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1. 发明授权

US09005912B2 Hybridoma cell line for producing antibody for type II collagen 有权
标题翻译：用于产生II型胶原抗体的杂交瘤细胞系
公开(公告)号：US09005912B2
公开(公告)日：2015-04-14
申请号：US13562123
申请日：2012-07-30
申请人： Chih-Hsin Hung , Chi-Yen Shen , Shyh-Ming Kuo , I-Fen Chen , Shih-Han Wang
发明人： Chih-Hsin Hung , Chi-Yen Shen , Shyh-Ming Kuo , I-Fen Chen , Shih-Han Wang
IPC分类号： C07K16/18 , G01N33/68 , G01N33/543 , C07K14/78
CPC分类号： C07K16/18 , C07K14/78 , C07K2317/34 , G01N33/543 , G01N33/6887 , G01N2333/78 , G01N2800/105
摘要： The present invention provides a hybridoma cell line (DSM ACC3145), wherein the hybridoma cell line produces an antibody which specifically binds to an amino acid sequence of type II collagen comprising: K-G-E-P-G-D-D-G-P-S-C (as set forth in SEQ ID NO. 1); and a method for detecting osteoarthritis, by identifying a presence of type II collagen in a urine sample through containing the urine sample with the said antibody.
摘要翻译：本发明提供了一种杂交瘤细胞系（DSM ACC3145），其中杂交瘤细胞系产生特异性结合II型胶原的氨基酸序列的抗体，其包含：K-G-E-P-G-D-D-G-P-S-C（如SEQ ID NO.1所示）以及通过用所述抗体含有尿液样品来鉴定尿液样品中II型胶原蛋白的存在来检测骨关节炎的方法。

2. 发明申请

US20130309694A1 HYBRIDOMA CELL LINE FOR PRODUCING ANTIBODY FOR TYPE II COLLAGEN 有权
标题翻译：用于生产II型胶原抗体的混合细胞系
公开(公告)号：US20130309694A1
公开(公告)日：2013-11-21
申请号：US13562123
申请日：2012-07-30
申请人： Chih-Hsin HUNG , Chi-Yen Shen , Shyh-Ming Kuo , I-Fen Chen , Shih-Han Wang
发明人： Chih-Hsin HUNG , Chi-Yen Shen , Shyh-Ming Kuo , I-Fen Chen , Shih-Han Wang
IPC分类号： G01N33/566 , G01N21/78 , G01N29/12 , C12N5/20
CPC分类号： C07K16/18 , C07K14/78 , C07K2317/34 , G01N33/543 , G01N33/6887 , G01N2333/78 , G01N2800/105
摘要： The present invention provides a hybridoma cell line (DSM ACC3145), wherein the hybridoma cell line produces an antibody which specifically binds to an amino acid sequence of type II collagen comprising: K-G-E-P-G-D-D-G-P-S-C (as set forth in SEQ ID NO. 1); and a method for detecting osteoarthritis, by identifying a presence of type II collagen in a urine sample through containing the urine sample with the said antibody.
摘要翻译：本发明提供了一种杂交瘤细胞系（DSM ACC3145），其中杂交瘤细胞系产生特异性结合II型胶原的氨基酸序列的抗体，其包含：K-G-E-P-G-D-D-G-P-S-C（如SEQ ID NO.1所示）以及通过用所述抗体含有尿液样品来鉴定尿液样品中II型胶原蛋白的存在来检测骨关节炎的方法。

3. 发明申请

US20110306152A1 System and Method for Determining Concentration of a Predetermined Osteoarthritis Biomarker in a Urine Sample 审中-公开
标题翻译：确定尿液样品中预定的骨关节炎生物标志物浓度的系统和方法
公开(公告)号：US20110306152A1
公开(公告)日：2011-12-15
申请号：US12797433
申请日：2010-06-09
申请人： Chi-Yen Shen , Chih-Hsin Hung , I-Fen Chen , Shih-Han Wang
发明人： Chi-Yen Shen , Chih-Hsin Hung , I-Fen Chen , Shih-Han Wang
IPC分类号： G01N33/564 , G01N33/48
CPC分类号： G01N33/54373 , G01N2333/78 , G01N2800/105
摘要： A system for determining concentration of a predetermined osteoarthritis biomarker in a urine sample includes first cell and first limiting elements, a quartz crystal microbalance (QCM) sensor device having a sample contacting side, and a monitoring device.The first cell element has a sensor confronting side formed with a recess portion. The first limiting element is disposed at the sensor confronting side, is disposed to surround the recess portion, contacts the sample contacting side, and cooperates with the recess portion and the sample contacting side to confine a sample receiving space for receiving the urine sample.The QCM sensor device includes a quartz resonator and an antibody applied to the quartz resonator and capable of binding with the biomarker, generates a concentration signal corresponding to mass of the biomarker that binds to the antibody, and is coupled to the monitoring device to provide the concentration signal thereto for processing thereby.
摘要翻译：用于测定尿液样本中的预定骨关节炎生物标志物的浓度的系统包括第一细胞和第一限制元件，具有样品接触侧的石英晶体微量天平（QCM）传感器装置和监测装置。第一电池元件具有形成有凹部的传感器面对侧。第一限制元件设置在传感器面对侧，被设置为围绕凹部，接触样品接触侧，并与凹部和样品接触侧配合以限制用于接收尿样的样品接收空间。 QCM传感器装置包括石英谐振器和应用于石英谐振器并且能够与生物标志物结合的抗体，产生对应于与抗体结合的生物标志物的质量的浓度信号，并且耦合到监测装置以提供浓度信号，从而进行处理。

4. 发明申请

US20120047994A1 NITROGEN GAS SENSOR AND ITS MANUFACTURING METHOD 审中-公开
标题翻译： NITROGEN气体传感器及其制造方法
公开(公告)号：US20120047994A1
公开(公告)日：2012-03-01
申请号：US12942845
申请日：2010-11-09
申请人： Chi-Yen Shen , Shih-Han Wang
发明人： Chi-Yen Shen , Shih-Han Wang
IPC分类号： G01N29/02 , H01L41/22
CPC分类号： H01L41/1132 , G01N29/022 , G01N2291/021 , G01N2291/0255 , G01N2291/0256 , G01N2291/02809 , G01N2291/0423 , G01N2291/045 , Y10T29/42
摘要： A nitrogenous gas sensor comprises a piezoelectricity plate which has a sensing surface; two transducers placed on the sensing surface of the piezoelectricity plate for transduction of electrostatic potential energy and acoustic energy, in order to generate surface acoustic waves on the piezoelectricity plate; and a sensing layer installed on the sensing surface of the piezoelectricity plate between the two transducers, which is consisted of polyaniline and tungsten oxide. Furthermore, a manufacturing method of the nitrogenous gas sensor comprises a step of “manufacturing transducer,” by placing two transducers on the sensing surface of the piezoelectric plate; and a step of “manufacturing sensing layer,” by mixing a solution of polyaniline and a solution of tungsten oxide to obtain a mixture of polyaniline and tungsten oxide, and further generating a sensing layer consisted of nano-scaled of complex polyaniline and tungsten oxide between the two transducer by dropping the mixture of polyaniline and tungsten oxide on the sensing surface of the piezoelectric plate.
摘要翻译：含氮气体传感器包括具有感测表面的压电板; 两个换能器放置在压电板的感测表面上，用于转换静电势能和声能，以便在压电板上产生表面声波; 以及安装在由聚苯胺和氧化钨组成的两个换能器之间的压电板的感测表面上的感测层。此外，氮气传感器的制造方法包括通过将两个换能器放置在压电板的感测表面上的“制造换能器”的步骤; 和“制造感测层”的步骤，通过混合聚苯胺溶液和氧化钨溶液以获得聚苯胺和氧化钨的混合物，并进一步产生由纳米级的复合聚苯胺和氧化钨组成的感测层，介于通过将聚苯胺和氧化钨的混合物滴落在压电板的感测表面上的两个换能器。

5. 发明申请

US20120199479A1 FLOW CELL DEVICE 失效
标题翻译：流槽装置
公开(公告)号：US20120199479A1
公开(公告)日：2012-08-09
申请号：US13020177
申请日：2011-02-03
申请人： Chi-Yen Shen , Jian-Jhong Chen , Yu-Fong Huang
发明人： Chi-Yen Shen , Jian-Jhong Chen , Yu-Fong Huang
IPC分类号： G01N27/28
CPC分类号： G01N27/08
摘要： A flow cell device is formed with: a plurality of cell recess portions adapted to cooperate with a plurality of sensor devices to confine a plurality of sample receiving space for receiving a liquid sample, respectively; a plurality of pairs of first and second guiding channels, each pair being in fluid communication with a respective one of the cell recess portions; a number of connecting recess portions each fluidly communicating the first and second guiding channels that respectively extend to a corresponding pair of the cell recess portions such that the liquid sample is able to flow through the sample receiving spaces sequentially; and inlet and outlet channels in fluid communication with the first and second guiding channels that respectively extend to a first one and a last one of the cell recess portions for introducing and discharging the liquid sample into and from the flow cell device, respectively.
摘要翻译：流动池装置形成有：多个单元凹部，其适于与多个传感器装置配合，以分别限制用于接收液体样品的多个样品接收空间; 多对第一和第二引导通道，每对引导通道与相应的单元凹槽部分流体连通; 多个连接凹部，其各自流体地连通所述第一和第二引导通道，所述第一和第二引导通道分别延伸到相应的一对所述单元凹槽部分，使得所述液体样品能够依次流过所述样品接收空间; 以及分别与第一和第二引导通道流体连通的入口和出口通道，其分别延伸到第一个和第二个单元凹槽部分，用于将液体样本分别引入和从流动池装置排出。

6. 发明授权

US07459094B2 Method for making a surface acoustic wave device package 失效
标题翻译：制造表面声波器件封装的方法
公开(公告)号：US07459094B2
公开(公告)日：2008-12-02
申请号：US11675751
申请日：2007-02-16
申请人： Chi-Yen Shen
发明人： Chi-Yen Shen
IPC分类号： B44C1/22 , C23F1/00 , H01L21/00
CPC分类号： H03H3/08 , C23F1/02 , H01L2224/48091 , H01L2924/16195 , H01L2924/181 , H03H9/0542 , H03H9/059 , H03H9/1085 , H03H9/1092 , H01L2924/00014 , H01L2924/00012
摘要： A method for making a SAW device package includes the steps of: forming a pattern of a metal layer, that defines transmitting and receiving transducers of a SAW die, on a wafer; forming a pattern of a first photo sensitive layer, which defines a peripheral wall of a cap of the SAW die, on the metal layer and the wafer through lithography techniques; forming a pattern of a second photo sensitive layer, which defines a cover wall of the cap of the SAW die, on the first photo sensitive layer through lithography techniques; curing the first and second photo sensitive layers; dicing the wafer into SAW dies; and encapsulating the SAW dies with a molding compound.
摘要翻译：一种用于制造SAW器件封装的方法包括以下步骤：在晶片上形成限定SAW模具的发射和接收换能器的金属层的图案; 通过光刻技术在金属层和晶片上形成限定SAW管芯盖的外围壁的第一光敏层的图案; 通过光刻技术在第一光敏层上形成限定SAW模具的盖的盖壁的第二光敏层的图案; 固化第一和第二光敏层; 将晶片切割成SAW模具; 并用模塑料包封SAW模具。

7. 发明授权

US07198725B2 Method for making a surface acoustic wave device package 有权
标题翻译：制造表面声波器件封装的方法
公开(公告)号：US07198725B2
公开(公告)日：2007-04-03
申请号：US10982204
申请日：2004-11-05
申请人： Chi-Yen Shen
发明人： Chi-Yen Shen
IPC分类号： B44C1/22 , C23F1/00
CPC分类号： H03H3/08 , C23F1/02 , H01L2224/48091 , H01L2924/16195 , H01L2924/181 , H03H9/0542 , H03H9/059 , H03H9/1085 , H03H9/1092 , H01L2924/00014 , H01L2924/00012
摘要： A method for making a SAW device package includes the steps of: forming a pattern of a metal layer, that defines transmitting and receiving transducers of a SAW die, on a wafer; forming a pattern of a first photo sensitive layer, which defines a peripheral wall of a cap of the SAW die, on the metal layer and the wafer through lithography techniques; forming a pattern of a second photo sensitive layer, which defines a cover wall of the cap of the SAW die, on the first photo sensitive layer through lithography techniques; curing the first and second photo sensitive layers; dicing the wafer into SAW dies; and encapsulating the SAW dies with a molding compound.
摘要翻译：一种用于制造SAW器件封装的方法包括以下步骤：在晶片上形成限定SAW模具的发射和接收换能器的金属层的图案; 通过光刻技术在金属层和晶片上形成限定SAW管芯盖的外围壁的第一光敏层的图案; 通过光刻技术在第一光敏层上形成限定SAW模具的盖的盖壁的第二光敏层的图案; 固化第一和第二光敏层; 将晶片切割成SAW模具; 并用模塑料包封SAW模具。

8. 发明授权

US08522602B2 System for detecting a liquid sample 有权
标题翻译：液体样品检测系统
公开(公告)号：US08522602B2
公开(公告)日：2013-09-03
申请号：US13091435
申请日：2011-04-21
申请人： Chi-Yen Shen , Ke-Nung Huang , Shen-Li Fu , Jian-Jhong Chen , Yu-Fong Huang
发明人： Chi-Yen Shen , Ke-Nung Huang , Shen-Li Fu , Jian-Jhong Chen , Yu-Fong Huang
IPC分类号： G01N11/00 , G01N1/00
CPC分类号： G01N33/54306 , G01N33/4915 , G01N35/1095
摘要： A system is provided for detecting a liquid sample, and includes: a flow cell assembly formed with a sample receiving space therein, and inlet and outlet channels extending to the sample receiving space for guiding the liquid sample into and away from the sample receiving space; a sensor device including a sample detecting unit that is disposed in the sample receiving space, and that is operable to detect the liquid sample and to generate a detection signal accordingly, and a signal conducting unit that is connected electrically to the sensor device for conducting the detection signal therefrom; and a liquid introducing unit and a liquid discharging unit coupled to the inlet and outlet channels and cooperating therewith to form an introducing path and a discharging path for introducing the liquid sample into and for discharging the liquid sample from the sample receiving space, respectively.
摘要翻译：提供了一种用于检测液体样品的系统，包括：形成有样品容纳空间的流通池组件，以及延伸到样品容纳空间的入口和出口通道，用于将液体样品引入和离开样品接收空间; 传感器装置，包括：样本检测单元，其设置在样本容纳空间中，并且可操作地检测液体样本并相应地产生检测信号;以及信号导通单元，其与传感器装置电连接，用于导电检测信号; 以及液体引入单元和液体排出单元，其联接到入口和出口通道并与之配合以形成引入路径和用于将液体样品分别从样品接收空间引入和排出液体样品的排出路径。

9. 发明授权

US08241570B1 Flow cell device 失效
标题翻译：流通池装置
公开(公告)号：US08241570B1
公开(公告)日：2012-08-14
申请号：US13020177
申请日：2011-02-03
申请人： Chi-Yen Shen , Jian-Jhong Chen , Yu-Fong Huang
发明人： Chi-Yen Shen , Jian-Jhong Chen , Yu-Fong Huang
IPC分类号： G01N15/06
CPC分类号： G01N27/08
摘要： A flow cell device is formed with: a plurality of cell recess portions adapted to cooperate with a plurality of sensor devices to confine a plurality of sample receiving space for receiving a liquid sample, respectively; a plurality of pairs of first and second guiding channels, each pair being in fluid communication with a respective one of the cell recess portions; a number of connecting recess portions each fluidly communicating the first and second guiding channels that respectively extend to a corresponding pair of the cell recess portions such that the liquid sample is able to flow through the sample receiving spaces sequentially; and inlet and outlet channels in fluid communication with the first and second guiding channels that respectively extend to a first one and a last one of the cell recess portions for introducing and discharging the liquid sample into and from the flow cell device, respectively.
摘要翻译：流动池装置形成有：多个单元凹部，其适于与多个传感器装置配合，以分别限制用于接收液体样品的多个样品接收空间; 多对第一和第二引导通道，每对引导通道与相应的单元凹槽部分流体连通; 多个连接凹部，其各自流体地连通所述第一和第二引导通道，所述第一和第二引导通道分别延伸到相应的一对所述单元凹槽部分，使得所述液体样品能够依次流过所述样品接收空间; 以及分别与第一和第二引导通道流体连通的入口和出口通道，其分别延伸到第一个和第二个单元凹槽部分，用于将液体样本分别引入和从流动池装置排出。

10. 发明申请

US20070187360A1 METHOD FOR MAKING A SURFACE ACOUSTIC WAVE DEVICE PACKAGE 失效
标题翻译：制造表面声波装置包装的方法
公开(公告)号：US20070187360A1
公开(公告)日：2007-08-16
申请号：US11675751
申请日：2007-02-16
申请人： Chi-Yen Shen
发明人： Chi-Yen Shen
IPC分类号： C23F1/00 , B44C1/22
CPC分类号： H03H3/08 , C23F1/02 , H01L2224/48091 , H01L2924/16195 , H01L2924/181 , H03H9/0542 , H03H9/059 , H03H9/1085 , H03H9/1092 , H01L2924/00014 , H01L2924/00012
摘要： A method for making a SAW device package includes the steps of: forming a pattern of a metal layer, that defines transmitting and receiving transducers of a SAW die, on a wafer; forming a pattern of a first photo sensitive layer, which defines a peripheral wall of a cap of the SAW die, on the metal layer and the wafer through lithography techniques; forming a pattern of a second photo sensitive layer, which defines a cover wall of the cap of the SAW die, on the first photo sensitive layer through lithography techniques; curing the first and second photo sensitive layers; dicing the wafer into SAW dies; and encapsulating the SAW dies with a molding compound.
摘要翻译：一种用于制造SAW器件封装的方法包括以下步骤：在晶片上形成限定SAW模具的发射和接收换能器的金属层的图案; 通过光刻技术在金属层和晶片上形成限定SAW管芯盖的外围壁的第一光敏层的图案; 通过光刻技术在第一光敏层上形成限定SAW模具的盖的盖壁的第二光敏层的图案; 固化第一和第二光敏层; 将晶片切割成SAW模具; 并用模塑料包封SAW模具。

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