2 3-deoxypentopyranosyl nucleic acid, its production and its use 失效
标题翻译： 3-脱氧吡喃糖基核酸，其生产及其应用
公开(公告)号：US07700761B2
公开(公告)日：2010-04-20
申请号：US11445037
申请日：2006-05-31
申请人： Christian Miculka , Thomas Wagner , Norbert Windhab
发明人： Christian Miculka , Thomas Wagner , Norbert Windhab
IPC分类号： C07H21/00 , C07H19/04
CPC分类号： C07H21/02 , C07H19/04 , C07H21/00 , F16H15/42 , Y02P20/55
摘要： Provided are processes for preparing a 3′-deoxypentopyranosyl oligomers with linkers for linking biomolecules. The processes can the steps of: bonding a 4′-protected-3′-deoxypentopyranosyl nucleoside to a solid support by coupling the 2′-OH group with a CPG support or other similar support with an amide linkage; deprotecting the 4′-protected-3′-deoxypentopyranosyl nucleoside at the 4′ position; deprotecting the 4′-protected-3′-deoxypentopyranosyl nucleoside at the 4′ position; and conjugating a linker to the free 4′ position. The resulting product can be conjugated via the linker to a biomolecule. The method can include, prior to addition of the linker, reacting the 4′-OH group of the 4′-protected-3′-deoxypentopyranosyl nucleoside that is linked to the solid support with a 4′-protected-3′-deoxypentopyranosyl nucleoside phosphoramidite in the presence of a coupling reagent, and oxidizing the reaction product. This step can be repeated one or more times to produce an oligomer of desired length.
摘要翻译：提供制备具有用于连接生物分子的接头的3'-脱氧吡喃糖基寡聚物的方法。该方法可以通过以下步骤：通过将2'-OH基团与CPG载体或其它类似载体与酰胺键偶联，将4'-保护的-3'-脱氧吡喃糖基核苷键合到固体支持物上; 在4'位保护4'-保护的3'-脱氧吡喃糖基核苷; 在4'位保护4'-保护的3'-脱氧吡喃糖基核苷; 并将接头缀合到游离的4'位置。所得产物可通过接头与生物分子结合。该方法可以包括在加入连接体之前，将与固体支持物连接的4'-保护的3'-脱氧吡喃糖基核苷的4'-OH基团与4'-保护的-3'-脱氧吡喃糖基核苷亚磷酰胺在偶联剂存在下反应，氧化反应产物。该步骤可以重复一次或多次以制备所需长度的低聚物。

7. 发明申请

US20050053945A1 Process for the preparation of a pentopyranosyl conjugate 审中-公开
标题翻译：制备戊吡喃糖结合物的方法
公开(公告)号：US20050053945A1
公开(公告)日：2005-03-10
申请号：US10654274
申请日：2003-09-02
申请人： Christian Miculka , Norbert Windhab , Tilmann Brandstetter , Gerhard Burdinski
发明人： Christian Miculka , Norbert Windhab , Tilmann Brandstetter , Gerhard Burdinski
IPC分类号： C12Q1/68 , A61K49/00 , C07H1/00 , C07H19/04 , C07H19/067 , C07H21/00 , C07K16/00 , G01N33/532 , G01N33/53 , C07H21/02 , C07H21/04 , C07K16/46
CPC分类号： C07H21/00 , A61K47/549 , A61K49/0013 , C07H19/04 , C07H21/02 , C07H21/04 , G01N33/532 , Y02P20/55 , Y10S977/728 , Y10S977/80 , Y10S977/836 , Y10S977/894 , Y10S977/896 , Y10S977/904 , Y10S977/914 , Y10S977/915 , Y10S977/924 , Y10S977/925
摘要： The invention relates to a pentopyranosylnucleoside of the formula (I) or of the formula (II) their preparation and use for the production of a therapeutic, diagnostic and/or electronic component.
摘要翻译：本发明涉及式（I）或式（II）的戊吡喃糖基核苷及其制备和用于制备治疗，诊断和/或电子成分的方法。

8. 发明授权

US06506896B1 Use of a pentopyranosyl nucleoside for producing an electronic component, and conjugates of said pentopyranosyl nucleoside 有权
标题翻译：戊吡喃糖基核苷用于制备电子成分的用途，以及所述五倍吡喃糖基核苷的共轭物
公开(公告)号：US06506896B1
公开(公告)日：2003-01-14
申请号：US09509039
申请日：2000-07-11
申请人： Christian Miculka , Norbert Windhab , Tilmann Brandstetter , Gerhard Burdinski
发明人： Christian Miculka , Norbert Windhab , Tilmann Brandstetter , Gerhard Burdinski
IPC分类号： C07H1920
CPC分类号： C07H21/00 , A61K47/549 , A61K49/0013 , C07H19/04 , C07H21/02 , C07H21/04 , G01N33/532 , Y10S977/728 , Y10S977/80 , Y10S977/836 , Y10S977/894 , Y10S977/896 , Y10S977/904 , Y10S977/914 , Y10S977/915 , Y10S977/924 , Y10S977/925
摘要： The invention relates to a pentopyranosylnucleoside of the formula (I) or of the formula (II) their preparation and use for the production of a therapeutic, diagnostic and/or electronic component.
摘要翻译：本发明涉及式（I）或式（II）的戊吡喃糖基核苷及其制备和用于制备治疗，诊断和/或电子成分的方法。

9. 发明申请

US20060217546A1 3-Deoxypentopyranosyl nucleic acid, its production and its use 失效
标题翻译： 3-脱氧吡喃糖基核酸，其生产及其用途
公开(公告)号：US20060217546A1
公开(公告)日：2006-09-28
申请号：US11445037
申请日：2006-05-31
申请人： Christian Miculka , Thomas Wagner , Norbert Windhab
发明人： Christian Miculka , Thomas Wagner , Norbert Windhab
IPC分类号： C07H21/02
CPC分类号： C07H21/02 , C07H19/04 , C07H21/00 , F16H15/42 , Y02P20/55
摘要： This invention relates to a process for preparing a 3′-deoxypentopyranosyl oligomer, which includes the steps of bonding a 4′-protected-3′-deoxypentopyranosyl nucleoside to a solid support, deprotecting the nucleoside at the 4′-position, reacting the 2′OH group with a 4′-protected-3′-deoxypentopyranosyl nucleoside phosphoramidite in the presence of a coupling reagent, and oxidizing the reaction product. The steps of deprotecting the nucleoside at the 4′position, reacting the 2′OH group with a 4′-protected-3′-deoxypentopyranosyl nucleoside phosphoramidite in the presence of a coupling reagent, and oxidizing the reaction product can be repeated one or more times to produce the desired length of oligomer.
摘要翻译：本发明涉及一种制备3'-脱氧吡喃糖基寡聚体的方法，其包括将4'-保护的-3'-脱氧吡喃糖基核苷键合到固体支持物上，使该核苷在4'位上脱保护，使2' 'OH基与4'-保护的-3'-脱氧吡喃糖基核苷亚磷酰胺在偶联剂存在下反应，并氧化反应产物。在4'-位上使核苷脱保护的步骤，在偶联剂存在下使2'OH基团与4'-保护的-3'-脱氧吡喃糖基核苷亚磷酰胺反应，并氧化反应产物可以重复一个或多个次以产生所需长度的低聚物。

10. 发明授权

US06608186B1 Pyranosyl nucleic acid conjugates 有权
标题翻译：吡喃糖基核酸缀合物
公开(公告)号：US06608186B1
公开(公告)日：2003-08-19
申请号：US09509058
申请日：2000-07-27
申请人： Christian Miculka , Norbert Windhab , Tilmann Brandstetter , Gerhard Burdinski
发明人： Christian Miculka , Norbert Windhab , Tilmann Brandstetter , Gerhard Burdinski
IPC分类号： C07H2100
CPC分类号： C07H21/00 , A61K47/549 , A61K49/0013 , C07H19/04 , C07H21/02 , C07H21/04 , G01N33/532 , Y10S977/728 , Y10S977/80 , Y10S977/836 , Y10S977/894 , Y10S977/896 , Y10S977/904 , Y10S977/914 , Y10S977/915 , Y10S977/924 , Y10S977/925
摘要： The invention relates to a pentopyranosylnucleoside of the formula (I) or of the formula (II) their preparation and use for the production of a therapeutic, diagnostic and/or electronic component.
摘要翻译：本发明涉及式（I）或式（II）的戊吡喃糖基核苷及其制备和用于制备治疗，诊断和/或电子成分的方法。

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