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1. 发明申请

US20130072393A1 PANCREATIC CANCER MARKERS, AND DETECTING METHODS, KITS, BIOCHIPS THEREOF 有权
标题翻译：胰腺癌标志物及其检测方法，其生物技术
公开(公告)号：US20130072393A1
公开(公告)日：2013-03-21
申请号：US13518801
申请日：2009-12-24
申请人： Chenyu Zhang , Rui Liu , Cheng Wang , Yi Ba , Chunni Zhang , Ke Zeng
发明人： Chenyu Zhang , Rui Liu , Cheng Wang , Yi Ba , Chunni Zhang , Ke Zeng
IPC分类号： C12Q1/68 , C40B40/06
CPC分类号： C12Q1/6886 , C12Q1/6813 , C12Q1/6837 , C12Q1/686 , C12Q2600/158 , C12Q2600/178 , C40B40/06
摘要： The present invention provides microRNAs for assessing the status of pancreatic cancer in a subject, and provides methods, kits, and biochips for detecting said microRNAs.
摘要翻译：本发明提供了用于评估受试者中胰腺癌状态的微小RNA，并提供了用于检测所述微小RNA的方法，试剂盒和生物芯片。

2. 发明授权

US09637793B2 Pancreatic cancer markers, and detecting methods, kits, biochips thereof 有权
公开(公告)号：US09637793B2
公开(公告)日：2017-05-02
申请号：US13518801
申请日：2009-12-24
申请人： Chenyu Zhang , Rui Liu , Cheng Wang , Yi Bai , Chunni Zhang , Ke Zeng
发明人： Chenyu Zhang , Rui Liu , Cheng Wang , Yi Bai , Chunni Zhang , Ke Zeng
IPC分类号： C12Q1/68 , C40B40/06
CPC分类号： C12Q1/6886 , C12Q1/6813 , C12Q1/6837 , C12Q1/686 , C12Q2600/158 , C12Q2600/178 , C40B40/06
摘要： The present invention provides microRNAs for assessing the status of pancreatic cancer in a subject, and provides methods, kits, and biochips for detecting said microRNAs.

3. 发明申请

US20100173288A1 SERUM/PLASMA MICRONAS AND USES THEREOF 审中-公开
公开(公告)号：US20100173288A1
公开(公告)日：2010-07-08
申请号：US12302196
申请日：2007-12-06
申请人： Chenyu Zhang , Junfeng Zhang , Xi Chen , Yi Ba , Jiangning Chen , Jin Wang , Ke Zeng , Hongjie Zhang
发明人： Chenyu Zhang , Junfeng Zhang , Xi Chen , Yi Ba , Jiangning Chen , Jin Wang , Ke Zeng , Hongjie Zhang
IPC分类号： C12Q1/68 , C12M1/34
CPC分类号： C12Q1/6886 , C12Q1/6809 , C12Q1/6876 , C12Q1/6883 , C12Q2600/158 , C12Q2600/178 , C12Q2525/207
摘要： This invention provides a combination of microRNAs for evaluating the physiological and/or pathological condition of a subject, wherein the combination comprises all detectable microRNAs stably existing in the serum/plasma of a subject; and a method for evaluating the physiological and/or pathological condition of a subject, wherein the method includes determining all detectable microRNAs stably existing in the serum/plasma of a subject; and a kit for evaluating the physiological and/or pathological condition of a subject, wherein the kit contains the tools for determining all detectable microRNAs that stably existing in the serum/plasma of a subject; and a biochip for evaluating the physiological and/or pathological condition of a subject, wherein the biochip contains the components for determining all detectable microRNAs stably existing in the serum/plasma of a subject. The aforementioned combination, method, kit and biochip can be used for diagnosis as well as differentially diagnosis of diseases including various tumors; various acute/chronic infectious diseases, e.g. viral diseases such as viral influenza, viral hepatitis, AIDS, SARS, bacterial diseases such as tuberculosis, bacterial pneumonia, and other acute/chronic infectious diseases caused by various pathogenic microorganisms; other acute/chronic diseases such as diseases of respiratory system, diseases of immune system, diseases of blood and hematopoietic system, diseases of circulatory system such as cardio-cerebrovascular diseases, metabolic diseases of endocrine system, diseases of digestive system, diseases of nervous system, diseases of urinary system, diseases of reproductive system and diseases of locomotor system, prediction of complications occurrence and malignant diseases relapse, evaluation of therapeutic effects, screening of pharmaceutical active ingredients, assessment of drug efficacy as well as forensic authentication and prohibited drug inspection and the like, possessing a number of advantages such as extensive detection spectrum, high sensitivity, low cost, convenience for sampling, ease for sample preservation, etc. The said method can be widely used in work related to general survey of diseases and so on, improve the low-specificity and low-sensitivity caused by individual differences which single markers are difficult to overcome, significantly increasing the clinical detection rate of diseases, all of which make it become an effective means for diagnosing diseases in an early phase.

4. 发明授权

US09388470B2 Serum or plasma microRNA as biomarkers for non-small cell lung cancer 有权
标题翻译：血清或血浆microRNA作为非小细胞肺癌的生物标志物
公开(公告)号：US09388470B2
公开(公告)日：2016-07-12
申请号：US12996967
申请日：2009-12-14
申请人： Chenyu Zhang , Ke Zeng , Junfeng Zhang , Yi Ba , Xi Chen , Haijin Li
发明人： Chenyu Zhang , Ke Zeng , Junfeng Zhang , Yi Ba , Xi Chen , Haijin Li
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/112 , C12Q2600/118 , C12Q2600/158 , C12Q2600/16 , C12Q2600/178
摘要： The present invention provides non-small cell lung cancer markers and the use thereof in diagnosing and monitoring diseases in vitro. The non-small cell lung cancer markers include at least one of the 26 selected detectable mature microRNAs existing stably in human serum or plasma. The invention also provides probe combinations, a kit and biochip for detecting the non-small cell lung cancer markers. The invention further provides a method for detecting the said lung cancer markers. The method in the present invention enables extensive detection spectrum, high sensitivity, low cost, convenient sample taking and preservation. The method can be applied in the general survey of disease, solves problems of the low specificity and sensitivity encountered with previous single markers, and increases significantly the clinical detection rate of diseases; it forms an effective means for diagnosing diseases at an early stage.
摘要翻译：本发明提供非小细胞肺癌标志物及其在体外诊断和监测疾病中的应用。非小细胞肺癌标志物包括稳定存在于人血清或血浆中的26种选择的可检测的成熟微RNA中的至少一种。本发明还提供探针组合，用于检测非小细胞肺癌标志物的试剂盒和生物芯片。本发明还提供了一种用于检测所述肺癌标志物的方法。本发明的方法能够广泛的检测光谱，高灵敏度，低成本，便于取样和保存。该方法可应用于疾病一般调查，解决了以前单个标记物遇到的低特异性和敏感性问题，大大提高了疾病的临床检出率; 它是早期诊断疾病的有效手段。

5. 发明申请

US20110117565A1 SERUM OR PLASMA MICRORNA AS BIOMARKERS FOR NON-SMALL CELL LUNG CANCER 有权
标题翻译：血清或血浆MICRORNA作为非小细胞肺癌的生物标志物
公开(公告)号：US20110117565A1
公开(公告)日：2011-05-19
申请号：US12996967
申请日：2009-12-14
申请人： Chenyu Zhang , Ke Zeng , Junfeng Zhang , Yi Ba , Xi Chen , Haijin Li
发明人： Chenyu Zhang , Ke Zeng , Junfeng Zhang , Yi Ba , Xi Chen , Haijin Li
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/112 , C12Q2600/118 , C12Q2600/158 , C12Q2600/16 , C12Q2600/178
摘要： The present invention provides non-small cell lung cancer markers and the use thereof. The non-small cell lung cancer markers in the present invention include at least one of the 26 selected detectable mature microRNAs existing stably in human serum or plasma. The invention also provides a probe combination, kit and biochip for detecting the non-small cell lung cancer markers. The invention further provides a method for detecting microRNAs in the serum of lung cancer patients. By detecting the variations of microRNAs in the serum of lung cancer patients, the disease can be diagnosed in vitro; the progression course of the disease can be predicted; the occurrence of complications, the rate of relapse and the prognosis of the disease can be monitored; the drug efficacy and therapeutic effects can be analyzed. The method in the present invention enables extensive detection spectrum, high sensitivity, low cost, convenient sample taking and preservation. The method can be applied in the general survey of disease, solves problems of the low specificity and sensitivity encountered with previous single markers, and increases significantly the clinical detection rate of diseases, all of which make it an effective means for diagnosing diseases at an early stage.
摘要翻译：本发明提供非小细胞肺癌标志物及其用途。本发明中的非小细胞肺癌标志物包括稳定存在于人血清或血浆中的26种选择的可检测的成熟微RNA中的至少一种。本发明还提供了用于检测非小细胞肺癌标志物的探针组合，试剂盒和生物芯片。本发明还提供了一种检测肺癌患者血清中微小RNA的方法。通过检测肺癌患者血清中microRNAs的变化，可以在体外诊断该疾病; 可以预测疾病的进展过程; 可以监测并发症的发生，复发率和预后; 可以分析药物的疗效和治疗效果。本发明的方法能够广泛的检测光谱，高灵敏度，低成本，便于取样和保存。该方法可应用于疾病综合调查，解决了以前单个标记物所遇到的低特异性和敏感性问题，并大大增加了疾病的临床检出率，这些都成为早期诊断疾病的有效手段阶段。

6. 发明申请

US20140302119A2 MICROVESICLES CARRYING SMALL INTERFERING RNAS PREPARATION METHODS AND USES THEREOF 有权
标题翻译：携带小干扰RNAS的微胶囊制备方法及其用途
公开(公告)号：US20140302119A2
公开(公告)日：2014-10-09
申请号：US13700067
申请日：2010-05-26
申请人： Chenyu Zhang , Ke Zeng , Danqing Liu , Yujing Zhang , Hongwei Gu
发明人： Chenyu Zhang , Ke Zeng , Danqing Liu , Yujing Zhang , Hongwei Gu
IPC分类号： C12N15/113 , C12Q1/68 , A61K9/127
CPC分类号： C12N15/113 , A61K9/127 , C12N15/111 , C12N15/88 , C12N2310/14 , C12N2320/32 , C12Q1/68
摘要： Microvesicles containing interfering RNAs, preparation methods and uses thereof are provided. Pharmaceutical compositions and kits comprising the microvesicles containing interfering RNAs are also provided. Microvesicles containing interfering RNAs, pharmaceutical compositions and kits comprising such microvesicles can be used to study the effects of interfering RNAs on receptor cells. As microvesicles containing interfering RNAs can stably, high efficiently and specifically deliver interfering RNAs, microvesicles containing interfering RNAs can be used to treat related diseases.
摘要翻译：提供含有干扰RNA的微泡，其制备方法和用途。还提供了包含含有干扰RNA的微泡的药物组合物和试剂盒。含有干扰RNA的微泡，包含这种微泡的药物组合物和试剂盒可用于研究干扰RNA对受体细胞的影响。由于含有干扰RNA的微泡可以稳定，高效且特异性地递送干扰RNA，所以含有干扰RNA的微泡可用于治疗相关疾病。

7. 发明授权

US09821009B2 Method for modulating microRNA content in living beings and the use thereof 有权
公开(公告)号：US09821009B2
公开(公告)日：2017-11-21
申请号：US13641074
申请日：2010-04-13
申请人： Ke Zeng , Chenyu Zhang , Junfeng Zhang , Haijin Li
发明人： Ke Zeng , Chenyu Zhang , Junfeng Zhang , Haijin Li
IPC分类号： C12N15/11 , A61K35/14 , A61K35/28 , A61K35/36 , C12N15/88
CPC分类号： A61K35/14 , A61K35/28 , A61K35/36 , C12N15/111 , C12N15/88 , C12N2310/141 , C12N2320/32
摘要： The present invention relates to a method for modulating miRNA content in living beings and the use thereof, whereof the miRNAs are delivered initiatively and selectively by microparticles/MVs/exosomes to the circulatory system and target cells/tissues to perform various functions. The invention provides a novel combination of molecules that mediates the inter-cellular communication: the miRNAs secreted by cells through cellular MVs. Meanwhile, the present invention also provides a method for preparing cellular MVs entrapping certain miRNAs, and, according to the regulation and modification of gene expression in cells and tissues with the miRNA-entrapping cellular MVs, provides a novel method for modulating miRNA content in living beings, which is effective and adoptable to all cell types.

8. 发明申请

US20130078225A1 Method for Modulating MicroRNA Content in Living Beings and the Use Thereof 有权
标题翻译：调节生物中微RNA含量的方法及其用途
公开(公告)号：US20130078225A1
公开(公告)日：2013-03-28
申请号：US13641074
申请日：2010-04-13
申请人： Ke Zeng , Chenyu Zhang , Junfeng Zhang , Haijin Li
发明人： Ke Zeng , Chenyu Zhang , Junfeng Zhang , Haijin Li
IPC分类号： A61K35/14 , A61K35/28 , A61K35/36
CPC分类号： A61K35/14 , A61K35/28 , A61K35/36 , C12N15/111 , C12N15/88 , C12N2310/141 , C12N2320/32
摘要： The present invention relates to a method for modulating miRNA content in living beings and the use thereof, whereof the miRNAs are delivered initiatively and selectively by microparticles/MVs/exosomes to the circulatory system and target cells/tissues to perform various functions. The invention provides a novel combination of molecules that mediates the inter-cellular communication: the miRNAs secreted by cells through cellular MVs. Meanwhile, the present invention also provides a method for preparing cellular MVs entrapping certain miRNAs, and, according to the regulation and modification of gene expression in cells and tissues with the miRNA-entrapping cellular MVs, provides a novel method for modulating miRNA content in living beings, which is effective and adoptable to all cell types.
摘要翻译：本发明涉及一种用于调节生物中miRNA含量的方法及其用途，其中miRNA通过微粒/ MV /外来体主动和选择性递送至循环系统和靶细胞/组织以执行各种功能。本发明提供介导细胞间通讯的分子的新型组合：通过细胞MV分泌细胞的miRNA。同时，本发明还提供了一种制备截留某些miRNA的细胞MV的方法，并且根据miRNA携带细胞MV对细胞和组织中基因表达的调节和修饰，提供了调节生物中miRNA含量的新方法生物，对所有细胞类型有效和可应用。

9. 发明授权

US09421167B2 Preparation of microvesicle-siRNA complexes and use thereof in AIDS treatment 有权
标题翻译：微泡 - siRNA复合物的制备及其在艾滋病治疗中的应用
公开(公告)号：US09421167B2
公开(公告)日：2016-08-23
申请号：US13700062
申请日：2010-12-09
申请人： Chenyu Zhang , Ke Zeng , Hongwei Gu , Minghui Cao , Liming Li
发明人： Chenyu Zhang , Ke Zeng , Hongwei Gu , Minghui Cao , Liming Li
IPC分类号： C12N15/11 , A61K9/127 , C12N15/113 , A61K9/51
CPC分类号： A61K9/127 , A61K9/5068 , A61K9/5184 , A61K31/713 , A61K47/6901 , C12N15/111 , C12N15/1131 , C12N15/1132 , C12N15/88 , C12N2310/14 , C12N2320/32 , Y10T428/2982
摘要： The present invention provides drugs for treating AIDS, which comprises microvesicles carrying anti-HIV specific siRNA. The present invention also provides a preparation method of the drug.
摘要翻译：本发明提供用于治疗AIDS的药物，其包含携带抗HIV特异性siRNA的微泡。本发明还提供了该药物的制备方法。

10. 发明授权

US09376679B2 Microvesicles carrying small interfering RNAs, preparation methods and uses thereof 有权
标题翻译：携带小干扰RNA的微泡，其制备方法和用途
公开(公告)号：US09376679B2
公开(公告)日：2016-06-28
申请号：US13700067
申请日：2010-05-26
申请人： Chenyu Zhang , Ke Zeng , Danqing Liu , Yujing Zhang , Hongwei Gu
发明人： Chenyu Zhang , Ke Zeng , Danqing Liu , Yujing Zhang , Hongwei Gu
IPC分类号： C12N15/113 , C12N15/11 , A61K9/127 , C12Q1/68 , C12N15/88
CPC分类号： C12N15/113 , A61K9/127 , C12N15/111 , C12N15/88 , C12N2310/14 , C12N2320/32 , C12Q1/68
摘要： Microvesicles containing interfering RNAs, preparation methods and uses thereof are provided. Pharmaceutical compositions and kits comprising the microvesicles containing interfering RNAs are also provided. Microvesicles containing interfering RNAs, pharmaceutical compositions and kits comprising such microvesicles can be used to study the effects of interfering RNAs on receptor cells. As microvesicles containing interfering RNAs can stably, high efficiently and specifically deliver interfering RNAs, microvesicles containing interfering RNAs can be used to treat related diseases.
摘要翻译：提供了含有干扰RNA的微泡，其制备方法和用途。还提供了包含含有干扰RNA的微泡的药物组合物和试剂盒。含有干扰RNA的微泡，包含这种微泡的药物组合物和试剂盒可用于研究干扰RNA对受体细胞的影响。由于含有干扰RNA的微泡可以稳定，高效且特异性地递送干扰RNA，所以含有干扰RNA的微泡可用于治疗相关疾病。

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