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1. 发明授权

US07704995B2 Protein kinase modulators and methods of use 失效
标题翻译：蛋白激酶调节剂和使用方法
公开(公告)号：US07704995B2
公开(公告)日：2010-04-27
申请号：US10513081
申请日：2003-05-02
申请人： Chris A. Buhr , Tae-Gon Baik , Sunghoon Ma , Zerom Tesfai , Longcheng Wang , Erick Wang Co , Sergey Epshteyn , Abigail R Kennedy , Baili Chen , Larisa Dubenko , Neel Kumar Anand , Tsze H. Tsang , John M. Nuss , Csaba J Peto , Kenneth D. Rice , Mohamed Abdulkader Ibrahim , Kevin Luke Schnepp , Xian Shi , James William Leahy , Jeff Chen , Lisa Esther Dalrymple , Timothy Patrick Forsyth , Tai Phat Huynh , Grace Mann , Larry Wayne Mann , Craig Stacy Takeuchi , Peter Lamb , David J. Matthews , Nicole Miller
发明人： Chris A. Buhr , Tae-Gon Baik , Sunghoon Ma , Zerom Tesfai , Longcheng Wang , Erick Wang Co , Sergey Epshteyn , Abigail R Kennedy , Baili Chen , Larisa Dubenko , Neel Kumar Anand , Tsze H. Tsang , John M. Nuss , Csaba J Peto , Kenneth D. Rice , Mohamed Abdulkader Ibrahim , Kevin Luke Schnepp , Xian Shi , James William Leahy , Jeff Chen , Lisa Esther Dalrymple , Timothy Patrick Forsyth , Tai Phat Huynh , Grace Mann , Larry Wayne Mann , Craig Stacy Takeuchi , Peter Lamb , David J. Matthews , Nicole Miller
IPC分类号： C07D279/16 , C07D279/12 , C07D417/12 , C07D265/36 , C07D413/12 , C07D403/12 , C07D401/12 , C07D405/12 , C07D409/12 , C07D411/12 , C07D419/12 , C07D241/18 , C07D241/20 , A61K31/55 , A61K31/497 , A61K31/5355 , A61K31/541 , C07D305/12 , C07D307/79 , A61K31/44 , A61P35/00
CPC分类号： C07D241/26 , C07D401/04 , C07D401/10 , C07D401/12 , C07D403/04 , C07D403/10 , C07D403/14 , C07D405/04 , C07D405/12 , C07D413/04 , C07D413/12
摘要： This invention relates to compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion, and to pharmaceutical compositions containing such compounds. Even more specifically, the invention relates to compounds that inhibit, regulate and/or modulate kinases, particularly Checkpoint Kinases, even more particularly Checkpoint Kinase 1, or Chk1. Methods of therapeutically or prophylactically using the compounds and compositions to treat kinase-dependent diseases and conditions are also an aspect of the invention, and include methods of treating cancer, as well as other disease states associated with unwanted angiogenesis and/or cellular proliferation, by administering effective amounts of such compounds.
摘要翻译：本发明涉及用于调节蛋白激酶酶活性以调节细胞活性如增殖，分化，程序性细胞死亡，迁移和化学侵蚀的化合物，以及含有这些化合物的药物组合物。更具体地，本发明涉及抑制，调节和/或调节激酶，特别是检查点激酶，甚至更特别是检查点激酶1或Chk1的化合物。治疗或预防性地使用化合物和组合物治疗激酶依赖性疾病和病症的方法也是本发明的一个方面，并且包括通过以下方法治疗癌症以及与不期望的血管生成和/或细胞增殖相关的其它疾病状态，施用有效量的这些化合物。

2. 发明授权

US08013156B2 Tie-2 modulators and methods of use 失效
标题翻译： Tie-2调制剂和使用方法
公开(公告)号：US08013156B2
公开(公告)日：2011-09-06
申请号：US10549300
申请日：2004-03-19
申请人： Lynne Canne Bannen , S. David Brown , Wei Cheng , Vasu Jammalamadaka , John M. Nuss , Morrison B. Mac , Jason Jevious Parks , Matthew A. Williams , Wei Xu , Atwood Kim Cheung , Lisa Esther Dalrymple , Sergey Epshteyn , Mohamed Abdulkader Ibrahim , James William Leahy , Gary Lee Lewis , Robin Tammie Noguchi , Larry Wayne Mann , Brian Hugh Ridgway , Joan C. Sangalang , Kevin Luke Schnepp , Xian Shi , Richard George Khoury
发明人： Lynne Canne Bannen , S. David Brown , Wei Cheng , Vasu Jammalamadaka , John M. Nuss , Morrison B. Mac , Jason Jevious Parks , Matthew A. Williams , Wei Xu , Atwood Kim Cheung , Lisa Esther Dalrymple , Sergey Epshteyn , Mohamed Abdulkader Ibrahim , James William Leahy , Gary Lee Lewis , Robin Tammie Noguchi , Larry Wayne Mann , Brian Hugh Ridgway , Joan C. Sangalang , Kevin Luke Schnepp , Xian Shi , Richard George Khoury
IPC分类号： C07D401/14 , C07D403/14 , A61K31/4425 , A61K31/495 , A61K31/506 , A61P19/02 , A61P35/00
CPC分类号： A61K31/496 , C07D213/75 , C07D239/42 , C07D401/12 , C07D401/14 , C07D403/12 , C07D417/12 , C07D417/14
摘要： The present invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. Compounds of the invention inhibit, regulate and/or modulate kinases, particularly Tie-2. Methods of using the compounds and pharmaceutical compositions thereof to treat kinase-dependent diseases and conditions are also an aspect of the invention.
摘要翻译：本发明提供调节蛋白激酶酶活性以调节细胞活性如增殖，分化，程序性细胞死亡，迁移和化学侵蚀的化合物。本发明的化合物抑制，调节和/或调节激酶，特别是Tie-2。使用化合物及其药物组合物治疗激酶依赖性疾病和病症的方法也是本发明的一个方面。

3. 发明授权

US07387555B1 Apparatus and method for boat engine exhaust injection system 失效
标题翻译：船用发动机排气喷射系统的装置和方法
公开(公告)号：US07387555B1
公开(公告)日：2008-06-17
申请号：US10901320
申请日：2004-07-28
申请人： Larry Wayne Mann
发明人： Larry Wayne Mann
IPC分类号： B63H21/00
CPC分类号： B63H21/32
摘要： An apparatus and method for injecting a boat engine's exhaust gasses into the boat propeller's propwash, aft of the propeller. The apparatus comprises piping which injects the boat engine's exhaust gasses into the propwash of the boat, aft of the propeller. This results in the movement of the exhaust gasses away from the boat thus protecting the health of the boat occupants, reduced levels of air pollutants, and a reduction in noise pollution. The injection piping includes several features that protect the boat in the event that the injection piping should strike a solid object in the water.
摘要翻译：一种用于将船用发动机的排放气体注入船用推进器的推进剂，螺旋桨后部的装置和方法。该装置包括将船用发动机的排放气体注入船的推进器，螺旋桨后部的管道。这样就可以使废气从船上移动，从而保护船员的健康，降低空气污染物的含量，降低噪音污染。注射管道包括在注射管道应该撞击水中的固体物体的情况下保护船的若干特征。

4. 发明授权

US06935909B2 Apparatus and method for a gliding board for fluid riding sports 失效
标题翻译：用于流体骑马运动的滑板的装置和方法
公开(公告)号：US06935909B2
公开(公告)日：2005-08-30
申请号：US10379106
申请日：2003-03-03
申请人： Larry Wayne Mann
发明人： Larry Wayne Mann
IPC分类号： B63B35/79 , B63B35/81
CPC分类号： B63B35/7906
摘要： A curved lower surface of a gliding board, such as a wakeboard or a surfboard, is provided with an anticlastic shape to resemble the shape of a saddle. The lower surface of the board is concave in a transverse cross section and convex in a longitudinal cross section along the entire length of the board.
摘要翻译：诸如滑水板或冲浪板的滑板的弯曲下表面设置有类似于鞍座形状的防弹性形状。板的下表面在横截面上是凹形的，并且沿着板的整个长度在纵向截面中凸出。

5. 发明授权

US07216601B1 Apparatus and method for a dual hull boat with control gate 失效
标题翻译：具有控制门的双船体船的装置和方法
公开(公告)号：US07216601B1
公开(公告)日：2007-05-15
申请号：US11296239
申请日：2005-12-08
申请人： Larry Wayne Mann
发明人： Larry Wayne Mann
IPC分类号： B63B1/32
CPC分类号： B63B1/32 , Y02T70/12
摘要： The current invention is an apparatus and method for an inner and outer dual hull boat capable of transforming between different levels of planing ability. The design is a gateway in the outer hull which allows water to pass through the void between the inner and outer hull. By controlling the position of a gate, the flow of water through the gateway in the forward moving boat can be controlled, which allows for the control of the planing or displacement capacity of the boat.
摘要翻译：本发明是一种能够在不同水平的刨削能力之间转换的内外双重船体船的装置和方法。该设计是外壳中的通道，允许水通过内外壳之间的空隙。通过控制门的位置，可以控制通过前进移动的船中的通道的水流，这允许控制船的刨床或排水能力。

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