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1. 发明申请

US20090240271A1 RETINAL INSTRUMENT 有权
标题翻译：离子仪器
公开(公告)号：US20090240271A1
公开(公告)日：2009-09-24
申请号：US12052992
申请日：2008-03-21
申请人： Charles L. Britton , Brian R. D'Urso , Edward Chaum , John T. Simpson , Justin S. Baba , M. Nance Ericson , Robert J. Warmack
发明人： Charles L. Britton , Brian R. D'Urso , Edward Chaum , John T. Simpson , Justin S. Baba , M. Nance Ericson , Robert J. Warmack
IPC分类号： A61F9/00
CPC分类号： A61F9/00736 , A61B17/205 , A61F9/007 , A61F9/00727
摘要： In one embodiment, the present invention provides a method of removing scar tissue from an eye that includes inserting a device including an array of micro-rods into an eye, wherein at least one glass micro-rod of the array of glass micro-rods includes a sharp feature; contacting a scar tissue with the array of micro-rods; and removing the array of micro-rods and the scar tissue from the eye. In another embodiment, the present invention provides a medical device for engaging a tissue including and an array of glass micro-rods, wherein at least one glass micro-rod of the array of glass micro-rods includes a sharp feature opposite a base of the array of glass micro-rods that is connected to the cannula, wherein the sharp feature of the at least one micro-rod is angled from a plane that is normal to a face of the base of the array of glass micro-rods.
摘要翻译：在一个实施方案中，本发明提供了一种从眼睛去除疤痕组织的方法，包括将包括微棒阵列的装置插入到眼睛中，其中玻璃微棒阵列的至少一个玻璃微棒包括一个尖锐的特征; 使疤痕组织与微杆阵列接触; 并从眼睛中移除微杆阵列和瘢痕组织。在另一个实施方案中，本发明提供了一种用于接合包括玻璃微棒和玻璃微棒的阵列的组织的医疗装置，其中所述玻璃微棒阵列的至少一个玻璃微棒包括与所述玻璃微棒的基底相对的尖锐特征连接到插管的玻璃微杆的阵列，其中所述至少一个微杆的尖锐特征从与所述玻璃微棒阵列的基部的面垂直的平面成角度。

2. 发明授权

US08425596B2 Retinal instrument 有权
标题翻译：视网膜仪
公开(公告)号：US08425596B2
公开(公告)日：2013-04-23
申请号：US12052992
申请日：2008-03-21
申请人： Charles L. Britton , Brian R. D'Urso , Edward Chaum , John T. Simpson , Justin S. Baba , M. Nance Ericson , Robert J. Warmack
发明人： Charles L. Britton , Brian R. D'Urso , Edward Chaum , John T. Simpson , Justin S. Baba , M. Nance Ericson , Robert J. Warmack
IPC分类号： A61F2/16
CPC分类号： A61F9/00736 , A61B17/205 , A61F9/007 , A61F9/00727
摘要： In one embodiment, the present invention provides a method of removing scar tissue from an eye that includes inserting a device including an array of micro-rods into an eye, wherein at least one glass micro-rod of the array of glass micro-rods includes a sharp feature; contacting a scar tissue with the array of micro-rods; and removing the array of micro-rods and the scar tissue from the eye. In another embodiment, the present invention provides a medical device for engaging a tissue including and an array of glass micro-rods, wherein at least one glass micro-rod of the array of glass micro-rods includes a sharp feature opposite a base of the array of glass micro-rods that is connected to the cannula, wherein the sharp feature of the at least one micro-rod is angled from a plane that is normal to a face of the base of the array of glass micro-rods.
摘要翻译：在一个实施方案中，本发明提供了一种从眼睛去除疤痕组织的方法，包括将包括微棒阵列的装置插入到眼睛中，其中玻璃微棒阵列的至少一个玻璃微棒包括一个尖锐的特征; 使疤痕组织与微杆阵列接触; 并从眼睛中移除微杆阵列和瘢痕组织。在另一个实施方案中，本发明提供了一种用于接合包括玻璃微棒和玻璃微棒的阵列的组织的医疗装置，其中所述玻璃微棒阵列的至少一个玻璃微棒包括与所述玻璃微棒的基底相对的尖锐特征连接到插管的玻璃微杆的阵列，其中所述至少一个微杆的尖锐特征从与所述玻璃微棒阵列的基部的面垂直的平面成角度。

3. 发明授权

US08591481B2 Microfabricated instruments and methods to treat recurrent corneal erosion 有权
标题翻译：微量手术和治疗复发性角膜糜烂的方法
公开(公告)号：US08591481B2
公开(公告)日：2013-11-26
申请号：US12052971
申请日：2008-03-21
申请人： Charles L. Britton , Brian R. D'Urso , Edward Chaum , John T. Simpson , Justin S. Baba , M. Nance Ericson , Robert J. Warmack
发明人： Charles L. Britton , Brian R. D'Urso , Edward Chaum , John T. Simpson , Justin S. Baba , M. Nance Ericson , Robert J. Warmack
IPC分类号： A61M5/158
CPC分类号： A61F9/007 , A61B2017/320004 , A61F9/0017
摘要： In one embodiment, the present invention provides a device and method for treating recurrent corneal erosion. In one embodiment, the method includes the steps of contacting an epithelium layer of a cornea with an array of glass micro-rods including a plurality of sharp features having a length that penetrates a Bowman's layer of the eye, wherein the plurality of sharp features of the array of glass micro-rods produces a plurality of punctures in the Bowman's layer of the eye that are of micro-scale or less. In another embodiment, the present invention provides a method and device for drug delivery. In one embodiment, the device includes an array of glass micro-rods, wherein at least one glass micro-rod of the array of glass micro-rods includes a sharp feature opposite a base of the array of glass micro-rods, wherein the sharp feature includes a treated surface for delivering a chemical compound to the eye.
摘要翻译：在一个实施方案中，本发明提供了用于治疗复发性角膜侵蚀的装置和方法。在一个实施例中，该方法包括以下步骤：使角膜的上皮层与玻璃微杆阵列接触，所述玻璃微杆包括具有穿透眼睛Bowman层的长度的多个尖锐特征，其中多个尖锐特征玻璃微棒的阵列在眼睛的Bowman层中产生微量级或更小的多个穿刺。在另一个实施方案中，本发明提供用于药物递送的方法和装置。在一个实施例中，该装置包括玻璃微棒阵列，其中玻璃微棒阵列的至少一个玻璃微棒包括与玻璃微棒阵列相对的尖锐特征，其中尖锐特征包括用于将化学化合物递送至眼睛的处理表面。

4. 发明申请

US20090240217A1 NOVEL MICROFABRICATED INSTRUMENTS AND METHODS TO TREAT RECURRENT CORNEAL EROSION 有权
标题翻译：新型微晶化仪器和治疗复发性角膜磨蚀的方法
公开(公告)号：US20090240217A1
公开(公告)日：2009-09-24
申请号：US12052971
申请日：2008-03-21
申请人： Charles L. Britton , Brian R. D'Urso , Edward Chaum , John T. Simpson , Justin S. Baba , M. Nance Ericson , Robert J. Warmack
发明人： Charles L. Britton , Brian R. D'Urso , Edward Chaum , John T. Simpson , Justin S. Baba , M. Nance Ericson , Robert J. Warmack
IPC分类号： A61F9/00
CPC分类号： A61F9/007 , A61B2017/320004 , A61F9/0017
摘要： In one embodiment, the present invention provides a device and method for treating recurrent corneal erosion. In one embodiment, the method includes the steps of contacting an epithelium layer of a cornea with an array of glass micro-rods including a plurality of sharp features having a length that penetrates a Bowman's layer of the eye, wherein the plurality of sharp features of the array of glass micro-rods produces a plurality of punctures in the Bowman's layer of the eye that are of micro-scale or less. In another embodiment, the present invention provides a method and device for drug delivery. In one embodiment, the device includes an array of glass micro-rods, wherein at least one glass micro-rod of the array of glass micro-rods includes a sharp feature opposite a base of the array of glass micro-rods, wherein the sharp feature includes a treated surface for delivering a chemical compound to the eye.
摘要翻译：在一个实施方案中，本发明提供了用于治疗复发性角膜侵蚀的装置和方法。在一个实施例中，该方法包括以下步骤：使角膜的上皮层与玻璃微杆阵列接触，所述玻璃微杆包括具有穿透眼睛的Bowman层的长度的多个尖锐特征，其中多个尖锐特征玻璃微棒的阵列在眼睛的Bowman层中产生微量级或更小的多个穿刺。在另一个实施方案中，本发明提供用于药物递送的方法和装置。在一个实施例中，该装置包括玻璃微棒阵列，其中玻璃微棒阵列的至少一个玻璃微棒包括与玻璃微棒阵列相对的尖锐特征，其中尖锐特征包括用于将化学化合物递送至眼睛的处理表面。

5. 发明申请

US20070281130A1 MULTI-TIPPED OPTICAL COMPONENT 失效
标题翻译：多针光学元件
公开(公告)号：US20070281130A1
公开(公告)日：2007-12-06
申请号：US11421547
申请日：2006-06-01
申请人： Brian R. D'Urso , John T. Simpson
发明人： Brian R. D'Urso , John T. Simpson
IPC分类号： B32B3/00
CPC分类号： G02B6/06 , G01Q60/22 , G01Q70/06 , G02B6/262 , Y10T428/24479
摘要： An optical component includes a support structure having a first composition including a recessive phase material and a second composition including protrusive phase material, the protrusive phase material defining a plurality of spaced apart surface features, each of the surface features comprising a distal end opposite the support structure, integrated with the support structure, and protruding distally from a surface of the support structure, each of the surface features reducing in cross sectional area distally from the support structure to provide a lowest cross sectional area at the distal end, the recessive phase material supporting and separating the surface features and defining a contiguous recessed surface area between the surface features, at least two of the protrusive features being characterized as optical waveguides.
摘要翻译：光学部件包括具有包括隐性相材料的第一组合物和包括突出相材料的第二组合物的支撑结构，所述突出相材料限定多个间隔开的表面特征，每个表面特征包括与支撑体相对的远端结构，与支撑结构一体并且从支撑结构的表面向远侧突出，每个表面特征使得横截面面积从支撑结构向远侧减小，以在远端提供最低横截面面积，隐性相材料支撑和分离表面特征并且在表面特征之间限定连续的凹陷表面区域，至少两个突出特征被表征为光波导。

6. 发明授权

US08193406B2 Super-hydrophobic bandages and method of making the same 有权
标题翻译：超疏水绷带及其制作方法
公开(公告)号：US08193406B2
公开(公告)日：2012-06-05
申请号：US12273800
申请日：2008-11-19
申请人： John T. Simpson , Brian R. D'Urso
发明人： John T. Simpson , Brian R. D'Urso
IPC分类号： A61F13/00 , B32B3/26
CPC分类号： B01D69/02 , A61F13/022 , A61F2013/00255 , A61F2013/00319 , A61F2013/004 , A61F2013/00863 , A61F2013/00889 , A61L15/42 , A61L15/425 , A61L2400/12 , B01D2325/02 , B01D2325/36 , B01D2325/38 , D06M23/08 , Y10S977/931 , Y10T428/249978 , Y10T428/249979 , Y10T428/249981
摘要： A bandage that includes a material, which can be breathable, having a first surface, and a plurality of superhydrophobic particles attached to the first surface. The plurality of superhydrophobic particles ranging in size from about 100 nanometers to about 10 micrometers. The superhydrophobic particles including a protrusive material defining a plurality of nanopores and a plurality of spaced apart nanostructures that define an external boundary of the hydrophobic particles. The nanopores providing a flow through porosity. The first surface can be rendered superhydrophobic by the attached superhydrophobic particles. The material can have a second surface opposite the first surface that is hydrophilic. The superhydrophobic particles can be adhered to the first surface by a binder. Also included is a method of making the bandages described herein.
摘要翻译：包括可以透气的具有第一表面的材料和附着到第一表面的多个超疏水性颗粒的绷带。多个超疏水颗粒的尺寸范围为约100纳米至约10微米。超疏水颗粒包括限定多个纳米孔的突出材料和限定疏水性颗粒的外部边界的多个间隔开的纳米结构。提供流过孔隙的纳米孔。第一表面可以通过附着的超疏水性颗粒变得超疏水。该材料可以具有与第一表面相对的第二表面，其是亲水的。超疏水性颗粒可以通过粘合剂粘附到第一表面。还包括制造本文所述的绷带的方法。

7. 发明授权

US08216674B2 Superhydrophobic diatomaceous earth 有权
标题翻译：超疏水硅藻土
公开(公告)号：US08216674B2
公开(公告)日：2012-07-10
申请号：US11777486
申请日：2007-07-13
申请人： John T. Simpson , Brian R. D'Urso
发明人： John T. Simpson , Brian R. D'Urso
IPC分类号： A61F13/00 , B05D5/00
CPC分类号： C09C1/3081 , C01P2004/03 , C01P2004/61 , Y10T428/25 , Y10T428/2991
摘要： A superhydrophobic powder is prepared by coating diatomaceous earth (DE) with a hydrophobic coating on the particle surface such that the coating conforms to the topography of the DE particles. The hydrophobic coating can be a self assembly monolayer of a perfluorinated silane coupling agent. The DE is preferably natural-grade DE where organic impurities have been removed. The superhydrophobic powder can be applied as a suspension in a binder solution to a substrate to produce a superhydrophobic surface on the substrate.
摘要翻译：通过在颗粒表面上涂覆疏水性涂层的硅藻土（DE）制备超疏水性粉末，使得涂层符合DE颗粒的形貌。疏水涂层可以是全氟化硅烷偶联剂的自组装单层。 DE优选为天然级DE，其中有机杂质被去除。超疏水性粉末可以作为粘合剂溶液中的悬浮液施加到基底上以在基底上产生超疏水表面。

8. 发明授权

US07258731B2 Composite, nanostructured, super-hydrophobic material 有权
标题翻译：复合，纳米结构，超疏水材料
公开(公告)号：US07258731B2
公开(公告)日：2007-08-21
申请号：US10900249
申请日：2004-07-27
申请人： Brian R. D'Urso , John T. Simpson
发明人： Brian R. D'Urso , John T. Simpson
IPC分类号： B44C1/22 , B32B5/18
CPC分类号： C03C17/30 , B05D5/083 , B05D2350/35 , B08B17/06 , B08B17/065 , B82Y30/00 , C03C11/005 , C03C15/00 , C03C2217/77 , C23F1/02 , F01D5/286 , F01D5/288 , F05D2230/90 , F05D2300/512 , Y02T50/672 , Y10T428/24364 , Y10T428/2438 , Y10T428/24479 , Y10T428/249955 , Y10T428/24996 , Y10T428/25 , Y10T428/315
摘要： A hydrophobic disordered composite material having a protrusive surface feature includes a recessive phase and a protrusive phase, the recessive phase having a higher susceptibility to a preselected etchant than the protrusive phase, the composite material having an etched surface wherein the protrusive phase protrudes from the surface to form a protrusive surface feature, the protrusive feature being hydrophobic.
摘要翻译：具有突出表面特征的疏水性无序复合材料包括隐性相和突出相，所述隐性相对于预选蚀刻剂比突出相具有更高的敏感性，所述复合材料具有蚀刻表面，其中所述突出相从所述表面突出以形成突出表面特征，突出特征是疏水性的。

9. 发明申请

US20070184247A1 Transparent, super-hydrophobic, disordered composite material 审中-公开
标题翻译：透明，超疏水，无序复合材料
公开(公告)号：US20070184247A1
公开(公告)日：2007-08-09
申请号：US11347139
申请日：2006-02-03
申请人： John T. Simpson , Brian R. D'Urso
发明人： John T. Simpson , Brian R. D'Urso
IPC分类号： B32B3/00 , B32B17/06
CPC分类号： C03C11/005 , C03B32/00 , C03C15/00 , C03C17/28 , C03C17/328 , C03C2217/76 , C03C2218/31 , Y10T428/24479
摘要： A super-hydrophobic disordered composite material having a protrusive surface feature includes a recessive phase and a protrusive phase, the recessive phase having a higher susceptibility to a preselected etchant than the protrusive phase, the composite material having an etched surface wherein the protrusive phase protrudes from the surface to form a protrusive surface feature, the protrusive feature being super-hydrophobic, the super-hydrophobic disordered composite material being transparent.
摘要翻译：具有突出表面特征的超疏水性无序复合材料包括隐性相和突出相，所述隐性相对于预选蚀刻剂比突出相具有更高的敏感性，所述复合材料具有蚀刻表面，其中所述突出相从表面形成突出表面特征，突出特征是超疏水的，超疏水性无序复合材料是透明的。

10. 发明授权

US09539149B2 Superhydrophobic, diatomaceous earth comprising bandages and method of making the same 有权
标题翻译：超疏水性，包含绷带的硅藻土及其制造方法
公开(公告)号：US09539149B2
公开(公告)日：2017-01-10
申请号：US12273823
申请日：2008-11-19
申请人： John T. Simpson , Brian R. D'Urso
发明人： John T. Simpson , Brian R. D'Urso
IPC分类号： A61F13/00 , B05D5/00 , A61F13/02 , A61L15/40 , A61L15/42 , D06M11/79 , D06M15/19 , D06M23/08 , D06M23/10
CPC分类号： A61F13/0289 , A61F13/022 , A61F2013/00255 , A61F2013/00319 , A61F2013/004 , A61F2013/00863 , A61F2013/00885 , A61F2013/00889 , A61L15/40 , A61L15/42 , D06M11/79 , D06M15/19 , D06M23/08 , D06M23/10 , D06M2200/12
摘要： A bandage comprising a substrate having a first surface with a plurality of superhydrophobic particles attached to the first surface. The plurality of superhydrophobic particles can be porous diatomaceous earth particles having a hydrophobic layer conforming to the surfaces of the DE particles, where the hydrophobic layer is bound to the DE particles. The plurality of attached superhydrophobic particles can render the first surface superhydrophobic, while a second surface opposite the first surface can be hydrophilic or hydrophobic. The substrate can be breathable in order to maintain skin health for the tissue underlying the bandage. The substrate can be selected from porous films, apertured films, textiles, nonwoven materials, impregnated composites thereof, and combinations thereof.
摘要翻译：一种绷带，包括具有附接到第一表面的多个超疏水性颗粒的第一表面的基底。多个超疏水性颗粒可以是具有与DE颗粒的表面一致的疏水层的多孔硅藻土颗粒，其中疏水层与DE颗粒结合。多个附着的超疏水颗粒可以使第一表面超疏水，而与第一表面相对的第二表面可以是亲水的或疏水的。底物可以是透气的，以便保持绷带下面的组织的皮肤健康。基材可以选自多孔膜，多孔膜，纺织品，非织造材料，其浸渍的复合材料及其组合。

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