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1. 发明申请

US20060142368A1 Compounds and methods for inducing apoptosis in proliferating cells 审中-公开
标题翻译：用于诱导增殖细胞凋亡的化合物和方法
公开(公告)号：US20060142368A1
公开(公告)日：2006-06-29
申请号：US11354528
申请日：2006-02-15
申请人： Ching-Shih Chen , Xueqin Song , Ho-Pi Lin
发明人： Ching-Shih Chen , Xueqin Song , Ho-Pi Lin
IPC分类号： A61K31/415
CPC分类号： A61K31/415
摘要： Compounds useful for inducing apoptosis in proliferative cells, particularly cancer cells, including but not limited to prostate cancer, leukemia, non-small cell lung cancer, colon cancer, CNS cancer, melanoma, ovarian cancer, renal cancer, bladder cancer, lymphoma, and breast cancer. These compounds are particularly useful in the treatment of androgen-independent cancers, including hormone-refractory prostate cancer. Further provided are methods of treating cancer in a subject in need of such treatment using the compounds of the present invention. Further provided are methods for using the compounds of the present invention to treat, inhibit, or delay the onset of cancer in a subject. Further provided are methods of inducing apoptosis in rapidly proliferating cells, particularly, though not necessarily cancer cells, using the compounds of the present invention.
摘要翻译：包括但不限于前列腺癌，白血病，非小细胞肺癌，结肠癌，CNS癌，黑素瘤，卵巢癌，肾癌，膀胱癌，淋巴瘤和增殖细胞中的诱导细胞凋亡的化合物，乳腺癌。这些化合物特别可用于治疗与雄激素无关的癌症，包括激素难治性前列腺癌。还提供了使用本发明的化合物治疗需要这种治疗的受试者的癌症的方法。还提供了使用本发明化合物治疗，抑制或延迟受试者的癌症发作的方法。还提供了使用本发明的化合物诱导快速增殖的细胞，特别是尽管不一定是癌细胞的细胞凋亡的方法。

2. 发明授权

US07026346B2 Compounds and methods for inducing apoptosis in proliferating cells 失效
公开(公告)号：US07026346B2
公开(公告)日：2006-04-11
申请号：US10409502
申请日：2003-04-08
申请人： Ching-Shih Chen , Xueqin Song , Ho-Pi Lin
发明人： Ching-Shih Chen , Xueqin Song , Ho-Pi Lin
IPC分类号： A61K31/415 , C07D231/10
CPC分类号： C07D231/12 , C07D261/08 , C07D263/38 , C07D307/58 , C07D333/18 , C07D401/04 , C07D403/04 , C07D405/04 , C07D409/04
摘要： Compounds useful for inducing apoptosis in proliferative cells, particularly cancer cells, including but not limited to prostate cancer, leukemia, non-smalll cell lung cancer, colon cancer, CNS cancer, melanoma, ovarian cancer, renal cancer, bladder cancer, lymphoma, and breast cancer. These compounds are particularly useful in the treatment of androgen-independent cancers, including hormone-refractory prostate cancer. Further provided are methods of treating cancer in a subject in need of such treatment using the compounds of the present invention. Further provided are methods for using the compounds of the present invention to treat, inhibit, or delay the onset of cancer in a subject. Further provided are methods of inducing apoptosis in rapidly proliferating cells, particularly, though not necessarily cancer cells, using the compounds of the present invention.

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