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1. 发明申请

US20110264420A1 MODELS FOR COMBINATORIAL PERTURBATIONS OF LIVING BIOLOGICAL SYSTEMS 失效
标题翻译：生物生物系统组合刺激模型
公开(公告)号：US20110264420A1
公开(公告)日：2011-10-27
申请号：US12994723
申请日：2009-05-27
申请人： Chris Sander , Sven Nelander , Wei Qing Wang , Peter Gennemark , Bjorn Nilsson
发明人： Chris Sander , Sven Nelander , Wei Qing Wang , Peter Gennemark , Bjorn Nilsson
IPC分类号： G06G7/60 , G06F17/10
CPC分类号： G06F19/12
摘要： Techniques for modeling living biological systems include receiving constant values for multiple interaction factors wij. A set of initial state values is received for state variables that indicate relevant properties of a living biological system. Also received is a set of trial values for perturbation variables that indicate factors that might affect one or more of the relevant properties of the biological system. A temporal change in a value for a particular state variable is determined based on a non-linear transformation of a sum of the trial value for the perturbation that affects the particular state added to a sum of all non-zero values for a product of wij and a state variable over all state variables.In some embodiments, measurement-based values are received for a measurable subset of the state variables. Values for the constant interaction factors wij are determined based on the measurement-based values.
摘要翻译：用于建模活体生物系统的技术包括接收多个相互作用因子wij的常数值。对于指示生物体系的相关属性的状态变量，接收一组初始状态值。还收到了一组扰动变量的试验值，表明可能影响生物系统的一个或多个相关属性的因素。基于对影响加入到wij的乘积的所有非零值的和的特定状态的扰动的和的和的非线性变换来确定特定状态变量的值的时间变化和所有状态变量的状态变量。在一些实施例中，为状态变量的可测量子集接收基于测量的值。基于测量值确定恒定相互作用因子wij的值。

2. 发明授权

US08577619B2 Models for combinatorial perturbations of living biological systems 失效
标题翻译：生物体系组合扰动模型
公开(公告)号：US08577619B2
公开(公告)日：2013-11-05
申请号：US12994723
申请日：2009-05-27
申请人： Chris Sander , Sven Nelander , Wei Qing Wang , Peter Gennemark , Björn Nilsson
发明人： Chris Sander , Sven Nelander , Wei Qing Wang , Peter Gennemark , Björn Nilsson
IPC分类号： G06F19/12 , G06F19/00
CPC分类号： G06F19/12
摘要： Techniques for modeling living biological systems include receiving constant values for multiple interaction factors wij. A set of initial state values is received for state variables that indicate relevant properties of a living biological system. Also received is a set of trial values for perturbation variables that indicate factors that might affect one or more of the relevant properties of the biological system. A temporal change in a value for a particular state variable is determined based on a non-linear transformation of a sum of the trial value for the perturbation that affects the particular state added to a sum of all non-zero values for a product of wij and a state variable over all state variables.In some embodiments, measurement-based values are received for a measurable subset of the state variables. Values for the constant interaction factors wij are determined based on the measurement-based values.
摘要翻译：用于建模活体生物系统的技术包括接收多个相互作用因子wij的常数值。对于指示生物体系的相关属性的状态变量，接收一组初始状态值。还收到一组扰动变量的试验值，表明可能影响生物系统的一个或多个相关属性的因素。基于对影响加入到wij的乘积的所有非零值的和的特定状态的扰动的和的和的非线性变换来确定特定状态变量的值的时间变化和所有状态变量的状态变量。在一些实施例中，为状态变量的可测量子集接收基于测量的值。基于测量值确定恒定相互作用因子wij的值。

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