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1. 发明授权

US07001729B2 Production of adenine nucleotide translocator (ANT), novel ANT ligands and screening assays therefor 失效
公开(公告)号：US07001729B2
公开(公告)日：2006-02-21
申请号：US09811131
申请日：2001-03-14
申请人： Christen M. Anderson , Robert E. Davis , William Clevenger , Sandra Eileen Wiley , Scott W. Miller , Tomas R. Szabo , Soumitra S. Ghosh , Walter H. Moos , Yazhong Pei
发明人： Christen M. Anderson , Robert E. Davis , William Clevenger , Sandra Eileen Wiley , Scott W. Miller , Tomas R. Szabo , Soumitra S. Ghosh , Walter H. Moos , Yazhong Pei
IPC分类号： G01N29/00 , G01N33/573 , C12N11/00
CPC分类号： C07K14/47 , C07K2319/00 , C07K2319/07 , C07K2319/21 , C07K2319/23 , C12N15/62 , C12N2799/021
摘要： Compositions and methods are provided for producing adenine nucleotide translocator (ANT) polypeptides and fusion proteins, including the production and use of recombinant expression constructs having a regulated promoter. ANT ligands and compositions and methods for identifying ANT ligands, agents that bind ANT and agents that interact with ANT are also disclosed.

2. 发明授权

US06906175B2 Production of adenine nucleotide translocator (ANT), novel ANT ligands and screening assays therefor. 失效
标题翻译：腺嘌呤核苷酸转运蛋白（ANT）的生产，新型ANT配体及其筛选试验。
公开(公告)号：US06906175B2
公开(公告)日：2005-06-14
申请号：US09809889
申请日：2001-03-16
申请人： Christen M. Anderson , Robert E. Davis , William Clevenger , Sandra Eileen Wiley , Scott W. Miller , Tomas R. Szabo , Soumitra S. Ghosh , Walter H. Moos , Yazhong Pei
发明人： Christen M. Anderson , Robert E. Davis , William Clevenger , Sandra Eileen Wiley , Scott W. Miller , Tomas R. Szabo , Soumitra S. Ghosh , Walter H. Moos , Yazhong Pei
IPC分类号： G01N33/50 , A61K31/704 , A61K31/7048 , A61K31/7056 , A61K31/7064 , A61K45/00 , A61P3/00 , A61P3/10 , A61P17/06 , A61P25/08 , A61P25/14 , A61P25/16 , A61P25/18 , A61P25/28 , A61P27/16 , A61P35/00 , A61P43/00 , C07H15/256 , C07H15/26 , C07K1/22 , C07K14/47 , C07K19/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/12 , C12N15/62 , C12P21/02 , C12Q1/02 , C12Q1/68 , G01N33/15 , G01N33/53 , G01N33/566 , C07K1/00 , C07K14/00
CPC分类号： C07K14/47 , C07K2319/00 , C07K2319/07 , C07K2319/21 , C07K2319/23 , C12N15/62 , C12N2799/021
摘要： Compositions and methods are provided for producing adenine nucleotide translocator (ANT) polypeptides and fusion proteins, including the production and use of recombinant expression constructs having a regulated promoter. ANT ligands and compositions and methods for identifying ANT ligands, agents that bind ANT and agents that interact with ANT are also disclosed.
摘要翻译：提供了用于产生腺嘌呤核苷酸转运蛋白（ANT）多肽和融合蛋白的组合物和方法，包括产生和使用具有调节启动子的重组表达构建体。还公开了ANT配体以及用于鉴定ANT配体的组合物和方法，结合ANT的试剂和与ANT相互作用的试剂。

3. 发明授权

US06902908B2 Production of adenine nucleotide translocator (ANT), novel ANT ligands and screening assays therefor 失效
标题翻译：腺嘌呤核苷酸转运蛋白（ANT）的生产，新型ANT配体及其筛选试验
公开(公告)号：US06902908B2
公开(公告)日：2005-06-07
申请号：US09811094
申请日：2001-03-14
申请人： Christen M. Anderson , Robert E. Davis , William Clevenger , Sandra Eileen Wiley , Scott W. Miller , Tomas R. Szabo , Soumitra S. Ghosh , Walter H. Moos , Yazhong Pei
发明人： Christen M. Anderson , Robert E. Davis , William Clevenger , Sandra Eileen Wiley , Scott W. Miller , Tomas R. Szabo , Soumitra S. Ghosh , Walter H. Moos , Yazhong Pei
IPC分类号： G01N33/50 , A61K31/704 , A61K31/7048 , A61K31/7056 , A61K31/7064 , A61K45/00 , A61P3/00 , A61P3/10 , A61P17/06 , A61P25/08 , A61P25/14 , A61P25/16 , A61P25/18 , A61P25/28 , A61P27/16 , A61P35/00 , A61P43/00 , C07H15/256 , C07H15/26 , C07K1/22 , C07K14/47 , C07K19/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/12 , C12N15/62 , C12P21/02 , C12Q1/02 , C12Q1/68 , G01N33/15 , G01N33/53 , G01N33/566 , C12N15/00 , C07H21/04 , C12N15/63
CPC分类号： C07K14/47 , C07K2319/00 , C07K2319/07 , C07K2319/21 , C07K2319/23 , C12N15/62 , C12N2799/021
摘要： Compositions and methods are provided for producing adenine nucleotide translocator (ANT) polypeptides and fusion proteins, including the production and use of recombinant expression constructs having a regulated promoter. ANT ligands and compositions and methods for identifying ANT ligands, agents that bind ANT and agents that interact with ANT are also disclosed.
摘要翻译：提供了用于产生腺嘌呤核苷酸转运蛋白（ANT）多肽和融合蛋白的组合物和方法，包括产生和使用具有调节启动子的重组表达构建体。还公开了ANT配体以及用于鉴定ANT配体的组合物和方法，结合ANT的试剂和与ANT相互作用的试剂。

4. 发明授权

US06887670B2 Production of adenine nucleotide translocator (ANT), novel ANT ligands and screening assays therefor 失效
公开(公告)号：US06887670B2
公开(公告)日：2005-05-03
申请号：US09811132
申请日：2001-03-14
申请人： Christen M. Anderson , Robert E. Davis , Tomas R. Szabo , Soumitra S. Ghosh , Walter H. Moos , Yazhong Pei
发明人： Christen M. Anderson , Robert E. Davis , Tomas R. Szabo , Soumitra S. Ghosh , Walter H. Moos , Yazhong Pei
IPC分类号： G01N33/50 , A61K31/704 , A61K31/7048 , A61K31/7056 , A61K31/7064 , A61K45/00 , A61P3/00 , A61P3/10 , A61P17/06 , A61P25/08 , A61P25/14 , A61P25/16 , A61P25/18 , A61P25/28 , A61P27/16 , A61P35/00 , A61P43/00 , C07H15/256 , C07H15/26 , C07K1/22 , C07K14/47 , C07K19/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/12 , C12N15/62 , C12P21/02 , C12Q1/02 , C12Q1/68 , G01N33/15 , G01N33/53 , G01N33/566 , C07K1/00 , C07K1/14 , C07K1/16 , C07K17/00
CPC分类号： C07K14/47 , C07K2319/00 , C07K2319/07 , C07K2319/21 , C07K2319/23 , C12N15/62 , C12N2799/021
摘要： Compositions and methods are provided for producing adenine nucleotide translocator (ANT) polypeptides and fusion proteins, including the production and use of recombinant expression constructs having a regulated promoter. ANT ligands and compositions and methods for identifying ANT ligands, agents that bind ANT and agents that interact with ANT are also disclosed.

5. 发明授权

US06552076B2 Compounds for altering mitochondrial function and cellular responses 失效
标题翻译：用于改变线粒体功能和细胞反应的化合物
公开(公告)号：US06552076B2
公开(公告)日：2003-04-22
申请号：US10020090
申请日：2001-12-14
申请人： Yazhong Pei , Walter H. Moos , Soumitra S. Ghosh
发明人： Yazhong Pei , Walter H. Moos , Soumitra S. Ghosh
IPC分类号： A61K3124
CPC分类号： C07C235/20 , C07C237/22 , C07C237/42 , C07D307/68
摘要： Compounds for treating diseases by altering mitochondrial function that affects cellular processes, as well as to compositions and methods related thereto. The compounds have the structure wherein R1, R2, R3 and A are as defined herein.
摘要翻译：通过改变影响细胞过程的线粒体功能来治疗疾病的化合物，以及与其相关的组合物和方法。化合物具有其中R 1，R 2，R 3和A如本文所定义的结构。

6. 发明授权

US06900197B2 Cobalt-porphyrin complexes and use thereof as an anti-obesity agent 失效
公开(公告)号：US06900197B2
公开(公告)日：2005-05-31
申请号：US10020867
申请日：2001-12-14
申请人： Tomas R. Szabo , Soumitra S. Ghosh , Robert E. Davis
发明人： Tomas R. Szabo , Soumitra S. Ghosh , Robert E. Davis
IPC分类号： A61K31/409 , A61K33/24 , A61P3/04 , C07D487/22 , C07F15/06 , A61K31/555 , A61K31/40 , A61K31/415
CPC分类号： C07D487/22
摘要： Cobalt-porphyrin (Co-P) complexes for use as anti-obesity agents, and compositions and methods related thereto. The Co-P complexes exhibit reduced redox activity compared to cobalt mesoporphyrin (Co-MP) and cobalt protoporphyrin (Co-PP), which alleviates the deleterious effects associated with administration of Co-P associated with oxidative stress, particularly in the context of injection site toxicity.

7. 发明授权

US06498191B2 Mitochondria protecting agents for treating mitochondria associated diseases 失效
标题翻译：线粒体保护剂用于治疗线粒体相关疾病
公开(公告)号：US06498191B2
公开(公告)日：2002-12-24
申请号：US09733271
申请日：2000-12-07
申请人： Soumitra S. Ghosh , Scott W. Miller , Robert E. Davis , Walter H. Moos
发明人： Soumitra S. Ghosh , Scott W. Miller , Robert E. Davis , Walter H. Moos
IPC分类号： A61K31225
CPC分类号： A61K31/155 , A61K31/00 , A61K31/05 , A61K31/06 , A61K31/136 , C07C39/08 , C07C39/11 , C07C39/19 , C07C69/017 , C07C215/78 , C07C215/80 , C07C217/84 , C07C279/18 , C07D215/20 , C07D311/72
摘要： The present invention relates generally to mitochondria protecting agents for treating diseases in which mitochondrial dysfunction leads to tissue degeneration and, more specifically, to compounds, compositions and methods related to the same. The methods of this invention involve administration of a pharmaceutically effective amount of a mitochondria protecting agent to a warm-blooded animal in need thereof, and composition of this invention contain a mitochondria protecting agent in combination with a pharmaceutically acceptable carrier or diluent. Mitochondrial associated diseases which may be treated by the present invention include (but are not limited to) Alzheimer's Disease, diabetes mellitus, Parkinson's Disease, neuronal and cardiac ischemia, Huntington's disease and stroke.
摘要翻译：本发明一般涉及用于治疗线粒体功能障碍导致组织变性的线粒体保护剂，更具体地涉及与其相关的化合物，组合物和方法。本发明的方法涉及向有需要的温血动物施用药学有效量的线粒体保护剂，本发明的组合物含有与药学上可接受的载体或稀释剂组合的线粒体保护剂。可以通过本发明治疗的线粒体相关疾病包括（但不限于）阿尔茨海默氏病，糖尿病，帕金森病，神经元和心脏缺血，亨廷顿病和中风。

8. 发明授权

US06511966B2 Mitochondria protecting agents for treating mitochondria associated diseases 失效
公开(公告)号：US06511966B2
公开(公告)日：2003-01-28
申请号：US09933911
申请日：2001-08-20
申请人： Soumitra S. Ghosh , Scott W. Miller , Robert E. Davis , Walter H. Moos
发明人： Soumitra S. Ghosh , Scott W. Miller , Robert E. Davis , Walter H. Moos
IPC分类号： A01N4304
CPC分类号： A61K31/155 , A61K31/00 , A61K31/05 , A61K31/06 , A61K31/136 , C07C39/08 , C07C39/11 , C07C39/19 , C07C69/017 , C07C215/78 , C07C215/80 , C07C217/84 , C07C279/18 , C07D215/20 , C07D311/72
摘要： The present invention relates generally to mitochondria protecting agents for treating diseases in which mitochondrial dysfunction leads to tissue degeneration and, more specifically, to compounds, compositions and methods related to the same. The methods of this invention involve administration of a pharmaceutically effective amount of a mitochondria protecting agent to a warm-blooded animal in need thereof, and composition of this invention contain a mitochondria protecting agent in combination with a pharmaceutically acceptable carrier or diluent. Mitochondrial associated diseases which may be treated by the present invention include (but are not limited to) Alzheimer's Disease, diabetes mellitus. Parkinson's Disease, neuronal and cardiac ischemia. Huntington's disease and stroke.

9. 发明授权

US06562821B2 Aryl-N-cyanoguanidines and methods related thereto 失效
标题翻译：芳基-N-氰基胍及其相关方法
公开(公告)号：US06562821B2
公开(公告)日：2003-05-13
申请号：US10085119
申请日：2002-02-27
申请人： Soumitra S. Ghosh , Tomas R. Szabo
发明人： Soumitra S. Ghosh , Tomas R. Szabo
IPC分类号： C07C27928
CPC分类号： A61K31/5375 , A61K31/155 , C07C279/28
摘要： Compounds, compositions and methods treating arthritic disorders such as osteoarthritis or rheumatoid arthritis, and for treating other diseases associated with altered mitochondrial function, such as cancer, psoriasis, stroke, Alzheimer's Disease and diabetes. The compounds of this invention have the following structure (I): including stereoisomers, prodrugs and pharmaceutically acceptable salts thereof, wherein R1-5 are as defined herein. The methods of this invention are directed to administering to a warm-blooded animal in need thereof an effective amount of a compound of structure (I), typically in the form of a pharmaceutical composition.
摘要翻译：治疗关节炎疾病如骨关节炎或类风湿性关节炎的化合物，组合物和方法，以及用于治疗与线粒体功能改变相关的其它疾病，例如癌症，牛皮癣，中风，阿尔茨海默氏病和糖尿病。本发明的化合物具有以下结构（I）：包括其立体异构体，前药和药学上可接受的盐，其中R1-5如本文所定义。本发明的方法涉及向有需要的温血动物施用有效量的结构式（I）的化合物，通常为药物组合物的形式。

10. 发明授权

US06927218B2 Aryl N-cyanoguanidines and methods related thereto 失效
公开(公告)号：US06927218B2
公开(公告)日：2005-08-09
申请号：US10386154
申请日：2003-03-11
申请人： Soumitra S. Ghosh , Tomas R. Szabo
发明人： Soumitra S. Ghosh , Tomas R. Szabo
IPC分类号： C07D295/12 , A61K31/155 , A61K31/277 , A61K31/5375 , A61P3/10 , A61P17/06 , A61P19/02 , A61P21/00 , A61P25/16 , A61P25/18 , A61P25/28 , A61P27/02 , A61P27/16 , A61P29/00 , A61P35/00 , A61P37/00 , A61P43/00 , C07C279/28
CPC分类号： A61K31/5375 , A61K31/155 , C07C279/28
摘要： Compounds, compositions and methods treating arthritic disorders such as osteoarthritis or rheumatoid arthritis, and for treating other diseases associated with altered mitochondrial function, such as cancer, psoriasis, stroke, Alzheimer's Disease and diabetes. The compounds of this invention have the following structure (I): including stereoisomers, prodrugs and pharmaceutically acceptable salts thereof, wherein R1-5 are as defined herein. The methods of this invention are directed to administering to a warm-blooded animal in need thereof an effective amount of a compound of structure (I), typically in the form of a pharmaceutical composition.

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