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1. 发明授权

US06635654B1 Ophthalmic compositions containing loratadine 有权
标题翻译：含有氯雷他定的眼用组合物
公开(公告)号：US06635654B1
公开(公告)日：2003-10-21
申请号：US10340355
申请日：2003-01-09
申请人： Chin-Ming Chang , Eldon Q. Farnes , Orest Olejnik , James N. Chang
发明人： Chin-Ming Chang , Eldon Q. Farnes , Orest Olejnik , James N. Chang
IPC分类号： A61K3144
CPC分类号： A61K9/0048 , A61K31/4545
摘要： The present invention is directed to an ophthalmic formulation which comprises a therapeutically effective amount of ethyl 4-(8-chloro-5,6-dihydro-11-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-1-piperidinecarboxylate, known as loratadine, a fatty acid ester, and a surfactant, which has been found to be useful in treating ocular allergies, especially allergic conjunctivitis, and related conditions.
摘要翻译：本发明涉及一种眼用制剂，其包含治疗有效量的4-（8-氯-5,6-二氢-11-苯并[5,6]环庚并[1,2-b]吡啶-11- 已经被发现可用于治疗眼部过敏症，特别是过敏性结膜炎和相关病症的已知的氯雷他定，脂肪酸酯和表面活性剂的亚胺基-1-哌啶羧酸酯。

2. 发明申请

US20080107719A1 Transdermal drug delivery system 审中-公开
标题翻译：透皮给药系统
公开(公告)号：US20080107719A1
公开(公告)日：2008-05-08
申请号：US11594517
申请日：2006-11-08
申请人： Sukhon Likitlersuang , Chin-Ming Chang , James Chang , Orest Olejnik
发明人： Sukhon Likitlersuang , Chin-Ming Chang , James Chang , Orest Olejnik
IPC分类号： A61K9/70 , A61K31/13 , A61P25/28
CPC分类号： A61K9/7084 , A61K9/0009 , A61K47/08 , A61K47/16 , A61K47/26 , A61N1/044 , A61N1/0444 , A61N1/0448 , A61N1/327
摘要： A transdermal drug delivery system includes a drug source, an adhesive for applying the system to a skin surface, a penetration enhancer for enhancing penetration of the drug into the skin surface, an energy source and a contact for conveying energy from said energy source through said adhesive and the penetrating enhancer.
摘要翻译：透皮药物递送系统包括药物源，用于将系统施用于皮肤表面的粘合剂，用于增强药物渗入皮肤表面的渗透促进剂，能量源和用于将能量从所述能量源传递通过所述皮肤表面的接触件粘合剂和渗透增强剂。

3. 发明申请

US20060258617A1 DRUG DELIVERY TO THE BACK OF THE EYE 审中-公开
标题翻译：药物递送到眼睛的背面
公开(公告)号：US20060258617A1
公开(公告)日：2006-11-16
申请号：US11460392
申请日：2006-07-27
申请人： Robert Lyon , Chin-Ming Chang , Joan-En Chang-Lin , James Chang , Orest Olejnik
发明人： Robert Lyon , Chin-Ming Chang , Joan-En Chang-Lin , James Chang , Orest Olejnik
IPC分类号： A61K31/724 , A61K31/717 , A61K31/573
CPC分类号： A61K9/0014 , A61K9/0048 , A61K31/57 , A61K31/573 , A61K31/724 , A61K47/38 , A61K47/40
摘要： Disclosed herein are methods of delivering drugs or therapeutically active agents to the back of the eye via topical administration of compositions comprising cyclodextrin derivatives. Compositions related thereto are also disclosed herein.
摘要翻译：本文公开了通过局部施用包含环糊精衍生物的组合物将药物或治疗活性剂递送至眼睛后部的方法。本文还公开了与其相关的组合物。

4. 发明申请

US20050234018A1 Drug delivery to the back of the eye 审中-公开
标题翻译：药物输送到眼睛的后面
公开(公告)号：US20050234018A1
公开(公告)日：2005-10-20
申请号：US10826843
申请日：2004-04-15
申请人： Robert Lyons , Chin-Ming Chang , Joan-En Chang-Lin , James Chang , Orest Olejnik
发明人： Robert Lyons , Chin-Ming Chang , Joan-En Chang-Lin , James Chang , Orest Olejnik
IPC分类号： A61K9/00 , A61K31/00 , A61K31/57 , A61K31/573 , A61K31/724 , A61K47/38 , A61K47/40
CPC分类号： A61K9/0014 , A61K9/0048 , A61K31/57 , A61K31/573 , A61K31/724 , A61K47/38 , A61K47/40
摘要： Disclosed herein are methods of delivering drugs or therapeutically active agents to the back of the eye via topical administration of compositions comprising cyclodextrin derivatives. Compositions related thereto are also disclosed herein.
摘要翻译：本文公开了通过局部施用包含环糊精衍生物的组合物将药物或治疗活性剂递送至眼睛后部的方法。本文还公开了与其相关的组合物。

5. 发明授权

US08257730B2 Steroid-containing sustained release intraocular implants and related methods 有权
标题翻译：类固醇持续释放眼内植入物及相关方法
公开(公告)号：US08257730B2
公开(公告)日：2012-09-04
申请号：US11118288
申请日：2005-04-29
申请人： Glenn T. Huang , Thierry Nivaggioli , Lon T. Spada , Hiroshi Sugimoto , Wendy M Blanda , James N. Chang , Orest Olejnik
发明人： Glenn T. Huang , Thierry Nivaggioli , Lon T. Spada , Hiroshi Sugimoto , Wendy M Blanda , James N. Chang , Orest Olejnik
IPC分类号： A61F2/00
CPC分类号： A61K9/0051 , A61K9/0092 , A61K31/573 , A61K31/58 , A61K45/06 , A61K2300/00
摘要： Biocompatible intraocular implants include a steroid and a polymer associated with each other to facilitate release of the steroid into an eye for a period of time greater than about two months. The steroid may be associated with a biodegradable polymer matrix, such as a matrix of a two biodegradable polymers. Or, the steroid may be associated with a polymeric coating having one or more openings effective to permit the steroid to be released into an external environment. The implants may be placed in an eye to treat one or more ocular conditions. The steroid is released from the implant for more than about two months, and may be release for more than several years.
摘要翻译：生物相容性眼内植入物包括彼此相关的类固醇和聚合物，以促进类固醇进入眼睛大于约两个月的时间。类固醇可以与可生物降解的聚合物基质相关联，例如两种可生物降解聚合物的基质。或者，类固醇可以与具有一个或多个开口有效以允许类固醇释放到外部环境中的聚合物涂层相关联。植入物可以放置在眼睛中以治疗一种或多种眼睛状况。类固醇从植入物中释放超过约两个月，可能会释放超过几年。

6. 发明申请

US20080145407A1 METHODS FOR REDUCING NEOVASCULARIZATION OR EDEMA 审中-公开
标题翻译：减少新生血管或EDEMA的方法
公开(公告)号：US20080145407A1
公开(公告)日：2008-06-19
申请号：US11932373
申请日：2007-10-31
申请人： Glenn T. Huang , Thierry Nivaggioli , Lon T. Spada , Hiroshi Sugimoto , Wendy M. Blanda , James N. Chang , Orest Olejnik
发明人： Glenn T. Huang , Thierry Nivaggioli , Lon T. Spada , Hiroshi Sugimoto , Wendy M. Blanda , James N. Chang , Orest Olejnik
IPC分类号： A61F2/16 , A61K31/56 , A61P27/02
CPC分类号： A61K9/0051 , A61F9/0017 , A61K9/0024 , A61K9/0092 , A61K9/1647 , A61K9/204 , A61K31/5377 , A61K31/56 , A61K31/573 , A61K31/58 , A61K45/06 , A61K47/593 , A61L27/18 , A61L27/54 , A61L27/58 , A61L31/06 , A61L31/148 , A61L31/16 , A61L2300/222 , A61L2300/436 , A61L2300/45 , A61L2300/604 , A61L2430/16 , A61K2300/00 , C08L67/04
摘要： Biocompatible intraocular implants include a steroid and an auxiliary agent, where the auxiliary agent is present in an amount sufficient to lessen the severity of at least one side effect compared to the use of an otherwise identical implant lacking said auxiliary agent. The steroid and the auxiliary agent may be present on the same intraocular implant or on different implants. The steroid and auxiliary agent may be associated with a biodegradable polymer matrix, such as a matrix of a two biodegradable polymers. Or, the steroid may be associated with a polymeric coating having one or more openings effective to permit the steroid to be released into an external environment. The implants containing the steroid and an auxiliary agent may be placed in an eye to treat one or more ocular conditions while reducing the side effects otherwise accompanying steroid use.
摘要翻译：生物相容性眼内植入物包括类固醇和辅助剂，其中与使用缺乏所述辅助剂的其它相同的植入物相比，辅助剂的存在量足以减轻至少一种副作用的严重性。类固醇和辅助剂可以存在于相同的眼内植入物或不同的植入物上。类固醇和辅助剂可以与可生物降解的聚合物基质相结合，例如两种可生物降解的聚合物的基质。或者，类固醇可以与具有一个或多个开口有效以允许类固醇释放到外部环境中的聚合物涂层相关联。包含类固醇和辅助剂的植入物可以放置在眼睛中以治疗一种或多种眼部病症，同时减少否则伴随类固醇使用的副作用。

7. 发明授权

US07297679B2 Cyclosporin compositions 有权
标题翻译：环孢菌素组合物
公开(公告)号：US07297679B2
公开(公告)日：2007-11-20
申请号：US11181178
申请日：2005-07-13
申请人： James N. Chang , Orest Olejnik , Bruce A. Firestone
发明人： James N. Chang , Orest Olejnik , Bruce A. Firestone
IPC分类号： A61K38/12
CPC分类号： A61K47/44 , A61K9/0048 , A61K9/107 , A61K38/13 , Y10S514/912 , Y10S514/975
摘要： A composition comprising from about 0.001% to about 0.4% cyclosporin A, a surfactant, and an oil having a specific gravity from 0.8 to 0.95 is disclosed herein.
摘要翻译：本文公开了包含约0.001％至约0.4％的环孢菌素A，表面活性剂和比重为0.8至0.95的油的组合物。

8. 发明授权

US08575108B2 Cyclosporin compositions 有权
公开(公告)号：US08575108B2
公开(公告)日：2013-11-05
申请号：US11940652
申请日：2007-11-15
申请人： James N. Chang , Orest Olejnik , Bruce A. Firestone
发明人： James N. Chang , Orest Olejnik , Bruce A. Firestone
IPC分类号： A61K38/13 , A61K38/12 , A61K9/36 , A61K31/175 , C07K17/08
CPC分类号： A61K47/44 , A61K9/0048 , A61K9/107 , A61K38/13 , Y10S514/912 , Y10S514/975
摘要： A composition comprising from about 0.001% to about 0.4% cyclosporin A, a surfactant, and an oil having a specific gravity from 0.8 to 0.95 is disclosed herein.

9. 发明授权

US08536134B2 Cyclosporin compositions 有权
公开(公告)号：US08536134B2
公开(公告)日：2013-09-17
申请号：US11679934
申请日：2007-02-28
申请人： James N. Chang , Orest Olejnik , Bruce A. Firestone
发明人： James N. Chang , Orest Olejnik , Bruce A. Firestone
IPC分类号： A61K38/13 , A61K38/12 , A61K9/36 , A61K31/715
CPC分类号： A61K38/13 , A61K9/0048 , Y10S514/912 , Y10S514/975
摘要： A composition comprising a therapeutically effective amount of cyclosporin A, a blend of oils having a specific gravity of from 0.90 to 1.07, and a surfactant is disclosed herein.

10. 发明申请

US20120270805A1 CYCLOSPORIN COMPOSITIONS 有权
标题翻译：环磷酰胺组合物
公开(公告)号：US20120270805A1
公开(公告)日：2012-10-25
申请号：US13536479
申请日：2012-06-28
申请人： JAMES N. CHANG , Orest Olejnik , Bruce A. Firestone
发明人： JAMES N. CHANG , Orest Olejnik , Bruce A. Firestone
IPC分类号： A61K38/13 , A61P27/02
CPC分类号： A61K38/13 , A61K9/0048 , A61K9/107 , A61K47/32 , A61K47/34 , A61K47/38 , A61K47/44
摘要： A composition is disclosed herein comprising from about 0.001% to about 0.4% cyclosporin A, castor oil, and a surfactant selected from the group consisting of alcohol ethoxylates, alcohols, alkyl glycosides, alkyl polyglycosides, alkylphenol ethoxylates, amine oxides, block polymers, carboxylated alcohol or alkylphenol ethoxylates, carboxylic acids/fatty acids, cellulose derivatives, ethoxylated alcohols, ethoxylated alkylphenols, ethoxylated aryl phenols, ethoxylated fatty acids, ethoxylated fatty acids, ethoxylated fatty esters and oils, fatty alcohols, fatty esters, glycol esters, lanolin-based derivatives, lecithin and lecithin derivatives, lignin and lignin derivatives, methyl esters, monoglycerides and derivatives, phosphalipids, polyacrylic acids, polyethylene glycols, polyethylene oxide-polypropylene oxide copolymers, polyethylene oxides, polymeric surfactants, polypropylene oxides, propoxylated alcohols, propoxylated alkyl phenols, propoxylated fatty acids, protein-based surfactants, sarcosine derivatives, silicone-based surfactants, sorbitan derivatives, stearates, sucrose and glucose esters and derivatives, and combinations thereof.
摘要翻译：本文公开了一种组合物，其包含约0.001％至约0.4％的环孢菌素A，蓖麻油和选自醇乙氧基化物，醇，烷基糖苷，烷基多糖苷，烷基酚乙氧基化物，氧化胺，嵌段聚合物，羧化的醇或烷基酚乙氧基化物，羧酸/脂肪酸，纤维素衍生物，乙氧基化醇，乙氧基化烷基酚，乙氧基化芳基酚，乙氧基化脂肪酸，乙氧基化脂肪酸，乙氧基化脂肪酯和油，脂肪醇，脂肪酯，二醇酯，羊毛脂基衍生物，卵磷脂和卵磷脂衍生物，木质素和木质素衍生物，甲酯，单酸甘油酯和衍生物，磷脂，聚丙烯酸，聚乙二醇，聚环氧乙烷 - 聚氧丙烯共聚物，聚环氧乙烷，聚合物表面活性剂，聚环氧丙烷，丙氧基化醇，丙氧基化烷基酚，丙氧基化脂肪酸，基于蛋白质的surfa 硅藻土衍生物，硅氧烷基表面活性剂，脱水山梨糖醇衍生物，硬脂酸盐，蔗糖和葡萄糖酯及其衍生物及其组合。

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