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1. 发明申请

US20100249273A1 POLYMERIC ARTICLES COMPRISING OXYGEN PERMEABILITY ENHANCING PARTICLES 审中-公开
标题翻译：包含氧气渗透性增强颗粒的聚合物
公开(公告)号：US20100249273A1
公开(公告)日：2010-09-30
申请号：US12721081
申请日：2010-03-10
申请人： Charles W. Scales , Gregory A. Hill , John B. Enns , Eric R. George
发明人： Charles W. Scales , Gregory A. Hill , John B. Enns , Eric R. George
IPC分类号： C08K9/10 , C08L29/04 , C08L33/04 , C08L83/04 , C08L27/18 , C08L89/00
CPC分类号： C08K3/22 , C08L33/04 , C08L43/04 , G02B1/04 , G02B1/041 , G02B1/043 , C08L2666/04
摘要： The present invention relates to a composition comprising a hydrogel polymer having less than 100% haze, and distributed therein an oxygen enhancing effective amount of oxygen permeable particles having an oxygen permeability of at least about 100 barrer, average particle size less than about 5000 nm.
摘要翻译：本发明涉及一种组合物，其包含具有小于100％雾度的水凝胶聚合物，并且其中分布有氧增强有效量的氧渗透性为至少约100巴尔，平均粒度小于约5000nm的透氧性颗粒。

2. 发明申请

US20110236582A1 Polyelectrolyte Complexes 审中-公开
标题翻译：聚电解质复合物
公开(公告)号：US20110236582A1
公开(公告)日：2011-09-29
申请号：US12749288
申请日：2010-03-29
申请人： David R. Scheuing , David J. Lestage , Carl W. Bennett , Mona M. Knock , Charles W. Scales , William L. Smith , Rui Zhang
发明人： David R. Scheuing , David J. Lestage , Carl W. Bennett , Mona M. Knock , Charles W. Scales , William L. Smith , Rui Zhang
IPC分类号： B05D3/00 , C09D5/14 , C09D5/00
CPC分类号： C09D133/02 , A01N25/10 , A01N33/12 , A01N59/00 , A01N59/16 , C09D5/14 , C11D1/62 , C11D3/3769 , C11D3/3953
摘要： The present invention relates to aqueous compositions of associative polyelectrolyte complexes (PECs), optionally containing surfactants, biocidal agents and/or oxidants, which can provide surface protection to treated articles including reduced soiling tendency, reduced cleaning effort and improved soil repellancy, as well as providing bacteriostatic properties to treated surfaces that thereby gain resistance to water, environmental exposure and microbial challenge. Treatment means and compositions are provided that employ associative polyelectrolyte complexes formed by combining a water soluble cationic first polyelectrolyte with a water soluble second polyelectrolyte bearing groups of opposite charge to the first polyelectrolyte under suitable mixing conditions where the one polyelectrolyte present in molar excess is added in the form of a first aqueous solution during a mixing step to a second aqueous solution comprising the oppositely charged polyelectrolyte present in molar deficiency. Also provided are means to form stable associative polyelectrolyte complexes in aqueous solutions having R values from about 0.10 to 20, including near stoichiometric R values approaching 1, being the ratio of charged groups present on the component polyelectrolytes employed.
摘要翻译：本发明涉及可以含有表面活性剂，杀生物剂和/或氧化剂的缔合性聚电解质配合物（PEC）的含水组合物，其可以为经处理的制品提供表面保护，包括减少污染趋势，降低清洁力和改善污垢排斥性，以及为处理过的表面提供抑菌特性，从而获得对水的抗性，环境暴露和微生物的攻击。提供了处理装置和组合物，其使用通过将水溶性阳离子第一聚电解质与具有相反电荷的水溶性第二聚电解质承载基团与第一聚电解质组合而形成的缔合聚电解质复合物，其中在其中加入以摩尔过量存在的一种聚电解质在混合步骤期间第一水溶液的形式包含摩尔不足存在的相反电荷的聚电解质的第二水溶液。还提供了在具有约0.10至20的R值的水溶液中形成稳定的缔合聚电解质络合物的方法，包括接近化学计量的R值接近1，即所用组分聚电解质上存在的带电基团的比例。

3. 发明授权

US07718432B2 Non-immunogenic, hydrophilic/cationic block copolymers and uses thereof 失效
标题翻译：非免疫原性，亲水/阳离子嵌段共聚物及其用途
公开(公告)号：US07718432B2
公开(公告)日：2010-05-18
申请号：US11725964
申请日：2007-03-20
申请人： Charles W. Scales , Faqing Huang , Charles L. McCormick
发明人： Charles W. Scales , Faqing Huang , Charles L. McCormick
IPC分类号： C12N15/63 , C12Q1/68 , C07H21/04 , C08F2/00
CPC分类号： A61K31/7088 , A61K47/58 , C08F220/60 , C12N15/1137 , C12N15/87 , C12N2310/14 , C12N2310/53 , C12N2320/51
摘要： The present invention provides novel non-immunogenic, hydrophilic/cationic block copolymers comprising a neutral-hydrophilic polymer and a cationic polymer, wherein both polymers have well-defined chain-end functionality. A representative example of such a block copolymer comprises poly(N-(2-hydroxypropyl)methacrylamide) (PHPMA) and poly(N-[3-(dimethylamino)propyl]methacrylamide) (PDMAPMA). Also provided is a synthesis method thereof in aqueous media via reversible addition fragmentation chain transfer (RAFT) polymerization. Further provided are uses of these block copolymers as drug delivery vehicles and protection agents.
摘要翻译：本发明提供了包含中性亲水性聚合物和阳离子聚合物的新型非免疫原性，亲水/阳离子嵌段共聚物，其中两种聚合物均具有良好的链端官能团。这种嵌段共聚物的代表性实例包括聚（N-（2-（2-羟丙基）甲基丙烯酰胺）（PHPMA）和聚（N- [3-（二甲基氨基）丙基]甲基丙烯酰胺）（PDMAPMA）。还提供了通过可逆加成断裂链转移（RAFT）聚合在水性介质中的合成方法。进一步提供这些嵌段共聚物作为药物递送载体和保护剂的用途。

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