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1. 发明申请

US20060241051A1 Metastin derivatives and use thereof 审中-公开
公开(公告)号：US20060241051A1
公开(公告)日：2006-10-26
申请号：US10540494
申请日：2003-12-26
申请人： Chieko Kitada , Taiji Asami , Naoki Nishizawa , Tetsuya Ohtaki , Naoki Tarui , Hirokazu Matsumoto , Jiro Noguchi , Hisanori Matsui
发明人： Chieko Kitada , Taiji Asami , Naoki Nishizawa , Tetsuya Ohtaki , Naoki Tarui , Hirokazu Matsumoto , Jiro Noguchi , Hisanori Matsui
IPC分类号： A61K38/10 , C07K7/08
CPC分类号： C07K14/47 , A61K38/00
摘要： The present invention provides a metastin derivative in which the amino acids comprising metastin were modified by alternative chemical substituents resulting in metastin derivitives, having excellent blood stability and exhibiting cancer metastasis inhibiting action or cancer growth inhibiting action.

2. 发明申请

US20090318365A1 METASTIN DERIVATIVES AND USE THEREOF 审中-公开
标题翻译：分子衍生物及其用途
公开(公告)号：US20090318365A1
公开(公告)日：2009-12-24
申请号：US12455563
申请日：2009-06-02
申请人： Chieko Kitada , Taiji Asami , Naoko Nishizawa , Tetsuya Ohtaki , Naoki Tarui , Hirokazu Matsumoto , Jiro Noguchi , Hisanori Matsui
发明人： Chieko Kitada , Taiji Asami , Naoko Nishizawa , Tetsuya Ohtaki , Naoki Tarui , Hirokazu Matsumoto , Jiro Noguchi , Hisanori Matsui
IPC分类号： A61K38/08 , C07K7/06
CPC分类号： C07K14/47 , A61K38/00
摘要： The present invention provides a metastin derivative in which the amino acids comprising metastin were modified by alternative chemical substituents resulting in metastin derivatives, having excellent blood stability and exhibiting cancer metastasis inhibiting action or cancer growth inhibiting action.
摘要翻译：本发明提供了一种转氨酶衍生物，其中包含转氨酶的氨基酸被替代的化学取代基修饰，导致转氨酶衍生物，具有优异的血液稳定性和显示出癌转移抑制作用或癌生长抑制作用。

3. 发明申请

US20120015868A1 Metastin derivatives and use thereof 有权
标题翻译： Metastin衍生物及其用途
公开(公告)号：US20120015868A1
公开(公告)日：2012-01-19
申请号：US13135230
申请日：2011-06-29
申请人： Chieko Kitada , Taiji Asami , Naoko Nishizawa , Tetsuya Ohtaki , Naoki Tarui , Hirokazu Matsumoto , Jiro Noguchi , Hisanori Matsui
发明人： Chieko Kitada , Taiji Asami , Naoko Nishizawa , Tetsuya Ohtaki , Naoki Tarui , Hirokazu Matsumoto , Jiro Noguchi , Hisanori Matsui
IPC分类号： A61K38/08 , A61P3/10 , A61P25/28 , A61P15/00 , A61P35/00 , A61P25/00 , A61P3/04 , A61P13/00 , C07K7/06 , A61P9/10
CPC分类号： C07K14/47 , A61K38/00
摘要： The present invention provides a metastin derivative in which the amino acids comprising metastin were modified by alternative chemical substituents resulting in metastin derivitives, having excellent blood stability and exhibiting cancer metastasis inhibiting action or cancer growth inhibiting action.
摘要翻译：本发明提供了一种转氨酶衍生物，其中包含转氨酶的氨基酸被替代的化学取代基修饰，导致转移衍生物，具有优异的血液稳定性和显示出癌转移抑制作用或癌生长抑制作用。

4. 发明授权

US08361968B2 Metastin derivatives and use thereof 有权
标题翻译： Metastin衍生物及其用途
公开(公告)号：US08361968B2
公开(公告)日：2013-01-29
申请号：US13135230
申请日：2011-06-29
申请人： Chieko Kitada , Taiji Asami , Naoko Nishizawa , Tetsuya Ohtaki , Naoki Tarui , Hirokazu Matsumoto
发明人： Chieko Kitada , Taiji Asami , Naoko Nishizawa , Tetsuya Ohtaki , Naoki Tarui , Hirokazu Matsumoto
IPC分类号： A61P35/04 , A61P35/00 , A61K38/08
CPC分类号： C07K14/47 , A61K38/00
摘要： The present invention provides a metastin derivative in which the amino acids comprising metastin were modified by alternative chemical substituents resulting in metastin derivitives, having excellent blood stability and exhibiting cancer metastasis inhibiting action or cancer growth inhibiting action.
摘要翻译：本发明提供了一种转氨酶衍生物，其中包含转氨酶的氨基酸被替代的化学取代基修饰，导致转移衍生物，具有优异的血液稳定性和显示出癌转移抑制作用或癌生长抑制作用。

5. 发明申请

US20060287227A1 Gonadal function improving agents 有权
标题翻译：性腺功能改善剂
公开(公告)号：US20060287227A1
公开(公告)日：2006-12-21
申请号：US10547974
申请日：2004-03-11
申请人： Tetsuya Ohtaki , Hisanori Matsui , Hirokazu Matsumoto , Chieko Kitada
发明人： Tetsuya Ohtaki , Hisanori Matsui , Hirokazu Matsumoto , Chieko Kitada
IPC分类号： A61K48/00 , A61K38/24
CPC分类号： G01N33/689 , A61K31/00 , A61K31/7088 , A61K38/1709
摘要： Metastin, compounds that promote the activity of metastin or its receptors and the like are excellent gonadal function improving agents, ovulation inducers or promoters, gonadotropic hormone secretion promoters, gonadotropic hormone secretion inhibitors, sex hormone secretion promoters, sex hormone secretion inhibitors, etc., and can be used as agents for preventing/treating sterility, hormone-sensitive cancers, endometriosis, etc. Metastin and its receptors are useful for screening for these pharmaceuticals.
摘要翻译：促甲状腺激素分泌抑制剂，雌激素分泌促进剂，性激素分泌抑制剂等的促性腺激素分泌抑制剂，促性腺激素分泌促进剂，性激素分泌抑制剂等的优良性腺功能改善剂，排卵诱导剂或促进剂，促性腺激素分泌促进剂，并且可以用作预防/治疗无菌，激素敏感性癌症，子宫内膜异位症等的药剂.MCastin及其受体可用于筛选这些药物。

6. 发明授权

US07754220B2 Methods of inhibiting secretion of follicle-stimulating hormone and testosterone 有权
标题翻译：抑制促卵泡激素和睾丸激素分泌的方法
公开(公告)号：US07754220B2
公开(公告)日：2010-07-13
申请号：US10547974
申请日：2004-03-11
申请人： Tetsuya Ohtaki , Hisanori Matsui , Hirokazu Matsumoto , Chieko Kitada
发明人： Tetsuya Ohtaki , Hisanori Matsui , Hirokazu Matsumoto , Chieko Kitada
IPC分类号： A61K38/16 , A61K38/17
CPC分类号： G01N33/689 , A61K31/00 , A61K31/7088 , A61K38/1709
摘要： Metastin, compounds that promote the activity of metastin or its receptors and the like are excellent gonadal function improving agents, ovulation inducers or promoters, gonadotropic hormone secretion promoters, gonadotropic hormone secretion inhibitors, sex hormone secretion promoters, sex hormone secretion inhibitors, etc., and can be used as agents for preventing/treating sterility, hormone-sensitive cancers, endometriosis, etc. Metastin and its receptors are useful for screening for these pharmaceuticals.
摘要翻译：促甲状腺激素分泌抑制剂，雌激素分泌促进剂，性激素分泌抑制剂等的促性腺激素分泌抑制剂，促性腺激素分泌促进剂，性激素分泌抑制剂等的优良性腺功能改善剂，排卵诱导剂或促进剂，促性腺激素分泌促进剂，并且可以用作预防/治疗无菌，激素敏感性癌症，子宫内膜异位症等的药剂.MCastin及其受体可用于筛选这些药物。

7. 发明申请

US20110052563A1 GONADAL FUNCTION IMPROVING AGENTS 审中-公开
标题翻译：全功能改善剂
公开(公告)号：US20110052563A1
公开(公告)日：2011-03-03
申请号：US12710864
申请日：2010-02-23
申请人： Tetsuya Ohtaki , Hisanori Matsui , Hirokazu Matsumoto , Chieko Kitada
发明人： Tetsuya Ohtaki , Hisanori Matsui , Hirokazu Matsumoto , Chieko Kitada
IPC分类号： A61K39/395 , A61K38/16 , A61K31/7088 , A61K31/711 , A61P15/08 , A61P15/00 , A61P5/00
CPC分类号： G01N33/689 , A61K31/00 , A61K31/7088 , A61K38/1709
摘要： Metastin, compounds that promote the activity of metastin or its receptors and the like are excellent gonadal function improving agents, ovulation inducers or promoters, gonadotropic hormone secretion promoters, gonadotropic hormone secretion inhibitors, sex hormone secretion promoters, sex hormone secretion inhibitors, etc., and can be used as agents for preventing/treating sterility, hormone-sensitive cancers, endometriosis, etc. Metastin and its receptors are useful for screening for these pharmaceuticals.
摘要翻译：促甲状腺激素分泌抑制剂，雌激素分泌促进剂，性激素分泌抑制剂等的促性腺激素分泌抑制剂，促性腺激素分泌促进剂，性激素分泌抑制剂等的优良性腺功能改善剂，排卵诱导剂或促进剂，促性腺激素分泌促进剂，并且可以用作预防/治疗无菌，激素敏感性癌症，子宫内膜异位症等的药剂.MCastin及其受体可用于筛选这些药物。

8. 发明授权

US5925731A Endothelin antagonist peptides 失效
标题翻译：内皮素拮抗剂肽
公开(公告)号：US5925731A
公开(公告)日：1999-07-20
申请号：US732289
申请日：1996-10-28
申请人： Chieko Kitada , Taiji Asami , Tetsuya Ohtaki , Toshifumi Watanabe
发明人： Chieko Kitada , Taiji Asami , Tetsuya Ohtaki , Toshifumi Watanabe
IPC分类号： A61K38/00 , C07K5/02 , C07K5/103 , C07K14/575 , A61K38/07
CPC分类号： C07K14/57536 , C07K5/0202 , C07K5/101 , A61K38/00
摘要： The peptide derivatives having endothelin receptor-antagonistic action or a salt thereof and medicinal compositions containing them are provided.Since peptide derivatives or a salt thereof of this invention exhibit remarkable endothelin receptor-antagonistic action with low toxicity, they are effective as medicines for prophylaxis and therapy of, for example, cardio- or cerebro-circulatory diseases hepatic diseases and/or renal diseases.
摘要翻译： PCT No.PCT / JP96 / 02778 371日期1996年10月28日第 102（e）1996年10月28日PCT PCT 1996年9月26日PCT公布。公开号WO97 / 11961 日期1997年3月3日提供具有内皮素受体拮抗作用的肽衍生物或其盐和含有它们的药物组合物。由于本发明的肽衍生物或其盐表现出显着的低毒性的内皮素受体拮抗作用，因此它们作为预防和治疗例如心脏或脑循环疾病肝脏疾病和/或肾脏疾病的药物是有效的。

9. 发明授权

US08778871B2 Metastin derivatives and use thereof 有权
标题翻译： Metastin衍生物及其用途
公开(公告)号：US08778871B2
公开(公告)日：2014-07-15
申请号：US12286671
申请日：2008-10-01
申请人： Chieko Kitada , Taiji Asami , Naoki Nishizawa
发明人： Chieko Kitada , Taiji Asami , Naoki Nishizawa
IPC分类号： A61K38/17 , C07K14/47
CPC分类号： C07K14/4703 , A61K38/00
摘要： The invention provides stable metastin derivatives having excellent biological activities (a cancer metastasis suppressing activity, a cancer growth suppressing activity, etc.). By modifying the constituent amino acids of metastin with specific modifying groups, metastin derivatives having more improved blood stability, etc. than native metastin and showing excellent cancer metastasis suppressing activity or cancer growth suppressing activity have been found. Furthermore, it has been found that these metastin derivatives exhibit effects of suppressing gonadotropic hormone secretion, suppressing sex hormone secretion, etc., which are wholly different from the effects heretofore known.
摘要翻译：本发明提供具有优异生物活性（癌转移抑制活性，癌生长抑制活性等）的稳定的转铁蛋白衍生物。已经发现通过用特异性修饰基修饰转氨酶的构成氨基酸，具有比天然转移蛋白更多的改善的血液稳定性的转氨酶衍生物，并且显示出优异的癌症转移抑制活性或癌症生长抑制活性。此外，已经发现这些转氨酶衍生物表现出抑制促性腺激素分泌，抑制性激素分泌等的作用，其完全不同于迄今已知的效果。

10. 发明授权

US07625869B2 Metastin derivatives and use thereof 失效
标题翻译： Metastin衍生物及其用途
公开(公告)号：US07625869B2
公开(公告)日：2009-12-01
申请号：US11630698
申请日：2005-06-23
申请人： Chieko Kitada , Taiji Asami , Naoki Nishizawa
发明人： Chieko Kitada , Taiji Asami , Naoki Nishizawa
IPC分类号： A61K38/08 , C07K7/06
CPC分类号： C07K14/4703 , A61K38/00
摘要： The invention provides stable metastin derivatives having excellent biological activities (a cancer metastasis suppressing activity, a cancer growth suppressing activity, etc.). By modifying the constituent amino acids of metastin with specific modifying groups, metastin derivatives having more improved blood stability, etc. than native metastin and showing excellent cancer metastasis suppressing activity or cancer growth suppressing activity have been found. Furthermore, it has been found that these metastin derivatives exhibit effects of suppressing gonadotropic hormone secretion, suppressing sex hormone secretion, etc., which are wholly different from the effects heretofore known.
摘要翻译：本发明提供具有优异生物活性（癌转移抑制活性，癌生长抑制活性等）的稳定的转铁蛋白衍生物。已经发现通过用特异性修饰基修饰转氨酶的构成氨基酸，具有比天然转移蛋白更多的改善的血液稳定性的转氨酶衍生物，并且显示出优异的癌症转移抑制活性或癌症生长抑制活性。此外，已经发现这些转氨酶衍生物表现出抑制促性腺激素分泌，抑制性激素分泌等的作用，其完全不同于迄今已知的效果。

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