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1. 发明申请

US20170058029A1 HUMAN ANTIBODY-PRODUCING CELL 审中-公开
标题翻译：人体抗体生产细胞
公开(公告)号：US20170058029A1
公开(公告)日：2017-03-02
申请号：US15308085
申请日：2015-05-01
申请人： Chiome Bioscience Inc.
发明人： Shuichi Hashimoto , Tomoaki Uchiki , Shigeshisa Kawata , Kenjiro Asagoshi , Takashi Yabuki , Hitomi Sano , Shunsuke Miyai , Naoki Takahashi , Aki Takesue , Atsushi Sawada
IPC分类号： C07K16/28 , C07K16/24 , C12N5/0781 , C07K16/18
CPC分类号： C07K16/28 , C07K16/18 , C07K16/22 , C07K16/244 , C07K2317/14 , C07K2317/21 , C07K2317/51 , C07K2317/515 , C07K2317/565 , C12N5/00 , C12N5/0635 , C12N5/10 , C12N15/00 , C12N15/09 , C12N2510/02 , C40B40/02
摘要： It is an object of the present invention to provide a chicken B cell that expresses a variety of human antibodies. The solution to the problem in the present invention is a chicken B cell, in which, in an antibody light chain gene locus thereof, all or a part of a DNA sequence derived from a human antibody light chain variable region and a human antibody light chain constant region are inserted, or the antibody light chain gene locus is replaced with all or a part of a DNA sequence derived from a human antibody light chain variable region and a human antibody light chain constant region, and in an antibody heavy chain gene locus thereof, all or a part of a DNA sequence derived from a human antibody heavy chain variable region and a human antibody heavy chain constant region are inserted, or the antibody heavy chain gene locus is replaced with all or a part of a DNA sequence derived from a human antibody heavy chain variable region and a human antibody heavy chain constant region, and in an antibody light chain pseudogene locus thereof, two or more DNA sequences derived from human antibody light chain variable regions are inserted, or the antibody light chain pseudogene locus is replaced with two or more DNA sequences derived from human antibody light chain variable regions, and/or in an antibody heavy chain pseudogene locus thereof, two or more DNA sequences derived from human antibody heavy chain variable regions are inserted, or the antibody heavy chain pseudogene locus is replaced with two or more DNA sequences derived from human antibody heavy chain variable regions.
摘要翻译：本发明的目的是提供一种表达多种人抗体的鸡B细胞。本发明的问题的解决方案是一种鸡B细胞，其中在抗体轻链基因座中，全部或部分源自人抗体轻链可变区和人抗体轻链的DNA序列或者抗体轻链基因座被全部或一部分来源于人抗体轻链可变区和人抗体轻链恒定区的DNA序列替换，并且在其抗体重链基因座中插入来自人抗体重链可变区和人抗体重链恒定区的DNA序列的全部或一部分，或者将全部或部分来源于人抗体重链可变区和人抗体重链恒定区，并且在抗体轻链假基因座中，衍生自人抗体轻链的两个或多个DNA序列插入可变区，或者将抗体轻链假基因座用来自人抗体轻链可变区和/或其抗体重链假基因座的两个或更多个DNA序列替换，来自人的两个或更多个DNA序列插入抗体重链可变区，或者用来自人抗体重链可变区的两个或多个DNA序列替换抗体重链假基因座。

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