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1. 发明申请

US20070298127A1 Diazene-bridged crown ether lithium compounds and methods for their use 有权
标题翻译：二亚桥桥冠醚锂化合物及其使用方法
公开(公告)号：US20070298127A1
公开(公告)日：2007-12-27
申请号：US11313513
申请日：2005-12-21
申请人： Paul Vanhoutte , Chi-Ming Che , Kwok-Fai So , Iona Sham
发明人： Paul Vanhoutte , Chi-Ming Che , Kwok-Fai So , Iona Sham
IPC分类号： A61K33/14 , A61P27/06 , C07C245/00 , C07D311/82
CPC分类号： A61K33/00 , A61K31/09 , A61K33/14 , A61K45/06 , A61K2300/00
摘要： This invention provides a method for treating an eye disease in a patient comprising: providing a photosensitive prodrug that releases upon exposure to light an active ingredient to treat the eye disease; administering the prodrug in a pharmaceutically accepted vehicle to the subject, and exposing the eye of the subject to an external light source to cause the prodrug to release the active ingredient. This invention also provides a composition for the treatment of glaucoma, comprising a compound containing a lithium ion-chelated in a crown ether- or aza-crown ether-containing chromene or diazene derivative and a pharmaceutically acceptable carrier.
摘要翻译：本发明提供了一种治疗患者眼部疾病的方法，包括：提供光敏前体药物，其在暴露于光时释放活性成分以治疗眼睛疾病; 在药学上可接受的载体中将前药施用于受试者，并将受试者的眼睛暴露于外部光源以使前药释放活性成分。本发明还提供了用于治疗青光眼的组合物，其包含在含冠醚或氮杂冠醚的色烯或二氮烯衍生物中含有锂离子螯合的化合物和药学上可接受的载体。

2. 发明申请

US20050153164A1 Materials for electroluminescent devices 有权
标题翻译：电致发光器件材料
公开(公告)号：US20050153164A1
公开(公告)日：2005-07-14
申请号：US10753528
申请日：2004-01-09
申请人： Chi-Ming Che , Iona Sham
发明人： Chi-Ming Che , Iona Sham
IPC分类号： C07F5/02 , C07F5/05 , C09K11/06 , H05B33/14 , H05B33/20
CPC分类号： H05B33/14 , C07F5/022 , C09K11/06 , C09K2211/1085 , Y10S428/917
摘要： Materials containing one or more borazine rings are employed as materials for electroluminescent devices. The compounds have molecular structures represented by the following formula: in which R1—R6 are independently a metal; a whole or part of an optionally substituted borazine ring; hydrogen; halogen; hydroxyl; optionally substituted alkyl, cycloalkyl, aryl, acyl, alkoxy, acyloxy, amino, acylamino, aralkyl, cyano, carboxyl, thio, vinyl, styryl, aminocarbonyl, carbamoyl, aryloxycarbonyl, phenoxycarbonyl, or alkoxycarbonyl, as well as recognized donor and acceptor groups. The compounds have high thermal stability as well as hole and electron mobilities.
摘要翻译：使用含有一个或多个环硼氮烷环的材料作为电致发光器件的材料。化合物具有由下式表示的分子结构：其中R 1 -R 6独立地是金属; 全部或部分任选取代的环硼氮烷环; 氢; 卤素; 羟; 任选取代的烷基，环烷基，芳基，酰基，烷氧基，酰氧基，氨基，酰氨基，芳烷基，氰基，羧基，硫代，乙烯基，苯乙烯基，氨基羰基，氨基甲酰基，芳氧基羰基，苯氧基羰基或烷氧基羰基，以及公认的供体和受体基团。这些化合物具有高的热稳定性以及孔和电子迁移率。

3. 发明申请

US20070105952A1 Pharmaceutical composition having a ruthenium oxalato compound and method of using the same 有权
标题翻译：具有草酸钌化合物的药物组合物及其使用方法
公开(公告)号：US20070105952A1
公开(公告)日：2007-05-10
申请号：US11256175
申请日：2005-10-24
申请人： Chi-Ming Che , Raymond Wai-Yin Sun , Ella Lai-Ming Wong
发明人： Chi-Ming Che , Raymond Wai-Yin Sun , Ella Lai-Ming Wong
IPC分类号： A61K31/28
CPC分类号： C07F15/0053 , A61K31/357 , Y02A50/463
摘要： The present invention relates to a pharmaceutical composition comprising one or more of the following ruthenium oxalato compounds I, II, III and IV as an active ingredient. The pharmaceutical composition can be used for the treatment of viral-infected patients or prophylactic treatment of patients at risk from viral infection.
摘要翻译：本发明涉及包含一种或多种以下草酸钌化合物I，II，III和IV作为活性成分的药物组合物。药物组合物可用于治疗病毒感染患者或预防性治疗患有病毒感染风险的患者。

4. 发明授权

US07157155B2 Materials for electroluminescent devices 有权
标题翻译：电致发光器件材料
公开(公告)号：US07157155B2
公开(公告)日：2007-01-02
申请号：US10753528
申请日：2004-01-09
申请人： Chi-Ming Che , Iona Hiu Tung Sham
发明人： Chi-Ming Che , Iona Hiu Tung Sham
IPC分类号： H01L51/54 , H05B33/12
CPC分类号： H05B33/14 , C07F5/022 , C09K11/06 , C09K2211/1085 , Y10S428/917
摘要： Materials containing one or more borazine rings are employed as materials for electroluminescent devices. The compounds have molecular structures represented by the following formula: in which R1–R6 are independently a metal; a whole or part of an optionally substituted borazine ring; hydrogen; halogen; hydroxyl; optionally substituted alkyl, cycloalkyl, aryl, acyl, alkoxy, acyloxy, amino, acylamino, aralkyl, cyano, carboxyl, thio, vinyl, styryl, aminocarbonyl, carbamoyl, aryloxycarbonyl, phenoxycarbonyl, or alkoxycarbonyl, as well as recognized donor and acceptor groups. The compounds have high thermal stability as well as hole and electron mobilities.
摘要翻译：使用含有一个或多个环硼氮烷环的材料作为电致发光器件的材料。化合物具有由下式表示的分子结构：其中R 1 -R 6独立地是金属; 全部或部分任选取代的环硼氮烷环; 氢; 卤素; 羟; 任选取代的烷基，环烷基，芳基，酰基，烷氧基，酰氧基，氨基，酰氨基，芳烷基，氰基，羧基，硫代，乙烯基，苯乙烯基，氨基羰基，氨基甲酰基，芳氧基羰基，苯氧基羰基或烷氧基羰基，以及公认的供体和受体基团。这些化合物具有高的热稳定性以及孔和电子迁移率。

5. 发明申请

US20060175605A1 Organometallic light-emitting material 审中-公开
公开(公告)号：US20060175605A1
公开(公告)日：2006-08-10
申请号：US11401537
申请日：2006-04-10
申请人： Chi-Ming Che , Wei Lu , Michael Chan
发明人： Chi-Ming Che , Wei Lu , Michael Chan
IPC分类号： C07F15/00 , H01L29/08 , H01J1/62
CPC分类号： C07F15/0086 , C07F15/0033 , C09K11/06 , C09K2211/10 , C09K2211/1007 , C09K2211/1029 , C09K2211/1092 , C09K2211/185 , H01L51/006 , H01L51/0071 , H01L51/0081 , H01L51/0087 , H01L51/5016 , H05B33/14 , Y10S428/917
摘要： Disclosed herein are novel light-emitting materials of Formula I and II below. These new complexes are synthesized and found to be sufficiently stable to allow sublimation and vacuum deposition. These new emitters are electrophosphorescent and can be used in organic light-emitting devices (OLEDs) for device elements capable of emitting light of color ranging from orange to red with high-efficiency and high-brightness. wherein E=Group 16 elements (including sulphur); M=Group 10 metal (including platinum); R1-R14 are each independently selected from the group consisting of hydrogen; halogen; alkyl; substituted alkyl; aryl; substituted aryl, with substituents selected from the group consisting of halogen, lower alkyl and recognized donor and acceptor groups. R1 can also be selected from (C≡C)nR15, where (C≡C) represents a carbon-carbon triple bond (acetylide group), n is selected from 1 to 10, and R15 is selected from alkyl, aryl, substituted aryl, and tri(alkyl)silyl.

6. 发明申请

US20050209470A1 Diastereoselective epoxidation of allylically substituted alkenes using metalloporphyrin catalysts 有权
标题翻译：使用金属卟啉催化剂对烯丙基取代的烯烃进行非对称选择性环氧化
公开(公告)号：US20050209470A1
公开(公告)日：2005-09-22
申请号：US11080436
申请日：2005-03-16
申请人： Chi-Ming Che , Man-Kin Wong
发明人： Chi-Ming Che , Man-Kin Wong
IPC分类号： B01J31/18 , B01J31/26 , B01J31/28 , B01J31/32 , C07D301/06 , C07D301/12 , C07D301/14 , C07D301/19 , C07D405/06 , C07D487/22
CPC分类号： B01J31/182 , B01J31/1815 , B01J2231/72 , B01J2531/025 , B01J2531/46 , B01J2531/57 , B01J2531/64 , B01J2531/72 , B01J2531/74 , B01J2531/821 , B01J2531/822 , B01J2531/825 , B01J2531/827 , B01J2531/842 , C07D301/12 , C07D301/14 , C07D301/19 , C07D405/06
摘要： Diastereoselective epoxidation of allylically substituted alkenes using metalloporphyrins as catalyst provides high trans-selectivities (i.e., trans-:cis-epoxide ratio). A diversity of cycloalkenes bearing different allylic substituents are shown to be efficiently epoxidized to afford the corresponding trans-epoxides with excellent trans-selectivities (up to >98%) and good yields (up to 99%). Acyclic allylic alkenes bearing different allylic substituents are efficiently epoxidized to afford the corresponding erythro-epoxides with good erythro-selectivities. The metalloporphyrin-catalyzed reactions exhibit up to 20 times higher trans-selectivities than the conventional method using m-chloroperoxybenzoic acid as oxidant.
摘要翻译：使用金属卟啉作为催化剂的烯丙基取代的烯烃的非对映选择性环氧化提供了高的反式选择性（即反式 - 顺式 - 环氧化物比）。显示出具有不同烯丙基取代基的环烯烃的多样性被有效地环氧化以提供具有优异的反式选择性（高达> 98％）和良好产率（高达99％）的相应的反式环氧化物。具有不同烯丙基取代基的非环烯丙基烯烃被有效地环氧化，得到具有良好的红选择性的相应的红环氧化物。与使用间氯过氧苯甲酸作为氧化剂的常规方法相比，金属卟啉催化的反应显示高达20倍的反式选择性。

7. 发明授权

US06653654B1 Electroluminescent materials 有权
标题翻译：电致发光材料
公开(公告)号：US06653654B1
公开(公告)日：2003-11-25
申请号：US10137272
申请日：2002-05-01
申请人： Chi-Ming Che
发明人： Chi-Ming Che
IPC分类号： C07D22102
CPC分类号： C07D213/38 , C07D213/30 , C07D471/04 , C09K11/06 , C09K2211/1007 , C09K2211/1011 , C09K2211/1014 , C09K2211/1029 , C09K2211/1044 , C09K2211/185 , H01L51/0087 , H01L51/5012 , Y10S428/917
摘要： Highly luminous, thermally stable and moisture-resistant light-emitting material derived from quadridentate ONNO-type ligands and a Group 10 metal were employed as emissive dopants in organic light-emitting devices. The dopants have molecular structures represented by the formula I and II: wherein M represents Group 10 metal (including platinum) and R1-R14 are each independantly selected from the group consisting of hydrogen; halogen; alkyl; substituted alkyl; aryl; substituted aryl, with substitutents selected from the group consisting of halogen, lower alkyl and recognized donor and acceptor groups.
摘要翻译：衍生自三元ONNO型配体和10族金属的高发光，热稳定和防潮的发光材料用作有机发光器件中的发射掺杂剂。掺杂剂具有由式I和II表示的分子结构：其中M表示第10族金属（包括铂），R1-R14各自独立地选自氢; 卤素; 烷基; 取代的烷基; 芳基; 取代的芳基，具有选自卤素，低级烷基和识别的供体和受体基团的取代基。

8. 发明授权

US08778830B2 Solid supported gold nanoparticles, methods of use thereof, and methods for making same 有权
标题翻译：固体负载金纳米颗粒，其使用方法及其制备方法
公开(公告)号：US08778830B2
公开(公告)日：2014-07-15
申请号：US13107043
申请日：2011-05-13
申请人： Chi-Ming Che , Man-Ho So
发明人： Chi-Ming Che , Man-Ho So
IPC分类号： B01J21/00 , B01J23/02 , B01J23/04
CPC分类号： C07D215/20 , B01J23/52 , B01J35/002 , B01J35/006 , B01J35/023 , B82Y30/00 , C07D215/06 , C07D221/10 , C07D471/06 , C07D491/056 , C07D513/04
摘要： Solid-supported gold nanoparticles for use as a catalyst for the synthesis of quinolines from anilines and aldehydes using oxygen as an oxidant are provided. Also provided are a method for the preparation of SiO2-supported gold nanoparticles by in situ deposition of gold nanoparticles to silica gel and a method for synthesizing quinolines from anilines and aldehydes using oxygen as an oxidant.
摘要翻译：提供了用作氧气作为氧化剂从苯胺和醛合成喹啉的催化剂的固体金属纳米粒子。还提供了通过将金纳米颗粒原位沉积到硅胶上制备SiO 2负载的金纳米颗粒的方法，以及使用氧作为氧化剂从苯胺和醛合成喹啉的方法。

9. 发明授权

US07482478B2 Diastereoselective epoxidation of allylically substituted alkenes using metalloporphyrin catalysts 有权
标题翻译：使用金属卟啉催化剂对烯丙基取代的烯烃进行非对称选择性环氧化
公开(公告)号：US07482478B2
公开(公告)日：2009-01-27
申请号：US11080436
申请日：2005-03-16
申请人： Chi-Ming Che , Man-Kin Wong
发明人： Chi-Ming Che , Man-Kin Wong
IPC分类号： C07D301/12
CPC分类号： B01J31/182 , B01J31/1815 , B01J2231/72 , B01J2531/025 , B01J2531/46 , B01J2531/57 , B01J2531/64 , B01J2531/72 , B01J2531/74 , B01J2531/821 , B01J2531/822 , B01J2531/825 , B01J2531/827 , B01J2531/842 , C07D301/12 , C07D301/14 , C07D301/19 , C07D405/06
摘要： Diastereoselective epoxidation of allylically substituted alkenes using metalloporphyrins as catalyst provides high trans-selectivities (i.e., trans-:cis-epoxide ratio). A diversity of cycloalkenes bearing different allylic substituents are shown to be efficiently epoxidized to afford the corresponding trans-epoxides with excellent trans-selectivities (up to >98%) and good yields (up to 99%). Acyclic allylic alkenes bearing different allylic substituents are efficiently epoxidized to afford the corresponding erythro-epoxides with good erythro-selectivities. The metalloporphyrin-catalyzed reactions exhibit up to 20 times higher trans-selectivities than the conventional method using m-chloroperoxybenzoic acid as oxidant.
摘要翻译：使用金属卟啉作为催化剂的烯丙基取代的烯烃的非对映选择性环氧化提供了高的反式选择性（即反式 - 顺式 - 环氧化物比）。显示出具有不同烯丙基取代基的环烯烃的多样性被有效地环氧化以提供具有优异的反式选择性（高达> 98％）和良好产率（高达99％）的相应的反式环氧化物。具有不同烯丙基取代基的非环烯丙基烯烃被有效地环氧化，得到具有良好的红选择性的相应的红环氧化物。与使用间氯过氧苯甲酸作为氧化剂的常规方法相比，金属卟啉催化的反应显示高达20倍的反式选择性。

10. 发明授权

US07468434B2 Diazene-bridge crown ether lithium compounds and methods for their use 有权
标题翻译：二氮烯桥冠醚锂化合物及其使用方法
公开(公告)号：US07468434B2
公开(公告)日：2008-12-23
申请号：US11313513
申请日：2005-12-21
申请人： Paul Michel Georges Vanhoutte , Chi-Ming Che , Kwok-Fai So , Iona Hiu Tung Sham
发明人： Paul Michel Georges Vanhoutte , Chi-Ming Che , Kwok-Fai So , Iona Hiu Tung Sham
IPC分类号： C07D225/00
CPC分类号： A61K33/00 , A61K31/09 , A61K33/14 , A61K45/06 , A61K2300/00
摘要： This invention provides a method for treating an eye disease in a patient comprising: providing a photosensitive prodrug that releases upon exposure to light an active ingredient to treat the eye disease; administering the prodrug in a pharmaceutically accepted vehicle to the subject, and exposing the eye of the subject to an external light source to cause the prodrug to release the active ingredient. This invention also provides a composition for the treatment of glaucoma, comprising a compound containing a lithium ion-chelated in a crown ether- or aza-crown ether-containing chromene or diazene derivative and a pharmaceutically acceptable carrier.
摘要翻译：本发明提供了一种治疗患者眼部疾病的方法，包括：提供光敏前体药物，其在暴露于光时释放活性成分以治疗眼睛疾病; 在药学上可接受的载体中将前药施用于受试者，并将受试者的眼睛暴露于外部光源以使前药释放活性成分。本发明还提供了用于治疗青光眼的组合物，其包含在含冠醚或氮杂冠醚的色烯或二氮烯衍生物中含有锂离子螯合的化合物和药学上可接受的载体。

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