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1. 发明申请

US20060009501A1 Materials and methods for immune system stimulation 有权
标题翻译：免疫系统刺激的材料和方法
公开(公告)号：US20060009501A1
公开(公告)日：2006-01-12
申请号：US11178620
申请日：2005-07-11
申请人： P.K. Nair , Steven Melnick , Cheppail Ramachandran
发明人： P.K. Nair , Steven Melnick , Cheppail Ramachandran
IPC分类号： A61K31/428
CPC分类号： C07H1/08 , C08B37/0009
摘要： The subject invention concerns a novel polysaccharide. RR1 is an α-D-glucan polysaccharide composed of a (1→4) linked back bone and (1→6) linked branches, which has been isolated from a medicinal herb, Tinospora cordifolia. RR1 exhibits unique immune-stimulating properties, is non-cytotoxic, and non-proliferating to normal lymphocytes, as well as tumor cell lines. The subject invention also concerns compositions containing an RR1 compound and methods for modulating an immune response in a subject using RR1 compounds. The present invention also provides methods for the use of an RR1 compound in conjunction with an antigen to stimulate an immune response, the RR1 compound providing an adjuvant-like activity in the generation of a Th1-type immune response to the antigen.
摘要翻译：本发明涉及新型多糖。 RR1是由药草（Tinospora cordifolia）分离出的（1-> 4）连接的背骨和（1-> 6）连接的分支组成的α-D-葡聚糖多糖。 RR1具有独特的免疫刺激性质，是非细胞毒性的，并且不增殖至正常淋巴细胞，以及肿瘤细胞系。本发明还涉及含有RR1化合物的组合物和使用RR1化合物调节受试者的免疫应答的方法。本发明还提供了使用RR1化合物与抗原结合以刺激免疫应答的方法，RR1化合物在产生针对抗原的Th1型免疫应答中具有佐剂样活性。

2. 发明申请

US20060167097A1 Compositions and uses of Amooranin compounds 审中-公开
标题翻译：氨基甜菜碱化合物的组成和用途
公开(公告)号：US20060167097A1
公开(公告)日：2006-07-27
申请号：US11106841
申请日：2005-04-15
申请人： Cheppail Ramachandran , P.K. Nair , Steven Melnick
发明人： Cheppail Ramachandran , P.K. Nair , Steven Melnick
IPC分类号： A61K31/20 , C07C61/29
CPC分类号： C07J63/008
摘要： Amooranin (AMR) has been found to cause tumor cell death through G2/m cell cycle arrest, caspase activation, and apoptosis. Furthermore, it has been demonstrated that AMR is a substrate for P-glycoprotein. Based on these activities, AMR compounds can be used in the treatment of a number of diseases in which aberrant cellular proliferation occurs such as drug-sensitive and drug-resistant cancers, autoimmune disorders, and inflammatory diseases.
摘要翻译：已发现Amooranin（AMR）通过G 2/2细胞周期停滞，胱天蛋白酶激活和凋亡引起肿瘤细胞死亡。此外，已经证明AMR是P-糖蛋白的底物。基于这些活动，AMR化合物可用于治疗许多发生异常细胞增殖的疾病，如药物敏感和耐药性癌症，自身免疫性疾病和炎性疾病。

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