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1. 发明申请

US20070150970A1 Compositions and methods for identifying modulators of transducisomes, a new class of therapeutic targets 审中-公开
标题翻译：用于鉴定转导体调节剂的组合物和方法，一类新的治疗靶点
公开(公告)号：US20070150970A1
公开(公告)日：2007-06-28
申请号：US11501473
申请日：2006-08-08
申请人： Charles Zuker , John Mendlein , Yumei Sun , Susan Tsunoda , Jimena Sierralta
发明人： Charles Zuker , John Mendlein , Yumei Sun , Susan Tsunoda , Jimena Sierralta
IPC分类号： A01K67/033 , C07H21/04 , C12N5/06 , C07K14/705 , C12N9/12 , C12N9/16
CPC分类号： G01N33/5041 , G01N2333/726 , G01N2333/912 , G01N2333/916
摘要： The invention provides cells and methods for identifying modulators of signal transduction, based on transducisome proteins that coordinate and assemble many types of signal transduction proteins. A transducisome is a PDZ domain containing protein that binds at least one signal transduction protein or a PDZ domain containing protein with at least one signal transduction protein bound. Examples of transducisome proteins include INAD, GRIP and other recently identified multi-PDZ domain proteins. Examples of signal transduction proteins include GPCRs, tyrosine kinase receptors, tyrosine phosphatase receptors, ion channels, phospholipases, adenylate cyclases, kinases and G-proteins. Also provided are methods for identifying modulators of signal transduction, proteins (and polynucleotides encoding the same) corresponding to transducisomes, modified transducisomes or defective transducisomes to use in assays of signal transduction, and a screening assay system for detecting protein-protein interactions.
摘要翻译：本发明提供用于鉴定信号转导调节剂的细胞和方法，其基于协调和组合许多类型的信号转导蛋白的传导蛋白。传导蛋白是含有蛋白质的PDZ结构域，其结合至少一个信号转导蛋白或含有至少一个信号转导蛋白结合的含有PDZ结构域的蛋白质。传导蛋白的实例包括INAD，GRIP和其他最近鉴定的多PDZ结构域蛋白。信号转导蛋白的实例包括GPCR，酪氨酸激酶受体，酪氨酸磷酸酶受体，离子通道，磷脂酶，腺苷酸环化酶，激酶和G蛋白。还提供了用于鉴定信号转导调节剂的方法，对应于用于信号转导测定的传导蛋白，修饰的传导蛋白或有缺陷的传导蛋白的蛋白质（和编码它们的多核苷酸）的方法，以及用于检测蛋白质 - 蛋白质相互作用的筛选测定系统。

2. 发明授权

US07087388B1 Compositions and methods for identifying modulators of transducisomes, a new class of therapeutic targets 有权
标题翻译：用于鉴定转导体调节剂的组合物和方法，一类新的治疗靶点
公开(公告)号：US07087388B1
公开(公告)日：2006-08-08
申请号：US09462517
申请日：1998-07-15
申请人： Charles S. Zuker , John D. Mendlein , Yumei Sun , Susan Tsunoda , Jimena Sierralta
发明人： Charles S. Zuker , John D. Mendlein , Yumei Sun , Susan Tsunoda , Jimena Sierralta
IPC分类号： G01N33/53 , C07K14/00
CPC分类号： G01N33/5041 , G01N2333/726 , G01N2333/912 , G01N2333/916
摘要： The invention provides cells and methods for identifying modulators of signal transduction, based on transducisome proteins that coordinate and assemble many types of signal transduction proteins. A transducisome is a PDZ domain containing protein that binds at least one signal transduction protein or a PDZ domain containing protein with at least one signal transduction protein bound. Examples of transducisome proteins include INAD, GRIP and other recently identified multi-PDZ domain proteins. Examples of signal transduction proteins include GPCRs, tyrosine kinase receptors, tyrosine phosphatase receptors, ion channels, phospholipases, adenylate cyclases, kinases and G-proteins. Also provided are methods for identifying modulators of signal transduction, proteins (and polynucleotides encoding the same) corresponding to transducisomes, modified transducisomes or defective transducisomes to use in assays of signal transduction, and a screening assay system for detecting protein-protein interactions.
摘要翻译：本发明提供用于鉴定信号转导调节剂的细胞和方法，其基于协调和组合许多类型的信号转导蛋白的传导蛋白。传导蛋白是含有蛋白质的PDZ结构域，其结合至少一个信号转导蛋白或含有至少一个信号转导蛋白结合的含有PDZ结构域的蛋白质。传导蛋白的实例包括INAD，GRIP和其他最近鉴定的多PDZ结构域蛋白。信号转导蛋白的实例包括GPCR，酪氨酸激酶受体，酪氨酸磷酸酶受体，离子通道，磷脂酶，腺苷酸环化酶，激酶和G蛋白。还提供了用于鉴定信号转导调节剂的方法，对应于用于信号转导测定的传导蛋白，修饰的传导蛋白或有缺陷的传导蛋白的蛋白质（和编码它们的多核苷酸）的方法，以及用于检测蛋白质 - 蛋白质相互作用的筛选测定系统。

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