专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20170197996A1 Cholinesterase Inhibitors 审中-公开
公开(公告)号：US20170197996A1
公开(公告)日：2017-07-13
申请号：US15258356
申请日：2016-09-07
申请人： Charles M. Thompson , John M. Gerdes , Syed K. Ahmed , Yamina Belabassi
发明人： Charles M. Thompson , John M. Gerdes , Syed K. Ahmed , Yamina Belabassi
IPC分类号： C07F9/40 , C07F9/38 , A61K51/04
CPC分类号： C07F9/4071 , A61K51/0489 , C07B59/004 , C07F9/38 , C07F9/4021
摘要： The invention provides compounds that inhibit cholinesterases, such as acetylcholinesterase and butyrylcholinesterase. Such compounds are useful to prevent or treat exposure of a patient (e.g., a human) to an organophosphoric nerve agent (e.g., sarin and VX) or to treat a patient suffering from a neurodegenerative disorder such as Alzheimer's Disease or Lewy Body Dementia. The compounds are further useful as diagnostic tools for use in medical or research radiography (e.g., positron emission tomography) when synthesized with a radionuclide (e.g., [18F]. Synthetic schemes to produce such compounds are also provided.

2. 发明申请

US20130343994A1 Cholinesterase Inhibitors 审中-公开
标题翻译：胆碱酯酶抑制剂
公开(公告)号：US20130343994A1
公开(公告)日：2013-12-26
申请号：US13926661
申请日：2013-06-25
申请人： Charles M. Thompson , John M. Gerdes , Syed K. Ahmed , Yamina Belabassi
发明人： Charles M. Thompson , John M. Gerdes , Syed K. Ahmed , Yamina Belabassi
IPC分类号： A61K51/04 , C07F9/40 , C07F9/38
CPC分类号： C07F9/4071 , A61K51/0489 , C07B59/004 , C07F9/38 , C07F9/4021
摘要： The invention provides compounds that inhibit cholinesterases, such as acetylcholinesterase and butyrylcholinesterase. Such compounds are useful to prevent or treat exposure of a patient (e.g., a human) to an organophosphoric nerve agent (e.g., sarin and VX) or to treat a patient suffering from a neurodegenerative disorder such as Alzheimer's Disease or Lewy Body Dementia. The compounds are further useful as diagnostic tools for use in medical or research radiography (e.g., positron emission tomography) when synthesized with a radionuclide (e.g., [18F]. Synthetic schemes to produce such compounds are also provided.
摘要翻译：本发明提供抑制胆碱酯酶如乙酰胆碱酯酶和丁酰胆碱酯酶的化合物。这样的化合物可用于预防或治疗患者（例如人）暴露于有机磷神经药物（例如沙林和VX）或治疗患有神经变性疾病如阿尔茨海默病或路易体痴呆的患者。当用放射性核素（例如[18 F]）合成时，这些化合物可用作用于医学或研究放射照相术（例如正电子发射断层摄影）的诊断工具。还提供了合成方案来制备这些化合物。

3. 发明授权

US4142594A Method and core barrel apparatus for obtaining and retrieving subterranean formation samples 失效
标题翻译：用于获取和取回地下地层样品的方法和核心桶装置
公开(公告)号：US4142594A
公开(公告)日：1979-03-06
申请号：US813358
申请日：1977-07-06
申请人： Charles M. Thompson , Charles W. Spehrley , Charles T. Thompson
发明人： Charles M. Thompson , Charles W. Spehrley , Charles T. Thompson
IPC分类号： E21B25/08 , E21B49/00
CPC分类号： E21B25/08
摘要： Core barrel apparatus and a method for obtaining and retrieving sealed core samples of subterranean formations are disclosed. The core barrel apparatus comprises inner and outer core barrels. The upper portion of the outer core barrel is adapted to be connected to a drill string. A core bit for cutting a core sample is mounted on the lower portion of the outer core barrels. The inner core barrel comprises a sample chamber for receiving a core sample as it is formed at the bottom of a bore hole and an expansion chamber for receiving sample fluids. The sample chamber and expansion chamber are selectively connected to one another. The expansion chamber is sealed closed while the sample is being cut and received within the sample chamber. The lower portion of the sample chamber adjacent the core bit is sealed by a flap-valve which includes a flexible flap member. The flexible flap member is deflected from its normal form of a flat disc into a semi-cylindrical form and stored adjacent to the inner circumference of the sample chamber while the sample is being cut. Once the core sample is within the sample chamber, the flap member is permitted to spring into its flat disc form and extend across the opening in the lower portion of the sample chamber in order to seal the core sample within the chamber. Thereafter the expansion chamber is opened to the sample chamber. As the apparatus is raised toward the surface and the pressure within the bore hole decreases, the expansion chamber expands in response to the pressure of the fluid within it and thereby maintains the pressure within the expansion chamber at or relatively near the bore hole pressure.
摘要翻译：公开了一种用于获得和回收地下地层的密封岩心样品的核心桶装置和方法。芯筒装置包括内芯和外芯。外芯筒的上部适于连接到钻柱。用于切割芯样品的芯钻头安装在外核心筒的下部。内芯筒包括样品室，用于在钻孔的底部形成芯样品，并且用于接收样品流体的膨胀室。样品室和膨胀室彼此选择性地连接。当样品被切割并接收在样品室内时，膨胀室被密封封闭。与核心钻头相邻的样品室的下部由包括柔性翼片构件的瓣阀密封。柔性折板构件从其平面盘的正常形式偏转成半圆柱形并且在样品被切割时与样品室的内周相邻地存储。一旦芯样品在样品室内，允许襟翼构件弹簧进入其平盘形状并延伸穿过样品室的下部的开口，以便将芯样品密封在室内。此后，将膨胀室向样品室开放。当装置朝向表面升高并且孔内的压力减小时，膨胀室响应于其内的流体的压力而膨胀，从而将膨胀室内的压力维持在或相对接近钻孔压力。

4. 发明授权

US4606418A Cutting means for drag drill bits 失效
标题翻译：用于拖钻钻头的切割装置
公开(公告)号：US4606418A
公开(公告)日：1986-08-19
申请号：US759459
申请日：1985-07-26
申请人： Charles M. Thompson
发明人： Charles M. Thompson
IPC分类号： E21B10/56 , E21B10/567 , E21B10/60 , E21B10/61
CPC分类号： E21B10/567 , E21B10/602 , E21B10/61
摘要： A rotary drill bit (10) having a plurality of diamond cutting elements (48) each having a cutting face (60) with a discharge nozzle (64) therein. The discharge nozzle (64) directs the flow of drilling fluid away from the cutting face (60) and is surrounded by the cutting face (60).
摘要翻译：一种具有多个金刚石切割元件（48）的旋转钻头（10），每个金刚石切割元件（48）均具有在其中具有排出喷嘴（64）的切割面（60）。排出喷嘴（64）使钻井液的流动远离切割面（60）并被切割面（60）包围。

5. 发明授权

US4258803A Core barrel for obtaining and retrieving subterranean formation samples 失效
标题翻译：用于获取和取回地下地层样品的核心桶
公开(公告)号：US4258803A
公开(公告)日：1981-03-31
申请号：US916466
申请日：1978-06-21
申请人： Charles M. Thompson , Charles T. Thompson
发明人： Charles M. Thompson , Charles T. Thompson
IPC分类号： E21B23/00 , E21B25/08 , E21B25/06
CPC分类号： E21B23/006 , E21B25/08
摘要： Core barrel apparatus for obtaining and retrieving sealed core samples of subterranean formations are disclosed. The core barrel comprises a sample chamber for receiving a core sample as it is formed at the bottom of a bore hole and an expansion chamber for receiving sample fluids. The expansion chamber comprises a cylinder having a movable sealing member therein adapted to movably seal the expansion chamber. The volume of the expansion chamber is determined by the position of the sealing member in the cylinder, movement of the sealing member changing the volume of the expansion chamber. The sample chamber and expansion chamber are selectively connected to one another by means of a seal therebetween. The expansion chamber is sealed closed by the sealing member at one end and said seal at the other end while the sample is being cut and received within the sample chamber. Thereafter, the lower portion of the sample chamber is sealed by a flap-valve and the expansion chamber is opened to the sample chamber. The movable sealing member moves during ascent to expand the expansion chamber and reduce the pressure therein. A cup-like member, a piston, a spheroidal member, and a bellows member are disclosed to be embodiments of the movable sealing member. Valving is provided in the sample and expansion chambers so that the chambers may be individually sealed and separated, and sample fluids removed from the chambers through the respective valves.
摘要翻译：公开了用于获得和回收地下地层的密封核心样品的岩心桶装置。芯筒包括样品室，用于在钻孔的底部形成芯样品并且用于接收样品流体的膨胀室。膨胀室包括其中具有适于可移动地密封膨胀室的可移动密封构件的气缸。膨胀室的体积由密封构件在气缸中的位置决定，密封构件的运动改变膨胀室的体积。样品室和膨胀室通过其间的密封件彼此选择性地连接。膨胀室在一端被密封件封闭，另一端密封，同时样品被切割并接收在样品室内。此后，样本室的下部由瓣阀密封，膨胀室向样品室开放。可移动密封件在上升期间移动以膨胀膨胀室并减小其中的压力。公开了杯状构件，活塞，球形构件和波纹管构件，以作为可移动密封构件的实施例。在样品和膨胀室中提供阀门，使得腔室可以被单独地密封和分离，并且样品流体通过相应的阀从腔室中移除。

6. 发明授权

US4646857A Means to secure cutting elements on drag type drill bits 失效
标题翻译：用于在铲式钻头上固定切割元件的方法
公开(公告)号：US4646857A
公开(公告)日：1987-03-03
申请号：US790974
申请日：1985-10-24
申请人： Charles M. Thompson
发明人： Charles M. Thompson
IPC分类号： E21B10/54 , E21B10/55 , E21B10/56 , E21B10/573 , E21B10/46
CPC分类号： E21B10/55 , E21B10/5735
摘要： A metal matrix (53) of a blade (30) on a drag-type rotary drill bit (10) is formed about a plurality of diamond cutting elements (56) so that the entire surface areas of the cutting faces (62) are exposed and engage the formation to be cut in a drilling operation. The cutting elements (56) are secured by a mechanical interlocking bond or attachment (68, 70) between the cutting elements (56) and matrix (53) without utilizing the cutting faces (62) for securement.
摘要翻译：围绕多个金刚石切割元件（56）形成在拖曳型旋转钻头（10）上的叶片（30）的金属基体（53），使得切割面（62）的整个表面区域露出并进行钻井作业中的切割。切割元件（56）通过在切割元件（56）和矩阵（53）之间的机械互锁结合或附接（68,70）固定，而不利用用于固定的切割面（62）。

7. 发明申请

US20150259336A1 Benzothiazole-based Pyridinium Compounds for the Treatment of Neurodegenerative Diseases or Nerve Agent Exposure 审中-公开
标题翻译：用于治疗神经变性疾病或神经药物暴露的苯并噻唑类吡啶鎓化合物
公开(公告)号：US20150259336A1
公开(公告)日：2015-09-17
申请号：US13592386
申请日：2012-08-23
申请人： Charles M. Thompson , Sandip Bharate
发明人： Charles M. Thompson , Sandip Bharate
IPC分类号： C07D417/12
CPC分类号： C07D417/12
摘要： The compositions of the invention are novel benzothiazol-based pyridinium compounds with potent acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitory activities. Such compositions can be used, for example, to treat Alzheimer's Disease and other neurodegenerative disorders. The compounds of the invention can also be used to prevent or treat the neurotoxic effects of nerve agents (e.g., sarin gas or insecticides).
摘要翻译：本发明的组合物是具有有效的乙酰胆碱酯酶（AChE）和丁酰胆碱酯酶（BChE）抑制活性的新型苯并噻唑基吡啶鎓化合物。这样的组合物可用于例如治疗阿尔茨海默病和其它神经变性疾病。本发明的化合物也可用于预防或治疗神经毒剂（例如，沙林天然气或杀虫剂）的神经毒性作用。

8. 发明授权

US4776412A Nozzle assembly for rotary drill bit and method of installation 失效
标题翻译：旋转钻头用喷嘴组件及安装方法
公开(公告)号：US4776412A
公开(公告)日：1988-10-11
申请号：US150283
申请日：1988-01-29
申请人： Charles M. Thompson
发明人： Charles M. Thompson
IPC分类号： B05B15/06 , B25B9/00 , B25B13/02 , B25B13/48 , E21B10/60 , E21B10/61 , E21B10/62
CPC分类号： E21B10/61 , B05B15/065 , B25B13/02 , B25B13/48 , B25B9/00 , E21B10/62
摘要： A rotary drill bit (10) has a nozzle assembly (24) positioned within a nozzle bore (22). Nozzle assembly (24) has a nozzle member (34) with a port (40) deviated from the longitudinal axis of the nozzle member (34). A retaining nut (54) is threaded within the threaded bore (22) while the nozzle member (34) is held against rotation thereby to maintain the port (40) in a predetermined rotational position upon final installation.

9. 发明授权

US09255091B2 Benzothiazole-based pyridinium compounds 有权
标题翻译：基于苯并噻唑的吡啶鎓化合物
公开(公告)号：US09255091B2
公开(公告)日：2016-02-09
申请号：US13592386
申请日：2012-08-23
申请人： Charles M. Thompson , Sandip Bharate
发明人： Charles M. Thompson , Sandip Bharate
IPC分类号： A61K31/44 , C07D213/72 , C07D417/12
CPC分类号： C07D417/12
摘要： The compositions of the invention are novel benzothiazol-based pyridinium compounds with potent acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitory activities. Such compositions can be used, for example, to treat Alzheimer's Disease and other neurodegenerative disorders. The compounds of the invention can also be used to prevent or treat the neurotoxic effects of nerve agents (e.g., sarin gas or insecticides).
摘要翻译：本发明的组合物是具有有效的乙酰胆碱酯酶（AChE）和丁酰胆碱酯酶（BChE）抑制活性的新型苯并噻唑基吡啶鎓化合物。这样的组合物可用于例如治疗阿尔茨海默病和其它神经变性疾病。本发明的化合物也可用于预防或治疗神经毒剂（例如，沙林天然气或杀虫剂）的神经毒性作用。

10. 发明授权

US4275935A Drilling stabilizer 失效
标题翻译：钻孔稳定器
公开(公告)号：US4275935A
公开(公告)日：1981-06-30
申请号：US56975
申请日：1979-07-17
申请人： Charles M. Thompson , Charles T. Thompson
发明人： Charles M. Thompson , Charles T. Thompson
IPC分类号： E21B7/04 , E21B17/10 , E21B47/022 , F16C29/02
CPC分类号： E21B17/1078 , E21B47/022 , E21B7/04
摘要： A stabilizer for a drill string is disclosed. The stabilizer is of split configuration having an open slot or split which extends for the length of the stabilizer. The split stabilizer is slipped over a drill collar and fasteners are used to draw the split stabilizer together to clamp the stabilizer to the drill collar. The stabilizer may thus be positioned at any desired axial location on the drill collar and non-rotatably locked thereto by the fasteners. Advantageously, the stabilizer is made of a non-magnetic material.
摘要翻译：公开了一种用于钻柱的稳定器。稳定器是具有开口狭槽或分裂的分开构造，其延伸稳定器的长度。分裂稳定器滑过钻铤，并且紧固件用于将分离稳定器拉到一起以将稳定器夹紧到钻铤。因此，稳定器可以被定位在钻铤上的任何期望的轴向位置处，并且由紧固件不可旋转地锁定在其上。有利地，稳定器由非磁性材料制成。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式