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1. 发明授权

US06066083A Implantable brachytherapy device having at least partial deactivation capability 失效
标题翻译：具有至少部分失活能力的植入式近距离放射治疗装置
公开(公告)号：US06066083A
公开(公告)日：2000-05-23
申请号：US200698
申请日：1998-11-27
申请人： Charles R. Slater , Scott L. Jahrmarkt , Scott T. Smith , Kevin W. Smith
发明人： Charles R. Slater , Scott L. Jahrmarkt , Scott T. Smith , Kevin W. Smith
IPC分类号： A61M36/12 , A61N5/10
CPC分类号： A61N5/1027 , A61N2005/1005 , A61N2005/1024
摘要： An implantable brachytherapy device includes a biocompatible outer capsule containing a radiation shielding element and a radioactive isotope between the shielding element and the wall of the outer capsule. When the device is at body temperature, radiation is emitted by the isotope through the wall of the outer capsule. When a predetermined amount of energy is applied to the device, the shielding element is adapted to at least partially surround the isotope, and thereby at least partially prevent the transmission of radiation through the outer capsule.
摘要翻译：可植入近程放射治疗装置包括生物相容性外胶囊，其包含辐射屏蔽元件和屏蔽元件与外胶囊壁之间的放射性同位素。当设备处于体温时，同位素通过外部胶囊的壁发射辐射。当预定量的能量被施加到装置时，屏蔽元件适于至少部分地围绕同位素，并且因此至少部分地防止辐射通过外部胶囊的传播。

2. 发明授权

US06471631B1 Implantable radiation therapy device having controllable radiation emission 有权
标题翻译：具有可控辐射发射的可植入放射治疗装置
公开(公告)号：US06471631B1
公开(公告)日：2002-10-29
申请号：US09575431
申请日：2000-05-22
申请人： Charles R. Slater , Scott L. Jahrmarkt , Scott T. Smith , Kevin W. Smith
发明人： Charles R. Slater , Scott L. Jahrmarkt , Scott T. Smith , Kevin W. Smith
IPC分类号： A61M3612
CPC分类号： A61N5/1027 , A61N2005/1005 , A61N2005/1024
摘要： An implantable radiation therapy device includes a biocompatible radiotranslucent outer capsule containing a radiation shielding element and a radioactive isotope at least partially shielded by the shielding element. When the device is at or below body temperature, radiation is prevented or limited from being transmitted through the outer capsule by the shielding element. When non-ambient energy is applied to the device, the shielding element and radioactive isotope are reconfigured such that an increased level of radiation is transmitted through the outer capsule and emitted by the device.
摘要翻译：可植入放射治疗装置包括生物相容的无辐射透明外胶囊，其包含至少部分被屏蔽元件屏蔽的辐射屏蔽元件和放射性同位素。当装置处于或低于体温时，防止或限制辐射通过屏蔽元件透过外胶囊。当非环境能量被施加到设备时，屏蔽元件和放射性同位素被重新配置，使得增加的辐射水平通过外部胶囊传输并被设备发射。

3. 发明授权

US06273851B1 Radioactive therapeutic seeds 失效
标题翻译：放射治疗种子
公开(公告)号：US06273851B1
公开(公告)日：2001-08-14
申请号：US09312215
申请日：1999-05-14
申请人： Charles R. Slater , Scott L. Jahrmarkt , Scott T. Smith , Thomas O. Bales , Kevin W. Smith
发明人： Charles R. Slater , Scott L. Jahrmarkt , Scott T. Smith , Thomas O. Bales , Kevin W. Smith
IPC分类号： A61M3600
CPC分类号： A61N5/1027 , A61N2005/1005 , A61N2005/1023 , A61N2005/1024
摘要： Radioactive therapeutic seeds include a substantially radiotransparent cylindrical capsule containing a radioactive isotope and, in particular embodiments, a radiopaque or MRI-visible marker. Each of the embodiments is designed to provide a substantially isotropic distribution of radiation. In one embodiment, the isotope is deposited on the outer surface of a hollow radiolucent tube and a collar is provided about a central portion of the tube. The capsule comprises two tubular halves positioned over the tube with the open ends of the halves forming an interference fit with the collar and welded thereabout. In another embodiment, the isotope bearing structure is a plurality of radiolucent spheres provided with a thin coating of silver to facilitate the adhesion of the isotope thereto. The spheres are provided in two capsule halves which are welded closed about a plug have an axial radiopaque marker therein. In yet another embodiment, the isotope bearing structure is a pair of silver tubes having surfaces on which the isotope is provided. One tube is positioned in each half of the capsule, and the halves are then welded about a plug provided with a marker. In each embodiment, the closed ends of the capsule are provided with tissue engaging members or connectors which can be coupled to discrete spacing links.
摘要翻译：放射性治疗种子包括含有放射性同位素的基本上无辐射透明的圆柱形胶囊，特别是不透射线或MRI可见标记。每个实施例被设计成提供基本上各向同性的辐射分布。在一个实施例中，同位素沉积在中空的射线可透管的外表面上，并且围绕管的中心部分提供轴环。胶囊包括位于管上方的两个管状半部，其半开口端形成与套环的过盈配合并在其周围焊接。在另一个实施方案中，同位素承载结构是多个具有薄的银涂层的射线可透过球，以便于同位素与其粘附。球体设置在两个胶囊半部中，其围绕塞子被焊接封闭，其中具有轴向不透射线的标记。在另一个实施方案中，同位素承载结构是具有其上提供同位素的表面的一对银管。一个管被定位在胶囊的每一半中，然后将半部焊接在设置有标记的塞子周围。在每个实施例中，胶囊的封闭端部设置有组织接合构件或可连接到分立间隔连接件的连接器。

4. 发明授权

US06796936B2 Implantable radiation therapy device having controllable radiation emission 失效
标题翻译：具有可控辐射发射的可植入放射治疗装置
公开(公告)号：US06796936B2
公开(公告)日：2004-09-28
申请号：US10281777
申请日：2002-10-28
申请人： Charles R. Slater , Scott L. Jahrmarkt , Scott T. Smith , Kevin W. Smith
发明人： Charles R. Slater , Scott L. Jahrmarkt , Scott T. Smith , Kevin W. Smith
IPC分类号： A61M3612
CPC分类号： A61N5/1027 , A61N2005/1005 , A61N2005/1024
摘要： An implantable radiation therapy device includes a biocompatible radiotranslucent outer capsule containing a radiation shielding element and a radioactive isotope at least partially shielded by the shielding element. When the device is at or below body temperature, radiation is prevented or limited from being transmitted through the outer capsule by the shielding element. When non-ambient energy is applied to the device, the shielding element and radioactive isotope are reconfigured such that an increased level of radiation is transmitted through the outer capsule and emitted by the device.
摘要翻译：可植入放射治疗装置包括生物相容的无辐射透明外胶囊，其包含至少部分被屏蔽元件屏蔽的辐射屏蔽元件和放射性同位素。当装置处于或低于体温时，防止或限制辐射通过屏蔽元件透过外胶囊。当非环境能量被施加到设备时，屏蔽元件和放射性同位素被重新配置，使得增加的辐射水平通过外部胶囊传输并被设备发射。

5. 发明授权

US06264599B1 Radioactive therapeutic seeds having fixation structure 失效
标题翻译：具有固定结构的放射性治疗种子
公开(公告)号：US06264599B1
公开(公告)日：2001-07-24
申请号：US09371194
申请日：1999-08-10
申请人： Charles R. Slater , Kevin W. Smith , Scott L. Jahrmarkt , Scott T. Smith
发明人： Charles R. Slater , Kevin W. Smith , Scott L. Jahrmarkt , Scott T. Smith
IPC分类号： A61N500
CPC分类号： A61N5/1027 , A61N2005/1023 , A61N2005/1024
摘要： Radioactive therapeutic seeds include a substantially radiotransparent cylindrical capsule provided with a radioactive isotope, a radiopaque marker, and an engagement structure adapted to engage tissue surrounding the seeds at the implant site. The engagement structure is also preferably adapted to releasably engage the inside of a delivery needle prior to implantation. The engagement structure is preferably adapted to prevent axial longitudinal movement and axial rotation of a seed about its longitudinal axis when the seed is implanted. According to a preferred embodiment of the invention, the engagement structure includes three spring elements which are biased away from the seed capsule and which provide positive fixation in the tissue, and also frictionally engage the inside of the needle.
摘要翻译：放射性治疗种子包括设置有放射性同位素，不透射线标记物和适于在植入部位接合种子周围的组织的接合结构的基本上无辐射透明的圆柱形胶囊。接合结构还优选地适于在植入之前可释放地接合输送针的内部。接合结构优选地适于在种子植入时防止种子围绕其纵向轴线的轴向纵向移动和轴向旋转。根据本发明的优选实施例，接合结构包括偏离种子囊的三个弹簧元件，并且在组织中提供正的固定，并且还摩擦地接合针的内部。

6. 发明授权

US6007475A Radioactive therapeutic seeds 失效
标题翻译：放射治疗种子
公开(公告)号：US6007475A
公开(公告)日：1999-12-28
申请号：US133082
申请日：1998-08-12
申请人： Charles R. Slater , Scott L. Jahrmarkt , Scott T. Smith
发明人： Charles R. Slater , Scott L. Jahrmarkt , Scott T. Smith
IPC分类号： A61M36/12 , A61N5/10 , A61N5/00
CPC分类号： A61N5/1027 , A61N2005/1024
摘要： Radioactive therapeutic seeds include a two part seed capsule, a radioactive isotope, and, preferably, a radiopaque marker. According to the invention, the seed capsule has an outer part, and an inner part which fits into the outer part and which carries the radioactive isotope. The capsule is sealed by welding the end(s) of the inner part to the end(s) of the outer part. According to one embodiment, the outer part of the seed capsule is a cylinder with one open end and one closed end. The inner part of the seed capsule has a reduced diameter portion which carries the isotope and a larger diameter portion which mates with the open end of the cylinder. According to another embodiment, the outer part of the seed capsule is a cylinder with two open ends. The inner part has a reduced diameter portion which carries the isotope and two larger diameter portions which mate with the open ends of the cylinder. According to some embodiments of the invention, the isotope is carried on a radiopaque structure which is mounted on the reduced diameter portion of the inner part of the seed capsule. According to another embodiment, the inner part of the seed capsule is a hollow member. According to another embodiment, the inner part of the seed capsule is made of radiopaque material.
摘要翻译：放射性治疗种子包括两部分种子胶囊，放射性同位素，优选不透不透标记物。根据本发明，种子囊具有外部部分和内部部分，其配合到外部部分并且携带放射性同位素。通过将内部件的端部焊接到外部件的端部来密封胶囊。根据一个实施例，种子囊的外部是具有一个开放端和一个封闭端的圆柱体。种子胶囊的内部部分具有减小的直径部分，其携带同位素和与气缸的开口端配合的较大直径部分。根据另一个实施例，种子囊的外部是具有两个开口端的圆筒。内部具有直径减小的部分，其携带与圆筒的开口端配合的同位素和两个较大直径的部分。根据本发明的一些实施方案，同位素承载在不透射线结构上，该结构安装在种子囊的内部部分的直径减小的部分上。根据另一实施例，种子囊的内部是中空构件。根据另一个实施例，种子囊的内部由不透射线的材料制成。

7. 发明申请

US20080200871A1 Valve System For a Medical Device Having an Inflatable Member 审中-公开
标题翻译：具有充气构件的医疗装置的阀系统
公开(公告)号：US20080200871A1
公开(公告)日：2008-08-21
申请号：US11813164
申请日：2006-01-13
申请人： Charles R. Slater , Brett E. Naglreiter , Peter K. Kratsch , Alejandro Espinosa , Scott T. Smith , Scott L. Jahrmarkt
发明人： Charles R. Slater , Brett E. Naglreiter , Peter K. Kratsch , Alejandro Espinosa , Scott T. Smith , Scott L. Jahrmarkt
IPC分类号： A61M29/00
CPC分类号： A61M39/223 , A61M25/0097 , A61M25/10
摘要： Methods and apparatus for treating the interior of a blood vessel include a variety of improved catheter designs, methods and apparatus for accessing and occluding a blood vessel.
摘要翻译：用于治疗血管内部的方法和装置包括各种改进的导管设计，用于进入和闭塞血管的方法和装置。

8. 发明授权

US6080099A Radioactive therapeutic seeds 失效
标题翻译：放射治疗种子
公开(公告)号：US6080099A
公开(公告)日：2000-06-27
申请号：US133081
申请日：1998-08-12
申请人： Charles R. Slater , Scott L. Jahrmarkt , Scott T. Smith
发明人： Charles R. Slater , Scott L. Jahrmarkt , Scott T. Smith
IPC分类号： A61M36/00 , A61M36/12 , A61N5/10 , A61N5/00
CPC分类号： A61N5/1027 , A61N2005/1005 , A61N2005/1023 , A61N2005/1024
摘要： Radioactive therapeutic seeds include a substantially cylindrical capsule containing a radioactive isotope and, preferably, a radiopaque marker. According to one embodiment, the capsule is made of titanium or stainless steel, the isotope is deposited on the surface of a hollow cylinder and a titanium or stainless steel tube is disposed inside the hollow cylinder. The capsule is sealed by swaging the end of the capsule against the inner tube and welding the swaged end and tube. The inner tube facilitates swaging and protects the contents of the capsule from the heat of welding. In alternate embodiments, a radiopaque marker is disposed inside the inner tube or the cylinder bearing the radioisotope is radiopaque. According to other embodiments, a gripping stem is installed on one or both ends of a capsule, a capsule is made of very thin material with rotary swaged ends welded shut and a supporting structure inside the capsule, a meltable isotope mixture is used to coat the interior of a capsule, a capsule is assembled from two halves which are placed over an interior tube and the halves are butt welded, a capsule is made of a borosilicate or elemental silicon glass tube with ends melted to seal the capsule. Bioabsorbable spacers are provided for use with seeds having gripping/linking stems so that seeds are linked together.
摘要翻译：放射性治疗种子包括含有放射性同位素，优选不透射线标记物的基本上圆柱形的胶囊。根据一个实施例，胶囊由钛或不锈钢制成，同位素沉积在中空圆柱体的表面上，钛或不锈钢管设置在中空圆柱体的内部。通过将胶囊端部抵靠内管将模具密封，并焊接模锻端和管。内管有助于模锻，并保护胶囊的内容物免受焊接热。在替代实施例中，不透射线的标记设置在内管或带有放射性同位素的不透射线的气缸内。根据其他实施例，夹持杆安装在胶囊的一端或两端，胶囊由非常薄的材料制成，其中旋转成型端部被焊接并且在胶囊内部具有支撑结构，可熔融的同位素混合物用于涂覆胶囊的内部，由放置在内部管上的两个半部组装，并且半部对接焊接，胶囊由硼硅酸盐或元素硅玻璃管制成，端部熔化以密封胶囊。提供生物可吸收隔离物用于具有夹持/连接茎的种子，使得种子连接在一起。

9. 发明授权

US06210316B1 Radioactive therapeutic seeds and methods of making the same 失效
标题翻译：放射治疗种子及其制作方法
公开(公告)号：US06210316B1
公开(公告)日：2001-04-03
申请号：US09133072
申请日：1998-08-12
申请人： Charles R. Slater , Scott L. Jahrmarkt , Scott T. Smith
发明人： Charles R. Slater , Scott L. Jahrmarkt , Scott T. Smith
IPC分类号： A61N500
CPC分类号： A61N5/1027 , A61N2005/1024
摘要： Radioactive therapeutic seeds include a seed capsule, a radioactive isotope, and a radiopaque marker. According to one embodiment of the invention, the radiopaque marker is a silver wire coil and the isotope is coated on the surface of the coil. According to a first method of the invention, the therapeutic dosage of the seed is adjusted during manufacture by expanding or contracting the coil before it sized and deposited in the capsule. According to second embodiment, the radiopaque marker is a silver rod and the isotope is coated on a radiotransparent coil which is placed over the rod. According to a third embodiment, the isotope is coated on a plurality of rings which are stacked on a radiopaque rod. According to a second method of the invention, the therapeutic dosage of the seed is adjusted during manufacture by stacking a mixture of radio-inactive rings with radioactive rings on the radiopaque rod before the capsule is sealed.
摘要翻译：放射性治疗种子包括种子胶囊，放射性同位素和不透射线的标记。根据本发明的一个实施例，不透射线的标记是银线盘，并且同位素涂覆在线圈的表面上。根据本发明的第一种方法，在制造期间通过在将线圈定尺寸并沉积在胶囊中之前使线圈膨胀或收缩来调节种子的治疗剂量。根据第二实施例，不透射线的标记是银棒，同位素涂覆在放置在杆上的无线电透射线圈上。根据第三实施例，同位素被涂覆在堆叠在不透射线棒上的多个环上。根据本发明的第二种方法，在制造期间通过在胶囊被密封之前将无线电非活性环与放射性环的混合物堆叠在不透射线的棒上来调节种子的治疗剂量。

10. 发明授权

US08328865B2 Highly flexible stent and method of manufacture 有权
标题翻译：高度灵活的支架和制造方法
公开(公告)号：US08328865B2
公开(公告)日：2012-12-11
申请号：US12526690
申请日：2008-02-07
申请人： Thomas O. Bales, Jr. , Scott L. Jahrmarkt , Charles R. Slater , Peter K. Kratsch
发明人： Thomas O. Bales, Jr. , Scott L. Jahrmarkt , Charles R. Slater , Peter K. Kratsch
IPC分类号： A61F2/06
CPC分类号： A61F2/915 , A61F2/88 , A61F2002/91541 , A61F2002/91558 , A61F2002/91575 , A61F2230/0054 , A61F2250/0036 , A61F2250/0098 , B21F45/00
摘要： Preferred embodiments of a stent with a high degree of flexibility are shown and described. The stent can include a continuous helical winding having interconnected struts joined at vertices, and having bridges connecting sections of the helical winding to each other. An annular ring can be provided at one or both ends of the helical winding, and the annular ring can have extensions extending to connect to the helical winding. One of the extensions can connect to a bridge and another extension can connect to a vertex. The struts at the ends of the helical winding can have strut lengths that differ from the strut lengths of the struts in a central portion of the winding between the ends of the winding.
摘要翻译：显示和描述了具有高度柔性的支架的优选实施例。支架可以包括具有在顶点处连接的互连的支柱的连续的螺旋绕组，并且具有将螺旋形绕组的部分彼此连接的桥。环形环可以设置在螺旋绕组的一端或两端，并且环形环可以具有延伸以连接到螺旋绕组的延伸部。其中一个扩展可以连接到一个网桥，另一个扩展可以连接到一个顶点。在螺旋绕组的端部处的支柱可以具有与绕组端部之间的绕组的中心部分中的支柱的支柱长度不同的支柱长度。

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