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1. 发明授权

US08832247B2 Methods and systems for caching content at multiple levels 有权
标题翻译：多级缓存内容的方法和系统
公开(公告)号：US08832247B2
公开(公告)日：2014-09-09
申请号：US11690669
申请日：2007-03-23
申请人： Chris King , Steve Mullaney , Jamshid Mahdavi , Ravikumar Venkata Duvvuri
发明人： Chris King , Steve Mullaney , Jamshid Mahdavi , Ravikumar Venkata Duvvuri
IPC分类号： G06F15/16 , G06F15/173 , G06F12/00 , H04L29/08 , G06F12/08
CPC分类号： H04L67/2842 , G06F12/0813 , G06F12/0875 , G06F12/0897 , G06F2212/154 , H04L67/28 , H04L67/2852
摘要： A cache includes an object cache layer and a byte cache layer, each configured to store information to storage devices included in the cache appliance. An application proxy layer may also be included. In addition, the object cache layer may be configured to identify content that should not be cached by the byte cache layer, which itself may be configured to compress contents of the object cache layer. In some cases the contents of the byte cache layer may be stored as objects within the object cache.
摘要翻译：缓存包括对象缓存层和字节缓存层，每个高速缓存层被配置为将信息存储到包括在缓存装置中的存储设备。还可以包括应用代理层。此外，对象高速缓存层可以被配置为识别字节缓存层不应该缓存的内容，该缓存层本身可以被配置为压缩对象高速缓存层的内容。在某些情况下，字节缓存层的内容可以作为对象存储在对象缓存内。

2. 发明申请

US20070245090A1 Methods and Systems for Caching Content at Multiple Levels 有权
标题翻译：多级缓存内容的方法与系统
公开(公告)号：US20070245090A1
公开(公告)日：2007-10-18
申请号：US11690669
申请日：2007-03-23
申请人： Chris King , Steve Mullaney , Jamshid Mahdavi , Ravikumar Duvvuri
发明人： Chris King , Steve Mullaney , Jamshid Mahdavi , Ravikumar Duvvuri
IPC分类号： G06F12/00
CPC分类号： H04L67/2842 , G06F12/0813 , G06F12/0875 , G06F12/0897 , G06F2212/154 , H04L67/28 , H04L67/2852
摘要： A cache includes an object cache layer and a byte cache layer, each configured to store information to storage devices included in the cache appliance. An application proxy layer may also be included. In addition, the object cache layer may be configured to identify content that should not be cached by the byte cache layer, which itself may be configured to compress contents of the object cache layer. In some cases the contents of the byte cache layer may be stored as objects within the object cache.
摘要翻译：缓存包括对象缓存层和字节缓存层，每个高速缓存层被配置为将信息存储到包括在缓存装置中的存储设备。还可以包括应用代理层。此外，对象高速缓存层可以被配置为识别字节缓存层不应该缓存的内容，该缓存层本身可以被配置为压缩对象高速缓存层的内容。在某些情况下，字节缓存层的内容可以作为对象存储在对象缓存内。

3. 发明申请

US20080134310A1 Using code access security for runtime accessibility checks 有权
标题翻译：使用代码访问安全性进行运行时辅助功能检查
公开(公告)号：US20080134310A1
公开(公告)日：2008-06-05
申请号：US11606671
申请日：2006-11-30
申请人： Shrikrishna V. Borde , Shawn Farkas , Haibo Luo , Michael D. Downen , Raja Krishnaswamy , Thottam R. Sriram , Chris King
发明人： Shrikrishna V. Borde , Shawn Farkas , Haibo Luo , Michael D. Downen , Raja Krishnaswamy , Thottam R. Sriram , Chris King
IPC分类号： H04L9/32 , G06F21/00
CPC分类号： G06F21/53 , G06F21/629 , H04L63/10
摘要： Various technologies and techniques are disclosed that use code access security for providing runtime accessibility checks. A request is received from a first program to access at least one private member of a second program at runtime. If the first program has a greater than or equal security context than the second program, then the first program is granted access to the at least one private member of the second program. This code access security check can be provided in a framework environment that is responsible for managing programs that are from unknown or untrusted sources.
摘要翻译：公开了使用代码访问安全性来提供运行时可访问性检查的各种技术和技术。从第一程序接收到在运行时访问第二程序的至少一个专用成员的请求。如果第一程序具有比第二程序大的或相等的安全上下文，则允许第一程序访问第二程序的至少一个私有成员。该代码访问安全检查可以在负责管理来自未知或不可信源的程序的框架环境中提供。

4. 发明申请

US20150379883A1 Firefighter Training Fixture 审中-公开
标题翻译：消防员训练器具
公开(公告)号：US20150379883A1
公开(公告)日：2015-12-31
申请号：US14752983
申请日：2015-06-28
申请人： Chris King
发明人： Chris King
IPC分类号： G09B9/00
CPC分类号： G09B19/00 , A62C99/0081 , A62C99/009 , G09B23/28 , G09B23/285 , G09B23/286
摘要： A firefighter training fixture for simulating a ceiling pull maneuver includes a pair of side sections and a ceiling section. The ceiling section is interposed between an upper portion of each of the side sections. The ceiling section has at least one compartment for receiving at least one ceiling panel. In some embodiments, the side section has adjustable arms that can increase the height of the ceiling section. In one embodiment, the receiving compartments are configured to receive a drywall panel. The ceiling section can also have piping extending across the receiving compartments to simulate electrical conduit or utility piping encountered by firefighters in the field. In some embodiments, a step ladder is attached to the fixture to allow for convenient installation of ceiling panels into the compartments.
摘要翻译：用于模拟天花板拉动机动的消防员训练器具包括一对侧部和天花板部分。顶部设置在每个侧部的上部之间。天花板部分具有至少一个用于容纳至少一个天花板面板的隔间。在一些实施例中，侧部具有可增加顶板部分的高度的可调臂。在一个实施例中，接收隔间被配置成接收干墙板。天花板部分还可以具有延伸穿过接收隔间的管道，以模拟现场消防员遇到的电气管道或公用管道。在一些实施例中，阶梯连接到固定装置，以便将天花板面板方便地安装到隔室中。

5. 发明申请

US20210113874A1 Firefighter Training Devices 有权
公开(公告)号：US20210113874A1
公开(公告)日：2021-04-22
申请号：US17072599
申请日：2020-10-16
申请人： Chris King
发明人： Chris King
IPC分类号： A62C99/00 , G09B23/00
摘要： Firefighter training devices for wall breaches, cutting chains and/or bars and/or performing roof ventilations are disclosed. In some embodiments, the device is a modular firefighter training fixture. In some embodiments, the modular firefighter training fixture includes a cut-training module, a roof module, and/or a horizontal wall module. In some embodiments, the device is a firefighter training tree. In some embodiments the device is a modular partition system.

6. 发明申请

US20110230526A1 Thiazolyl Mglur5 Antagonists and Methods for Their Use 有权
标题翻译：噻唑基Mglur5拮抗剂及其使用方法
公开(公告)号：US20110230526A1
公开(公告)日：2011-09-22
申请号：US13016304
申请日：2011-01-28
申请人： Nicholas D. Cosford , Thomas J. Seiders , Joseph E. Payne , Jeffrey R. Roppe , Dehua Huang , Nicholas D. Smith , Steve F. Poon , Chris King , Brian W. Eastman , Bowei Wang , Jeannie M. Arruda , Jean-Michel Vernier , Xiumin Zhao
发明人： Nicholas D. Cosford , Thomas J. Seiders , Joseph E. Payne , Jeffrey R. Roppe , Dehua Huang , Nicholas D. Smith , Steve F. Poon , Chris King , Brian W. Eastman , Bowei Wang , Jeannie M. Arruda , Jean-Michel Vernier , Xiumin Zhao
IPC分类号： A61K31/4439 , A61P25/00 , A61P25/22 , A61P25/24 , A61P25/28
CPC分类号： C07D417/06 , C07D417/14 , C07D471/04
摘要： The identification of a unique series of compounds which possesses special advantages in terms of drug-like properties due to their possessing advantageous properties in terms of potency and/or pharmacokinetic and/or selectivity and/or in vivo receptor occupancy properties. Specifically, the selection of a 1,3-thiazol-2-yl ring member linked by an ethynylene to the 3 position of a pyridyl ring or the 5 position of a pyrimidinyl ring, wherein the ring is substituted with selected substituents, results in a compound having superior drug-like properties. The invention includes pharmaceutically acceptable salt forms of these heterocyclic compounds, in particular chloride salts and trifluoroacetate salts.
摘要翻译：由于它们在效力和/或药代动力学和/或选择性和/或体内受体占有性方面具有有利的性质，鉴定了具有药物性质特征的独特系列化合物。具体地说，通过亚乙炔基连接到吡啶环的3位或嘧啶环的5位上的1,3-噻唑-2-基环成员的选择，其中环被选定的取代基取代，得到具有优异药物性质的化合物。本发明包括这些杂环化合物的药学上可接受的盐形式，特别是氯化物盐和三氟乙酸盐。

7. 发明授权

US10083623B2 Firefighter training fixture 有权
公开(公告)号：US10083623B2
公开(公告)日：2018-09-25
申请号：US14752983
申请日：2015-06-28
申请人： Chris King
发明人： Chris King
IPC分类号： G09B23/28 , G09B19/00 , A62C99/00
CPC分类号： G09B19/00 , A62C99/0081 , A62C99/009 , G09B23/28 , G09B23/285 , G09B23/286
摘要： A firefighter training fixture for simulating a ceiling pull maneuver includes a pair of side sections and a ceiling section. The ceiling section is interposed between an upper portion of each of the side sections. The ceiling section has at least one compartment for receiving at least one ceiling panel. In some embodiments, the side section has adjustable arms that can increase the height of the ceiling section. In one embodiment, the receiving compartments are configured to receive a drywall panel. The ceiling section can also have piping extending across the receiving compartments to simulate electrical conduit or utility piping encountered by firefighters in the field. In some embodiments, a step ladder is attached to the fixture to allow for convenient installation of ceiling panels into the compartments.

8. 发明授权

US08609852B2 Thiazolyl mGluR5 antagonists and methods for their use 有权
标题翻译：噻唑基mGluR5拮抗剂及其使用方法
公开(公告)号：US08609852B2
公开(公告)日：2013-12-17
申请号：US13558537
申请日：2012-07-26
申请人： Nicholas D. Cosford , Thomas J. Seiders , Joseph E. Payne , Jeffrey R. Roppe , Dehua Huang , Nicholas D. Smith , Steve F. Poon , Chris King , Brian W. Eastman , Bowei Wang , Jeannie M. Arruda , Jean-Michel Vernier , Xiumin Zhao
发明人： Nicholas D. Cosford , Thomas J. Seiders , Joseph E. Payne , Jeffrey R. Roppe , Dehua Huang , Nicholas D. Smith , Steve F. Poon , Chris King , Brian W. Eastman , Bowei Wang , Jeannie M. Arruda , Jean-Michel Vernier , Xiumin Zhao
IPC分类号： A61P25/00 , A61K31/55 , A61K31/54 , A61K31/505 , A61K31/44 , A61K31/47 , A61K31/445 , C07D401/00 , C07D403/00 , C07D417/00 , C07D239/02 , C07D211/00
CPC分类号： C07D417/06 , C07D417/14 , C07D471/04
摘要： The identification of a unique series of compounds which possesses special advantages in terms of drug-like properties due to their possessing advantageous properties in terms of potency and/or pharmacokinetic and/or selectivity and/or in vivo receptor occupancy properties. Specifically, the selection of a 1,3-thiazol-2-yl ring member linked by an ethynylene to the 3 position of a pyridyl ring or the 5 position of a pyrimidinyl ring, wherein the ring is substituted with selected substituents, results in a compound having superior drug-like properties. The invention includes pharmaceutically acceptable salt forms of these heterocyclic compounds, in particular chloride salts and trifluoroacetate salts.
摘要翻译：由于在效力和/或药代动力学和/或选择性和/或体内受体占有性方面具有有利的性质，鉴定了具有药物性质特征的独特系列化合物。具体地说，通过亚乙炔基连接到吡啶环的3位或嘧啶环的5位上的1,3-噻唑-2-基环成员的选择，其中环被选定的取代基取代，得到具有优异药物性质的化合物。本发明包括这些杂环化合物的药学上可接受的盐形式，特别是氯化物盐和三氟乙酸盐。

9. 发明授权

US08242143B2 Thiazolyl mGluR5 antagonists and methods for their use 有权
标题翻译：噻唑基mGluR5拮抗剂及其使用方法
公开(公告)号：US08242143B2
公开(公告)日：2012-08-14
申请号：US13016304
申请日：2011-01-28
申请人： Nicholas D. Cosford , Thomas J. Seiders , Joseph Payne , Jeffrey R. Roppe , Dehua Huang , Nicholas D. Smith , Steve F. Poon , Chris King , Brian W. Eastman , Bowei Wang , Jeannie M. Arruda , Jean-Michel Vernier , Xiumin Zhao
发明人： Nicholas D. Cosford , Thomas J. Seiders , Joseph Payne , Jeffrey R. Roppe , Dehua Huang , Nicholas D. Smith , Steve F. Poon , Chris King , Brian W. Eastman , Bowei Wang , Jeannie M. Arruda , Jean-Michel Vernier , Xiumin Zhao
IPC分类号： A61P25/00 , A61K31/44 , C07D417/00
CPC分类号： C07D417/06 , C07D417/14 , C07D471/04
摘要： The identification of a unique series of compounds which possesses special advantages in terms of drug-like properties due to their possessing advantageous properties in terms of potency and/or pharmacokinetic and/or selectivity and/or in vivo receptor occupancy properties. Specifically, the selection of a 1,3-thiazol-2-yl ring member linked by an ethynylene to the 3 position of a pyridyl ring or the 5 position of a pyrimidinyl ring, wherein the ring is substituted with selected substituents, results in a compound having superior drug-like properties. The invention includes pharmaceutically acceptable salt forms of these heterocyclic compounds, in particular chloride salts and trifluoroacetate salts.
摘要翻译：由于在效力和/或药代动力学和/或选择性和/或体内受体占有性方面具有有利的性质，鉴定了具有药物性质特征的独特系列化合物。具体地说，通过亚乙炔基连接到吡啶环的3位或嘧啶环的5位上的1,3-噻唑-2-基环成员的选择，其中环被选定的取代基取代，得到具有优异药物性质的化合物。本发明包括这些杂环化合物的药学上可接受的盐形式，特别是氯化物盐和三氟乙酸盐。

10. 发明申请

US20090203903A1 Thiazolyl mglur5 antagonists and methods for their use 有权
标题翻译：噻唑基mglur5拮抗剂及其使用方法
公开(公告)号：US20090203903A1
公开(公告)日：2009-08-13
申请号：US11664902
申请日：2005-10-06
申请人： Nicholas D. Cosford , Thomas J. Seiders , Joseph Payne , Jeffrey R. Roppe , Dehua Huang , Nicholas D. Smith , Steve F. Poon , Chris King , Brian W. Eastman , Bowei Wang , Jeannie M. Arruda , Jean-Michel Vernier , Xiumin Zhao
发明人： Nicholas D. Cosford , Thomas J. Seiders , Joseph Payne , Jeffrey R. Roppe , Dehua Huang , Nicholas D. Smith , Steve F. Poon , Chris King , Brian W. Eastman , Bowei Wang , Jeannie M. Arruda , Jean-Michel Vernier , Xiumin Zhao
IPC分类号： C07D417/14 , C07D417/06
CPC分类号： C07D417/06 , C07D417/14 , C07D471/04
摘要： The identification of a unique series of compounds which possesses special advantages in terms of drug-like properties due to their possessing advantageous properties in terms of potency and/or pharmacokinetic and/or selectivity and/or in vivo receptor occupancy properties. Specifically, the selection of a 1,3-thiazol-2-yl ring member linked by an ethynylene to the 3 position of a pyridyl ring or the 5 position of a pyrimidinyl ring, wherein the ring is substituted with selected substituents, results in a compound having superior drug-like properties. The invention includes pharmaceutically acceptable salt forms of these heterocyclic compounds, in particular chloride salts and trifluoroacetate salts.
摘要翻译：由于在效力和/或药代动力学和/或选择性和/或体内受体占有性方面具有有利的性质，鉴定了具有药物性质特征的独特系列化合物。具体地说，通过亚乙炔基连接到吡啶环的3位或嘧啶环的5位上的1,3-噻唑-2-基环成员的选择，其中环被选定的取代基取代，得到具有优异药物性质的化合物。本发明包括这些杂环化合物的药学上可接受的盐形式，特别是氯化物盐和三氟乙酸盐。

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