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1. 发明申请

US20130089594A1 MACROPOROUS BIOENGINEERED SCAFFOLDS FOR CELL TRANSPLANTATION 审中-公开
标题翻译：用于细胞移植的大面积生物制剂
公开(公告)号：US20130089594A1
公开(公告)日：2013-04-11
申请号：US13641034
申请日：2011-04-12
申请人： Cheryl Stabler Anderson , Eileen Pedraza , Christopher A. Fraker , Peter Buchwald , Norma Sue Kenyon , Luca Inverardi , Antonello Pileggi , Paul Latta , Jeffrey Hubbell , Jessica Weaver , Camillo D. Ricordi
发明人： Cheryl Stabler Anderson , Eileen Pedraza , Christopher A. Fraker , Peter Buchwald , Norma Sue Kenyon , Luca Inverardi , Antonello Pileggi , Paul Latta , Jeffrey Hubbell , Jessica Weaver , Camillo D. Ricordi
IPC分类号： A61L27/18 , A61L27/26
CPC分类号： A61L27/18 , A61K9/0024 , A61K35/12 , A61L27/26 , A61L27/3804 , A61L27/54 , A61L27/56 , A61L2300/414 , C12N5/0676 , C12N2533/30 , C08L83/04
摘要： The present invention provides highly porous, biocompatible and biostable scaffold constructs for improving overall cell engraftment, survival, function and long-term viability. These scaffolds can provide mechanical protection to implanted cells, afford retrievability from a subject, and allow for both intra-device vascularization and a means to spatially distribute the cells within the device. The scaffold surface or material may be modified with one or more different adhesion proteins and optionally other biological factors for enhanced cell adherence and viability. Further, the scaffold surface or material may be modified with one or more agents with slow/sustained release characteristics to aid engraftment, survival, function or long-term viability. Implanted cells of the invention may be insulin-producing cells such as islets.
摘要翻译：本发明提供了高度多孔，生物相容性和生物稳定性的支架构架，用于改善整体细胞移植，存活，功能和长期存活力。这些支架可以为植入细胞提供机械保护，从受试者提供可检索性，并且允许装置内血管化和在装置内空间分配细胞的手段。支架表面或材料可以用一种或多种不同的粘附蛋白和任选的其它生物因子修饰，以增强细胞粘附和活力。此外，支架表面或材料可以用一种或多种具有缓释/持续释放特性的试剂进行修饰以有助于植入，存活，功能或长期存活。本发明的植入细胞可以是胰岛素产生细胞如胰岛。

2. 发明授权

US08702684B2 Therapeutic hybrid implantable devices 有权
标题翻译：治疗性混合植入式装置
公开(公告)号：US08702684B2
公开(公告)日：2014-04-22
申请号：US12524918
申请日：2008-02-01
申请人： Nicholas Bodor , Peter Buchwald , Christopher A. Fraker , Jeffrey Hubbell , Luca Inverardi , Norma Sue Kenyon , Paul Latta , Antonello Pileggi , Cheryl Stabler Anderson , Fabio Grassi , Camillo Ricordi
发明人： Nicholas Bodor , Peter Buchwald , Christopher A. Fraker , Jeffrey Hubbell , Luca Inverardi , Norma Sue Kenyon , Paul Latta , Antonello Pileggi , Cheryl Stabler Anderson , Fabio Grassi , Camillo Ricordi
IPC分类号： A61K9/22 , A61M31/00
CPC分类号： A61F2/022 , A61K35/39 , A61K38/18 , A61K38/185 , A61K38/1866 , A61K38/19 , A61K38/22 , A61K38/55 , A61M5/14244 , A61M5/14276 , A61M5/1452 , A61M2202/097
摘要： A device (10) for receiving implanted biological material includes a mechanoprotective surface (16) defining an adjacent space, an assembly (26, 28) for locally delivering media to said space, and a pump or slow/sustained release reservoir structure (14) operatively coupled to the assembly. The device may comprise an additional plunger body for being disposed in said space. The implanted biological material may be encapsulated or non-encapsulated.
摘要翻译：用于接收植入的生物材料的装置（10）包括限定相邻空间的机械保护表面（16），用于将介质局部输送到所述空间的组件（26,28），以及泵或缓/缓释储存器结构（14）可操作地联接到组件。该装置可以包括用于设置在所述空间中的附加柱塞体。植入的生物材料可以被包封或非包封。

3. 发明申请

US20100204683A1 THERAPEUTIC HYBRID IMPLANTABLE DEVICES 有权
标题翻译：治疗混合植入式装置
公开(公告)号：US20100204683A1
公开(公告)日：2010-08-12
申请号：US12524918
申请日：2008-02-01
申请人： Nicholas Bodor , Peter Buchwald , Christopher A. Fraker , Jeffrey Hubbell , Luca Inverardi , Norma Sue Kenyon , Paul Latta , Antonello Pileggi , Cheryl Stabler Anderson , Fabio Grassi , Camillo Ricordi
发明人： Nicholas Bodor , Peter Buchwald , Christopher A. Fraker , Jeffrey Hubbell , Luca Inverardi , Norma Sue Kenyon , Paul Latta , Antonello Pileggi , Cheryl Stabler Anderson , Fabio Grassi , Camillo Ricordi
IPC分类号： A61M5/14
CPC分类号： A61F2/022 , A61K35/39 , A61K38/18 , A61K38/185 , A61K38/1866 , A61K38/19 , A61K38/22 , A61K38/55 , A61M5/14244 , A61M5/14276 , A61M5/1452 , A61M2202/097
摘要： A device (10) for receiving implanted biological material includes a mechanoprotective surface (16) defining an adjacent space, an assembly (26, 28) for locally delivering media to said space, and a pump or slow/sustained release reservoir structure (14) operatively coupled to the assembly. The device may comprise an additional plunger body for being disposed in said space. The implanted biological material may be encapsulated or non-encapsulated.
摘要翻译：用于接收植入的生物材料的装置（10）包括限定相邻空间的机械保护表面（16），用于将介质局部输送到所述空间的组件（26,28），以及泵或缓/缓释储存器结构（14）可操作地联接到组件。该装置可以包括用于设置在所述空间中的附加柱塞体。植入的生物材料可以被包封或非包封。

4. 发明授权

US08551770B2 Enhanced oxygen cell culture platforms 有权
标题翻译：增强氧气细胞培养平台
公开(公告)号：US08551770B2
公开(公告)日：2013-10-08
申请号：US11775012
申请日：2007-07-09
申请人： Christopher A. Fraker , Juan Dominguez-Bendala , Ricordi Camillo , Luca Inverardi
发明人： Christopher A. Fraker , Juan Dominguez-Bendala , Ricordi Camillo , Luca Inverardi
IPC分类号： C12Q1/02 , C12N1/00
CPC分类号： C12M23/12 , C12M23/04 , C12M23/20 , C12M23/24 , C12M25/04
摘要： Provided is a cell culture apparatus for culturing cells, that provides enhanced oxygen delivery and supply to cells without the need for stirring or sparging. Oxygen diffusion occurs on both sides of the culture vessel, top and bottom. A gas-permeable membrane that includes perfluorocarbons in its composition allows for the rapid, enhanced and uniform transfer of oxygen between the environment of cells or tissues contained in the cell culture container apparatus and the atmosphere of the incubator in which the cell culture apparatus is incubated.
摘要翻译：本发明提供了一种用于培养细胞的细胞培养装置，其提供增强的氧输送和供应到细胞而不需要搅拌或喷射。氧扩散发生在培养容器的两侧，顶部和底部。在其组成中包含全氟化碳的气体渗透膜允许在细胞培养容器装置中包含的细胞或组织的环境和细胞培养装置孵育的培养箱的气氛之间快速，增强和均匀地转移氧气。

5. 发明授权

US06630154B1 Polymer formulations containing perfluorinated compounds for the engineering of cells and tissues for transplantation that improves cell metabolism and survival, and methods for making same 失效
标题翻译：含有全氟化合物用于移植细胞和组织工程改进细胞新陈代谢和存活的聚合物制剂及其制备方法
公开(公告)号：US06630154B1
公开(公告)日：2003-10-07
申请号：US09477466
申请日：2000-01-04
申请人： Christopher Fraker , Luca Inverardi , Marcos Mares-Guia , Camillo Ricordi
发明人： Christopher Fraker , Luca Inverardi , Marcos Mares-Guia , Camillo Ricordi
IPC分类号： A61F202
CPC分类号： A61K31/734 , A61K31/02 , A61K31/715 , A61K31/726 , A61K45/06 , C08B37/0069 , C08B37/0084 , C08K5/02 , C08L5/04 , C08L5/08 , A61K2300/00 , C08L2666/26 , C08L2666/02
摘要： Disclosed and claimed are: a composition including at least one glycosaminoglycan, e.g., CIS, at least one perfluorinated substance and at least one alginate, e.g., sodium alginate, wherein: the at least one glycosaminoglycan and/or the perfluorinated substance and/or the alginate are cross-linked or polymerized, e.g., the alginate is cross-linked or polymerized, for instance by addition of an inorganic salt, such as a calcium salt; or the at least one glycosaminoglycan, the perfluorinated substance and the alginate are covalently bound, e.g., by means of a coupling reaction involving a linker molecule such as DVS; or the at least one glycosaminoglycan and/or the perfluorinated substance and/or the alginate are cross-linked or polymerized, e.g., the alginate is cross-linked or polymerized, for instance by addition of an inorganic salt, such as a calcium salt, and the at least one glycosaminoglycan and the alginate are covalently bound, e.g., by means of a coupling reaction involving a linker molecule such as DVS, and the covalent binding can have been performed prior to cross-linking or polymerizing or vice versa; and, gels comprising the composition; mixtures of such gels or of at least one such gel and at least one such composition; and, methods for making and using such compositions and gels, including products therefrom such as “paints”, sprays, matrices, beads, microcapsules.
摘要翻译：公开和要求保护的是：包含至少一种葡糖胺聚糖（例如CIS），至少一种全氟化物质和至少一种藻酸盐（例如海藻酸钠）的组合物，其中：至少一种糖胺聚糖和/或全氟化物质和/或海藻酸盐是交联或聚合的，例如藻酸盐是交联或聚合的，例如通过加入无机盐如钙盐; 或至少一种糖胺聚糖，全氟化物质和藻酸盐共价结合，例如通过涉及连接分子如DVS的偶联反应; 或至少一种糖胺聚糖和/或全氟化物质和/或藻酸盐进行交联或聚合，例如藻酸盐被交联或聚合，例如通过加入无机盐如钙盐和所述至少一种葡糖胺聚糖和藻酸盐是共价结合的，例如通过涉及连接分子如DVS的偶联反应，并且共价结合可以在交联或聚合之前进行，反之亦然; 和包含该组合物的凝胶; 这种凝胶或至少一种此类凝胶和至少一种此类组合物的混合物; 以及制造和使用这些组合物和凝胶（包括其产品）如“油漆”，喷雾剂，基质，珠粒，微胶囊的方法。

6. 发明授权

US11466255B2 Methods and compositions for converting non-endocrine pancreatic tissue into insulin-producing cells 有权
公开(公告)号：US11466255B2
公开(公告)日：2022-10-11
申请号：US15573870
申请日：2016-05-02
申请人： Juan Dominguez-Bendala , Luca Inverardi , Ricardo L. Pastori , Camillo Ricordi
发明人： Juan Dominguez-Bendala , Luca Inverardi , Ricardo L. Pastori , Camillo Ricordi
IPC分类号： A61K38/18 , A61P5/50 , A61P3/10 , C12N5/071 , A61K48/00 , A61K35/39
摘要： Compositions and methods are provided for generating islet-like cell clusters. The methods include culturing a whole non-islet pancreatic cell discard or cells sorted therefrom with an effective amount of a molecule having Bone Morphogenetic Protein (BMP) activity (e.g., a BMP polypeptide). The effective amount of said molecule having BMP activity (e.g., BMP polypeptide) is sufficient to induce the formation of islet-like cell clusters. The methods further include treating or attenuating insulin-deficiency disorders, including type 1 diabetes. In one non-limiting embodiment, an insulin-deficiency disorder in a subject is treated or attenuated by culturing a whole non-islet pancreatic cell discard or cells sorted therefrom with an effective amount of a molecule having BMP activity (e.g., a BMP polypeptide) such that tho formation of islet-like cell clusters occurs. A therapeutically effective amount of the islet-like cell clusters which produce insulin are then transplanted into a subject in need to treat the insulin-deficiency disorder.

7. 发明申请

US20080009027A1 Enhanced Oxygen Cell Culture Platforms 有权
标题翻译：增强氧细胞培养平台
公开(公告)号：US20080009027A1
公开(公告)日：2008-01-10
申请号：US11775012
申请日：2007-07-09
申请人： Christopher Fraker , Juan Dominguez-Bendala , Ricordi Camillo , Luca Inverardi
发明人： Christopher Fraker , Juan Dominguez-Bendala , Ricordi Camillo , Luca Inverardi
IPC分类号： C12Q1/02 , C12N1/00 , C12N5/06
CPC分类号： C12M23/12 , C12M23/04 , C12M23/20 , C12M23/24 , C12M25/04
摘要： Provided is a cell culture apparatus for culturing cells, that provides enhanced oxygen delivery and supply to cells without the need for stirring or sparging. Oxygen diffusion occurs on both sides of the culture vessel, top and bottom. A gas-permeable membrane that includes perfluorocarbons in its composition allows for the rapid, enhanced and uniform transfer of oxygen between the environment of cells or tissues contained in the cell culture container apparatus and the atmosphere of the incubator in which the cell culture apparatus is incubated.
摘要翻译：本发明提供了一种用于培养细胞的细胞培养装置，其提供增强的氧输送和供应到细胞而不需要搅拌或喷射。氧扩散发生在培养容器的两侧，顶部和底部。在其组成中包含全氟化碳的气体渗透膜允许在细胞培养容器装置中包含的细胞或组织的环境和细胞培养装置孵育的培养箱的气氛之间快速，增强和均匀地转移氧气。

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