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1. 发明授权

US08756797B2 Pressure-sensitive cover installer 有权
标题翻译：压敏盖安装
公开(公告)号：US08756797B2
公开(公告)日：2014-06-24
申请号：US13095924
申请日：2011-04-28
申请人： Chi-An Yu , Yan-Hao Li , Shi-Hong Lai , Zhi-Qiang Zhang
发明人： Chi-An Yu , Yan-Hao Li , Shi-Hong Lai , Zhi-Qiang Zhang
IPC分类号： B23P21/00
CPC分类号： G01L5/0085 , B32B37/10 , B32B2457/00 , G01L5/0038
摘要： A pressure-sensitive cover installer includes a base, a fixing body defining a recessed portion for receiving a main body, a support portion, an air cylinder movably connected to the support portion, a positioning fixture defining a number of through holes therein, and for receiving a number of covers, a controller, a motor for controlling movement of the air cylinder, a pressure sensing member fixed below the air cylinder, and a display. The air cylinder is forced by the motor to drive the pressure sensing member to press the covers onto the main body; the main body resists the pressure sensing member to generate a pressure of a resistance. The pressure sensing member senses the pressure of the resistance to generate a pressure signal to the controller. The controller analyzes the pressure signal to generate a pressure value to be displayed on the display.
摘要翻译：压敏盖安装件包括底座，限定用于接收主体的凹部的固定体，支撑部，可移动地连接到支撑部的气缸，在其中限定多个通孔的定位夹具，接收多个盖，控制器，用于控制气缸的运动的马达，固定在气缸下方的压力感测构件和显示器。气缸被电动机驱动以驱动压力感测构件将盖子压到主体上; 主体抵抗压力感测构件以产生电阻的压力。压力感测构件感测电阻的压力以向控制器产生压力信号。控制器分析压力信号以产生要显示在显示器上的压力值。

2. 发明授权

US07160120B2 Electrical connector having strengthened members 失效
标题翻译：具有加强构件的电连接器
公开(公告)号：US07160120B2
公开(公告)日：2007-01-09
申请号：US11159981
申请日：2005-06-22
申请人： Zhi-Qiang Zhang , Ning Wang
发明人： Zhi-Qiang Zhang , Ning Wang
IPC分类号： H01R12/00
CPC分类号： H01R13/6581
摘要： An electrical connector includes an insulative housing (1), a plurality of terminals (2) retained in the insulative housing, a shell (3) and a pair of strengthened members (4). The insulative housing comprises a base portion (10) and a terminal supporting portion (12) extending forwardly from the base portion. Each terminal has a contact portion (20) extending along the terminal supporting portion. The shell is attached to the insulative housing and has a mating frame (31) surrounding the contact portions and the terminal supporting portion to define a mating cavity therebetween. Strengthened members are buried at opposite ends of the terminal supporting portion.
摘要翻译：电连接器包括绝缘壳体（1），保持在绝缘壳体中的多个端子（2），壳体（3）和一对加强构件（4）。绝缘壳体包括基部（10）和从基部向前延伸的端子支撑部（12）。每个端子具有沿着端子支撑部分延伸的接触部分（20）。壳体附接到绝缘壳体并且具有围绕接触部分和端子支撑部分的配合框架（31），以在它们之间限定配合腔室。加强构件被埋在端子支撑部分的相对端。

3. 发明授权

US08344112B2 IGF-1R specific antibodies useful in the detection and diagnosis of cellular proliferative disorders 失效
标题翻译：可用于检测和诊断细胞增殖性疾病的IGF-1R特异性抗体
公开(公告)号：US08344112B2
公开(公告)日：2013-01-01
申请号：US12670863
申请日：2008-07-25
申请人： Liliane Goetsch , David Brooks , Michael Chastain , Zhi-Qiang Zhang , Nathalie Corvaia
发明人： Liliane Goetsch , David Brooks , Michael Chastain , Zhi-Qiang Zhang , Nathalie Corvaia
IPC分类号： C07K16/00 , A61K39/395
CPC分类号： G01N33/574 , C07K16/2863 , C07K2317/56 , C07K2317/565 , C07K2317/76 , G01N2333/71
摘要： The present invention relates to mammalian antibodies, designated 12B1 and antigen-binding portions thereof that specifically bind to insulin-like growth factor I receptor (IGF-IR), preferably human IGF-IR. Also included are chimeric, bispecific, derivatized, single chain antibodies derived from the antibodies disclosed herein. Nucleic acid molecules encoding the mammalian antibodies as well as methods of use thereof are also disclosed. Also included are pharmaceutical compositions comprising these antibodies and methods of using the antibodies and compositions thereof for treatment and diagnosis of pathological hyperproliferative oncogenic disorders associated with expression of IGF-1R.
摘要翻译：本发明涉及特异性结合胰岛素样生长因子I受体（IGF-1R）的哺乳动物抗体，其命名为12B1及其抗原结合部分，优选人IGF-1R。还包括衍生自本文公开的抗体的嵌合，双特异性，衍生的单链抗体。还公开了编码哺乳动物抗体的核酸分子及其使用方法。还包括包含这些抗体的药物组合物和使用抗体及其组合物治疗和诊断与IGF-1R表达相关的病理性过度增殖性致癌性疾病的方法。

4. 外观设计

USD573542S1 Electrical connector 有权
公开(公告)号：USD573542S1
公开(公告)日：2008-07-22
申请号：US29292655
申请日：2007-10-23
申请人： Ye-Fei Yu , Zhi-Qiang Zhang
设计人： Ye-Fei Yu , Zhi-Qiang Zhang

5. 发明申请

US20100215573A1 IGF-1R SPECIFIC ANTIBODIES USEFUL IN THE DETECTION AND DIAGNOSIS OF CELLULAR PROLIFERATIVE DISORDERS 失效
标题翻译： IGF-1R特异性抗体用于细胞增生性疾病的检测和诊断
公开(公告)号：US20100215573A1
公开(公告)日：2010-08-26
申请号：US12670863
申请日：2008-07-25
申请人： Liliane Goetsch , David Brooks , Michael Chastain , Zhi-Qiang Zhang , Nathalie Corvaia
发明人： Liliane Goetsch , David Brooks , Michael Chastain , Zhi-Qiang Zhang , Nathalie Corvaia
IPC分类号： A61K51/00 , C07K16/18 , C12N5/20 , G01N33/53 , G01N33/574 , A61K49/00 , A61P35/00
CPC分类号： G01N33/574 , C07K16/2863 , C07K2317/56 , C07K2317/565 , C07K2317/76 , G01N2333/71
摘要： The present invention relates to mammalian antibodies, designated 12B1 and antigen-binding portions thereof that specifically bind to insulin-like growth factor I receptor (IGF-IR), preferably human IGF-IR. Also included are chimeric, bispecific, derivatized, single chain antibodies derived from the antibodies disclosed herein. Nucleic acid molecules encoding the mammalian antibodies as well as methods of use thereof are also disclosed. Also included are pharmaceutical compositions comprising these antibodies and methods of using the antibodies and compositions thereof for treatment and diagnosis of pathological hyperproliferative oncogenic disorders associated with expression of IGf-1R.
摘要翻译：本发明涉及特异性结合胰岛素样生长因子I受体（IGF-1R）的哺乳动物抗体，其命名为12B1及其抗原结合部分，优选人IGF-1R。还包括衍生自本文公开的抗体的嵌合，双特异性，衍生的单链抗体。还公开了编码哺乳动物抗体的核酸分子及其使用方法。还包括包含这些抗体的药物组合物和使用抗体及其组合物治疗和诊断与IGf-1R表达相关的病理性过度增生性致癌性疾病的方法。

6. 发明申请

US20060105630A1 Electrical connector having strengthened members 失效
标题翻译：具有加强构件的电连接器
公开(公告)号：US20060105630A1
公开(公告)日：2006-05-18
申请号：US11159981
申请日：2005-06-22
申请人： Zhi-Qiang Zhang , Ning Wang
发明人： Zhi-Qiang Zhang , Ning Wang
IPC分类号： H01R13/648
CPC分类号： H01R13/6581
摘要： An electrical connector includes an insulative housing (1), a plurality of terminals (2) retained in the insulative housing, a shell (3) and a pair of strengthened members (4). The insulative housing comprises a base portion (10) and a terminal supporting portion (12) extending forwardly from the base portion. Each terminal has a contact portion (20) extending along the terminal supporting portion. The shell is attached to the insulative housing and has a mating frame (31) surrounding the contact portions and the terminal supporting portion to define a mating cavity therebetween. Strengthened members are buried at opposite ends of the terminal supporting portion.
摘要翻译：电连接器包括绝缘壳体（1），保持在绝缘壳体中的多个端子（2），壳体（3）和一对加强构件（4）。绝缘壳体包括基部（10）和从基部向前延伸的端子支撑部（12）。每个端子具有沿着端子支撑部分延伸的接触部分（20）。壳体附接到绝缘壳体并且具有围绕接触部分和端子支撑部分的配合框架（31），以在它们之间限定配合腔室。加强构件被埋在端子支撑部分的相对端。

7. 发明申请

US20220404338A1 IN VITRO CELL BASED POTENCY ASSAY 有权
公开(公告)号：US20220404338A1
公开(公告)日：2022-12-22
申请号：US17779427
申请日：2020-11-30
申请人： Peter A. DEPHILLIPS , Nisarg M. PATEL , Jingyuan XU , Zhi-Qiang ZHANG , Merck Sharp & Dohme LLC
发明人： Peter A. DePhillips , Nisarg M. Patel , Jingyuan Xu , Zhi-Qiang Zhang
IPC分类号： G01N33/50
摘要： The present disclosure provides an in vitro cell based potency assay to determine the relative potency of a composition, including a pharmaceutical composition, comprising an mRNA encapsulated in a lipid nanoparticle (LNP) as compared to a reference sample. Also provided is a process for releasing or accepting a batch of a pharmaceutical composition comprising an mRNA encapsulated in an LNP using the in vitro cell based potency assay. The methods and processes described comprise (i) transfecting a population of cells with a test sample of the composition, (ii) transfecting a different population of cells with a reference sample of the pharmaceutical composition, wherein the cells in step (ii) are the same cell type as the cells in step (i); (iii) detecting the amount of expression of a polypeptide encoded by the mRNA in the transfected cells; and comparing the amount of expression, thereby determining the relative in vitro potency of the composition.

8. 发明申请

US20130084243A1 IGF-1R SPECIFIC ANTIBODIES USEFUL IN THE DETECTION AND DIAGNOSIS OF CELLULAR PROLIFERATIVE DISORDERS 审中-公开
公开(公告)号：US20130084243A1
公开(公告)日：2013-04-04
申请号：US13688574
申请日：2012-11-29
申请人： Liliane Goetsch , David Brooks , Michael Chastain , Zhi-Qiang Zhang , Nathalie Corvaia
发明人： Liliane Goetsch , David Brooks , Michael Chastain , Zhi-Qiang Zhang , Nathalie Corvaia
IPC分类号： C07K16/28 , G01N33/68
CPC分类号： C07K16/2863 , A61K51/103 , C07K2317/14 , C07K2317/33 , C07K2317/565 , C07K2317/76 , G01N33/57484 , G01N33/68 , G01N2333/72 , G01N2800/52 , G01N2800/56
摘要： The present invention relates to mammalian antibodies, designated 12B1 and antigen-binding portions thereof that specifically bind to insulin-like growth factor I receptor (IGF-IR), preferably human IGF-IR. Also included are chimeric, bispecific, derivatized, single chain antibodies derived from the antibodies disclosed herein. Nucleic acid molecules encoding the mammalian antibodies as well as methods of use thereof are also disclosed. Also included are pharmaceutical compositions comprising these antibodies and methods of using the antibodies and compositions thereof for treatment and diagnosis of pathological hyperproliferative oncogenic disorders associated with expression of IGf-1R.

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