专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明公开

US20230287032A1 SYNTHESIS OF FLUORINATED NUCLEOTIDES 审中-公开
公开(公告)号：US20230287032A1
公开(公告)日：2023-09-14
申请号：US18040679
申请日：2021-08-11
申请人： Cheol Keun CHUNG , Zhijian LIU , Peter E. MALIGRES , Edna MAO , Jennifer V. OBLIGACION , Eric M. PHILLIPS , Michael PIRNOT , Marc POIRIER , Zhiguo Jake SONG , Tao WANG , Merck Sharp & Dohme LLC
发明人： Cheol Keun Chung , Zhijian Liu , Peter E. Maligres , Edna Mao , Jennifer V. Obligacion , Eric M. Phillips , Michael Pirnot , Marc Poirier , Zhiguo Jake Song , Tao Wang
IPC分类号： C07H19/16
CPC分类号： C07H19/16
摘要： The present invention relates to efficient processes useful in the preparation of fluorinated nucleosides, such as (O—{[(2R,3R,4S,5R)-5-(6-amino-9H-purin-9-yl)-4-fluoro-3-hydroxyoxolan-2-yl]methyl}O,O-dihydrogen phosphorothioate, also known as 2′-(S)-fluoro-thio-adenosine monophosphate or 2′-F-thio-AMP. Such fluorinated nucleosides may be useful as a biologically active compound and or as an intermediate for the synthesis of more complex biologically active compounds. The present invention also encompasses intermediates useful in the disclosed synthetic processes and the methods of their preparation.

2. 发明公开

US20240182511A1 NOVEL FORMS OF CYCLIC DINUCLEOTIDE COMPOUNDS 审中-公开
公开(公告)号：US20240182511A1
公开(公告)日：2024-06-06
申请号：US18552676
申请日：2022-04-04
申请人： Stephanus AXNANDA , Zachary E. DANCE , David J. LAMBERTO , Zhijian LIU , Feng Peng , Marc POIRIER , Matthew A. WINSTON , Merck Sharp & Dohme LLC
发明人： Stephanus Axnanda , Zachary E. Dance , David J. Lamberto , Zhijian Liu , Feng Peng , Marc Poirier , Matthew S. Winston
IPC分类号： C07H21/00 , A61K31/7084
CPC分类号： C07H21/00 , A61K31/7084
摘要： Novel forms of 2-amino-9-[(2R,5R,7R,8S,10R,12aR,14R,15S,15aR,16R)-14-(6-amino-9H-purin-9)-yl)-15,16-difluoro-2,10-dihydroxy-2,10-disulfidooctahydro-12H-5.8-methanofuro[3,2-1][1,3,6,9,11,2,10]pentaoxa-diphosphacyclotetradecin-7-yl]-1,9-dihydro-6H-purin-6-one, which include crystalline salts and hydrates of 2-amino-9)-[(2R,5R,7R,8,S,10R,12aR,14R,15S,15aR,16R)-14-(6-amino-9H-purin-9-yl)-15,16-difluoro-2,10-dihydroxy-2,10-disulfido-octahydro-12H-5,8-methanofuro[3,2-1][1,3,6,9,11,2,10]pentaoxa-diphosphacyclotetradecin-7-yl]-1,9-dihydro-6H-purin-6-one, may be useful as inductors of type I interferon production, specifically as STING active agents.

3. 发明授权

US08618314B2 Exo- and diastereo-selective synthesis of himbacine analogs 有权
标题翻译：烟草类似物的外切和非对映选择性合成
公开(公告)号：US08618314B2
公开(公告)日：2013-12-31
申请号：US13563136
申请日：2012-07-31
申请人： George G. Wu , Anantha Sudhakar , Tao Wang , Ji Xie , Frank X. Chen , Marc Poirier , Mingsheng Huang , Vijay Sabesan , Daw-long Kwok , Jian Cui , Xiaojing Yang , Tiruvettipuram K. Thiruvengadam , Jing Liao , Illia Zavialov , Hoa N. Nguyen , Ngiap Kie Lim
发明人： George G. Wu , Anantha Sudhakar , Tao Wang , Ji Xie , Frank X. Chen , Marc Poirier , Mingsheng Huang , Vijay Sabesan , Daw-long Kwok , Jian Cui , Xiaojing Yang , Tiruvettipuram K. Thiruvengadam , Jing Liao , Illia Zavialov , Hoa N. Nguyen , Ngiap Kie Lim
IPC分类号： C07D307/92
CPC分类号： C07D263/56 , C07C69/606 , C07C69/732 , C07C201/10 , C07C201/12 , C07C205/44 , C07C205/55 , C07C231/10 , C07C231/12 , C07C235/28 , C07C303/32 , C07C309/08 , C07C2601/16 , C07D277/64 , C07D307/92 , C07D333/56 , C07D405/06 , C07D413/06 , C07D417/06 , C07F7/1804 , C07F9/58 , Y02P20/55 , C07C233/28
摘要： This application discloses a novel process for the preparation of himbacine analogs useful as thrombin receptor antagonists. The process is based in part on the use of a base-promoted dynamic epimerization of a chiral nitro center. The chemistry taught herein can be exemplified by the following:
摘要翻译：本申请公开了一种制备可用作凝血酶受体拮抗剂的烟肼类似物的新方法。该方法部分基于使用手性硝基中心的碱促进的动态差向异构化。本文教导的化学结构可以举例说明如下：

4. 发明授权

US07605275B2 Exo- and diastereo- selective syntheses of himbacine analogs 有权
标题翻译：烟草类似物的外切和非对映选择性合成
公开(公告)号：US07605275B2
公开(公告)日：2009-10-20
申请号：US11331324
申请日：2006-01-12
申请人： Frank Xing Chen , Marc Poirier , Mingsheng Huang , Vijay Sabesan , George Wu , Anantha R. Sudhakar , Tao Wang , Ji Xie , Jing Liao , Ilia A. Zavialov , Hoa N. Nguyen , Ngiap Kie Lim , Daw-long Kwok , Jian Cui , Xiaojing Yang , Tiruvettipuram K. Thiruvengadam
发明人： Frank Xing Chen , Marc Poirier , Mingsheng Huang , Vijay Sabesan , George Wu , Anantha R. Sudhakar , Tao Wang , Ji Xie , Jing Liao , Ilia A. Zavialov , Hoa N. Nguyen , Ngiap Kie Lim , Daw-long Kwok , Jian Cui , Xiaojing Yang , Tiruvettipuram K. Thiruvengadam
IPC分类号： C07D307/92
CPC分类号： C07D263/56 , C07C69/606 , C07C69/732 , C07C201/10 , C07C201/12 , C07C205/44 , C07C205/55 , C07C231/10 , C07C231/12 , C07C235/28 , C07C303/32 , C07C309/08 , C07C2601/16 , C07D277/64 , C07D307/92 , C07D333/56 , C07D405/06 , C07D413/06 , C07D417/06 , C07F7/1804 , C07F9/58 , Y02P20/55 , C07C233/28
摘要： This application discloses a novel process for the preparation of himbacine analogs useful as thrombin receptor antagonists. The process is based in part on the use of a base-promoted dynamic epimerization of a chiral nitro center. The chemistry taught herein can be exemplified by the following:
摘要翻译：本申请公开了一种制备可用作凝血酶受体拮抗剂的烟肼类似物的新方法。该方法部分基于使用手性硝基中心的碱促进的动态差向异构化。本文教导的化学结构可以举例说明如下：

5. 发明授权

US08258319B2 Exo- and diastereo- selective synthesis of himbacine analogs 有权
标题翻译：烟草类似物的外切和非对映选择性合成
公开(公告)号：US08258319B2
公开(公告)日：2012-09-04
申请号：US13168029
申请日：2011-06-24
申请人： George G. Wu , Anantha Sudhakar , Tao Wang , Ji Xie , Frank X. Chen , Marc Poirier , Mingsheng Huang , Vijay Sabesan , Daw-long Kwok , Jian Cui , Xiaojing Yang , Tiruvettipuram K. Thiruvengadam , Jing Liao , Ilia Zavialov , Hoa N. Nguyen , Ngiap Kie. Lim
发明人： George G. Wu , Anantha Sudhakar , Tao Wang , Ji Xie , Frank X. Chen , Marc Poirier , Mingsheng Huang , Vijay Sabesan , Daw-long Kwok , Jian Cui , Xiaojing Yang , Tiruvettipuram K. Thiruvengadam , Jing Liao , Ilia Zavialov , Hoa N. Nguyen , Ngiap Kie. Lim
IPC分类号： C07D307/92
CPC分类号： C07D263/56 , C07C69/606 , C07C69/732 , C07C201/10 , C07C201/12 , C07C205/44 , C07C205/55 , C07C231/10 , C07C231/12 , C07C235/28 , C07C303/32 , C07C309/08 , C07C2601/16 , C07D277/64 , C07D307/92 , C07D333/56 , C07D405/06 , C07D413/06 , C07D417/06 , C07F7/1804 , C07F9/58 , Y02P20/55 , C07C233/28
摘要： This application discloses a novel process for the preparation of himbacine analogs useful as thrombin receptor antagonists. The process is based in part on the use of a base-promoted dynamic epimerization of a chiral nitro center. The chemistry taught herein can be exemplified by the following:
摘要翻译：本申请公开了一种制备可用作凝血酶受体拮抗剂的烟肼类似物的新方法。该方法部分基于使用手性硝基中心的碱促进的动态差向异构化。本文教导的化学结构可以举例说明如下：

6. 发明授权

US07989653B2 Exo- and diastereo-selective syntheses of himbacine analogs 有权
标题翻译：烟草类似物的外切和非对映选择性合成
公开(公告)号：US07989653B2
公开(公告)日：2011-08-02
申请号：US12505079
申请日：2009-07-17
申请人： George G. Wu , Anantha Sudhakar , Tao Wang , Ji Xie , Frank X. Chen , Marc Poirier , Mingsheng Huang , Vijay Sabesan , Daw-Iong Kwok , Jian Cui , Xiaojing Yang , Tiruvettipuram K. Thiruvengadam , Jing Liao , Ilia Zavialov , Hoa N. Nguyen , Ngiap Kie Lim
发明人： George G. Wu , Anantha Sudhakar , Tao Wang , Ji Xie , Frank X. Chen , Marc Poirier , Mingsheng Huang , Vijay Sabesan , Daw-Iong Kwok , Jian Cui , Xiaojing Yang , Tiruvettipuram K. Thiruvengadam , Jing Liao , Ilia Zavialov , Hoa N. Nguyen , Ngiap Kie Lim
IPC分类号： C07C69/608
CPC分类号： C07D263/56 , C07C69/606 , C07C69/732 , C07C201/10 , C07C201/12 , C07C205/44 , C07C205/55 , C07C231/10 , C07C231/12 , C07C235/28 , C07C303/32 , C07C309/08 , C07C2601/16 , C07D277/64 , C07D307/92 , C07D333/56 , C07D405/06 , C07D413/06 , C07D417/06 , C07F7/1804 , C07F9/58 , Y02P20/55 , C07C233/28
摘要： This application discloses a novel process for the preparation of himbacine analogs useful as thrombin receptor antagonists. The process is based in part on the use of a base-promoted dynamic epimerization of a chiral nitro center. The chemistry taught herein can be exemplified by the following:
摘要翻译：本申请公开了一种制备可用作凝血酶受体拮抗剂的烟肼类似物的新方法。该方法部分基于使用手性硝基中心的碱促进的动态差向异构化。本文教导的化学结构可以举例说明如下：

7. 发明申请

US20060247450A1 Exo- and diastereo- selective syntheses of himbacine analogs 有权
公开(公告)号：US20060247450A1
公开(公告)日：2006-11-02
申请号：US11331324
申请日：2006-01-12
申请人： George Wu , Anantha Sudhakar , Tao Wang , Ji Xie , Frank Chen , Marc Poirier , Mingsheng Huang , Vijay Sabesan , Daw-long Kwok , Jian Cui , Xiaojing Yang , Tiruvettipuram Thiruvengadam , Jing Liao , Ilia Zavialov , Hoa Nguyen , Ngiap Lim
发明人： George Wu , Anantha Sudhakar , Tao Wang , Ji Xie , Frank Chen , Marc Poirier , Mingsheng Huang , Vijay Sabesan , Daw-long Kwok , Jian Cui , Xiaojing Yang , Tiruvettipuram Thiruvengadam , Jing Liao , Ilia Zavialov , Hoa Nguyen , Ngiap Lim
IPC分类号： C07D307/02
CPC分类号： C07D263/56 , C07C69/606 , C07C69/732 , C07C201/10 , C07C201/12 , C07C205/44 , C07C205/55 , C07C231/10 , C07C231/12 , C07C235/28 , C07C303/32 , C07C309/08 , C07C2601/16 , C07D277/64 , C07D307/92 , C07D333/56 , C07D405/06 , C07D413/06 , C07D417/06 , C07F7/1804 , C07F9/58 , Y02P20/55 , C07C233/28
摘要： This application discloses a novel process for the preparation of himbacine analogs useful as thrombin receptor antagonists. The process is based in part on the use of a base-promoted dynamic epimerization of a chiral nitro center. The chemistry taught herein can be exemplified by the following:

8. 发明申请

US20110251392A1 EXO- AND DIASTEREO- SELECTIVE SYNTHESIS OF HIMBACINE ANALOGS 有权
标题翻译：乙酰胺类似物的外源和二硫选择性合成
公开(公告)号：US20110251392A1
公开(公告)日：2011-10-13
申请号：US13168029
申请日：2011-06-24
申请人： George Wu , Anantha R. Sudhakar , Mingsheng Huang , Tao Wang , Vijay Sabesan , Ji Xie , Frank Xing Chen , Marc Poirier , Daw-long Kwok , Jian Cui , Xiaojing Yang , Tiruvettipuram K. Thiruvengadam , Jing Liao , Ilia A. Zavialov , Hoa N. Nguyen , Ngiap Kie. Lim
发明人： George Wu , Anantha R. Sudhakar , Mingsheng Huang , Tao Wang , Vijay Sabesan , Ji Xie , Frank Xing Chen , Marc Poirier , Daw-long Kwok , Jian Cui , Xiaojing Yang , Tiruvettipuram K. Thiruvengadam , Jing Liao , Ilia A. Zavialov , Hoa N. Nguyen , Ngiap Kie. Lim
IPC分类号： C07F9/141 , C07C205/56 , C07C309/16 , C07D213/02 , C07C235/00 , C07C205/44 , C07D307/77 , C07D277/64
CPC分类号： C07D263/56 , C07C69/606 , C07C69/732 , C07C201/10 , C07C201/12 , C07C205/44 , C07C205/55 , C07C231/10 , C07C231/12 , C07C235/28 , C07C303/32 , C07C309/08 , C07C2601/16 , C07D277/64 , C07D307/92 , C07D333/56 , C07D405/06 , C07D413/06 , C07D417/06 , C07F7/1804 , C07F9/58 , Y02P20/55 , C07C233/28
摘要： This application discloses a novel process for the preparation of himbacine analogs useful as thrombin receptor antagonists. The process is based in part on the use of a base-promoted dynamic epimerization of a chiral nitro center. The chemistry taught herein can be exemplified by the following:
摘要翻译：本申请公开了一种制备可用作凝血酶受体拮抗剂的烟肼类似物的新方法。该方法部分基于使用手性硝基中心的碱促进的动态差向异构化。本文教导的化学结构可以举例说明如下：

9. 发明申请

US20090281321A1 EXO- AND DIASTEREO- SELECTIVE SYNTHESES OF HIMBACINE ANALOGS 有权
标题翻译：乙酰胺类似物的外 - 和二选择性合成
公开(公告)号：US20090281321A1
公开(公告)日：2009-11-12
申请号：US12505079
申请日：2009-07-17
申请人： George Wu , Anantha R. Sudhakar , Tao Wang , Ji Xie , Frank Xing Chen , Marc Poirier , Mingsheng Huang , Vijay Sabesan , Daw-long Kwok , Jian Cui , Xiaojing Yang , Tiruvettipuram K. Thiruvengadam , Jing Liao , Ilia A. Zavialov , Hoa N. Nguyen , Ngiap Kie Lim
发明人： George Wu , Anantha R. Sudhakar , Tao Wang , Ji Xie , Frank Xing Chen , Marc Poirier , Mingsheng Huang , Vijay Sabesan , Daw-long Kwok , Jian Cui , Xiaojing Yang , Tiruvettipuram K. Thiruvengadam , Jing Liao , Ilia A. Zavialov , Hoa N. Nguyen , Ngiap Kie Lim
IPC分类号： C07C69/608 , C07D405/08 , C07F9/40 , C07D307/92 , C07D417/08 , C07D277/64
CPC分类号： C07D263/56 , C07C69/606 , C07C69/732 , C07C201/10 , C07C201/12 , C07C205/44 , C07C205/55 , C07C231/10 , C07C231/12 , C07C235/28 , C07C303/32 , C07C309/08 , C07C2601/16 , C07D277/64 , C07D307/92 , C07D333/56 , C07D405/06 , C07D413/06 , C07D417/06 , C07F7/1804 , C07F9/58 , Y02P20/55 , C07C233/28
摘要： This application discloses a novel process for the preparation of himbacine analogs useful as thrombin receptor antagonists. The process is based in part on the use of a base-promoted dynamic epimerization of a chiral nitro center. The chemistry taught herein can be exemplified by the following:
摘要翻译：本申请公开了一种制备可用作凝血酶受体拮抗剂的烟肼类似物的新方法。该方法部分基于使用手性硝基中心的碱促进的动态差向异构化。本文教导的化学结构可以举例说明如下：

10. 发明授权

US08374912B2 System and method for managing and optimizing advertising campaigns managed on the internet 有权
标题翻译：用于管理和优化在互联网上管理的广告活动的系统和方法
公开(公告)号：US08374912B2
公开(公告)日：2013-02-12
申请号：US12750352
申请日：2010-03-30
申请人： Sandrine Paroz , Richard Couture , Martin Mailloux , Martin LeSauteur , Marc Poirier , Benoit Allaire
发明人： Sandrine Paroz , Richard Couture , Martin Mailloux , Martin LeSauteur , Marc Poirier , Benoit Allaire
IPC分类号： G06Q30/00
CPC分类号： G06Q90/00 , G06Q30/02 , G06Q30/0256 , G06Q30/0275
摘要： The system of the present invention is used to optimize the returns of advertising campaigns on the internet. The system allows to create portfolios of keywords and to optimize these portfolios. Moreover, the system allows to classify the keywords in the portfolios according to their past data and to agitate the keywords which held a stagnant position over a pre-set period of time.The system support different implementations of the keyword classification in portfolios, different implementations of keyword bids agitation and different implementations of optimization. The various implementations can meet the specific aspects of different industries and/or the distinctive optimization approach of different agencies.The system can leverage the cloud computing whereby shared data, process and information are provided to computers and other devices on-demand. The delivery model involves the provision of dynamically scalable and virtualized resources as a service over the Internet. Some or all of the system components can be executed in the cloud through an on-demand instantiation of the resources required to perform the task.
摘要翻译：本发明的系统用于优化互联网广告活动的回报。该系统允许创建关键字组合并优化这些投资组合。此外，该系统允许根据其过去的数据对投资组合中的关键词进行分类，并且在预设的时间段内搅动保持停滞的关键词。系统支持关键字分类在投资组合中的不同实现，关键字出价激励的不同实现以及优化的不同实现。各种实现可以满足不同行业的特定方面和/或不同机构的独特优化方法。该系统可以利用云计算，从而根据需要将共享数据，过程和信息提供给计算机和其他设备。交付模型涉及通过互联网提供动态可扩展和虚拟化的资源作为服务。部分或全部系统组件可以通过对执行任务所需资源的按需实例化在云中执行。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式